Amino acid dipepetide frequency for Streptococcus satellite phage Javan217

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.444AlaAla: 0.444 ± 0.425
0.0AlaCys: 0.0 ± 0.0
7.542AlaAsp: 7.542 ± 2.341
3.993AlaGlu: 3.993 ± 1.355
3.106AlaPhe: 3.106 ± 0.979
2.218AlaGly: 2.218 ± 1.082
0.0AlaHis: 0.0 ± 0.0
3.993AlaIle: 3.993 ± 1.839
3.549AlaLys: 3.549 ± 1.262
3.549AlaLeu: 3.549 ± 1.191
1.775AlaMet: 1.775 ± 0.895
0.887AlaAsn: 0.887 ± 0.522
0.887AlaPro: 0.887 ± 0.493
1.331AlaGln: 1.331 ± 0.564
2.218AlaArg: 2.218 ± 0.903
3.993AlaSer: 3.993 ± 1.076
3.106AlaThr: 3.106 ± 1.302
2.662AlaVal: 2.662 ± 0.917
0.0AlaTrp: 0.0 ± 0.0
3.993AlaTyr: 3.993 ± 0.875
0.0AlaXaa: 0.0 ± 0.0
Cys
0.444CysAla: 0.444 ± 0.425
0.0CysCys: 0.0 ± 0.0
0.887CysAsp: 0.887 ± 0.516
0.0CysGlu: 0.0 ± 0.0
0.444CysPhe: 0.444 ± 0.365
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.444CysIle: 0.444 ± 0.491
0.444CysLys: 0.444 ± 0.548
0.887CysLeu: 0.887 ± 0.502
0.444CysMet: 0.444 ± 0.365
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.444CysTyr: 0.444 ± 0.365
0.0CysXaa: 0.0 ± 0.0
Asp
1.331AspAla: 1.331 ± 0.483
1.331AspCys: 1.331 ± 0.754
6.211AspAsp: 6.211 ± 1.209
3.549AspGlu: 3.549 ± 1.057
2.218AspPhe: 2.218 ± 0.972
3.106AspGly: 3.106 ± 1.078
0.887AspHis: 0.887 ± 0.707
4.437AspIle: 4.437 ± 1.518
4.437AspLys: 4.437 ± 1.601
6.211AspLeu: 6.211 ± 1.015
2.662AspMet: 2.662 ± 0.78
7.986AspAsn: 7.986 ± 1.003
1.775AspPro: 1.775 ± 0.686
0.887AspGln: 0.887 ± 0.699
3.106AspArg: 3.106 ± 0.972
2.662AspSer: 2.662 ± 0.94
4.437AspThr: 4.437 ± 1.334
4.437AspVal: 4.437 ± 1.215
0.0AspTrp: 0.0 ± 0.0
3.549AspTyr: 3.549 ± 0.937
0.0AspXaa: 0.0 ± 0.0
Glu
4.437GluAla: 4.437 ± 1.392
0.887GluCys: 0.887 ± 0.588
2.218GluAsp: 2.218 ± 0.806
5.768GluGlu: 5.768 ± 1.86
3.993GluPhe: 3.993 ± 0.935
0.887GluGly: 0.887 ± 0.699
1.775GluHis: 1.775 ± 0.995
5.768GluIle: 5.768 ± 1.805
10.204GluLys: 10.204 ± 2.085
14.641GluLeu: 14.641 ± 3.844
2.662GluMet: 2.662 ± 0.977
5.324GluAsn: 5.324 ± 1.76
1.775GluPro: 1.775 ± 0.886
4.437GluGln: 4.437 ± 1.394
3.993GluArg: 3.993 ± 1.544
0.887GluSer: 0.887 ± 0.692
3.549GluThr: 3.549 ± 1.354
4.88GluVal: 4.88 ± 1.733
1.775GluTrp: 1.775 ± 0.707
3.106GluTyr: 3.106 ± 1.368
0.0GluXaa: 0.0 ± 0.0
Phe
0.887PheAla: 0.887 ± 0.851
0.0PheCys: 0.0 ± 0.0
2.218PheAsp: 2.218 ± 0.75
2.662PheGlu: 2.662 ± 0.845
3.106PhePhe: 3.106 ± 0.77
2.218PheGly: 2.218 ± 0.759
0.444PheHis: 0.444 ± 0.365
1.775PheIle: 1.775 ± 0.763
7.098PheLys: 7.098 ± 1.417
2.218PheLeu: 2.218 ± 1.039
1.331PheMet: 1.331 ± 0.568
1.775PheAsn: 1.775 ± 1.058
0.887PhePro: 0.887 ± 0.588
0.0PheGln: 0.0 ± 0.0
2.662PheArg: 2.662 ± 0.701
3.549PheSer: 3.549 ± 0.839
1.331PheThr: 1.331 ± 0.54
1.775PheVal: 1.775 ± 0.579
0.0PheTrp: 0.0 ± 0.0
1.331PheTyr: 1.331 ± 0.752
0.0PheXaa: 0.0 ± 0.0
Gly
1.775GlyAla: 1.775 ± 0.779
0.0GlyCys: 0.0 ± 0.0
2.218GlyAsp: 2.218 ± 0.685
0.887GlyGlu: 0.887 ± 0.569
2.662GlyPhe: 2.662 ± 0.672
0.444GlyGly: 0.444 ± 0.425
0.887GlyHis: 0.887 ± 0.411
3.993GlyIle: 3.993 ± 0.891
5.324GlyLys: 5.324 ± 1.454
6.211GlyLeu: 6.211 ± 1.993
0.0GlyMet: 0.0 ± 0.0
2.218GlyAsn: 2.218 ± 1.076
0.0GlyPro: 0.0 ± 0.0
0.444GlyGln: 0.444 ± 0.35
0.887GlyArg: 0.887 ± 0.541
2.662GlySer: 2.662 ± 0.9
3.993GlyThr: 3.993 ± 0.924
3.993GlyVal: 3.993 ± 0.943
0.444GlyTrp: 0.444 ± 0.37
4.437GlyTyr: 4.437 ± 1.307
0.0GlyXaa: 0.0 ± 0.0
His
3.106HisAla: 3.106 ± 0.991
0.0HisCys: 0.0 ± 0.0
0.887HisAsp: 0.887 ± 0.666
0.887HisGlu: 0.887 ± 0.612
0.887HisPhe: 0.887 ± 0.569
0.444HisGly: 0.444 ± 0.425
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
1.775HisLys: 1.775 ± 0.805
2.218HisLeu: 2.218 ± 0.68
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
0.887HisArg: 0.887 ± 0.597
0.887HisSer: 0.887 ± 0.522
1.775HisThr: 1.775 ± 0.77
1.775HisVal: 1.775 ± 0.804
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
7.542IleAla: 7.542 ± 1.486
0.444IleCys: 0.444 ± 0.548
4.437IleAsp: 4.437 ± 1.003
4.88IleGlu: 4.88 ± 1.424
1.331IlePhe: 1.331 ± 0.673
2.218IleGly: 2.218 ± 0.692
0.0IleHis: 0.0 ± 0.0
4.437IleIle: 4.437 ± 1.074
6.211IleLys: 6.211 ± 1.614
3.106IleLeu: 3.106 ± 0.956
1.775IleMet: 1.775 ± 0.808
4.88IleAsn: 4.88 ± 1.203
1.331IlePro: 1.331 ± 0.722
3.993IleGln: 3.993 ± 1.35
4.88IleArg: 4.88 ± 2.091
3.993IleSer: 3.993 ± 0.782
3.549IleThr: 3.549 ± 0.945
3.106IleVal: 3.106 ± 0.92
0.887IleTrp: 0.887 ± 0.565
3.993IleTyr: 3.993 ± 1.16
0.0IleXaa: 0.0 ± 0.0
Lys
5.324LysAla: 5.324 ± 1.247
0.0LysCys: 0.0 ± 0.0
8.429LysAsp: 8.429 ± 1.068
11.535LysGlu: 11.535 ± 2.325
1.775LysPhe: 1.775 ± 1.224
3.993LysGly: 3.993 ± 1.07
3.549LysHis: 3.549 ± 0.959
6.655LysIle: 6.655 ± 1.583
6.211LysLys: 6.211 ± 1.555
11.979LysLeu: 11.979 ± 2.269
2.662LysMet: 2.662 ± 0.842
5.768LysAsn: 5.768 ± 1.7
2.218LysPro: 2.218 ± 1.334
4.88LysGln: 4.88 ± 1.183
3.993LysArg: 3.993 ± 1.21
3.993LysSer: 3.993 ± 1.063
5.768LysThr: 5.768 ± 1.972
7.542LysVal: 7.542 ± 1.277
0.444LysTrp: 0.444 ± 0.425
3.993LysTyr: 3.993 ± 1.003
0.0LysXaa: 0.0 ± 0.0
Leu
3.993LeuAla: 3.993 ± 1.011
0.0LeuCys: 0.0 ± 0.0
5.768LeuAsp: 5.768 ± 1.583
11.979LeuGlu: 11.979 ± 2.949
2.662LeuPhe: 2.662 ± 0.996
5.324LeuGly: 5.324 ± 1.595
0.444LeuHis: 0.444 ± 0.454
4.88LeuIle: 4.88 ± 1.464
9.76LeuLys: 9.76 ± 1.57
10.204LeuLeu: 10.204 ± 1.998
3.993LeuMet: 3.993 ± 0.888
9.76LeuAsn: 9.76 ± 2.556
3.549LeuPro: 3.549 ± 1.135
3.106LeuGln: 3.106 ± 1.766
3.549LeuArg: 3.549 ± 1.18
7.542LeuSer: 7.542 ± 1.651
6.211LeuThr: 6.211 ± 0.987
7.098LeuVal: 7.098 ± 2.074
1.331LeuTrp: 1.331 ± 0.483
3.993LeuTyr: 3.993 ± 1.041
0.0LeuXaa: 0.0 ± 0.0
Met
3.106MetAla: 3.106 ± 0.777
0.0MetCys: 0.0 ± 0.0
1.331MetAsp: 1.331 ± 0.466
2.218MetGlu: 2.218 ± 0.857
0.444MetPhe: 0.444 ± 0.35
0.887MetGly: 0.887 ± 0.789
0.0MetHis: 0.0 ± 0.0
2.218MetIle: 2.218 ± 1.117
1.775MetLys: 1.775 ± 0.631
2.662MetLeu: 2.662 ± 0.778
0.0MetMet: 0.0 ± 0.0
2.662MetAsn: 2.662 ± 0.856
0.0MetPro: 0.0 ± 0.0
0.444MetGln: 0.444 ± 0.467
0.887MetArg: 0.887 ± 0.676
0.887MetSer: 0.887 ± 0.484
1.775MetThr: 1.775 ± 1.078
3.106MetVal: 3.106 ± 1.128
0.0MetTrp: 0.0 ± 0.0
1.331MetTyr: 1.331 ± 0.761
0.0MetXaa: 0.0 ± 0.0
Asn
3.993AsnAla: 3.993 ± 1.742
0.887AsnCys: 0.887 ± 0.522
3.549AsnAsp: 3.549 ± 0.946
7.098AsnGlu: 7.098 ± 2.041
1.331AsnPhe: 1.331 ± 0.846
4.88AsnGly: 4.88 ± 1.742
1.775AsnHis: 1.775 ± 0.854
3.993AsnIle: 3.993 ± 1.241
7.986AsnLys: 7.986 ± 1.985
4.437AsnLeu: 4.437 ± 1.207
1.775AsnMet: 1.775 ± 1.024
2.662AsnAsn: 2.662 ± 1.152
1.331AsnPro: 1.331 ± 0.466
2.218AsnGln: 2.218 ± 1.031
2.662AsnArg: 2.662 ± 1.088
3.549AsnSer: 3.549 ± 1.779
4.88AsnThr: 4.88 ± 1.39
2.662AsnVal: 2.662 ± 1.125
1.331AsnTrp: 1.331 ± 0.719
2.218AsnTyr: 2.218 ± 0.636
0.0AsnXaa: 0.0 ± 0.0
Pro
0.444ProAla: 0.444 ± 0.365
0.0ProCys: 0.0 ± 0.0
0.887ProAsp: 0.887 ± 0.478
1.331ProGlu: 1.331 ± 0.708
1.331ProPhe: 1.331 ± 0.752
0.0ProGly: 0.0 ± 0.0
0.0ProHis: 0.0 ± 0.0
1.331ProIle: 1.331 ± 0.64
2.662ProLys: 2.662 ± 1.0
0.444ProLeu: 0.444 ± 0.37
0.444ProMet: 0.444 ± 0.365
1.331ProAsn: 1.331 ± 0.587
1.775ProPro: 1.775 ± 0.813
0.444ProGln: 0.444 ± 0.365
2.662ProArg: 2.662 ± 0.637
0.444ProSer: 0.444 ± 0.425
2.662ProThr: 2.662 ± 0.977
2.218ProVal: 2.218 ± 0.754
0.0ProTrp: 0.0 ± 0.0
1.775ProTyr: 1.775 ± 0.724
0.0ProXaa: 0.0 ± 0.0
Gln
3.993GlnAla: 3.993 ± 1.308
0.444GlnCys: 0.444 ± 0.365
1.331GlnAsp: 1.331 ± 0.764
3.549GlnGlu: 3.549 ± 1.238
0.887GlnPhe: 0.887 ± 0.411
0.887GlnGly: 0.887 ± 0.517
1.775GlnHis: 1.775 ± 0.961
2.662GlnIle: 2.662 ± 1.135
3.993GlnLys: 3.993 ± 1.279
4.437GlnLeu: 4.437 ± 1.32
0.887GlnMet: 0.887 ± 0.518
0.887GlnAsn: 0.887 ± 0.411
0.887GlnPro: 0.887 ± 0.699
2.662GlnGln: 2.662 ± 0.916
1.331GlnArg: 1.331 ± 0.664
2.662GlnSer: 2.662 ± 0.73
0.887GlnThr: 0.887 ± 0.692
0.887GlnVal: 0.887 ± 0.493
0.444GlnTrp: 0.444 ± 0.35
1.331GlnTyr: 1.331 ± 0.67
0.0GlnXaa: 0.0 ± 0.0
Arg
0.444ArgAla: 0.444 ± 0.425
0.0ArgCys: 0.0 ± 0.0
3.106ArgAsp: 3.106 ± 1.261
4.437ArgGlu: 4.437 ± 1.399
2.218ArgPhe: 2.218 ± 0.967
2.218ArgGly: 2.218 ± 0.964
0.444ArgHis: 0.444 ± 0.365
3.993ArgIle: 3.993 ± 1.15
3.549ArgLys: 3.549 ± 1.145
5.324ArgLeu: 5.324 ± 1.798
0.444ArgMet: 0.444 ± 0.454
3.549ArgAsn: 3.549 ± 0.985
1.331ArgPro: 1.331 ± 0.631
3.549ArgGln: 3.549 ± 1.328
2.218ArgArg: 2.218 ± 1.111
0.887ArgSer: 0.887 ± 0.851
2.218ArgThr: 2.218 ± 1.017
1.775ArgVal: 1.775 ± 0.754
0.444ArgTrp: 0.444 ± 0.476
2.218ArgTyr: 2.218 ± 0.998
0.0ArgXaa: 0.0 ± 0.0
Ser
1.775SerAla: 1.775 ± 1.264
0.0SerCys: 0.0 ± 0.0
3.993SerAsp: 3.993 ± 1.076
5.324SerGlu: 5.324 ± 1.283
1.331SerPhe: 1.331 ± 0.533
1.775SerGly: 1.775 ± 0.954
0.444SerHis: 0.444 ± 0.365
2.218SerIle: 2.218 ± 1.002
5.768SerLys: 5.768 ± 1.814
5.324SerLeu: 5.324 ± 1.807
0.887SerMet: 0.887 ± 0.695
5.324SerAsn: 5.324 ± 1.393
0.887SerPro: 0.887 ± 0.699
2.662SerGln: 2.662 ± 0.587
1.331SerArg: 1.331 ± 0.752
0.887SerSer: 0.887 ± 0.733
3.106SerThr: 3.106 ± 0.666
3.549SerVal: 3.549 ± 0.928
0.444SerTrp: 0.444 ± 0.35
3.106SerTyr: 3.106 ± 0.924
0.0SerXaa: 0.0 ± 0.0
Thr
2.662ThrAla: 2.662 ± 1.164
0.0ThrCys: 0.0 ± 0.0
5.768ThrAsp: 5.768 ± 1.403
4.88ThrGlu: 4.88 ± 1.228
1.775ThrPhe: 1.775 ± 0.822
2.662ThrGly: 2.662 ± 0.949
1.331ThrHis: 1.331 ± 0.697
3.993ThrIle: 3.993 ± 0.86
7.098ThrLys: 7.098 ± 1.553
7.098ThrLeu: 7.098 ± 1.698
0.444ThrMet: 0.444 ± 0.365
0.887ThrAsn: 0.887 ± 0.478
1.331ThrPro: 1.331 ± 0.678
1.331ThrGln: 1.331 ± 0.803
2.662ThrArg: 2.662 ± 1.149
3.106ThrSer: 3.106 ± 1.063
3.993ThrThr: 3.993 ± 1.409
7.986ThrVal: 7.986 ± 1.407
0.444ThrTrp: 0.444 ± 0.454
2.218ThrTyr: 2.218 ± 0.772
0.0ThrXaa: 0.0 ± 0.0
Val
2.218ValAla: 2.218 ± 0.861
0.0ValCys: 0.0 ± 0.0
1.775ValAsp: 1.775 ± 0.812
3.993ValGlu: 3.993 ± 1.192
3.993ValPhe: 3.993 ± 0.905
3.993ValGly: 3.993 ± 1.091
0.887ValHis: 0.887 ± 0.683
7.542ValIle: 7.542 ± 2.07
7.098ValLys: 7.098 ± 1.533
7.098ValLeu: 7.098 ± 1.481
1.775ValMet: 1.775 ± 0.922
5.324ValAsn: 5.324 ± 2.051
1.775ValPro: 1.775 ± 0.711
2.662ValGln: 2.662 ± 1.143
1.775ValArg: 1.775 ± 0.84
4.88ValSer: 4.88 ± 2.258
3.549ValThr: 3.549 ± 0.977
1.775ValVal: 1.775 ± 0.62
0.444ValTrp: 0.444 ± 0.474
2.662ValTyr: 2.662 ± 0.868
0.0ValXaa: 0.0 ± 0.0
Trp
0.887TrpAla: 0.887 ± 0.572
0.0TrpCys: 0.0 ± 0.0
0.444TrpAsp: 0.444 ± 0.425
1.331TrpGlu: 1.331 ± 0.57
0.0TrpPhe: 0.0 ± 0.0
0.444TrpGly: 0.444 ± 0.35
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
1.331TrpLeu: 1.331 ± 0.553
0.444TrpMet: 0.444 ± 0.397
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.444TrpGln: 0.444 ± 0.37
0.444TrpArg: 0.444 ± 0.548
0.887TrpSer: 0.887 ± 0.522
0.0TrpThr: 0.0 ± 0.0
1.331TrpVal: 1.331 ± 0.631
0.0TrpTrp: 0.0 ± 0.0
0.444TrpTyr: 0.444 ± 0.35
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.444TyrAla: 0.444 ± 0.365
0.444TyrCys: 0.444 ± 0.35
2.218TyrAsp: 2.218 ± 1.086
3.106TyrGlu: 3.106 ± 0.893
1.775TyrPhe: 1.775 ± 0.736
4.88TyrGly: 4.88 ± 1.439
0.887TyrHis: 0.887 ± 0.502
2.662TyrIle: 2.662 ± 1.364
5.768TyrLys: 5.768 ± 2.057
5.768TyrLeu: 5.768 ± 1.121
0.887TyrMet: 0.887 ± 0.577
3.993TyrAsn: 3.993 ± 1.044
0.444TyrPro: 0.444 ± 0.365
1.331TyrGln: 1.331 ± 0.707
2.218TyrArg: 2.218 ± 0.79
1.775TyrSer: 1.775 ± 0.583
4.88TyrThr: 4.88 ± 0.962
2.662TyrVal: 2.662 ± 0.725
0.0TyrTrp: 0.0 ± 0.0
3.106TyrTyr: 3.106 ± 0.888
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 16 proteins (2255 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski