Amino acid dipepetide frequency for Streptococcus phage Javan517

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.973AlaAla: 3.973 ± 1.34
0.414AlaCys: 0.414 ± 0.229
4.635AlaAsp: 4.635 ± 0.63
5.628AlaGlu: 5.628 ± 0.807
2.069AlaPhe: 2.069 ± 0.355
3.642AlaGly: 3.642 ± 0.593
0.414AlaHis: 0.414 ± 0.174
5.794AlaIle: 5.794 ± 0.691
6.787AlaLys: 6.787 ± 0.706
6.87AlaLeu: 6.87 ± 0.805
1.573AlaMet: 1.573 ± 0.446
3.973AlaAsn: 3.973 ± 0.59
1.655AlaPro: 1.655 ± 0.314
3.476AlaGln: 3.476 ± 0.608
2.897AlaArg: 2.897 ± 0.462
4.138AlaSer: 4.138 ± 0.88
3.725AlaThr: 3.725 ± 0.728
3.89AlaVal: 3.89 ± 0.594
0.745AlaTrp: 0.745 ± 0.272
2.483AlaTyr: 2.483 ± 0.396
0.0AlaXaa: 0.0 ± 0.0
Cys
0.166CysAla: 0.166 ± 0.12
0.083CysCys: 0.083 ± 0.082
0.331CysAsp: 0.331 ± 0.129
0.414CysGlu: 0.414 ± 0.21
0.662CysPhe: 0.662 ± 0.215
0.248CysGly: 0.248 ± 0.153
0.166CysHis: 0.166 ± 0.156
0.331CysIle: 0.331 ± 0.204
0.828CysLys: 0.828 ± 0.252
0.993CysLeu: 0.993 ± 0.266
0.331CysMet: 0.331 ± 0.176
0.248CysAsn: 0.248 ± 0.143
0.166CysPro: 0.166 ± 0.114
0.414CysGln: 0.414 ± 0.186
0.331CysArg: 0.331 ± 0.157
0.166CysSer: 0.166 ± 0.118
0.083CysThr: 0.083 ± 0.08
0.579CysVal: 0.579 ± 0.195
0.083CysTrp: 0.083 ± 0.083
0.331CysTyr: 0.331 ± 0.157
0.0CysXaa: 0.0 ± 0.0
Asp
4.469AspAla: 4.469 ± 0.733
0.331AspCys: 0.331 ± 0.154
4.883AspAsp: 4.883 ± 0.747
5.132AspGlu: 5.132 ± 0.757
3.476AspPhe: 3.476 ± 0.457
6.208AspGly: 6.208 ± 0.662
0.91AspHis: 0.91 ± 0.261
3.725AspIle: 3.725 ± 0.486
6.042AspLys: 6.042 ± 0.713
7.284AspLeu: 7.284 ± 0.94
1.655AspMet: 1.655 ± 0.307
4.801AspAsn: 4.801 ± 0.645
1.407AspPro: 1.407 ± 0.315
1.821AspGln: 1.821 ± 0.342
2.483AspArg: 2.483 ± 0.45
2.98AspSer: 2.98 ± 0.45
3.393AspThr: 3.393 ± 0.52
5.38AspVal: 5.38 ± 0.696
0.745AspTrp: 0.745 ± 0.272
3.062AspTyr: 3.062 ± 0.545
0.0AspXaa: 0.0 ± 0.0
Glu
5.38GluAla: 5.38 ± 0.758
0.414GluCys: 0.414 ± 0.188
3.89GluAsp: 3.89 ± 0.672
6.456GluGlu: 6.456 ± 0.941
3.145GluPhe: 3.145 ± 0.508
2.897GluGly: 2.897 ± 0.506
0.828GluHis: 0.828 ± 0.262
7.035GluIle: 7.035 ± 0.999
5.877GluLys: 5.877 ± 0.765
8.277GluLeu: 8.277 ± 0.826
1.986GluMet: 1.986 ± 0.388
3.476GluAsn: 3.476 ± 0.54
1.407GluPro: 1.407 ± 0.409
2.483GluGln: 2.483 ± 0.497
3.559GluArg: 3.559 ± 0.606
4.387GluSer: 4.387 ± 0.584
4.387GluThr: 4.387 ± 0.589
4.883GluVal: 4.883 ± 0.769
0.662GluTrp: 0.662 ± 0.223
3.311GluTyr: 3.311 ± 0.566
0.0GluXaa: 0.0 ± 0.0
Phe
2.069PheAla: 2.069 ± 0.419
0.662PheCys: 0.662 ± 0.232
4.221PheAsp: 4.221 ± 0.465
2.98PheGlu: 2.98 ± 0.612
1.159PhePhe: 1.159 ± 0.401
2.317PheGly: 2.317 ± 0.493
0.248PheHis: 0.248 ± 0.128
2.483PheIle: 2.483 ± 0.48
3.393PheLys: 3.393 ± 0.583
2.566PheLeu: 2.566 ± 0.47
0.497PheMet: 0.497 ± 0.195
2.483PheAsn: 2.483 ± 0.474
0.331PhePro: 0.331 ± 0.175
0.993PheGln: 0.993 ± 0.338
2.235PheArg: 2.235 ± 0.498
2.152PheSer: 2.152 ± 0.43
2.4PheThr: 2.4 ± 0.441
2.483PheVal: 2.483 ± 0.391
0.083PheTrp: 0.083 ± 0.078
1.407PheTyr: 1.407 ± 0.298
0.0PheXaa: 0.0 ± 0.0
Gly
4.138GlyAla: 4.138 ± 0.798
0.745GlyCys: 0.745 ± 0.25
3.642GlyAsp: 3.642 ± 0.786
4.304GlyGlu: 4.304 ± 0.585
2.731GlyPhe: 2.731 ± 0.483
2.566GlyGly: 2.566 ± 0.399
1.655GlyHis: 1.655 ± 0.342
4.635GlyIle: 4.635 ± 0.748
4.966GlyLys: 4.966 ± 0.517
4.552GlyLeu: 4.552 ± 0.821
1.159GlyMet: 1.159 ± 0.29
3.311GlyAsn: 3.311 ± 0.632
0.993GlyPro: 0.993 ± 0.315
2.4GlyGln: 2.4 ± 0.511
2.317GlyArg: 2.317 ± 0.467
3.062GlySer: 3.062 ± 0.475
3.228GlyThr: 3.228 ± 0.484
5.38GlyVal: 5.38 ± 0.918
0.745GlyTrp: 0.745 ± 0.359
1.821GlyTyr: 1.821 ± 0.528
0.0GlyXaa: 0.0 ± 0.0
His
0.662HisAla: 0.662 ± 0.228
0.083HisCys: 0.083 ± 0.076
0.662HisAsp: 0.662 ± 0.256
0.828HisGlu: 0.828 ± 0.248
0.993HisPhe: 0.993 ± 0.262
1.242HisGly: 1.242 ± 0.347
0.166HisHis: 0.166 ± 0.111
0.745HisIle: 0.745 ± 0.219
0.993HisLys: 0.993 ± 0.349
1.655HisLeu: 1.655 ± 0.425
0.166HisMet: 0.166 ± 0.133
0.828HisAsn: 0.828 ± 0.215
0.414HisPro: 0.414 ± 0.177
0.579HisGln: 0.579 ± 0.231
0.662HisArg: 0.662 ± 0.229
1.159HisSer: 1.159 ± 0.342
1.324HisThr: 1.324 ± 0.318
0.745HisVal: 0.745 ± 0.284
0.083HisTrp: 0.083 ± 0.092
0.662HisTyr: 0.662 ± 0.283
0.0HisXaa: 0.0 ± 0.0
Ile
5.463IleAla: 5.463 ± 0.798
0.248IleCys: 0.248 ± 0.154
6.704IleAsp: 6.704 ± 0.811
5.545IleGlu: 5.545 ± 0.871
1.904IlePhe: 1.904 ± 0.428
3.311IleGly: 3.311 ± 0.486
0.828IleHis: 0.828 ± 0.281
4.304IleIle: 4.304 ± 0.667
8.028IleLys: 8.028 ± 0.796
4.138IleLeu: 4.138 ± 0.619
1.242IleMet: 1.242 ± 0.326
5.049IleAsn: 5.049 ± 0.673
1.738IlePro: 1.738 ± 0.363
1.655IleGln: 1.655 ± 0.337
1.904IleArg: 1.904 ± 0.482
5.297IleSer: 5.297 ± 0.692
5.214IleThr: 5.214 ± 0.58
4.469IleVal: 4.469 ± 0.746
0.579IleTrp: 0.579 ± 0.206
3.145IleTyr: 3.145 ± 0.562
0.0IleXaa: 0.0 ± 0.0
Lys
6.787LysAla: 6.787 ± 0.816
0.579LysCys: 0.579 ± 0.192
6.042LysAsp: 6.042 ± 0.685
6.373LysGlu: 6.373 ± 0.866
1.738LysPhe: 1.738 ± 0.298
4.387LysGly: 4.387 ± 0.826
1.159LysHis: 1.159 ± 0.267
6.787LysIle: 6.787 ± 0.928
8.36LysLys: 8.36 ± 0.951
6.787LysLeu: 6.787 ± 0.722
2.731LysMet: 2.731 ± 0.495
5.959LysAsn: 5.959 ± 0.632
3.062LysPro: 3.062 ± 0.602
3.973LysGln: 3.973 ± 0.638
3.725LysArg: 3.725 ± 0.562
5.38LysSer: 5.38 ± 0.613
5.628LysThr: 5.628 ± 0.734
7.118LysVal: 7.118 ± 0.838
1.324LysTrp: 1.324 ± 0.268
3.725LysTyr: 3.725 ± 0.579
0.0LysXaa: 0.0 ± 0.0
Leu
6.87LeuAla: 6.87 ± 0.795
0.248LeuCys: 0.248 ± 0.125
6.787LeuAsp: 6.787 ± 0.887
7.201LeuGlu: 7.201 ± 0.655
2.814LeuPhe: 2.814 ± 0.474
4.469LeuGly: 4.469 ± 0.621
0.745LeuHis: 0.745 ± 0.318
5.297LeuIle: 5.297 ± 0.884
8.773LeuLys: 8.773 ± 0.691
5.794LeuLeu: 5.794 ± 0.817
1.49LeuMet: 1.49 ± 0.399
5.132LeuAsn: 5.132 ± 0.561
2.152LeuPro: 2.152 ± 0.383
2.649LeuGln: 2.649 ± 0.478
3.476LeuArg: 3.476 ± 0.455
5.545LeuSer: 5.545 ± 0.661
4.304LeuThr: 4.304 ± 0.471
4.221LeuVal: 4.221 ± 0.546
0.745LeuTrp: 0.745 ± 0.233
3.145LeuTyr: 3.145 ± 0.509
0.0LeuXaa: 0.0 ± 0.0
Met
1.738MetAla: 1.738 ± 0.446
0.083MetCys: 0.083 ± 0.083
1.076MetAsp: 1.076 ± 0.311
1.49MetGlu: 1.49 ± 0.396
0.745MetPhe: 0.745 ± 0.275
1.324MetGly: 1.324 ± 0.377
0.331MetHis: 0.331 ± 0.156
1.407MetIle: 1.407 ± 0.288
1.242MetLys: 1.242 ± 0.31
1.904MetLeu: 1.904 ± 0.509
0.414MetMet: 0.414 ± 0.214
1.324MetAsn: 1.324 ± 0.348
1.076MetPro: 1.076 ± 0.285
1.324MetGln: 1.324 ± 0.446
1.904MetArg: 1.904 ± 0.348
1.655MetSer: 1.655 ± 0.399
1.821MetThr: 1.821 ± 0.334
0.828MetVal: 0.828 ± 0.285
0.166MetTrp: 0.166 ± 0.107
0.497MetTyr: 0.497 ± 0.193
0.0MetXaa: 0.0 ± 0.0
Asn
3.89AsnAla: 3.89 ± 0.644
0.497AsnCys: 0.497 ± 0.176
3.393AsnAsp: 3.393 ± 0.469
3.559AsnGlu: 3.559 ± 0.607
1.738AsnPhe: 1.738 ± 0.421
4.304AsnGly: 4.304 ± 0.612
1.159AsnHis: 1.159 ± 0.334
3.725AsnIle: 3.725 ± 0.551
4.718AsnLys: 4.718 ± 0.612
4.304AsnLeu: 4.304 ± 0.361
1.159AsnMet: 1.159 ± 0.339
3.973AsnAsn: 3.973 ± 0.714
2.152AsnPro: 2.152 ± 0.41
2.98AsnGln: 2.98 ± 0.58
2.483AsnArg: 2.483 ± 0.395
3.559AsnSer: 3.559 ± 0.665
3.393AsnThr: 3.393 ± 0.737
2.98AsnVal: 2.98 ± 0.343
0.91AsnTrp: 0.91 ± 0.335
2.069AsnTyr: 2.069 ± 0.378
0.0AsnXaa: 0.0 ± 0.0
Pro
0.993ProAla: 0.993 ± 0.305
0.166ProCys: 0.166 ± 0.096
2.152ProAsp: 2.152 ± 0.475
2.152ProGlu: 2.152 ± 0.358
1.49ProPhe: 1.49 ± 0.363
1.159ProGly: 1.159 ± 0.294
0.745ProHis: 0.745 ± 0.25
1.407ProIle: 1.407 ± 0.37
2.649ProLys: 2.649 ± 0.435
1.904ProLeu: 1.904 ± 0.476
0.579ProMet: 0.579 ± 0.19
1.242ProAsn: 1.242 ± 0.323
0.414ProPro: 0.414 ± 0.213
1.407ProGln: 1.407 ± 0.365
1.076ProArg: 1.076 ± 0.353
1.821ProSer: 1.821 ± 0.372
1.49ProThr: 1.49 ± 0.441
2.152ProVal: 2.152 ± 0.377
0.083ProTrp: 0.083 ± 0.078
1.49ProTyr: 1.49 ± 0.322
0.0ProXaa: 0.0 ± 0.0
Gln
2.98GlnAla: 2.98 ± 0.464
0.248GlnCys: 0.248 ± 0.138
1.904GlnAsp: 1.904 ± 0.443
2.98GlnGlu: 2.98 ± 0.549
1.076GlnPhe: 1.076 ± 0.255
3.145GlnGly: 3.145 ± 0.571
0.331GlnHis: 0.331 ± 0.159
2.731GlnIle: 2.731 ± 0.559
3.89GlnLys: 3.89 ± 0.726
3.145GlnLeu: 3.145 ± 0.538
0.993GlnMet: 0.993 ± 0.309
1.904GlnAsn: 1.904 ± 0.458
0.993GlnPro: 0.993 ± 0.27
1.655GlnGln: 1.655 ± 0.612
2.317GlnArg: 2.317 ± 0.46
3.393GlnSer: 3.393 ± 0.565
2.98GlnThr: 2.98 ± 0.494
1.904GlnVal: 1.904 ± 0.419
0.497GlnTrp: 0.497 ± 0.174
0.993GlnTyr: 0.993 ± 0.29
0.0GlnXaa: 0.0 ± 0.0
Arg
2.814ArgAla: 2.814 ± 0.433
0.414ArgCys: 0.414 ± 0.165
2.317ArgAsp: 2.317 ± 0.408
2.649ArgGlu: 2.649 ± 0.498
1.738ArgPhe: 1.738 ± 0.324
1.821ArgGly: 1.821 ± 0.357
0.993ArgHis: 0.993 ± 0.345
3.145ArgIle: 3.145 ± 0.407
3.725ArgLys: 3.725 ± 0.596
3.642ArgLeu: 3.642 ± 0.653
1.076ArgMet: 1.076 ± 0.259
2.069ArgAsn: 2.069 ± 0.367
0.828ArgPro: 0.828 ± 0.306
2.152ArgGln: 2.152 ± 0.417
2.4ArgArg: 2.4 ± 0.446
1.904ArgSer: 1.904 ± 0.349
2.317ArgThr: 2.317 ± 0.534
2.649ArgVal: 2.649 ± 0.563
0.579ArgTrp: 0.579 ± 0.22
2.152ArgTyr: 2.152 ± 0.576
0.0ArgXaa: 0.0 ± 0.0
Ser
4.056SerAla: 4.056 ± 0.71
0.497SerCys: 0.497 ± 0.212
4.469SerAsp: 4.469 ± 0.677
4.469SerGlu: 4.469 ± 0.524
3.062SerPhe: 3.062 ± 0.479
4.221SerGly: 4.221 ± 0.729
0.993SerHis: 0.993 ± 0.239
4.387SerIle: 4.387 ± 0.593
5.297SerLys: 5.297 ± 0.621
4.718SerLeu: 4.718 ± 0.714
1.407SerMet: 1.407 ± 0.327
3.228SerAsn: 3.228 ± 0.501
1.159SerPro: 1.159 ± 0.293
2.649SerGln: 2.649 ± 0.469
1.904SerArg: 1.904 ± 0.406
3.062SerSer: 3.062 ± 0.777
2.98SerThr: 2.98 ± 0.747
4.138SerVal: 4.138 ± 0.534
1.49SerTrp: 1.49 ± 0.33
2.317SerTyr: 2.317 ± 0.578
0.0SerXaa: 0.0 ± 0.0
Thr
4.718ThrAla: 4.718 ± 0.974
0.248ThrCys: 0.248 ± 0.126
4.552ThrAsp: 4.552 ± 0.616
3.476ThrGlu: 3.476 ± 0.515
2.317ThrPhe: 2.317 ± 0.482
3.807ThrGly: 3.807 ± 0.575
0.91ThrHis: 0.91 ± 0.258
5.049ThrIle: 5.049 ± 0.537
5.297ThrLys: 5.297 ± 0.753
4.883ThrLeu: 4.883 ± 0.645
1.407ThrMet: 1.407 ± 0.45
2.649ThrAsn: 2.649 ± 0.456
2.4ThrPro: 2.4 ± 0.381
2.731ThrGln: 2.731 ± 0.518
2.069ThrArg: 2.069 ± 0.39
3.311ThrSer: 3.311 ± 0.585
4.966ThrThr: 4.966 ± 0.777
4.138ThrVal: 4.138 ± 0.581
0.497ThrTrp: 0.497 ± 0.184
2.235ThrTyr: 2.235 ± 0.496
0.0ThrXaa: 0.0 ± 0.0
Val
4.718ValAla: 4.718 ± 0.564
0.331ValCys: 0.331 ± 0.198
4.801ValAsp: 4.801 ± 0.579
6.208ValGlu: 6.208 ± 0.893
2.4ValPhe: 2.4 ± 0.651
4.635ValGly: 4.635 ± 0.643
0.745ValHis: 0.745 ± 0.269
4.635ValIle: 4.635 ± 0.508
5.628ValLys: 5.628 ± 0.732
4.304ValLeu: 4.304 ± 0.751
1.821ValMet: 1.821 ± 0.365
3.393ValAsn: 3.393 ± 0.502
1.904ValPro: 1.904 ± 0.489
1.738ValGln: 1.738 ± 0.329
2.152ValArg: 2.152 ± 0.362
4.469ValSer: 4.469 ± 0.455
4.221ValThr: 4.221 ± 0.537
4.304ValVal: 4.304 ± 0.554
0.662ValTrp: 0.662 ± 0.238
2.317ValTyr: 2.317 ± 0.523
0.0ValXaa: 0.0 ± 0.0
Trp
0.414TrpAla: 0.414 ± 0.174
0.166TrpCys: 0.166 ± 0.119
0.91TrpAsp: 0.91 ± 0.225
0.662TrpGlu: 0.662 ± 0.251
0.662TrpPhe: 0.662 ± 0.254
0.662TrpGly: 0.662 ± 0.316
0.083TrpHis: 0.083 ± 0.088
0.745TrpIle: 0.745 ± 0.185
1.242TrpLys: 1.242 ± 0.29
0.91TrpLeu: 0.91 ± 0.283
0.166TrpMet: 0.166 ± 0.113
0.414TrpAsn: 0.414 ± 0.17
0.331TrpPro: 0.331 ± 0.165
0.828TrpGln: 0.828 ± 0.236
0.579TrpArg: 0.579 ± 0.226
0.579TrpSer: 0.579 ± 0.2
0.662TrpThr: 0.662 ± 0.337
0.745TrpVal: 0.745 ± 0.221
0.0TrpTrp: 0.0 ± 0.0
0.331TrpTyr: 0.331 ± 0.183
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.483TyrAla: 2.483 ± 0.501
0.497TyrCys: 0.497 ± 0.183
2.814TyrAsp: 2.814 ± 0.531
2.235TyrGlu: 2.235 ± 0.365
1.242TyrPhe: 1.242 ± 0.386
1.986TyrGly: 1.986 ± 0.417
1.242TyrHis: 1.242 ± 0.429
2.4TyrIle: 2.4 ± 0.37
3.89TyrLys: 3.89 ± 0.723
3.228TyrLeu: 3.228 ± 0.507
0.414TyrMet: 0.414 ± 0.179
1.49TyrAsn: 1.49 ± 0.358
1.986TyrPro: 1.986 ± 0.436
2.152TyrGln: 2.152 ± 0.45
0.993TyrArg: 0.993 ± 0.293
2.483TyrSer: 2.483 ± 0.503
3.145TyrThr: 3.145 ± 0.619
2.4TyrVal: 2.4 ± 0.5
0.414TyrTrp: 0.414 ± 0.167
1.49TyrTyr: 1.49 ± 0.331
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 61 proteins (12083 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski