Amino acid dipepetide frequency for Prunus yedoensis var. nudiflora

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.369AlaAla: 6.369 ± 0.033	1.34AlaCys: 1.34 ± 0.013	3.103AlaAsp: 3.103 ± 0.018	4.249AlaGlu: 4.249 ± 0.022	2.798AlaPhe: 2.798 ± 0.016	4.147AlaGly: 4.147 ± 0.021	1.385AlaHis: 1.385 ± 0.011	3.726AlaIle: 3.726 ± 0.017	3.911AlaLys: 3.911 ± 0.02	6.834AlaLeu: 6.834 ± 0.027	1.849AlaMet: 1.849 ± 0.012	2.621AlaAsn: 2.621 ± 0.015	2.918AlaPro: 2.918 ± 0.021	2.286AlaGln: 2.286 ± 0.015	3.389AlaArg: 3.389 ± 0.015	6.112AlaSer: 6.112 ± 0.026	3.668AlaThr: 3.668 ± 0.017	4.765AlaVal: 4.765 ± 0.021	0.834AlaTrp: 0.834 ± 0.009	1.845AlaTyr: 1.845 ± 0.013	0.0AlaXaa: 0.0 ± 0.0
Cys	1.021CysAla: 1.021 ± 0.009	0.547CysCys: 0.547 ± 0.006	0.845CysAsp: 0.845 ± 0.008	0.876CysGlu: 0.876 ± 0.009	0.897CysPhe: 0.897 ± 0.009	1.446CysGly: 1.446 ± 0.012	0.487CysHis: 0.487 ± 0.007	1.003CysIle: 1.003 ± 0.01	1.176CysLys: 1.176 ± 0.012	1.928CysLeu: 1.928 ± 0.014	0.488CysMet: 0.488 ± 0.006	0.878CysAsn: 0.878 ± 0.009	0.956CysPro: 0.956 ± 0.009	0.639CysGln: 0.639 ± 0.007	1.079CysArg: 1.079 ± 0.01	1.869CysSer: 1.869 ± 0.012	0.914CysThr: 0.914 ± 0.009	1.068CysVal: 1.068 ± 0.01	0.273CysTrp: 0.273 ± 0.005	0.537CysTyr: 0.537 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	3.386AspAla: 3.386 ± 0.019	0.939AspCys: 0.939 ± 0.009	3.462AspAsp: 3.462 ± 0.019	3.861AspGlu: 3.861 ± 0.02	2.35AspPhe: 2.35 ± 0.014	3.757AspGly: 3.757 ± 0.018	1.302AspHis: 1.302 ± 0.011	2.884AspIle: 2.884 ± 0.015	2.621AspLys: 2.621 ± 0.017	5.083AspLeu: 5.083 ± 0.024	1.359AspMet: 1.359 ± 0.011	2.02AspAsn: 2.02 ± 0.014	2.622AspPro: 2.622 ± 0.016	1.882AspGln: 1.882 ± 0.012	2.333AspArg: 2.333 ± 0.014	4.071AspSer: 4.071 ± 0.023	2.169AspThr: 2.169 ± 0.014	3.594AspVal: 3.594 ± 0.016	0.735AspTrp: 0.735 ± 0.008	1.517AspTyr: 1.517 ± 0.013	0.0AspXaa: 0.0 ± 0.0
Glu	4.965GluAla: 4.965 ± 0.023	0.897GluCys: 0.897 ± 0.009	3.904GluAsp: 3.904 ± 0.021	6.055GluGlu: 6.055 ± 0.03	2.388GluPhe: 2.388 ± 0.014	3.9GluGly: 3.9 ± 0.018	1.262GluHis: 1.262 ± 0.01	3.629GluIle: 3.629 ± 0.02	4.586GluLys: 4.586 ± 0.022	5.943GluLeu: 5.943 ± 0.026	1.731GluMet: 1.731 ± 0.011	3.015GluAsn: 3.015 ± 0.019	2.208GluPro: 2.208 ± 0.014	2.149GluGln: 2.149 ± 0.014	3.316GluArg: 3.316 ± 0.02	4.409GluSer: 4.409 ± 0.02	3.01GluThr: 3.01 ± 0.018	4.193GluVal: 4.193 ± 0.02	0.745GluTrp: 0.745 ± 0.007	1.59GluTyr: 1.59 ± 0.011	0.0GluXaa: 0.0 ± 0.0
Phe	2.492PheAla: 2.492 ± 0.017	0.924PheCys: 0.924 ± 0.01	2.335PheAsp: 2.335 ± 0.014	2.298PheGlu: 2.298 ± 0.013	1.91PhePhe: 1.91 ± 0.014	3.188PheGly: 3.188 ± 0.018	1.1PheHis: 1.1 ± 0.01	2.015PheIle: 2.015 ± 0.014	2.155PheLys: 2.155 ± 0.013	4.328PheLeu: 4.328 ± 0.018	1.009PheMet: 1.009 ± 0.009	1.781PheAsn: 1.781 ± 0.013	2.046PhePro: 2.046 ± 0.013	1.613PheGln: 1.613 ± 0.012	2.039PheArg: 2.039 ± 0.013	4.029PheSer: 4.029 ± 0.019	2.0PheThr: 2.0 ± 0.013	2.768PheVal: 2.768 ± 0.015	0.616PheTrp: 0.616 ± 0.008	1.256PheTyr: 1.256 ± 0.011	0.0PheXaa: 0.0 ± 0.0
Gly	3.959GlyAla: 3.959 ± 0.022	1.359GlyCys: 1.359 ± 0.012	3.4GlyAsp: 3.4 ± 0.015	3.621GlyGlu: 3.621 ± 0.017	3.324GlyPhe: 3.324 ± 0.015	5.378GlyGly: 5.378 ± 0.039	1.602GlyHis: 1.602 ± 0.012	3.587GlyIle: 3.587 ± 0.018	4.084GlyLys: 4.084 ± 0.018	6.248GlyLeu: 6.248 ± 0.027	1.581GlyMet: 1.581 ± 0.013	3.158GlyAsn: 3.158 ± 0.019	2.597GlyPro: 2.597 ± 0.015	2.183GlyGln: 2.183 ± 0.014	3.693GlyArg: 3.693 ± 0.02	6.103GlySer: 6.103 ± 0.027	3.299GlyThr: 3.299 ± 0.018	4.3GlyVal: 4.3 ± 0.022	0.957GlyTrp: 0.957 ± 0.008	2.051GlyTyr: 2.051 ± 0.015	0.0GlyXaa: 0.0 ± 0.0
His	1.45HisAla: 1.45 ± 0.011	0.555HisCys: 0.555 ± 0.006	1.17HisAsp: 1.17 ± 0.01	1.319HisGlu: 1.319 ± 0.011	1.051HisPhe: 1.051 ± 0.009	1.815HisGly: 1.815 ± 0.014	1.026HisHis: 1.026 ± 0.013	1.217HisIle: 1.217 ± 0.01	1.218HisLys: 1.218 ± 0.01	2.507HisLeu: 2.507 ± 0.014	0.578HisMet: 0.578 ± 0.007	1.013HisAsn: 1.013 ± 0.01	1.401HisPro: 1.401 ± 0.012	1.093HisGln: 1.093 ± 0.01	1.376HisArg: 1.376 ± 0.01	1.921HisSer: 1.921 ± 0.012	1.003HisThr: 1.003 ± 0.009	1.581HisVal: 1.581 ± 0.011	0.319HisTrp: 0.319 ± 0.005	0.698HisTyr: 0.698 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	3.524IleAla: 3.524 ± 0.019	1.084IleCys: 1.084 ± 0.009	2.763IleAsp: 2.763 ± 0.015	3.105IleGlu: 3.105 ± 0.017	2.193IlePhe: 2.193 ± 0.013	3.408IleGly: 3.408 ± 0.016	1.283IleHis: 1.283 ± 0.011	2.645IleIle: 2.645 ± 0.017	2.837IleLys: 2.837 ± 0.015	5.082IleLeu: 5.082 ± 0.022	1.147IleMet: 1.147 ± 0.009	2.111IleAsn: 2.111 ± 0.013	3.025IlePro: 3.025 ± 0.022	1.949IleGln: 1.949 ± 0.012	2.576IleArg: 2.576 ± 0.015	4.803IleSer: 4.803 ± 0.018	2.557IleThr: 2.557 ± 0.016	3.356IleVal: 3.356 ± 0.016	0.719IleTrp: 0.719 ± 0.007	1.446IleTyr: 1.446 ± 0.011	0.0IleXaa: 0.0 ± 0.0
Lys	4.139LysAla: 4.139 ± 0.019	0.998LysCys: 0.998 ± 0.01	3.176LysAsp: 3.176 ± 0.018	4.521LysGlu: 4.521 ± 0.024	2.173LysPhe: 2.173 ± 0.014	3.698LysGly: 3.698 ± 0.017	1.361LysHis: 1.361 ± 0.011	3.09LysIle: 3.09 ± 0.015	4.567LysLys: 4.567 ± 0.028	6.072LysLeu: 6.072 ± 0.024	1.487LysMet: 1.487 ± 0.01	2.622LysAsn: 2.622 ± 0.014	2.829LysPro: 2.829 ± 0.017	2.307LysGln: 2.307 ± 0.013	3.623LysArg: 3.623 ± 0.016	4.586LysSer: 4.586 ± 0.023	2.856LysThr: 2.856 ± 0.016	3.839LysVal: 3.839 ± 0.018	0.8LysTrp: 0.8 ± 0.009	1.609LysTyr: 1.609 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	6.614LeuAla: 6.614 ± 0.028	1.935LeuCys: 1.935 ± 0.014	5.15LeuAsp: 5.15 ± 0.023	6.348LeuGlu: 6.348 ± 0.029	3.831LeuPhe: 3.831 ± 0.019	6.149LeuGly: 6.149 ± 0.025	2.683LeuHis: 2.683 ± 0.014	4.607LeuIle: 4.607 ± 0.023	6.167LeuLys: 6.167 ± 0.025	10.07LeuLeu: 10.07 ± 0.037	2.222LeuMet: 2.222 ± 0.013	4.009LeuAsn: 4.009 ± 0.018	5.327LeuPro: 5.327 ± 0.025	4.395LeuGln: 4.395 ± 0.022	5.417LeuArg: 5.417 ± 0.022	8.762LeuSer: 8.762 ± 0.04	4.539LeuThr: 4.539 ± 0.022	6.557LeuVal: 6.557 ± 0.023	1.195LeuTrp: 1.195 ± 0.01	2.488LeuTyr: 2.488 ± 0.017	0.0LeuXaa: 0.0 ± 0.0
Met	2.224MetAla: 2.224 ± 0.014	0.343MetCys: 0.343 ± 0.005	1.414MetAsp: 1.414 ± 0.011	2.009MetGlu: 2.009 ± 0.012	0.817MetPhe: 0.817 ± 0.009	1.686MetGly: 1.686 ± 0.01	0.534MetHis: 0.534 ± 0.007	1.154MetIle: 1.154 ± 0.01	1.639MetLys: 1.639 ± 0.012	2.248MetLeu: 2.248 ± 0.014	0.688MetMet: 0.688 ± 0.008	1.022MetAsn: 1.022 ± 0.008	1.126MetPro: 1.126 ± 0.01	0.941MetGln: 0.941 ± 0.009	1.275MetArg: 1.275 ± 0.01	1.825MetSer: 1.825 ± 0.011	1.066MetThr: 1.066 ± 0.01	1.733MetVal: 1.733 ± 0.011	0.268MetTrp: 0.268 ± 0.005	0.578MetTyr: 0.578 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.704AsnAla: 2.704 ± 0.015	0.858AsnCys: 0.858 ± 0.008	2.016AsnAsp: 2.016 ± 0.012	2.465AsnGlu: 2.465 ± 0.015	1.977AsnPhe: 1.977 ± 0.014	3.311AsnGly: 3.311 ± 0.02	1.129AsnHis: 1.129 ± 0.01	2.403AsnIle: 2.403 ± 0.016	2.416AsnLys: 2.416 ± 0.015	4.78AsnLeu: 4.78 ± 0.028	1.115AsnMet: 1.115 ± 0.011	2.399AsnAsn: 2.399 ± 0.018	2.47AsnPro: 2.47 ± 0.015	1.753AsnGln: 1.753 ± 0.014	1.974AsnArg: 1.974 ± 0.013	3.965AsnSer: 3.965 ± 0.023	1.957AsnThr: 1.957 ± 0.013	2.747AsnVal: 2.747 ± 0.016	0.602AsnTrp: 0.602 ± 0.007	1.325AsnTyr: 1.325 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	3.109ProAla: 3.109 ± 0.019	0.809ProCys: 0.809 ± 0.009	2.498ProAsp: 2.498 ± 0.015	3.131ProGlu: 3.131 ± 0.016	1.983ProPhe: 1.983 ± 0.014	2.687ProGly: 2.687 ± 0.016	1.189ProHis: 1.189 ± 0.01	2.402ProIle: 2.402 ± 0.015	2.888ProLys: 2.888 ± 0.014	4.422ProLeu: 4.422 ± 0.021	1.002ProMet: 1.002 ± 0.009	2.49ProAsn: 2.49 ± 0.014	3.841ProPro: 3.841 ± 0.04	1.927ProGln: 1.927 ± 0.016	2.398ProArg: 2.398 ± 0.015	5.259ProSer: 5.259 ± 0.025	2.771ProThr: 2.771 ± 0.015	3.01ProVal: 3.01 ± 0.02	0.637ProTrp: 0.637 ± 0.006	1.342ProTyr: 1.342 ± 0.012	0.0ProXaa: 0.0 ± 0.0
Gln	2.516GlnAla: 2.516 ± 0.015	0.606GlnCys: 0.606 ± 0.007	1.7GlnAsp: 1.7 ± 0.013	2.408GlnGlu: 2.408 ± 0.015	1.431GlnPhe: 1.431 ± 0.01	2.264GlnGly: 2.264 ± 0.012	0.957GlnHis: 0.957 ± 0.01	2.016GlnIle: 2.016 ± 0.014	2.333GlnLys: 2.333 ± 0.015	3.823GlnLeu: 3.823 ± 0.02	1.005GlnMet: 1.005 ± 0.01	1.835GlnAsn: 1.835 ± 0.015	1.849GlnPro: 1.849 ± 0.015	2.074GlnGln: 2.074 ± 0.023	2.143GlnArg: 2.143 ± 0.013	2.97GlnSer: 2.97 ± 0.017	1.84GlnThr: 1.84 ± 0.012	2.446GlnVal: 2.446 ± 0.013	0.493GlnTrp: 0.493 ± 0.006	0.932GlnTyr: 0.932 ± 0.008	0.0GlnXaa: 0.0 ± 0.0
Arg	3.321ArgAla: 3.321 ± 0.017	0.98ArgCys: 0.98 ± 0.009	2.569ArgAsp: 2.569 ± 0.015	3.265ArgGlu: 3.265 ± 0.02	2.195ArgPhe: 2.195 ± 0.014	3.216ArgGly: 3.216 ± 0.018	1.276ArgHis: 1.276 ± 0.011	2.755ArgIle: 2.755 ± 0.015	3.757ArgLys: 3.757 ± 0.021	5.073ArgLeu: 5.073 ± 0.02	1.358ArgMet: 1.358 ± 0.011	2.433ArgAsn: 2.433 ± 0.013	2.423ArgPro: 2.423 ± 0.017	1.844ArgGln: 1.844 ± 0.012	3.92ArgArg: 3.92 ± 0.024	4.276ArgSer: 4.276 ± 0.025	2.461ArgThr: 2.461 ± 0.016	3.378ArgVal: 3.378 ± 0.018	0.738ArgTrp: 0.738 ± 0.007	1.398ArgTyr: 1.398 ± 0.011	0.0ArgXaa: 0.0 ± 0.0
Ser	5.459SerAla: 5.459 ± 0.022	1.742SerCys: 1.742 ± 0.015	4.315SerAsp: 4.315 ± 0.019	4.793SerGlu: 4.793 ± 0.022	3.959SerPhe: 3.959 ± 0.017	5.95SerGly: 5.95 ± 0.024	2.06SerHis: 2.06 ± 0.014	4.434SerIle: 4.434 ± 0.019	4.912SerLys: 4.912 ± 0.022	8.788SerLeu: 8.788 ± 0.035	2.136SerMet: 2.136 ± 0.016	4.145SerAsn: 4.145 ± 0.022	4.534SerPro: 4.534 ± 0.028	3.123SerGln: 3.123 ± 0.017	4.347SerArg: 4.347 ± 0.023	11.03SerSer: 11.03 ± 0.044	4.801SerThr: 4.801 ± 0.021	5.232SerVal: 5.232 ± 0.022	1.245SerTrp: 1.245 ± 0.011	2.304SerTyr: 2.304 ± 0.015	0.0SerXaa: 0.0 ± 0.0
Thr	3.356ThrAla: 3.356 ± 0.017	0.956ThrCys: 0.956 ± 0.01	2.229ThrAsp: 2.229 ± 0.012	2.792ThrGlu: 2.792 ± 0.019	2.057ThrPhe: 2.057 ± 0.013	3.242ThrGly: 3.242 ± 0.019	1.105ThrHis: 1.105 ± 0.01	2.695ThrIle: 2.695 ± 0.017	2.752ThrLys: 2.752 ± 0.015	4.752ThrLeu: 4.752 ± 0.02	1.207ThrMet: 1.207 ± 0.01	2.151ThrAsn: 2.151 ± 0.013	2.591ThrPro: 2.591 ± 0.014	1.705ThrGln: 1.705 ± 0.013	2.378ThrArg: 2.378 ± 0.014	4.681ThrSer: 4.681 ± 0.023	3.093ThrThr: 3.093 ± 0.017	3.296ThrVal: 3.296 ± 0.017	0.699ThrTrp: 0.699 ± 0.008	1.412ThrTyr: 1.412 ± 0.012	0.0ThrXaa: 0.0 ± 0.0
Val	4.896ValAla: 4.896 ± 0.019	1.2ValCys: 1.2 ± 0.011	3.709ValAsp: 3.709 ± 0.018	4.434ValGlu: 4.434 ± 0.019	2.737ValPhe: 2.737 ± 0.016	4.316ValGly: 4.316 ± 0.02	1.558ValHis: 1.558 ± 0.012	3.267ValIle: 3.267 ± 0.014	3.845ValLys: 3.845 ± 0.02	6.406ValLeu: 6.406 ± 0.023	1.549ValMet: 1.549 ± 0.011	2.579ValAsn: 2.579 ± 0.014	3.285ValPro: 3.285 ± 0.019	2.376ValGln: 2.376 ± 0.013	3.109ValArg: 3.109 ± 0.016	5.394ValSer: 5.394 ± 0.02	3.163ValThr: 3.163 ± 0.016	5.062ValVal: 5.062 ± 0.026	0.809ValTrp: 0.809 ± 0.008	1.903ValTyr: 1.903 ± 0.013	0.0ValXaa: 0.0 ± 0.0
Trp	0.819TrpAla: 0.819 ± 0.009	0.249TrpCys: 0.249 ± 0.004	0.72TrpAsp: 0.72 ± 0.008	0.783TrpGlu: 0.783 ± 0.008	0.58TrpPhe: 0.58 ± 0.007	0.803TrpGly: 0.803 ± 0.008	0.3TrpHis: 0.3 ± 0.005	0.68TrpIle: 0.68 ± 0.007	0.967TrpLys: 0.967 ± 0.009	1.32TrpLeu: 1.32 ± 0.011	0.345TrpMet: 0.345 ± 0.005	0.737TrpAsn: 0.737 ± 0.009	0.528TrpPro: 0.528 ± 0.007	0.451TrpGln: 0.451 ± 0.007	0.863TrpArg: 0.863 ± 0.008	1.015TrpSer: 1.015 ± 0.009	0.688TrpThr: 0.688 ± 0.007	0.91TrpVal: 0.91 ± 0.009	0.258TrpTrp: 0.258 ± 0.005	0.335TrpTyr: 0.335 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.825TyrAla: 1.825 ± 0.014	0.607TyrCys: 0.607 ± 0.006	1.468TyrAsp: 1.468 ± 0.012	1.56TyrGlu: 1.56 ± 0.012	1.249TyrPhe: 1.249 ± 0.011	2.125TyrGly: 2.125 ± 0.016	0.714TyrHis: 0.714 ± 0.007	1.4TyrIle: 1.4 ± 0.011	1.521TyrLys: 1.521 ± 0.011	2.76TyrLeu: 2.76 ± 0.016	0.737TyrMet: 0.737 ± 0.009	1.345TyrAsn: 1.345 ± 0.012	1.221TyrPro: 1.221 ± 0.01	0.95TyrGln: 0.95 ± 0.01	1.386TyrArg: 1.386 ± 0.01	2.23TyrSer: 2.23 ± 0.015	1.294TyrThr: 1.294 ± 0.01	1.761TyrVal: 1.761 ± 0.013	0.412TyrTrp: 0.412 ± 0.006	0.948TyrTyr: 0.948 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 40375 proteins (12929275 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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