Amino acid dipepetide frequency for Bergeyella cardium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.793AlaAla: 3.793 ± 0.118
0.551AlaCys: 0.551 ± 0.032
3.597AlaAsp: 3.597 ± 0.092
5.03AlaGlu: 5.03 ± 0.128
3.409AlaPhe: 3.409 ± 0.094
4.387AlaGly: 4.387 ± 0.091
1.251AlaHis: 1.251 ± 0.05
4.85AlaIle: 4.85 ± 0.1
5.296AlaLys: 5.296 ± 0.107
6.459AlaLeu: 6.459 ± 0.121
1.623AlaMet: 1.623 ± 0.054
3.2AlaAsn: 3.2 ± 0.076
1.947AlaPro: 1.947 ± 0.065
2.839AlaGln: 2.839 ± 0.075
2.129AlaArg: 2.129 ± 0.062
3.949AlaSer: 3.949 ± 0.096
3.317AlaThr: 3.317 ± 0.081
4.245AlaVal: 4.245 ± 0.111
0.501AlaTrp: 0.501 ± 0.033
2.573AlaTyr: 2.573 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
0.435CysAla: 0.435 ± 0.03
0.095CysCys: 0.095 ± 0.016
0.333CysAsp: 0.333 ± 0.021
0.449CysGlu: 0.449 ± 0.026
0.384CysPhe: 0.384 ± 0.03
0.571CysGly: 0.571 ± 0.034
0.168CysHis: 0.168 ± 0.02
0.632CysIle: 0.632 ± 0.032
0.455CysLys: 0.455 ± 0.028
0.591CysLeu: 0.591 ± 0.033
0.119CysMet: 0.119 ± 0.016
0.355CysAsn: 0.355 ± 0.026
0.325CysPro: 0.325 ± 0.032
0.185CysGln: 0.185 ± 0.019
0.25CysArg: 0.25 ± 0.021
0.511CysSer: 0.511 ± 0.032
0.399CysThr: 0.399 ± 0.027
0.37CysVal: 0.37 ± 0.025
0.054CysTrp: 0.054 ± 0.01
0.296CysTyr: 0.296 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
3.49AspAla: 3.49 ± 0.093
0.387AspCys: 0.387 ± 0.027
2.547AspAsp: 2.547 ± 0.069
4.299AspGlu: 4.299 ± 0.102
3.905AspPhe: 3.905 ± 0.079
3.308AspGly: 3.308 ± 0.072
0.732AspHis: 0.732 ± 0.037
4.533AspIle: 4.533 ± 0.089
4.579AspLys: 4.579 ± 0.089
4.742AspLeu: 4.742 ± 0.097
1.059AspMet: 1.059 ± 0.043
2.615AspAsn: 2.615 ± 0.077
1.538AspPro: 1.538 ± 0.058
1.065AspGln: 1.065 ± 0.044
1.949AspArg: 1.949 ± 0.054
2.763AspSer: 2.763 ± 0.073
2.515AspThr: 2.515 ± 0.063
2.865AspVal: 2.865 ± 0.074
0.695AspTrp: 0.695 ± 0.032
3.004AspTyr: 3.004 ± 0.073
0.0AspXaa: 0.0 ± 0.0
Glu
4.715GluAla: 4.715 ± 0.116
0.316GluCys: 0.316 ± 0.02
3.509GluAsp: 3.509 ± 0.082
5.679GluGlu: 5.679 ± 0.13
2.833GluPhe: 2.833 ± 0.073
4.139GluGly: 4.139 ± 0.092
1.244GluHis: 1.244 ± 0.043
6.199GluIle: 6.199 ± 0.111
6.81GluLys: 6.81 ± 0.132
6.053GluLeu: 6.053 ± 0.119
1.633GluMet: 1.633 ± 0.05
4.673GluAsn: 4.673 ± 0.093
1.723GluPro: 1.723 ± 0.057
2.749GluGln: 2.749 ± 0.069
3.053GluArg: 3.053 ± 0.073
3.159GluSer: 3.159 ± 0.072
3.533GluThr: 3.533 ± 0.086
4.85GluVal: 4.85 ± 0.088
0.664GluTrp: 0.664 ± 0.032
2.748GluTyr: 2.748 ± 0.069
0.0GluXaa: 0.0 ± 0.0
Phe
3.009PheAla: 3.009 ± 0.076
0.43PheCys: 0.43 ± 0.031
2.817PheAsp: 2.817 ± 0.081
2.972PheGlu: 2.972 ± 0.07
2.77PhePhe: 2.77 ± 0.084
3.687PheGly: 3.687 ± 0.08
0.836PheHis: 0.836 ± 0.038
4.425PheIle: 4.425 ± 0.099
3.492PheLys: 3.492 ± 0.077
4.562PheLeu: 4.562 ± 0.111
1.138PheMet: 1.138 ± 0.042
3.138PheAsn: 3.138 ± 0.082
1.803PhePro: 1.803 ± 0.056
1.682PheGln: 1.682 ± 0.061
1.879PheArg: 1.879 ± 0.053
4.477PheSer: 4.477 ± 0.104
2.557PheThr: 2.557 ± 0.068
3.009PheVal: 3.009 ± 0.069
0.568PheTrp: 0.568 ± 0.038
2.285PheTyr: 2.285 ± 0.07
0.0PheXaa: 0.0 ± 0.0
Gly
4.489GlyAla: 4.489 ± 0.114
0.54GlyCys: 0.54 ± 0.036
3.189GlyAsp: 3.189 ± 0.075
4.076GlyGlu: 4.076 ± 0.088
3.572GlyPhe: 3.572 ± 0.084
4.578GlyGly: 4.578 ± 0.113
1.05GlyHis: 1.05 ± 0.04
5.443GlyIle: 5.443 ± 0.091
5.844GlyLys: 5.844 ± 0.1
5.689GlyLeu: 5.689 ± 0.096
1.463GlyMet: 1.463 ± 0.051
3.511GlyAsn: 3.511 ± 0.091
0.902GlyPro: 0.902 ± 0.041
1.81GlyGln: 1.81 ± 0.058
2.46GlyArg: 2.46 ± 0.062
3.881GlySer: 3.881 ± 0.096
3.495GlyThr: 3.495 ± 0.092
4.481GlyVal: 4.481 ± 0.1
0.737GlyTrp: 0.737 ± 0.036
2.793GlyTyr: 2.793 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
0.778HisAla: 0.778 ± 0.037
0.197HisCys: 0.197 ± 0.02
0.547HisAsp: 0.547 ± 0.031
0.698HisGlu: 0.698 ± 0.035
1.179HisPhe: 1.179 ± 0.044
0.902HisGly: 0.902 ± 0.043
0.569HisHis: 0.569 ± 0.037
1.555HisIle: 1.555 ± 0.049
1.347HisLys: 1.347 ± 0.051
2.116HisLeu: 2.116 ± 0.067
0.268HisMet: 0.268 ± 0.022
0.987HisAsn: 0.987 ± 0.042
0.938HisPro: 0.938 ± 0.04
0.889HisGln: 0.889 ± 0.043
0.819HisArg: 0.819 ± 0.041
1.329HisSer: 1.329 ± 0.045
1.101HisThr: 1.101 ± 0.043
0.233HisVal: 0.233 ± 0.02
0.234HisTrp: 0.234 ± 0.02
0.911HisTyr: 0.911 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
5.427IleAla: 5.427 ± 0.117
0.586IleCys: 0.586 ± 0.033
4.763IleAsp: 4.763 ± 0.094
5.281IleGlu: 5.281 ± 0.106
3.917IlePhe: 3.917 ± 0.086
5.084IleGly: 5.084 ± 0.112
1.415IleHis: 1.415 ± 0.048
6.688IleIle: 6.688 ± 0.139
6.292IleLys: 6.292 ± 0.11
7.342IleLeu: 7.342 ± 0.119
1.373IleMet: 1.373 ± 0.054
4.782IleAsn: 4.782 ± 0.104
3.381IlePro: 3.381 ± 0.077
2.649IleGln: 2.649 ± 0.067
2.867IleArg: 2.867 ± 0.074
6.688IleSer: 6.688 ± 0.111
4.391IleThr: 4.391 ± 0.097
4.17IleVal: 4.17 ± 0.108
0.581IleTrp: 0.581 ± 0.029
3.014IleTyr: 3.014 ± 0.072
0.0IleXaa: 0.0 ± 0.0
Lys
5.512LysAla: 5.512 ± 0.107
0.374LysCys: 0.374 ± 0.024
4.838LysAsp: 4.838 ± 0.084
6.775LysGlu: 6.775 ± 0.132
3.184LysPhe: 3.184 ± 0.083
4.996LysGly: 4.996 ± 0.095
1.356LysHis: 1.356 ± 0.046
7.149LysIle: 7.149 ± 0.125
7.398LysLys: 7.398 ± 0.153
6.396LysLeu: 6.396 ± 0.113
2.228LysMet: 2.228 ± 0.056
5.563LysAsn: 5.563 ± 0.112
2.635LysPro: 2.635 ± 0.067
2.955LysGln: 2.955 ± 0.076
3.059LysArg: 3.059 ± 0.084
4.703LysSer: 4.703 ± 0.097
4.709LysThr: 4.709 ± 0.088
5.053LysVal: 5.053 ± 0.09
0.753LysTrp: 0.753 ± 0.032
3.473LysTyr: 3.473 ± 0.078
0.0LysXaa: 0.0 ± 0.0
Leu
5.922LeuAla: 5.922 ± 0.109
0.661LeuCys: 0.661 ± 0.037
4.556LeuAsp: 4.556 ± 0.102
5.815LeuGlu: 5.815 ± 0.124
4.576LeuPhe: 4.576 ± 0.11
6.061LeuGly: 6.061 ± 0.107
1.657LeuHis: 1.657 ± 0.06
6.936LeuIle: 6.936 ± 0.144
7.779LeuLys: 7.779 ± 0.131
8.34LeuLeu: 8.34 ± 0.158
2.292LeuMet: 2.292 ± 0.06
5.279LeuAsn: 5.279 ± 0.108
3.825LeuPro: 3.825 ± 0.088
3.32LeuGln: 3.32 ± 0.089
3.599LeuArg: 3.599 ± 0.086
8.002LeuSer: 8.002 ± 0.136
4.46LeuThr: 4.46 ± 0.093
4.919LeuVal: 4.919 ± 0.101
0.816LeuTrp: 0.816 ± 0.036
3.444LeuTyr: 3.444 ± 0.081
0.0LeuXaa: 0.0 ± 0.0
Met
1.529MetAla: 1.529 ± 0.059
0.102MetCys: 0.102 ± 0.014
1.089MetAsp: 1.089 ± 0.05
1.497MetGlu: 1.497 ± 0.055
0.921MetPhe: 0.921 ± 0.054
1.48MetGly: 1.48 ± 0.055
0.308MetHis: 0.308 ± 0.023
1.624MetIle: 1.624 ± 0.057
2.457MetLys: 2.457 ± 0.057
2.024MetLeu: 2.024 ± 0.063
0.697MetMet: 0.697 ± 0.043
1.405MetAsn: 1.405 ± 0.048
0.839MetPro: 0.839 ± 0.041
0.824MetGln: 0.824 ± 0.039
0.873MetArg: 0.873 ± 0.043
1.392MetSer: 1.392 ± 0.049
1.062MetThr: 1.062 ± 0.033
1.244MetVal: 1.244 ± 0.052
0.146MetTrp: 0.146 ± 0.015
0.624MetTyr: 0.624 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.784AsnAla: 3.784 ± 0.079
0.391AsnCys: 0.391 ± 0.025
2.746AsnAsp: 2.746 ± 0.064
3.609AsnGlu: 3.609 ± 0.087
3.045AsnPhe: 3.045 ± 0.08
3.662AsnGly: 3.662 ± 0.087
1.05AsnHis: 1.05 ± 0.037
5.167AsnIle: 5.167 ± 0.099
4.19AsnLys: 4.19 ± 0.093
5.621AsnLeu: 5.621 ± 0.109
1.184AsnMet: 1.184 ± 0.057
3.152AsnAsn: 3.152 ± 0.102
2.863AsnPro: 2.863 ± 0.074
2.07AsnGln: 2.07 ± 0.054
2.161AsnArg: 2.161 ± 0.07
3.239AsnSer: 3.239 ± 0.081
3.381AsnThr: 3.381 ± 0.088
2.739AsnVal: 2.739 ± 0.076
0.68AsnTrp: 0.68 ± 0.043
2.532AsnTyr: 2.532 ± 0.061
0.0AsnXaa: 0.0 ± 0.0
Pro
2.153ProAla: 2.153 ± 0.062
0.234ProCys: 0.234 ± 0.019
1.893ProAsp: 1.893 ± 0.054
3.025ProGlu: 3.025 ± 0.074
1.806ProPhe: 1.806 ± 0.057
1.512ProGly: 1.512 ± 0.057
0.739ProHis: 0.739 ± 0.038
2.53ProIle: 2.53 ± 0.067
3.057ProLys: 3.057 ± 0.072
3.038ProLeu: 3.038 ± 0.076
0.754ProMet: 0.754 ± 0.041
2.175ProAsn: 2.175 ± 0.058
0.946ProPro: 0.946 ± 0.047
1.505ProGln: 1.505 ± 0.051
1.004ProArg: 1.004 ± 0.038
2.449ProSer: 2.449 ± 0.062
1.99ProThr: 1.99 ± 0.066
2.35ProVal: 2.35 ± 0.066
0.253ProTrp: 0.253 ± 0.023
1.539ProTyr: 1.539 ± 0.059
0.0ProXaa: 0.0 ± 0.0
Gln
2.083GlnAla: 2.083 ± 0.065
0.165GlnCys: 0.165 ± 0.017
1.616GlnAsp: 1.616 ± 0.053
2.658GlnGlu: 2.658 ± 0.071
1.517GlnPhe: 1.517 ± 0.05
2.039GlnGly: 2.039 ± 0.062
0.554GlnHis: 0.554 ± 0.031
2.771GlnIle: 2.771 ± 0.07
3.614GlnLys: 3.614 ± 0.082
3.269GlnLeu: 3.269 ± 0.084
0.948GlnMet: 0.948 ± 0.041
2.411GlnAsn: 2.411 ± 0.068
1.285GlnPro: 1.285 ± 0.055
1.546GlnGln: 1.546 ± 0.064
1.489GlnArg: 1.489 ± 0.057
2.19GlnSer: 2.19 ± 0.061
1.997GlnThr: 1.997 ± 0.063
1.952GlnVal: 1.952 ± 0.06
0.406GlnTrp: 0.406 ± 0.027
1.494GlnTyr: 1.494 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
2.391ArgAla: 2.391 ± 0.066
0.216ArgCys: 0.216 ± 0.02
1.873ArgAsp: 1.873 ± 0.06
2.916ArgGlu: 2.916 ± 0.079
1.952ArgPhe: 1.952 ± 0.058
2.129ArgGly: 2.129 ± 0.059
0.615ArgHis: 0.615 ± 0.038
3.093ArgIle: 3.093 ± 0.07
3.291ArgLys: 3.291 ± 0.083
3.59ArgLeu: 3.59 ± 0.08
0.979ArgMet: 0.979 ± 0.046
2.241ArgAsn: 2.241 ± 0.068
1.172ArgPro: 1.172 ± 0.048
1.327ArgGln: 1.327 ± 0.046
1.558ArgArg: 1.558 ± 0.056
1.803ArgSer: 1.803 ± 0.063
1.893ArgThr: 1.893 ± 0.057
2.117ArgVal: 2.117 ± 0.07
0.384ArgTrp: 0.384 ± 0.025
1.664ArgTyr: 1.664 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
4.44SerAla: 4.44 ± 0.102
0.583SerCys: 0.583 ± 0.035
3.234SerAsp: 3.234 ± 0.069
4.294SerGlu: 4.294 ± 0.092
3.925SerPhe: 3.925 ± 0.106
4.737SerGly: 4.737 ± 0.101
1.077SerHis: 1.077 ± 0.041
5.217SerIle: 5.217 ± 0.105
4.783SerLys: 4.783 ± 0.089
6.766SerLeu: 6.766 ± 0.124
1.225SerMet: 1.225 ± 0.05
3.108SerAsn: 3.108 ± 0.084
2.503SerPro: 2.503 ± 0.065
2.447SerGln: 2.447 ± 0.067
2.248SerArg: 2.248 ± 0.062
4.307SerSer: 4.307 ± 0.11
3.443SerThr: 3.443 ± 0.09
4.272SerVal: 4.272 ± 0.095
0.636SerTrp: 0.636 ± 0.033
2.7SerTyr: 2.7 ± 0.073
0.0SerXaa: 0.0 ± 0.0
Thr
3.799ThrAla: 3.799 ± 0.085
0.267ThrCys: 0.267 ± 0.024
3.256ThrAsp: 3.256 ± 0.09
3.733ThrGlu: 3.733 ± 0.079
2.466ThrPhe: 2.466 ± 0.065
3.65ThrGly: 3.65 ± 0.079
1.14ThrHis: 1.14 ± 0.047
3.779ThrIle: 3.779 ± 0.074
3.844ThrLys: 3.844 ± 0.077
5.115ThrLeu: 5.115 ± 0.101
0.897ThrMet: 0.897 ± 0.042
2.63ThrAsn: 2.63 ± 0.066
2.566ThrPro: 2.566 ± 0.069
2.071ThrGln: 2.071 ± 0.06
1.602ThrArg: 1.602 ± 0.053
3.417ThrSer: 3.417 ± 0.081
2.926ThrThr: 2.926 ± 0.075
2.982ThrVal: 2.982 ± 0.083
0.398ThrTrp: 0.398 ± 0.031
2.194ThrTyr: 2.194 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
3.978ValAla: 3.978 ± 0.1
0.471ValCys: 0.471 ± 0.025
3.171ValAsp: 3.171 ± 0.067
4.216ValGlu: 4.216 ± 0.095
3.254ValPhe: 3.254 ± 0.071
3.823ValGly: 3.823 ± 0.094
0.782ValHis: 0.782 ± 0.04
4.246ValIle: 4.246 ± 0.093
4.449ValLys: 4.449 ± 0.105
5.704ValLeu: 5.704 ± 0.104
1.317ValMet: 1.317 ± 0.051
2.822ValAsn: 2.822 ± 0.076
2.041ValPro: 2.041 ± 0.065
1.952ValGln: 1.952 ± 0.061
2.053ValArg: 2.053 ± 0.064
4.274ValSer: 4.274 ± 0.089
2.59ValThr: 2.59 ± 0.07
3.793ValVal: 3.793 ± 0.099
0.527ValTrp: 0.527 ± 0.03
2.415ValTyr: 2.415 ± 0.062
0.0ValXaa: 0.0 ± 0.0
Trp
0.671TrpAla: 0.671 ± 0.035
0.078TrpCys: 0.078 ± 0.012
0.571TrpAsp: 0.571 ± 0.034
0.76TrpGlu: 0.76 ± 0.033
0.483TrpPhe: 0.483 ± 0.025
0.624TrpGly: 0.624 ± 0.039
0.163TrpHis: 0.163 ± 0.015
0.634TrpIle: 0.634 ± 0.035
0.87TrpLys: 0.87 ± 0.039
0.946TrpLeu: 0.946 ± 0.038
0.251TrpMet: 0.251 ± 0.019
0.622TrpAsn: 0.622 ± 0.036
0.153TrpPro: 0.153 ± 0.015
0.374TrpGln: 0.374 ± 0.024
0.352TrpArg: 0.352 ± 0.024
0.54TrpSer: 0.54 ± 0.032
0.411TrpThr: 0.411 ± 0.028
0.607TrpVal: 0.607 ± 0.038
0.124TrpTrp: 0.124 ± 0.015
0.411TrpTyr: 0.411 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.545TyrAla: 2.545 ± 0.072
0.335TyrCys: 0.335 ± 0.024
2.449TyrAsp: 2.449 ± 0.073
2.501TyrGlu: 2.501 ± 0.062
2.442TyrPhe: 2.442 ± 0.071
2.634TyrGly: 2.634 ± 0.067
0.892TyrHis: 0.892 ± 0.044
3.222TyrIle: 3.222 ± 0.082
3.259TyrLys: 3.259 ± 0.077
3.895TyrLeu: 3.895 ± 0.078
0.686TyrMet: 0.686 ± 0.03
2.596TyrAsn: 2.596 ± 0.08
1.568TyrPro: 1.568 ± 0.05
1.743TyrGln: 1.743 ± 0.055
1.799TyrArg: 1.799 ± 0.049
2.872TyrSer: 2.872 ± 0.065
2.562TyrThr: 2.562 ± 0.081
1.624TyrVal: 1.624 ± 0.057
0.488TyrTrp: 0.488 ± 0.031
2.129TyrTyr: 2.129 ± 0.084
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1779 proteins (588511 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski