Amino acid dipepetide frequency for Sphingomonas adhaesiva

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
25.31AlaAla: 25.31 ± 0.345
1.124AlaCys: 1.124 ± 0.033
9.066AlaAsp: 9.066 ± 0.118
7.077AlaGlu: 7.077 ± 0.118
4.544AlaPhe: 4.544 ± 0.071
13.938AlaGly: 13.938 ± 0.222
2.586AlaHis: 2.586 ± 0.054
7.371AlaIle: 7.371 ± 0.095
3.351AlaLys: 3.351 ± 0.069
15.359AlaLeu: 15.359 ± 0.197
4.262AlaMet: 4.262 ± 0.069
3.058AlaAsn: 3.058 ± 0.065
7.95AlaPro: 7.95 ± 0.119
5.003AlaGln: 5.003 ± 0.077
12.126AlaArg: 12.126 ± 0.166
6.162AlaSer: 6.162 ± 0.093
8.329AlaThr: 8.329 ± 0.1
10.018AlaVal: 10.018 ± 0.116
1.836AlaTrp: 1.836 ± 0.049
2.54AlaTyr: 2.54 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
1.018CysAla: 1.018 ± 0.031
0.081CysCys: 0.081 ± 0.009
0.506CysAsp: 0.506 ± 0.019
0.304CysGlu: 0.304 ± 0.018
0.246CysPhe: 0.246 ± 0.019
0.751CysGly: 0.751 ± 0.031
0.176CysHis: 0.176 ± 0.014
0.312CysIle: 0.312 ± 0.02
0.099CysLys: 0.099 ± 0.009
0.598CysLeu: 0.598 ± 0.024
0.116CysMet: 0.116 ± 0.01
0.155CysAsn: 0.155 ± 0.012
0.417CysPro: 0.417 ± 0.022
0.172CysGln: 0.172 ± 0.012
0.565CysArg: 0.565 ± 0.025
0.354CysSer: 0.354 ± 0.019
0.355CysThr: 0.355 ± 0.017
0.502CysVal: 0.502 ± 0.022
0.105CysTrp: 0.105 ± 0.009
0.148CysTyr: 0.148 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
9.744AspAla: 9.744 ± 0.117
0.394AspCys: 0.394 ± 0.018
3.839AspAsp: 3.839 ± 0.074
3.077AspGlu: 3.077 ± 0.062
1.888AspPhe: 1.888 ± 0.042
6.326AspGly: 6.326 ± 0.086
1.402AspHis: 1.402 ± 0.04
2.507AspIle: 2.507 ± 0.053
1.325AspLys: 1.325 ± 0.04
5.653AspLeu: 5.653 ± 0.069
1.398AspMet: 1.398 ± 0.038
1.209AspAsn: 1.209 ± 0.037
3.887AspPro: 3.887 ± 0.06
1.726AspGln: 1.726 ± 0.042
5.669AspArg: 5.669 ± 0.069
2.062AspSer: 2.062 ± 0.046
3.225AspThr: 3.225 ± 0.094
4.755AspVal: 4.755 ± 0.083
1.19AspTrp: 1.19 ± 0.036
1.647AspTyr: 1.647 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
7.239GluAla: 7.239 ± 0.115
0.255GluCys: 0.255 ± 0.016
2.368GluAsp: 2.368 ± 0.053
2.514GluGlu: 2.514 ± 0.059
1.189GluPhe: 1.189 ± 0.038
4.026GluGly: 4.026 ± 0.06
1.014GluHis: 1.014 ± 0.035
2.303GluIle: 2.303 ± 0.05
1.364GluLys: 1.364 ± 0.044
4.25GluLeu: 4.25 ± 0.074
1.174GluMet: 1.174 ± 0.033
0.967GluAsn: 0.967 ± 0.035
2.216GluPro: 2.216 ± 0.047
1.777GluGln: 1.777 ± 0.041
5.146GluArg: 5.146 ± 0.083
1.693GluSer: 1.693 ± 0.036
2.64GluThr: 2.64 ± 0.052
3.426GluVal: 3.426 ± 0.066
0.718GluTrp: 0.718 ± 0.025
0.807GluTyr: 0.807 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.953PheAla: 4.953 ± 0.075
0.279PheCys: 0.279 ± 0.016
2.655PheAsp: 2.655 ± 0.051
1.609PheGlu: 1.609 ± 0.04
1.145PhePhe: 1.145 ± 0.037
3.385PheGly: 3.385 ± 0.066
0.675PheHis: 0.675 ± 0.023
1.105PheIle: 1.105 ± 0.031
0.624PheLys: 0.624 ± 0.026
2.9PheLeu: 2.9 ± 0.062
0.627PheMet: 0.627 ± 0.022
0.871PheAsn: 0.871 ± 0.033
1.335PhePro: 1.335 ± 0.038
0.862PheGln: 0.862 ± 0.03
2.253PheArg: 2.253 ± 0.045
1.581PheSer: 1.581 ± 0.041
1.928PheThr: 1.928 ± 0.051
2.649PheVal: 2.649 ± 0.056
0.468PheTrp: 0.468 ± 0.024
0.835PheTyr: 0.835 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
12.228GlyAla: 12.228 ± 0.185
0.767GlyCys: 0.767 ± 0.028
5.66GlyAsp: 5.66 ± 0.152
4.534GlyGlu: 4.534 ± 0.074
3.411GlyPhe: 3.411 ± 0.057
8.995GlyGly: 8.995 ± 0.228
1.898GlyHis: 1.898 ± 0.044
4.212GlyIle: 4.212 ± 0.074
2.563GlyLys: 2.563 ± 0.057
8.235GlyLeu: 8.235 ± 0.102
2.303GlyMet: 2.303 ± 0.052
2.187GlyAsn: 2.187 ± 0.067
3.452GlyPro: 3.452 ± 0.064
2.898GlyGln: 2.898 ± 0.056
7.234GlyArg: 7.234 ± 0.087
4.415GlySer: 4.415 ± 0.107
5.54GlyThr: 5.54 ± 0.127
7.02GlyVal: 7.02 ± 0.091
1.745GlyTrp: 1.745 ± 0.045
2.373GlyTyr: 2.373 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
2.723HisAla: 2.723 ± 0.061
0.197HisCys: 0.197 ± 0.014
1.393HisAsp: 1.393 ± 0.04
0.876HisGlu: 0.876 ± 0.032
0.707HisPhe: 0.707 ± 0.028
2.025HisGly: 2.025 ± 0.044
0.574HisHis: 0.574 ± 0.028
0.742HisIle: 0.742 ± 0.03
0.32HisLys: 0.32 ± 0.016
1.885HisLeu: 1.885 ± 0.049
0.401HisMet: 0.401 ± 0.018
0.376HisAsn: 0.376 ± 0.023
1.355HisPro: 1.355 ± 0.037
0.519HisGln: 0.519 ± 0.022
1.691HisArg: 1.691 ± 0.038
0.714HisSer: 0.714 ± 0.026
0.682HisThr: 0.682 ± 0.021
1.554HisVal: 1.554 ± 0.041
0.331HisTrp: 0.331 ± 0.015
0.502HisTyr: 0.502 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
8.437IleAla: 8.437 ± 0.098
0.289IleCys: 0.289 ± 0.016
3.89IleAsp: 3.89 ± 0.066
2.917IleGlu: 2.917 ± 0.059
1.169IlePhe: 1.169 ± 0.038
4.916IleGly: 4.916 ± 0.072
0.8IleHis: 0.8 ± 0.027
1.436IleIle: 1.436 ± 0.038
0.885IleLys: 0.885 ± 0.031
3.337IleLeu: 3.337 ± 0.065
0.654IleMet: 0.654 ± 0.027
1.045IleAsn: 1.045 ± 0.034
1.948IlePro: 1.948 ± 0.043
1.036IleGln: 1.036 ± 0.037
3.153IleArg: 3.153 ± 0.051
1.863IleSer: 1.863 ± 0.047
2.216IleThr: 2.216 ± 0.053
4.328IleVal: 4.328 ± 0.066
0.485IleTrp: 0.485 ± 0.023
0.837IleTyr: 0.837 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
3.211LysAla: 3.211 ± 0.073
0.109LysCys: 0.109 ± 0.01
1.236LysAsp: 1.236 ± 0.041
0.949LysGlu: 0.949 ± 0.035
0.575LysPhe: 0.575 ± 0.023
2.216LysGly: 2.216 ± 0.055
0.373LysHis: 0.373 ± 0.019
0.959LysIle: 0.959 ± 0.035
0.845LysLys: 0.845 ± 0.033
2.453LysLeu: 2.453 ± 0.059
0.607LysMet: 0.607 ± 0.029
0.557LysAsn: 0.557 ± 0.024
1.515LysPro: 1.515 ± 0.042
0.682LysGln: 0.682 ± 0.028
1.85LysArg: 1.85 ± 0.044
1.113LysSer: 1.113 ± 0.038
1.307LysThr: 1.307 ± 0.038
1.769LysVal: 1.769 ± 0.051
0.281LysTrp: 0.281 ± 0.017
0.45LysTyr: 0.45 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
15.296LeuAla: 15.296 ± 0.163
0.654LeuCys: 0.654 ± 0.027
6.281LeuAsp: 6.281 ± 0.075
4.112LeuGlu: 4.112 ± 0.069
3.426LeuPhe: 3.426 ± 0.067
8.032LeuGly: 8.032 ± 0.101
1.832LeuHis: 1.832 ± 0.043
4.245LeuIle: 4.245 ± 0.066
2.406LeuLys: 2.406 ± 0.055
9.299LeuLeu: 9.299 ± 0.14
1.948LeuMet: 1.948 ± 0.046
2.144LeuAsn: 2.144 ± 0.048
5.805LeuPro: 5.805 ± 0.083
2.141LeuGln: 2.141 ± 0.042
7.23LeuArg: 7.23 ± 0.103
5.627LeuSer: 5.627 ± 0.076
5.92LeuThr: 5.92 ± 0.087
7.311LeuVal: 7.311 ± 0.09
1.157LeuTrp: 1.157 ± 0.034
1.861LeuTyr: 1.861 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
3.301MetAla: 3.301 ± 0.062
0.134MetCys: 0.134 ± 0.011
1.047MetAsp: 1.047 ± 0.033
0.933MetGlu: 0.933 ± 0.035
0.642MetPhe: 0.642 ± 0.03
1.736MetGly: 1.736 ± 0.045
0.395MetHis: 0.395 ± 0.017
1.234MetIle: 1.234 ± 0.034
0.773MetLys: 0.773 ± 0.027
2.495MetLeu: 2.495 ± 0.051
0.63MetMet: 0.63 ± 0.027
0.594MetAsn: 0.594 ± 0.025
1.387MetPro: 1.387 ± 0.037
0.667MetGln: 0.667 ± 0.028
1.832MetArg: 1.832 ± 0.039
1.201MetSer: 1.201 ± 0.028
1.877MetThr: 1.877 ± 0.043
1.671MetVal: 1.671 ± 0.04
0.208MetTrp: 0.208 ± 0.015
0.247MetTyr: 0.247 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
3.105AsnAla: 3.105 ± 0.065
0.176AsnCys: 0.176 ± 0.013
1.391AsnAsp: 1.391 ± 0.046
0.913AsnGlu: 0.913 ± 0.031
0.767AsnPhe: 0.767 ± 0.035
2.268AsnGly: 2.268 ± 0.076
0.386AsnHis: 0.386 ± 0.02
1.063AsnIle: 1.063 ± 0.033
0.447AsnLys: 0.447 ± 0.022
2.195AsnLeu: 2.195 ± 0.066
0.427AsnMet: 0.427 ± 0.024
0.594AsnAsn: 0.594 ± 0.031
1.585AsnPro: 1.585 ± 0.037
0.653AsnGln: 0.653 ± 0.023
1.716AsnArg: 1.716 ± 0.037
0.936AsnSer: 0.936 ± 0.035
1.098AsnThr: 1.098 ± 0.044
1.822AsnVal: 1.822 ± 0.058
0.331AsnTrp: 0.331 ± 0.018
0.603AsnTyr: 0.603 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
8.93ProAla: 8.93 ± 0.117
0.309ProCys: 0.309 ± 0.015
3.929ProAsp: 3.929 ± 0.062
2.807ProGlu: 2.807 ± 0.056
1.806ProPhe: 1.806 ± 0.039
5.18ProGly: 5.18 ± 0.075
1.045ProHis: 1.045 ± 0.032
2.149ProIle: 2.149 ± 0.047
1.129ProLys: 1.129 ± 0.035
5.073ProLeu: 5.073 ± 0.074
1.085ProMet: 1.085 ± 0.031
1.117ProAsn: 1.117 ± 0.036
3.173ProPro: 3.173 ± 0.088
1.565ProGln: 1.565 ± 0.036
3.581ProArg: 3.581 ± 0.067
2.447ProSer: 2.447 ± 0.043
2.624ProThr: 2.624 ± 0.048
4.657ProVal: 4.657 ± 0.065
0.67ProTrp: 0.67 ± 0.026
1.082ProTyr: 1.082 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
4.257GlnAla: 4.257 ± 0.067
0.169GlnCys: 0.169 ± 0.013
1.384GlnAsp: 1.384 ± 0.039
1.139GlnGlu: 1.139 ± 0.033
0.954GlnPhe: 0.954 ± 0.03
2.401GlnGly: 2.401 ± 0.056
0.524GlnHis: 0.524 ± 0.022
1.454GlnIle: 1.454 ± 0.038
0.724GlnLys: 0.724 ± 0.031
3.027GlnLeu: 3.027 ± 0.057
0.757GlnMet: 0.757 ± 0.026
0.709GlnAsn: 0.709 ± 0.027
1.756GlnPro: 1.756 ± 0.037
1.188GlnGln: 1.188 ± 0.044
2.687GlnArg: 2.687 ± 0.055
1.396GlnSer: 1.396 ± 0.042
1.528GlnThr: 1.528 ± 0.036
2.367GlnVal: 2.367 ± 0.043
0.422GlnTrp: 0.422 ± 0.018
0.571GlnTyr: 0.571 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
11.172ArgAla: 11.172 ± 0.162
0.537ArgCys: 0.537 ± 0.024
5.245ArgAsp: 5.245 ± 0.084
3.755ArgGlu: 3.755 ± 0.066
3.154ArgPhe: 3.154 ± 0.058
6.016ArgGly: 6.016 ± 0.085
1.922ArgHis: 1.922 ± 0.049
4.296ArgIle: 4.296 ± 0.061
1.478ArgLys: 1.478 ± 0.038
8.798ArgLeu: 8.798 ± 0.108
2.046ArgMet: 2.046 ± 0.046
1.656ArgAsn: 1.656 ± 0.044
4.096ArgPro: 4.096 ± 0.076
2.527ArgGln: 2.527 ± 0.05
7.137ArgArg: 7.137 ± 0.125
3.415ArgSer: 3.415 ± 0.058
4.077ArgThr: 4.077 ± 0.064
5.804ArgVal: 5.804 ± 0.077
1.449ArgTrp: 1.449 ± 0.042
2.05ArgTyr: 2.05 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
6.147SerAla: 6.147 ± 0.09
0.325SerCys: 0.325 ± 0.02
2.709SerAsp: 2.709 ± 0.048
1.858SerGlu: 1.858 ± 0.044
1.787SerPhe: 1.787 ± 0.043
4.91SerGly: 4.91 ± 0.096
0.843SerHis: 0.843 ± 0.029
2.276SerIle: 2.276 ± 0.057
0.999SerLys: 0.999 ± 0.036
4.264SerLeu: 4.264 ± 0.061
0.993SerMet: 0.993 ± 0.033
1.164SerAsn: 1.164 ± 0.041
2.535SerPro: 2.535 ± 0.054
1.245SerGln: 1.245 ± 0.036
3.236SerArg: 3.236 ± 0.065
2.321SerSer: 2.321 ± 0.076
2.437SerThr: 2.437 ± 0.057
3.388SerVal: 3.388 ± 0.067
0.701SerTrp: 0.701 ± 0.025
1.187SerTyr: 1.187 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
7.541ThrAla: 7.541 ± 0.126
0.384ThrCys: 0.384 ± 0.019
3.116ThrAsp: 3.116 ± 0.056
1.959ThrGlu: 1.959 ± 0.046
1.873ThrPhe: 1.873 ± 0.05
5.825ThrGly: 5.825 ± 0.136
0.953ThrHis: 0.953 ± 0.031
3.178ThrIle: 3.178 ± 0.06
1.14ThrLys: 1.14 ± 0.037
6.373ThrLeu: 6.373 ± 0.097
1.214ThrMet: 1.214 ± 0.033
1.246ThrAsn: 1.246 ± 0.043
3.768ThrPro: 3.768 ± 0.059
1.573ThrGln: 1.573 ± 0.042
4.004ThrArg: 4.004 ± 0.068
2.408ThrSer: 2.408 ± 0.06
3.028ThrThr: 3.028 ± 0.063
4.637ThrVal: 4.637 ± 0.089
0.678ThrTrp: 0.678 ± 0.027
1.138ThrTyr: 1.138 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
12.109ValAla: 12.109 ± 0.125
0.485ValCys: 0.485 ± 0.02
4.843ValAsp: 4.843 ± 0.067
4.256ValGlu: 4.256 ± 0.067
2.167ValPhe: 2.167 ± 0.047
5.677ValGly: 5.677 ± 0.086
1.309ValHis: 1.309 ± 0.034
3.502ValIle: 3.502 ± 0.055
1.789ValLys: 1.789 ± 0.041
6.888ValLeu: 6.888 ± 0.084
1.661ValMet: 1.661 ± 0.046
1.879ValAsn: 1.879 ± 0.054
4.447ValPro: 4.447 ± 0.065
1.976ValGln: 1.976 ± 0.047
5.86ValArg: 5.86 ± 0.082
3.75ValSer: 3.75 ± 0.061
5.326ValThr: 5.326 ± 0.095
6.029ValVal: 6.029 ± 0.083
0.832ValTrp: 0.832 ± 0.029
1.321ValTyr: 1.321 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
1.433TrpAla: 1.433 ± 0.038
0.124TrpCys: 0.124 ± 0.011
0.746TrpAsp: 0.746 ± 0.031
0.514TrpGlu: 0.514 ± 0.021
0.538TrpPhe: 0.538 ± 0.022
0.976TrpGly: 0.976 ± 0.033
0.389TrpHis: 0.389 ± 0.019
0.636TrpIle: 0.636 ± 0.026
0.374TrpLys: 0.374 ± 0.021
1.678TrpLeu: 1.678 ± 0.045
0.34TrpMet: 0.34 ± 0.017
0.405TrpAsn: 0.405 ± 0.019
0.736TrpPro: 0.736 ± 0.03
0.583TrpGln: 0.583 ± 0.023
1.584TrpArg: 1.584 ± 0.046
0.854TrpSer: 0.854 ± 0.029
0.882TrpThr: 0.882 ± 0.028
0.84TrpVal: 0.84 ± 0.03
0.283TrpTrp: 0.283 ± 0.015
0.286TrpTyr: 0.286 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.856TyrAla: 2.856 ± 0.049
0.187TyrCys: 0.187 ± 0.016
1.62TyrAsp: 1.62 ± 0.036
0.982TyrGlu: 0.982 ± 0.032
0.751TyrPhe: 0.751 ± 0.03
2.068TyrGly: 2.068 ± 0.05
0.47TyrHis: 0.47 ± 0.021
0.659TyrIle: 0.659 ± 0.026
0.425TyrLys: 0.425 ± 0.02
1.965TyrLeu: 1.965 ± 0.04
0.356TyrMet: 0.356 ± 0.018
0.546TyrAsn: 0.546 ± 0.029
0.995TyrPro: 0.995 ± 0.028
0.624TyrGln: 0.624 ± 0.025
2.077TyrArg: 2.077 ± 0.05
1.017TyrSer: 1.017 ± 0.041
1.02TyrThr: 1.02 ± 0.035
1.561TyrVal: 1.561 ± 0.037
0.307TyrTrp: 0.307 ± 0.018
0.564TyrTyr: 0.564 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3413 proteins (1123567 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski