Amino acid dipepetide frequency for Sphingobium sp. TCM1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.69AlaAla: 18.69 ± 0.177
1.125AlaCys: 1.125 ± 0.027
8.076AlaAsp: 8.076 ± 0.074
6.952AlaGlu: 6.952 ± 0.08
4.363AlaPhe: 4.363 ± 0.058
11.359AlaGly: 11.359 ± 0.095
2.439AlaHis: 2.439 ± 0.044
7.179AlaIle: 7.179 ± 0.079
3.845AlaLys: 3.845 ± 0.069
14.236AlaLeu: 14.236 ± 0.127
4.164AlaMet: 4.164 ± 0.055
3.017AlaAsn: 3.017 ± 0.046
6.314AlaPro: 6.314 ± 0.087
4.988AlaGln: 4.988 ± 0.064
10.072AlaArg: 10.072 ± 0.088
6.515AlaSer: 6.515 ± 0.073
6.585AlaThr: 6.585 ± 0.073
8.36AlaVal: 8.36 ± 0.074
1.658AlaTrp: 1.658 ± 0.036
2.657AlaTyr: 2.657 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
1.068CysAla: 1.068 ± 0.026
0.107CysCys: 0.107 ± 0.007
0.524CysAsp: 0.524 ± 0.019
0.383CysGlu: 0.383 ± 0.015
0.298CysPhe: 0.298 ± 0.014
0.868CysGly: 0.868 ± 0.025
0.212CysHis: 0.212 ± 0.015
0.4CysIle: 0.4 ± 0.016
0.176CysLys: 0.176 ± 0.011
0.74CysLeu: 0.74 ± 0.023
0.153CysMet: 0.153 ± 0.011
0.189CysAsn: 0.189 ± 0.01
0.435CysPro: 0.435 ± 0.018
0.227CysGln: 0.227 ± 0.013
0.586CysArg: 0.586 ± 0.025
0.441CysSer: 0.441 ± 0.016
0.403CysThr: 0.403 ± 0.016
0.552CysVal: 0.552 ± 0.02
0.125CysTrp: 0.125 ± 0.01
0.183CysTyr: 0.183 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.949AspAla: 7.949 ± 0.075
0.481AspCys: 0.481 ± 0.019
3.333AspAsp: 3.333 ± 0.049
3.223AspGlu: 3.223 ± 0.049
2.163AspPhe: 2.163 ± 0.035
5.889AspGly: 5.889 ± 0.074
1.482AspHis: 1.482 ± 0.033
3.198AspIle: 3.198 ± 0.043
1.752AspLys: 1.752 ± 0.04
5.955AspLeu: 5.955 ± 0.065
1.704AspMet: 1.704 ± 0.037
1.37AspAsn: 1.37 ± 0.031
3.854AspPro: 3.854 ± 0.053
1.913AspGln: 1.913 ± 0.039
5.104AspArg: 5.104 ± 0.062
2.444AspSer: 2.444 ± 0.048
2.463AspThr: 2.463 ± 0.045
4.084AspVal: 4.084 ± 0.058
1.137AspTrp: 1.137 ± 0.03
1.743AspTyr: 1.743 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
7.443GluAla: 7.443 ± 0.079
0.305GluCys: 0.305 ± 0.015
2.629GluAsp: 2.629 ± 0.047
3.017GluGlu: 3.017 ± 0.055
1.389GluPhe: 1.389 ± 0.032
4.465GluGly: 4.465 ± 0.061
1.034GluHis: 1.034 ± 0.027
2.845GluIle: 2.845 ± 0.047
2.039GluLys: 2.039 ± 0.046
4.599GluLeu: 4.599 ± 0.06
1.481GluMet: 1.481 ± 0.034
1.305GluAsn: 1.305 ± 0.03
2.412GluPro: 2.412 ± 0.043
2.148GluGln: 2.148 ± 0.042
4.698GluArg: 4.698 ± 0.067
2.228GluSer: 2.228 ± 0.039
2.943GluThr: 2.943 ± 0.044
3.21GluVal: 3.21 ± 0.05
0.699GluTrp: 0.699 ± 0.022
0.91GluTyr: 0.91 ± 0.024
0.0GluXaa: 0.0 ± 0.0
Phe
4.741PheAla: 4.741 ± 0.054
0.338PheCys: 0.338 ± 0.015
2.682PheAsp: 2.682 ± 0.045
1.844PheGlu: 1.844 ± 0.038
1.276PhePhe: 1.276 ± 0.029
3.543PheGly: 3.543 ± 0.052
0.766PheHis: 0.766 ± 0.019
1.472PheIle: 1.472 ± 0.033
0.849PheLys: 0.849 ± 0.026
3.208PheLeu: 3.208 ± 0.043
0.763PheMet: 0.763 ± 0.025
1.005PheAsn: 1.005 ± 0.028
1.493PhePro: 1.493 ± 0.035
0.906PheGln: 0.906 ± 0.021
2.249PheArg: 2.249 ± 0.033
2.038PheSer: 2.038 ± 0.041
2.022PheThr: 2.022 ± 0.038
2.438PheVal: 2.438 ± 0.039
0.52PheTrp: 0.52 ± 0.018
0.875PheTyr: 0.875 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
10.215GlyAla: 10.215 ± 0.088
0.829GlyCys: 0.829 ± 0.025
5.018GlyAsp: 5.018 ± 0.072
4.671GlyGlu: 4.671 ± 0.055
3.581GlyPhe: 3.581 ± 0.051
8.058GlyGly: 8.058 ± 0.089
1.915GlyHis: 1.915 ± 0.038
4.509GlyIle: 4.509 ± 0.062
3.364GlyLys: 3.364 ± 0.047
8.867GlyLeu: 8.867 ± 0.091
2.45GlyMet: 2.45 ± 0.047
2.213GlyAsn: 2.213 ± 0.043
3.63GlyPro: 3.63 ± 0.048
3.258GlyGln: 3.258 ± 0.044
6.629GlyArg: 6.629 ± 0.076
4.771GlySer: 4.771 ± 0.061
4.661GlyThr: 4.661 ± 0.064
6.312GlyVal: 6.312 ± 0.066
1.704GlyTrp: 1.704 ± 0.037
2.406GlyTyr: 2.406 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
2.371HisAla: 2.371 ± 0.042
0.221HisCys: 0.221 ± 0.012
1.309HisAsp: 1.309 ± 0.03
1.007HisGlu: 1.007 ± 0.024
0.843HisPhe: 0.843 ± 0.025
2.132HisGly: 2.132 ± 0.043
0.59HisHis: 0.59 ± 0.025
1.005HisIle: 1.005 ± 0.024
0.479HisLys: 0.479 ± 0.017
1.922HisLeu: 1.922 ± 0.04
0.572HisMet: 0.572 ± 0.018
0.45HisAsn: 0.45 ± 0.018
1.286HisPro: 1.286 ± 0.029
0.57HisGln: 0.57 ± 0.02
1.527HisArg: 1.527 ± 0.036
0.927HisSer: 0.927 ± 0.025
0.566HisThr: 0.566 ± 0.021
1.715HisVal: 1.715 ± 0.033
0.369HisTrp: 0.369 ± 0.015
0.606HisTyr: 0.606 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
8.026IleAla: 8.026 ± 0.083
0.464IleCys: 0.464 ± 0.018
4.006IleAsp: 4.006 ± 0.052
3.323IleGlu: 3.323 ± 0.043
1.711IlePhe: 1.711 ± 0.033
5.137IleGly: 5.137 ± 0.068
0.984IleHis: 0.984 ± 0.023
2.246IleIle: 2.246 ± 0.045
1.153IleLys: 1.153 ± 0.031
4.439IleLeu: 4.439 ± 0.066
0.992IleMet: 0.992 ± 0.025
1.397IleAsn: 1.397 ± 0.031
2.217IlePro: 2.217 ± 0.035
1.27IleGln: 1.27 ± 0.03
3.419IleArg: 3.419 ± 0.046
2.708IleSer: 2.708 ± 0.047
2.462IleThr: 2.462 ± 0.043
4.055IleVal: 4.055 ± 0.055
0.642IleTrp: 0.642 ± 0.02
1.007IleTyr: 1.007 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
4.351LysAla: 4.351 ± 0.06
0.153LysCys: 0.153 ± 0.01
1.653LysAsp: 1.653 ± 0.034
1.265LysGlu: 1.265 ± 0.036
0.813LysPhe: 0.813 ± 0.026
2.854LysGly: 2.854 ± 0.046
0.479LysHis: 0.479 ± 0.018
1.437LysIle: 1.437 ± 0.035
1.017LysLys: 1.017 ± 0.032
2.954LysLeu: 2.954 ± 0.05
0.75LysMet: 0.75 ± 0.025
0.7LysAsn: 0.7 ± 0.024
1.996LysPro: 1.996 ± 0.041
0.886LysGln: 0.886 ± 0.021
2.059LysArg: 2.059 ± 0.039
1.561LysSer: 1.561 ± 0.036
1.629LysThr: 1.629 ± 0.038
2.196LysVal: 2.196 ± 0.047
0.394LysTrp: 0.394 ± 0.017
0.565LysTyr: 0.565 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
13.833LeuAla: 13.833 ± 0.118
0.883LeuCys: 0.883 ± 0.025
6.161LeuAsp: 6.161 ± 0.073
4.711LeuGlu: 4.711 ± 0.068
3.755LeuPhe: 3.755 ± 0.049
8.224LeuGly: 8.224 ± 0.079
1.915LeuHis: 1.915 ± 0.033
4.928LeuIle: 4.928 ± 0.064
3.039LeuLys: 3.039 ± 0.051
10.003LeuLeu: 10.003 ± 0.118
2.278LeuMet: 2.278 ± 0.042
2.447LeuAsn: 2.447 ± 0.044
5.809LeuPro: 5.809 ± 0.064
2.401LeuGln: 2.401 ± 0.041
6.841LeuArg: 6.841 ± 0.08
6.336LeuSer: 6.336 ± 0.074
5.561LeuThr: 5.561 ± 0.061
6.982LeuVal: 6.982 ± 0.077
1.292LeuTrp: 1.292 ± 0.029
2.04LeuTyr: 2.04 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
3.671MetAla: 3.671 ± 0.045
0.149MetCys: 0.149 ± 0.01
1.271MetAsp: 1.271 ± 0.029
1.175MetGlu: 1.175 ± 0.032
0.749MetPhe: 0.749 ± 0.025
2.104MetGly: 2.104 ± 0.041
0.417MetHis: 0.417 ± 0.016
1.408MetIle: 1.408 ± 0.033
0.939MetLys: 0.939 ± 0.029
2.838MetLeu: 2.838 ± 0.051
0.736MetMet: 0.736 ± 0.023
0.703MetAsn: 0.703 ± 0.02
1.535MetPro: 1.535 ± 0.035
0.831MetGln: 0.831 ± 0.023
1.886MetArg: 1.886 ± 0.033
1.52MetSer: 1.52 ± 0.033
1.921MetThr: 1.921 ± 0.033
1.718MetVal: 1.718 ± 0.035
0.225MetTrp: 0.225 ± 0.012
0.255MetTyr: 0.255 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
3.208AsnAla: 3.208 ± 0.051
0.228AsnCys: 0.228 ± 0.013
1.442AsnAsp: 1.442 ± 0.031
1.057AsnGlu: 1.057 ± 0.029
0.91AsnPhe: 0.91 ± 0.031
2.462AsnGly: 2.462 ± 0.053
0.455AsnHis: 0.455 ± 0.016
1.434AsnIle: 1.434 ± 0.037
0.613AsnLys: 0.613 ± 0.019
2.483AsnLeu: 2.483 ± 0.047
0.605AsnMet: 0.605 ± 0.019
0.683AsnAsn: 0.683 ± 0.025
1.736AsnPro: 1.736 ± 0.037
0.78AsnGln: 0.78 ± 0.024
1.789AsnArg: 1.789 ± 0.037
1.241AsnSer: 1.241 ± 0.028
0.938AsnThr: 0.938 ± 0.032
1.797AsnVal: 1.797 ± 0.035
0.407AsnTrp: 0.407 ± 0.017
0.665AsnTyr: 0.665 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
7.063ProAla: 7.063 ± 0.082
0.334ProCys: 0.334 ± 0.014
4.016ProAsp: 4.016 ± 0.051
3.208ProGlu: 3.208 ± 0.046
1.878ProPhe: 1.878 ± 0.032
4.759ProGly: 4.759 ± 0.056
1.122ProHis: 1.122 ± 0.028
2.501ProIle: 2.501 ± 0.04
1.437ProLys: 1.437 ± 0.033
4.916ProLeu: 4.916 ± 0.066
1.349ProMet: 1.349 ± 0.028
1.185ProAsn: 1.185 ± 0.032
2.777ProPro: 2.777 ± 0.058
1.783ProGln: 1.783 ± 0.039
3.115ProArg: 3.115 ± 0.049
2.699ProSer: 2.699 ± 0.041
2.594ProThr: 2.594 ± 0.043
4.47ProVal: 4.47 ± 0.05
0.722ProTrp: 0.722 ± 0.023
1.097ProTyr: 1.097 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
4.583GlnAla: 4.583 ± 0.058
0.226GlnCys: 0.226 ± 0.015
1.606GlnAsp: 1.606 ± 0.031
1.432GlnGlu: 1.432 ± 0.03
1.063GlnPhe: 1.063 ± 0.026
2.758GlnGly: 2.758 ± 0.044
0.596GlnHis: 0.596 ± 0.02
1.789GlnIle: 1.789 ± 0.038
0.98GlnLys: 0.98 ± 0.027
3.108GlnLeu: 3.108 ± 0.049
0.931GlnMet: 0.931 ± 0.027
0.775GlnAsn: 0.775 ± 0.025
1.871GlnPro: 1.871 ± 0.035
1.237GlnGln: 1.237 ± 0.034
2.581GlnArg: 2.581 ± 0.044
1.789GlnSer: 1.789 ± 0.038
1.65GlnThr: 1.65 ± 0.04
2.372GlnVal: 2.372 ± 0.04
0.487GlnTrp: 0.487 ± 0.018
0.64GlnTyr: 0.64 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
8.825ArgAla: 8.825 ± 0.096
0.518ArgCys: 0.518 ± 0.019
4.509ArgAsp: 4.509 ± 0.052
3.801ArgGlu: 3.801 ± 0.056
3.08ArgPhe: 3.08 ± 0.055
5.074ArgGly: 5.074 ± 0.068
1.798ArgHis: 1.798 ± 0.039
4.302ArgIle: 4.302 ± 0.055
2.161ArgLys: 2.161 ± 0.043
8.275ArgLeu: 8.275 ± 0.08
2.014ArgMet: 2.014 ± 0.038
1.863ArgAsn: 1.863 ± 0.035
3.853ArgPro: 3.853 ± 0.053
2.625ArgGln: 2.625 ± 0.048
5.78ArgArg: 5.78 ± 0.071
3.743ArgSer: 3.743 ± 0.054
3.631ArgThr: 3.631 ± 0.046
4.654ArgVal: 4.654 ± 0.059
1.229ArgTrp: 1.229 ± 0.033
2.009ArgTyr: 2.009 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.522SerAla: 6.522 ± 0.07
0.449SerCys: 0.449 ± 0.019
3.199SerAsp: 3.199 ± 0.045
2.378SerGlu: 2.378 ± 0.038
2.204SerPhe: 2.204 ± 0.044
5.386SerGly: 5.386 ± 0.068
0.975SerHis: 0.975 ± 0.027
2.813SerIle: 2.813 ± 0.051
1.357SerLys: 1.357 ± 0.037
5.246SerLeu: 5.246 ± 0.056
1.259SerMet: 1.259 ± 0.029
1.323SerAsn: 1.323 ± 0.031
2.875SerPro: 2.875 ± 0.04
1.585SerGln: 1.585 ± 0.033
3.571SerArg: 3.571 ± 0.05
2.768SerSer: 2.768 ± 0.058
2.545SerThr: 2.545 ± 0.051
3.629SerVal: 3.629 ± 0.05
0.826SerTrp: 0.826 ± 0.025
1.404SerTyr: 1.404 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
6.235ThrAla: 6.235 ± 0.07
0.369ThrCys: 0.369 ± 0.016
2.987ThrAsp: 2.987 ± 0.051
2.178ThrGlu: 2.178 ± 0.034
1.652ThrPhe: 1.652 ± 0.036
5.316ThrGly: 5.316 ± 0.061
0.968ThrHis: 0.968 ± 0.027
2.991ThrIle: 2.991 ± 0.044
1.282ThrLys: 1.282 ± 0.033
5.765ThrLeu: 5.765 ± 0.064
1.24ThrMet: 1.24 ± 0.029
1.238ThrAsn: 1.238 ± 0.029
3.399ThrPro: 3.399 ± 0.048
1.548ThrGln: 1.548 ± 0.032
3.497ThrArg: 3.497 ± 0.043
2.58ThrSer: 2.58 ± 0.046
2.59ThrThr: 2.59 ± 0.048
4.005ThrVal: 4.005 ± 0.059
0.582ThrTrp: 0.582 ± 0.021
1.119ThrTyr: 1.119 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
9.678ValAla: 9.678 ± 0.09
0.522ValCys: 0.522 ± 0.018
4.475ValAsp: 4.475 ± 0.052
4.473ValGlu: 4.473 ± 0.066
1.914ValPhe: 1.914 ± 0.04
5.546ValGly: 5.546 ± 0.064
1.414ValHis: 1.414 ± 0.03
3.606ValIle: 3.606 ± 0.057
2.144ValLys: 2.144 ± 0.043
5.926ValLeu: 5.926 ± 0.073
1.732ValMet: 1.732 ± 0.038
1.982ValAsn: 1.982 ± 0.037
3.73ValPro: 3.73 ± 0.049
2.18ValGln: 2.18 ± 0.039
5.078ValArg: 5.078 ± 0.058
3.916ValSer: 3.916 ± 0.048
4.476ValThr: 4.476 ± 0.062
5.016ValVal: 5.016 ± 0.072
0.763ValTrp: 0.763 ± 0.024
1.374ValTyr: 1.374 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
1.375TrpAla: 1.375 ± 0.03
0.13TrpCys: 0.13 ± 0.008
0.791TrpAsp: 0.791 ± 0.024
0.573TrpGlu: 0.573 ± 0.019
0.518TrpPhe: 0.518 ± 0.02
0.989TrpGly: 0.989 ± 0.031
0.37TrpHis: 0.37 ± 0.016
0.727TrpIle: 0.727 ± 0.02
0.478TrpLys: 0.478 ± 0.018
1.756TrpLeu: 1.756 ± 0.038
0.395TrpMet: 0.395 ± 0.015
0.456TrpAsn: 0.456 ± 0.017
0.722TrpPro: 0.722 ± 0.023
0.594TrpGln: 0.594 ± 0.02
1.319TrpArg: 1.319 ± 0.033
0.9TrpSer: 0.9 ± 0.026
0.898TrpThr: 0.898 ± 0.026
0.852TrpVal: 0.852 ± 0.028
0.252TrpTrp: 0.252 ± 0.013
0.305TrpTyr: 0.305 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.747TyrAla: 2.747 ± 0.048
0.239TyrCys: 0.239 ± 0.012
1.554TyrAsp: 1.554 ± 0.035
1.126TyrGlu: 1.126 ± 0.028
0.866TyrPhe: 0.866 ± 0.028
2.14TyrGly: 2.14 ± 0.04
0.537TyrHis: 0.537 ± 0.019
0.868TyrIle: 0.868 ± 0.026
0.607TyrLys: 0.607 ± 0.02
2.206TyrLeu: 2.206 ± 0.039
0.482TyrMet: 0.482 ± 0.017
0.632TyrAsn: 0.632 ± 0.022
1.08TyrPro: 1.08 ± 0.026
0.742TyrGln: 0.742 ± 0.025
1.945TyrArg: 1.945 ± 0.041
1.19TyrSer: 1.19 ± 0.033
1.004TyrThr: 1.004 ± 0.029
1.529TyrVal: 1.529 ± 0.035
0.369TyrTrp: 0.369 ± 0.017
0.647TyrTyr: 0.647 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4732 proteins (1512876 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski