Amino acid dipepetide frequency for Halomarina oriensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.992AlaAla: 9.992 ± 0.149	0.773AlaCys: 0.773 ± 0.033	7.17AlaAsp: 7.17 ± 0.114	6.616AlaGlu: 6.616 ± 0.111	3.705AlaPhe: 3.705 ± 0.069	7.865AlaGly: 7.865 ± 0.105	1.95AlaHis: 1.95 ± 0.044	5.234AlaIle: 5.234 ± 0.075	1.879AlaLys: 1.879 ± 0.048	9.239AlaLeu: 9.239 ± 0.121	1.805AlaMet: 1.805 ± 0.05	2.486AlaAsn: 2.486 ± 0.051	3.466AlaPro: 3.466 ± 0.057	2.54AlaGln: 2.54 ± 0.052	5.334AlaArg: 5.334 ± 0.083	5.177AlaSer: 5.177 ± 0.083	6.722AlaThr: 6.722 ± 0.088	9.287AlaVal: 9.287 ± 0.106	1.005AlaTrp: 1.005 ± 0.032	2.657AlaTyr: 2.657 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.714CysAla: 0.714 ± 0.028	0.114CysCys: 0.114 ± 0.011	0.638CysAsp: 0.638 ± 0.025	0.683CysGlu: 0.683 ± 0.029	0.237CysPhe: 0.237 ± 0.015	0.89CysGly: 0.89 ± 0.037	0.245CysHis: 0.245 ± 0.017	0.338CysIle: 0.338 ± 0.017	0.141CysLys: 0.141 ± 0.012	0.683CysLeu: 0.683 ± 0.03	0.133CysMet: 0.133 ± 0.013	0.221CysAsn: 0.221 ± 0.015	0.572CysPro: 0.572 ± 0.028	0.25CysGln: 0.25 ± 0.018	0.515CysArg: 0.515 ± 0.022	0.623CysSer: 0.623 ± 0.028	0.487CysThr: 0.487 ± 0.023	0.614CysVal: 0.614 ± 0.026	0.124CysTrp: 0.124 ± 0.011	0.233CysTyr: 0.233 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.124AspAla: 8.124 ± 0.115	0.682AspCys: 0.682 ± 0.029	5.926AspAsp: 5.926 ± 0.095	6.133AspGlu: 6.133 ± 0.087	1.733AspPhe: 1.733 ± 0.041	6.657AspGly: 6.657 ± 0.104	2.043AspHis: 2.043 ± 0.052	3.874AspIle: 3.874 ± 0.064	1.107AspLys: 1.107 ± 0.036	5.848AspLeu: 5.848 ± 0.087	1.156AspMet: 1.156 ± 0.038	1.629AspAsn: 1.629 ± 0.04	4.28AspPro: 4.28 ± 0.075	2.103AspGln: 2.103 ± 0.053	6.341AspArg: 6.341 ± 0.094	4.153AspSer: 4.153 ± 0.071	4.863AspThr: 4.863 ± 0.071	6.315AspVal: 6.315 ± 0.101	0.955AspTrp: 0.955 ± 0.034	1.68AspTyr: 1.68 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	6.266GluAla: 6.266 ± 0.095	0.574GluCys: 0.574 ± 0.027	4.231GluAsp: 4.231 ± 0.079	6.166GluGlu: 6.166 ± 0.129	2.627GluPhe: 2.627 ± 0.057	4.051GluGly: 4.051 ± 0.066	2.283GluHis: 2.283 ± 0.049	4.351GluIle: 4.351 ± 0.083	1.891GluLys: 1.891 ± 0.054	7.39GluLeu: 7.39 ± 0.117	1.79GluMet: 1.79 ± 0.045	2.547GluAsn: 2.547 ± 0.055	3.43GluPro: 3.43 ± 0.07	3.717GluGln: 3.717 ± 0.071	6.851GluArg: 6.851 ± 0.11	4.986GluSer: 4.986 ± 0.083	7.182GluThr: 7.182 ± 0.1	3.92GluVal: 3.92 ± 0.056	1.138GluTrp: 1.138 ± 0.039	2.827GluTyr: 2.827 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.096PheAla: 3.096 ± 0.054	0.322PheCys: 0.322 ± 0.018	3.188PheAsp: 3.188 ± 0.057	3.165PheGlu: 3.165 ± 0.057	1.072PhePhe: 1.072 ± 0.044	3.187PheGly: 3.187 ± 0.068	0.69PheHis: 0.69 ± 0.027	1.488PheIle: 1.488 ± 0.041	0.619PheLys: 0.619 ± 0.026	2.844PheLeu: 2.844 ± 0.068	0.534PheMet: 0.534 ± 0.025	0.849PheAsn: 0.849 ± 0.025	1.349PhePro: 1.349 ± 0.04	0.852PheGln: 0.852 ± 0.032	1.751PheArg: 1.751 ± 0.045	1.97PheSer: 1.97 ± 0.051	2.218PheThr: 2.218 ± 0.055	3.077PheVal: 3.077 ± 0.059	0.396PheTrp: 0.396 ± 0.02	0.881PheTyr: 0.881 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	6.785GlyAla: 6.785 ± 0.092	0.782GlyCys: 0.782 ± 0.031	5.123GlyAsp: 5.123 ± 0.083	5.591GlyGlu: 5.591 ± 0.077	2.945GlyPhe: 2.945 ± 0.057	6.398GlyGly: 6.398 ± 0.104	1.731GlyHis: 1.731 ± 0.04	4.572GlyIle: 4.572 ± 0.079	1.947GlyLys: 1.947 ± 0.049	6.895GlyLeu: 6.895 ± 0.103	1.765GlyMet: 1.765 ± 0.046	2.166GlyAsn: 2.166 ± 0.051	2.953GlyPro: 2.953 ± 0.057	2.346GlyGln: 2.346 ± 0.057	4.421GlyArg: 4.421 ± 0.069	5.24GlySer: 5.24 ± 0.081	6.172GlyThr: 6.172 ± 0.097	7.268GlyVal: 7.268 ± 0.106	1.202GlyTrp: 1.202 ± 0.043	2.865GlyTyr: 2.865 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.177HisAla: 2.177 ± 0.052	0.243HisCys: 0.243 ± 0.014	1.97HisAsp: 1.97 ± 0.049	1.951HisGlu: 1.951 ± 0.044	0.589HisPhe: 0.589 ± 0.026	2.079HisGly: 2.079 ± 0.05	0.672HisHis: 0.672 ± 0.026	1.04HisIle: 1.04 ± 0.029	0.389HisLys: 0.389 ± 0.019	1.805HisLeu: 1.805 ± 0.041	0.316HisMet: 0.316 ± 0.018	0.624HisAsn: 0.624 ± 0.026	1.468HisPro: 1.468 ± 0.033	0.713HisGln: 0.713 ± 0.027	1.604HisArg: 1.604 ± 0.045	1.127HisSer: 1.127 ± 0.033	1.499HisThr: 1.499 ± 0.042	1.948HisVal: 1.948 ± 0.047	0.263HisTrp: 0.263 ± 0.017	0.649HisTyr: 0.649 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.43IleAla: 5.43 ± 0.08	0.36IleCys: 0.36 ± 0.019	5.166IleAsp: 5.166 ± 0.084	5.332IleGlu: 5.332 ± 0.083	1.07IlePhe: 1.07 ± 0.034	4.834IleGly: 4.834 ± 0.089	1.152IleHis: 1.152 ± 0.031	2.124IleIle: 2.124 ± 0.055	1.04IleLys: 1.04 ± 0.029	3.369IleLeu: 3.369 ± 0.084	0.625IleMet: 0.625 ± 0.028	1.445IleAsn: 1.445 ± 0.034	2.412IlePro: 2.412 ± 0.05	1.404IleGln: 1.404 ± 0.035	2.894IleArg: 2.894 ± 0.062	2.669IleSer: 2.669 ± 0.058	3.556IleThr: 3.556 ± 0.059	4.334IleVal: 4.334 ± 0.082	0.359IleTrp: 0.359 ± 0.019	1.064IleTyr: 1.064 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	1.931LysAla: 1.931 ± 0.045	0.127LysCys: 0.127 ± 0.012	1.189LysAsp: 1.189 ± 0.038	1.527LysGlu: 1.527 ± 0.042	0.586LysPhe: 0.586 ± 0.027	1.405LysGly: 1.405 ± 0.043	0.627LysHis: 0.627 ± 0.023	0.955LysIle: 0.955 ± 0.04	0.688LysLys: 0.688 ± 0.033	1.839LysLeu: 1.839 ± 0.048	0.423LysMet: 0.423 ± 0.02	0.786LysAsn: 0.786 ± 0.031	1.057LysPro: 1.057 ± 0.036	1.095LysGln: 1.095 ± 0.038	2.011LysArg: 2.011 ± 0.043	1.352LysSer: 1.352 ± 0.039	1.686LysThr: 1.686 ± 0.05	1.066LysVal: 1.066 ± 0.036	0.247LysTrp: 0.247 ± 0.016	0.65LysTyr: 0.65 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	8.923LeuAla: 8.923 ± 0.121	0.814LeuCys: 0.814 ± 0.036	7.046LeuAsp: 7.046 ± 0.092	5.801LeuGlu: 5.801 ± 0.085	3.349LeuPhe: 3.349 ± 0.09	7.106LeuGly: 7.106 ± 0.092	1.71LeuHis: 1.71 ± 0.042	4.214LeuIle: 4.214 ± 0.073	1.868LeuLys: 1.868 ± 0.05	8.772LeuLeu: 8.772 ± 0.156	1.41LeuMet: 1.41 ± 0.038	2.253LeuAsn: 2.253 ± 0.053	4.261LeuPro: 4.261 ± 0.078	2.493LeuGln: 2.493 ± 0.053	5.436LeuArg: 5.436 ± 0.074	6.432LeuSer: 6.432 ± 0.089	6.182LeuThr: 6.182 ± 0.081	7.221LeuVal: 7.221 ± 0.108	0.939LeuTrp: 0.939 ± 0.035	2.414LeuTyr: 2.414 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	1.753MetAla: 1.753 ± 0.038	0.134MetCys: 0.134 ± 0.011	1.286MetAsp: 1.286 ± 0.043	1.135MetGlu: 1.135 ± 0.036	0.551MetPhe: 0.551 ± 0.023	1.432MetGly: 1.432 ± 0.039	0.393MetHis: 0.393 ± 0.019	0.883MetIle: 0.883 ± 0.036	0.526MetLys: 0.526 ± 0.023	1.457MetLeu: 1.457 ± 0.039	0.342MetMet: 0.342 ± 0.019	0.774MetAsn: 0.774 ± 0.032	0.72MetPro: 0.72 ± 0.025	0.51MetGln: 0.51 ± 0.025	1.104MetArg: 1.104 ± 0.031	1.56MetSer: 1.56 ± 0.042	1.661MetThr: 1.661 ± 0.041	1.323MetVal: 1.323 ± 0.036	0.173MetTrp: 0.173 ± 0.013	0.464MetTyr: 0.464 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.025AsnAla: 3.025 ± 0.052	0.282AsnCys: 0.282 ± 0.016	2.259AsnAsp: 2.259 ± 0.042	2.245AsnGlu: 2.245 ± 0.055	0.701AsnPhe: 0.701 ± 0.028	2.649AsnGly: 2.649 ± 0.058	0.698AsnHis: 0.698 ± 0.027	1.245AsnIle: 1.245 ± 0.039	0.628AsnLys: 0.628 ± 0.028	1.955AsnLeu: 1.955 ± 0.047	0.461AsnMet: 0.461 ± 0.021	0.87AsnAsn: 0.87 ± 0.031	1.66AsnPro: 1.66 ± 0.045	0.934AsnGln: 0.934 ± 0.037	1.989AsnArg: 1.989 ± 0.046	1.37AsnSer: 1.37 ± 0.041	1.843AsnThr: 1.843 ± 0.044	2.437AsnVal: 2.437 ± 0.05	0.393AsnTrp: 0.393 ± 0.02	0.79AsnTyr: 0.79 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	4.07ProAla: 4.07 ± 0.076	0.297ProCys: 0.297 ± 0.016	4.227ProAsp: 4.227 ± 0.07	4.224ProGlu: 4.224 ± 0.067	1.664ProPhe: 1.664 ± 0.042	3.214ProGly: 3.214 ± 0.064	1.023ProHis: 1.023 ± 0.032	2.432ProIle: 2.432 ± 0.056	0.994ProLys: 0.994 ± 0.033	3.686ProLeu: 3.686 ± 0.066	0.874ProMet: 0.874 ± 0.028	1.474ProAsn: 1.474 ± 0.045	2.231ProPro: 2.231 ± 0.051	1.346ProGln: 1.346 ± 0.038	2.178ProArg: 2.178 ± 0.047	3.102ProSer: 3.102 ± 0.061	3.701ProThr: 3.701 ± 0.071	3.895ProVal: 3.895 ± 0.067	0.627ProTrp: 0.627 ± 0.027	1.231ProTyr: 1.231 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.787GlnAla: 2.787 ± 0.056	0.245GlnCys: 0.245 ± 0.015	1.517GlnAsp: 1.517 ± 0.036	1.999GlnGlu: 1.999 ± 0.051	1.304GlnPhe: 1.304 ± 0.038	1.839GlnGly: 1.839 ± 0.045	0.746GlnHis: 0.746 ± 0.03	1.501GlnIle: 1.501 ± 0.037	0.735GlnLys: 0.735 ± 0.032	3.359GlnLeu: 3.359 ± 0.063	0.672GlnMet: 0.672 ± 0.025	0.991GlnAsn: 0.991 ± 0.033	1.604GlnPro: 1.604 ± 0.041	1.592GlnGln: 1.592 ± 0.059	2.458GlnArg: 2.458 ± 0.058	2.143GlnSer: 2.143 ± 0.041	2.333GlnThr: 2.333 ± 0.052	1.724GlnVal: 1.724 ± 0.036	0.481GlnTrp: 0.481 ± 0.024	1.134GlnTyr: 1.134 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	5.794ArgAla: 5.794 ± 0.094	0.611ArgCys: 0.611 ± 0.027	4.344ArgAsp: 4.344 ± 0.068	5.57ArgGlu: 5.57 ± 0.078	2.403ArgPhe: 2.403 ± 0.051	3.979ArgGly: 3.979 ± 0.058	1.335ArgHis: 1.335 ± 0.035	3.438ArgIle: 3.438 ± 0.058	1.578ArgLys: 1.578 ± 0.046	6.097ArgLeu: 6.097 ± 0.089	1.27ArgMet: 1.27 ± 0.031	1.874ArgAsn: 1.874 ± 0.042	2.484ArgPro: 2.484 ± 0.054	2.12ArgGln: 2.12 ± 0.049	4.43ArgArg: 4.43 ± 0.076	4.334ArgSer: 4.334 ± 0.069	4.515ArgThr: 4.515 ± 0.074	4.837ArgVal: 4.837 ± 0.072	0.799ArgTrp: 0.799 ± 0.033	2.056ArgTyr: 2.056 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.111SerAla: 5.111 ± 0.072	0.458SerCys: 0.458 ± 0.023	4.672SerAsp: 4.672 ± 0.07	4.731SerGlu: 4.731 ± 0.074	2.175SerPhe: 2.175 ± 0.052	5.533SerGly: 5.533 ± 0.088	1.361SerHis: 1.361 ± 0.036	3.291SerIle: 3.291 ± 0.057	1.45SerLys: 1.45 ± 0.045	5.317SerLeu: 5.317 ± 0.078	1.274SerMet: 1.274 ± 0.038	1.844SerAsn: 1.844 ± 0.046	2.695SerPro: 2.695 ± 0.06	1.718SerGln: 1.718 ± 0.041	3.313SerArg: 3.313 ± 0.058	3.598SerSer: 3.598 ± 0.075	4.298SerThr: 4.298 ± 0.072	5.773SerVal: 5.773 ± 0.082	0.702SerTrp: 0.702 ± 0.03	1.58SerTyr: 1.58 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	7.594ThrAla: 7.594 ± 0.1	0.441ThrCys: 0.441 ± 0.021	6.314ThrAsp: 6.314 ± 0.088	5.848ThrGlu: 5.848 ± 0.096	2.26ThrPhe: 2.26 ± 0.048	6.106ThrGly: 6.106 ± 0.081	1.626ThrHis: 1.626 ± 0.04	3.971ThrIle: 3.971 ± 0.065	1.389ThrLys: 1.389 ± 0.033	6.132ThrLeu: 6.132 ± 0.071	1.203ThrMet: 1.203 ± 0.037	2.062ThrAsn: 2.062 ± 0.044	3.942ThrPro: 3.942 ± 0.079	1.879ThrGln: 1.879 ± 0.041	3.51ThrArg: 3.51 ± 0.057	3.345ThrSer: 3.345 ± 0.062	5.674ThrThr: 5.674 ± 0.113	7.524ThrVal: 7.524 ± 0.096	0.691ThrTrp: 0.691 ± 0.029	1.87ThrTyr: 1.87 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	7.882ValAla: 7.882 ± 0.096	0.782ValCys: 0.782 ± 0.028	6.011ValAsp: 6.011 ± 0.082	6.117ValGlu: 6.117 ± 0.085	3.188ValPhe: 3.188 ± 0.075	6.793ValGly: 6.793 ± 0.099	1.783ValHis: 1.783 ± 0.04	3.919ValIle: 3.919 ± 0.066	1.504ValLys: 1.504 ± 0.043	8.077ValLeu: 8.077 ± 0.11	1.448ValMet: 1.448 ± 0.039	2.174ValAsn: 2.174 ± 0.054	4.096ValPro: 4.096 ± 0.066	2.134ValGln: 2.134 ± 0.05	4.869ValArg: 4.869 ± 0.075	5.551ValSer: 5.551 ± 0.077	6.003ValThr: 6.003 ± 0.072	7.675ValVal: 7.675 ± 0.123	0.919ValTrp: 0.919 ± 0.032	2.311ValTyr: 2.311 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.881TrpAla: 0.881 ± 0.028	0.14TrpCys: 0.14 ± 0.013	0.767TrpAsp: 0.767 ± 0.031	0.866TrpGlu: 0.866 ± 0.03	0.49TrpPhe: 0.49 ± 0.021	0.844TrpGly: 0.844 ± 0.032	0.279TrpHis: 0.279 ± 0.018	0.67TrpIle: 0.67 ± 0.028	0.334TrpLys: 0.334 ± 0.017	1.264TrpLeu: 1.264 ± 0.037	0.245TrpMet: 0.245 ± 0.015	0.493TrpAsn: 0.493 ± 0.022	0.466TrpPro: 0.466 ± 0.024	0.449TrpGln: 0.449 ± 0.022	0.778TrpArg: 0.778 ± 0.026	0.691TrpSer: 0.691 ± 0.033	0.883TrpThr: 0.883 ± 0.033	0.822TrpVal: 0.822 ± 0.033	0.227TrpTrp: 0.227 ± 0.017	0.446TrpTyr: 0.446 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.568TyrAla: 2.568 ± 0.049	0.274TyrCys: 0.274 ± 0.016	2.558TyrAsp: 2.558 ± 0.052	2.52TyrGlu: 2.52 ± 0.05	0.898TyrPhe: 0.898 ± 0.027	2.303TyrGly: 2.303 ± 0.052	0.778TyrHis: 0.778 ± 0.025	1.099TyrIle: 1.099 ± 0.036	0.541TyrLys: 0.541 ± 0.024	2.616TyrLeu: 2.616 ± 0.059	0.435TyrMet: 0.435 ± 0.022	0.873TyrAsn: 0.873 ± 0.029	1.344TyrPro: 1.344 ± 0.034	0.969TyrGln: 0.969 ± 0.033	2.083TyrArg: 2.083 ± 0.049	1.471TyrSer: 1.471 ± 0.04	1.902TyrThr: 1.902 ± 0.045	2.178TyrVal: 2.178 ± 0.047	0.394TyrTrp: 0.394 ± 0.021	0.96TyrTyr: 0.96 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3340 proteins (990830 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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