Amino acid dipepetide frequency for Bacillus bataviensis LMG 21833

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.243AlaAla: 6.243 ± 0.089	0.616AlaCys: 0.616 ± 0.02	3.404AlaAsp: 3.404 ± 0.053	4.711AlaGlu: 4.711 ± 0.064	3.295AlaPhe: 3.295 ± 0.045	5.532AlaGly: 5.532 ± 0.07	1.237AlaHis: 1.237 ± 0.029	6.043AlaIle: 6.043 ± 0.076	4.856AlaLys: 4.856 ± 0.061	6.969AlaLeu: 6.969 ± 0.076	2.025AlaMet: 2.025 ± 0.039	2.941AlaAsn: 2.941 ± 0.041	2.229AlaPro: 2.229 ± 0.04	2.095AlaGln: 2.095 ± 0.039	2.523AlaArg: 2.523 ± 0.049	3.97AlaSer: 3.97 ± 0.054	3.305AlaThr: 3.305 ± 0.054	5.351AlaVal: 5.351 ± 0.078	0.6AlaTrp: 0.6 ± 0.02	2.189AlaTyr: 2.189 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.463CysAla: 0.463 ± 0.019	0.101CysCys: 0.101 ± 0.008	0.398CysAsp: 0.398 ± 0.017	0.485CysGlu: 0.485 ± 0.018	0.357CysPhe: 0.357 ± 0.017	0.686CysGly: 0.686 ± 0.021	0.246CysHis: 0.246 ± 0.019	0.513CysIle: 0.513 ± 0.019	0.409CysLys: 0.409 ± 0.014	0.702CysLeu: 0.702 ± 0.022	0.182CysMet: 0.182 ± 0.011	0.304CysAsn: 0.304 ± 0.015	0.361CysPro: 0.361 ± 0.016	0.235CysGln: 0.235 ± 0.013	0.294CysArg: 0.294 ± 0.016	0.512CysSer: 0.512 ± 0.019	0.372CysThr: 0.372 ± 0.018	0.423CysVal: 0.423 ± 0.016	0.082CysTrp: 0.082 ± 0.007	0.275CysTyr: 0.275 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.169AspAla: 3.169 ± 0.046	0.367AspCys: 0.367 ± 0.016	2.253AspAsp: 2.253 ± 0.041	3.883AspGlu: 3.883 ± 0.058	2.449AspPhe: 2.449 ± 0.037	3.357AspGly: 3.357 ± 0.055	1.161AspHis: 1.161 ± 0.032	3.865AspIle: 3.865 ± 0.057	3.062AspLys: 3.062 ± 0.048	5.011AspLeu: 5.011 ± 0.055	1.245AspMet: 1.245 ± 0.025	1.772AspAsn: 1.772 ± 0.034	1.982AspPro: 1.982 ± 0.038	2.067AspGln: 2.067 ± 0.034	2.125AspArg: 2.125 ± 0.038	2.538AspSer: 2.538 ± 0.038	2.323AspThr: 2.323 ± 0.037	3.587AspVal: 3.587 ± 0.05	0.648AspTrp: 0.648 ± 0.023	2.115AspTyr: 2.115 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	4.892GluAla: 4.892 ± 0.067	0.385GluCys: 0.385 ± 0.015	3.371GluAsp: 3.371 ± 0.052	6.113GluGlu: 6.113 ± 0.078	2.697GluPhe: 2.697 ± 0.04	4.094GluGly: 4.094 ± 0.057	1.443GluHis: 1.443 ± 0.031	5.757GluIle: 5.757 ± 0.061	6.818GluLys: 6.818 ± 0.071	6.875GluLeu: 6.875 ± 0.076	2.302GluMet: 2.302 ± 0.04	3.637GluAsn: 3.637 ± 0.05	1.941GluPro: 1.941 ± 0.036	3.052GluGln: 3.052 ± 0.052	3.233GluArg: 3.233 ± 0.052	3.37GluSer: 3.37 ± 0.046	3.697GluThr: 3.697 ± 0.048	4.814GluVal: 4.814 ± 0.061	0.842GluTrp: 0.842 ± 0.024	2.2GluTyr: 2.2 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.266PheAla: 3.266 ± 0.048	0.408PheCys: 0.408 ± 0.018	2.325PheAsp: 2.325 ± 0.037	2.872PheGlu: 2.872 ± 0.046	2.514PhePhe: 2.514 ± 0.048	3.519PheGly: 3.519 ± 0.055	1.059PheHis: 1.059 ± 0.027	4.093PheIle: 4.093 ± 0.06	2.621PheLys: 2.621 ± 0.042	4.949PheLeu: 4.949 ± 0.064	1.222PheMet: 1.222 ± 0.026	1.95PheAsn: 1.95 ± 0.038	1.792PhePro: 1.792 ± 0.037	1.624PheGln: 1.624 ± 0.032	1.651PheArg: 1.651 ± 0.032	3.454PheSer: 3.454 ± 0.054	2.63PheThr: 2.63 ± 0.044	3.154PheVal: 3.154 ± 0.049	0.529PheTrp: 0.529 ± 0.021	1.781PheTyr: 1.781 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.005GlyAla: 5.005 ± 0.079	0.645GlyCys: 0.645 ± 0.021	3.145GlyAsp: 3.145 ± 0.05	4.45GlyGlu: 4.45 ± 0.051	3.659GlyPhe: 3.659 ± 0.059	5.054GlyGly: 5.054 ± 0.079	1.445GlyHis: 1.445 ± 0.033	6.209GlyIle: 6.209 ± 0.07	5.466GlyLys: 5.466 ± 0.059	6.813GlyLeu: 6.813 ± 0.069	2.166GlyMet: 2.166 ± 0.04	2.909GlyAsn: 2.909 ± 0.047	1.727GlyPro: 1.727 ± 0.036	2.27GlyGln: 2.27 ± 0.042	2.62GlyArg: 2.62 ± 0.043	4.091GlySer: 4.091 ± 0.061	4.181GlyThr: 4.181 ± 0.054	5.127GlyVal: 5.127 ± 0.065	0.866GlyTrp: 0.866 ± 0.023	2.839GlyTyr: 2.839 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.237HisAla: 1.237 ± 0.031	0.22HisCys: 0.22 ± 0.012	1.066HisAsp: 1.066 ± 0.027	1.301HisGlu: 1.301 ± 0.031	1.136HisPhe: 1.136 ± 0.023	1.437HisGly: 1.437 ± 0.036	0.666HisHis: 0.666 ± 0.024	1.432HisIle: 1.432 ± 0.03	1.07HisLys: 1.07 ± 0.03	2.097HisLeu: 2.097 ± 0.037	0.491HisMet: 0.491 ± 0.017	0.785HisAsn: 0.785 ± 0.02	1.137HisPro: 1.137 ± 0.03	0.852HisGln: 0.852 ± 0.023	0.857HisArg: 0.857 ± 0.022	1.274HisSer: 1.274 ± 0.027	1.045HisThr: 1.045 ± 0.024	1.401HisVal: 1.401 ± 0.03	0.24HisTrp: 0.24 ± 0.013	0.849HisTyr: 0.849 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.084IleAla: 6.084 ± 0.067	0.678IleCys: 0.678 ± 0.023	4.223IleAsp: 4.223 ± 0.057	5.538IleGlu: 5.538 ± 0.071	3.586IlePhe: 3.586 ± 0.06	6.196IleGly: 6.196 ± 0.066	1.721IleHis: 1.721 ± 0.039	6.277IleIle: 6.277 ± 0.078	4.925IleLys: 4.925 ± 0.06	7.62IleLeu: 7.62 ± 0.091	1.924IleMet: 1.924 ± 0.04	3.494IleAsn: 3.494 ± 0.053	3.557IlePro: 3.557 ± 0.058	2.859IleGln: 2.859 ± 0.044	3.131IleArg: 3.131 ± 0.048	5.242IleSer: 5.242 ± 0.061	4.433IleThr: 4.433 ± 0.061	5.519IleVal: 5.519 ± 0.062	0.71IleTrp: 0.71 ± 0.022	2.49IleTyr: 2.49 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.82LysAla: 4.82 ± 0.065	0.331LysCys: 0.331 ± 0.016	3.865LysAsp: 3.865 ± 0.06	6.674LysGlu: 6.674 ± 0.075	2.133LysPhe: 2.133 ± 0.04	4.816LysGly: 4.816 ± 0.058	1.272LysHis: 1.272 ± 0.026	5.183LysIle: 5.183 ± 0.062	6.088LysLys: 6.088 ± 0.08	6.169LysLeu: 6.169 ± 0.069	2.332LysMet: 2.332 ± 0.039	3.661LysAsn: 3.661 ± 0.053	2.334LysPro: 2.334 ± 0.042	3.034LysGln: 3.034 ± 0.048	3.226LysArg: 3.226 ± 0.044	3.698LysSer: 3.698 ± 0.05	3.91LysThr: 3.91 ± 0.061	4.946LysVal: 4.946 ± 0.057	0.891LysTrp: 0.891 ± 0.026	2.302LysTyr: 2.302 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	7.293LeuAla: 7.293 ± 0.077	0.688LeuCys: 0.688 ± 0.018	4.686LeuAsp: 4.686 ± 0.06	6.482LeuGlu: 6.482 ± 0.075	5.084LeuPhe: 5.084 ± 0.076	6.665LeuGly: 6.665 ± 0.072	1.914LeuHis: 1.914 ± 0.039	7.536LeuIle: 7.536 ± 0.091	6.927LeuLys: 6.927 ± 0.065	10.324LeuLeu: 10.324 ± 0.111	2.539LeuMet: 2.539 ± 0.039	4.403LeuAsn: 4.403 ± 0.049	4.012LeuPro: 4.012 ± 0.059	3.448LeuGln: 3.448 ± 0.05	3.493LeuArg: 3.493 ± 0.044	6.731LeuSer: 6.731 ± 0.073	5.787LeuThr: 5.787 ± 0.069	6.384LeuVal: 6.384 ± 0.067	0.825LeuTrp: 0.825 ± 0.026	3.069LeuTyr: 3.069 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.148MetAla: 2.148 ± 0.039	0.137MetCys: 0.137 ± 0.009	1.471MetAsp: 1.471 ± 0.032	2.036MetGlu: 2.036 ± 0.039	1.119MetPhe: 1.119 ± 0.028	1.957MetGly: 1.957 ± 0.043	0.404MetHis: 0.404 ± 0.015	2.294MetIle: 2.294 ± 0.04	2.558MetLys: 2.558 ± 0.039	2.523MetLeu: 2.523 ± 0.045	0.866MetMet: 0.866 ± 0.023	1.563MetAsn: 1.563 ± 0.033	1.039MetPro: 1.039 ± 0.031	0.878MetGln: 0.878 ± 0.025	0.975MetArg: 0.975 ± 0.025	1.569MetSer: 1.569 ± 0.035	1.545MetThr: 1.545 ± 0.03	1.901MetVal: 1.901 ± 0.032	0.188MetTrp: 0.188 ± 0.012	0.734MetTyr: 0.734 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.748AsnAla: 2.748 ± 0.042	0.332AsnCys: 0.332 ± 0.015	2.157AsnAsp: 2.157 ± 0.04	3.356AsnGlu: 3.356 ± 0.053	1.841AsnPhe: 1.841 ± 0.035	3.574AsnGly: 3.574 ± 0.052	1.102AsnHis: 1.102 ± 0.026	3.384AsnIle: 3.384 ± 0.051	3.088AsnLys: 3.088 ± 0.042	4.074AsnLeu: 4.074 ± 0.052	1.222AsnMet: 1.222 ± 0.029	2.039AsnAsn: 2.039 ± 0.047	2.31AsnPro: 2.31 ± 0.038	2.098AsnGln: 2.098 ± 0.041	2.046AsnArg: 2.046 ± 0.037	2.422AsnSer: 2.422 ± 0.044	2.189AsnThr: 2.189 ± 0.043	3.003AsnVal: 3.003 ± 0.049	0.561AsnTrp: 0.561 ± 0.022	1.56AsnTyr: 1.56 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	2.401ProAla: 2.401 ± 0.045	0.219ProCys: 0.219 ± 0.013	1.965ProAsp: 1.965 ± 0.034	3.002ProGlu: 3.002 ± 0.039	2.113ProPhe: 2.113 ± 0.04	2.445ProGly: 2.445 ± 0.043	0.799ProHis: 0.799 ± 0.022	3.001ProIle: 3.001 ± 0.05	2.447ProLys: 2.447 ± 0.04	3.608ProLeu: 3.608 ± 0.05	0.883ProMet: 0.883 ± 0.025	1.801ProAsn: 1.801 ± 0.031	1.007ProPro: 1.007 ± 0.031	1.186ProGln: 1.186 ± 0.029	1.104ProArg: 1.104 ± 0.027	2.294ProSer: 2.294 ± 0.037	2.053ProThr: 2.053 ± 0.038	2.92ProVal: 2.92 ± 0.053	0.381ProTrp: 0.381 ± 0.016	1.41ProTyr: 1.41 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	2.538GlnAla: 2.538 ± 0.048	0.196GlnCys: 0.196 ± 0.012	1.563GlnAsp: 1.563 ± 0.033	2.691GlnGlu: 2.691 ± 0.042	1.701GlnPhe: 1.701 ± 0.036	2.182GlnGly: 2.182 ± 0.036	0.728GlnHis: 0.728 ± 0.019	2.685GlnIle: 2.685 ± 0.042	2.828GlnLys: 2.828 ± 0.044	3.93GlnLeu: 3.93 ± 0.055	1.13GlnMet: 1.13 ± 0.026	1.695GlnAsn: 1.695 ± 0.041	1.229GlnPro: 1.229 ± 0.031	1.666GlnGln: 1.666 ± 0.041	1.395GlnArg: 1.395 ± 0.027	2.026GlnSer: 2.026 ± 0.036	1.963GlnThr: 1.963 ± 0.037	2.374GlnVal: 2.374 ± 0.04	0.387GlnTrp: 0.387 ± 0.016	1.342GlnTyr: 1.342 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.372ArgAla: 2.372 ± 0.042	0.253ArgCys: 0.253 ± 0.014	1.987ArgAsp: 1.987 ± 0.036	3.06ArgGlu: 3.06 ± 0.047	1.872ArgPhe: 1.872 ± 0.042	2.273ArgGly: 2.273 ± 0.037	0.751ArgHis: 0.751 ± 0.023	3.114ArgIle: 3.114 ± 0.051	3.231ArgLys: 3.231 ± 0.047	3.869ArgLeu: 3.869 ± 0.049	1.23ArgMet: 1.23 ± 0.027	1.915ArgAsn: 1.915 ± 0.039	1.354ArgPro: 1.354 ± 0.035	1.388ArgGln: 1.388 ± 0.032	1.724ArgArg: 1.724 ± 0.039	2.123ArgSer: 2.123 ± 0.041	1.944ArgThr: 1.944 ± 0.036	2.596ArgVal: 2.596 ± 0.045	0.399ArgTrp: 0.399 ± 0.015	1.441ArgTyr: 1.441 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	3.858SerAla: 3.858 ± 0.054	0.46SerCys: 0.46 ± 0.02	2.651SerAsp: 2.651 ± 0.041	3.794SerGlu: 3.794 ± 0.052	3.464SerPhe: 3.464 ± 0.055	4.587SerGly: 4.587 ± 0.06	1.244SerHis: 1.244 ± 0.029	5.037SerIle: 5.037 ± 0.069	3.935SerLys: 3.935 ± 0.052	6.147SerLeu: 6.147 ± 0.062	1.712SerMet: 1.712 ± 0.037	2.496SerAsn: 2.496 ± 0.046	2.232SerPro: 2.232 ± 0.04	1.953SerGln: 1.953 ± 0.034	2.26SerArg: 2.26 ± 0.038	3.817SerSer: 3.817 ± 0.057	3.092SerThr: 3.092 ± 0.046	4.015SerVal: 4.015 ± 0.056	0.658SerTrp: 0.658 ± 0.023	2.157SerTyr: 2.157 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	4.144ThrAla: 4.144 ± 0.056	0.371ThrCys: 0.371 ± 0.014	2.535ThrAsp: 2.535 ± 0.044	3.304ThrGlu: 3.304 ± 0.049	2.673ThrPhe: 2.673 ± 0.041	4.371ThrGly: 4.371 ± 0.056	1.035ThrHis: 1.035 ± 0.027	4.764ThrIle: 4.764 ± 0.06	3.489ThrLys: 3.489 ± 0.047	5.112ThrLeu: 5.112 ± 0.057	1.335ThrMet: 1.335 ± 0.027	2.506ThrAsn: 2.506 ± 0.043	2.304ThrPro: 2.304 ± 0.043	1.356ThrGln: 1.356 ± 0.033	1.798ThrArg: 1.798 ± 0.031	3.224ThrSer: 3.224 ± 0.047	2.909ThrThr: 2.909 ± 0.044	4.151ThrVal: 4.151 ± 0.051	0.531ThrTrp: 0.531 ± 0.02	1.811ThrTyr: 1.811 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	4.794ValAla: 4.794 ± 0.062	0.58ValCys: 0.58 ± 0.019	3.535ValAsp: 3.535 ± 0.051	4.769ValGlu: 4.769 ± 0.059	3.263ValPhe: 3.263 ± 0.054	4.728ValGly: 4.728 ± 0.064	1.293ValHis: 1.293 ± 0.026	5.774ValIle: 5.774 ± 0.068	4.959ValLys: 4.959 ± 0.058	6.729ValLeu: 6.729 ± 0.07	1.937ValMet: 1.937 ± 0.033	3.256ValAsn: 3.256 ± 0.052	2.773ValPro: 2.773 ± 0.041	2.238ValGln: 2.238 ± 0.042	2.494ValArg: 2.494 ± 0.045	4.472ValSer: 4.472 ± 0.054	4.092ValThr: 4.092 ± 0.051	4.94ValVal: 4.94 ± 0.068	0.621ValTrp: 0.621 ± 0.021	2.256ValTyr: 2.256 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	0.649TrpAla: 0.649 ± 0.02	0.09TrpCys: 0.09 ± 0.008	0.534TrpAsp: 0.534 ± 0.022	0.689TrpGlu: 0.689 ± 0.023	0.558TrpPhe: 0.558 ± 0.018	0.714TrpGly: 0.714 ± 0.024	0.233TrpHis: 0.233 ± 0.014	0.814TrpIle: 0.814 ± 0.022	0.788TrpLys: 0.788 ± 0.023	1.193TrpLeu: 1.193 ± 0.033	0.346TrpMet: 0.346 ± 0.016	0.578TrpAsn: 0.578 ± 0.02	0.275TrpPro: 0.275 ± 0.014	0.375TrpGln: 0.375 ± 0.015	0.406TrpArg: 0.406 ± 0.019	0.608TrpSer: 0.608 ± 0.02	0.462TrpThr: 0.462 ± 0.018	0.682TrpVal: 0.682 ± 0.021	0.145TrpTrp: 0.145 ± 0.01	0.374TrpTyr: 0.374 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.012TyrAla: 2.012 ± 0.035	0.321TyrCys: 0.321 ± 0.013	1.847TyrAsp: 1.847 ± 0.036	2.322TyrGlu: 2.322 ± 0.041	1.898TyrPhe: 1.898 ± 0.037	2.5TyrGly: 2.5 ± 0.047	0.841TyrHis: 0.841 ± 0.022	2.428TyrIle: 2.428 ± 0.038	2.117TyrLys: 2.117 ± 0.038	3.579TyrLeu: 3.579 ± 0.048	0.815TyrMet: 0.815 ± 0.022	1.402TyrAsn: 1.402 ± 0.03	1.445TyrPro: 1.445 ± 0.033	1.577TyrGln: 1.577 ± 0.032	1.539TyrArg: 1.539 ± 0.032	2.135TyrSer: 2.135 ± 0.034	1.789TyrThr: 1.789 ± 0.038	2.214TyrVal: 2.214 ± 0.038	0.412TyrTrp: 0.412 ± 0.017	1.382TyrTyr: 1.382 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5206 proteins (1530599 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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