Amino acid dipepetide frequency for Pelotomaculum schinkii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.6AlaAla: 9.6 ± 0.137	1.175AlaCys: 1.175 ± 0.033	4.108AlaAsp: 4.108 ± 0.075	5.373AlaGlu: 5.373 ± 0.068	3.04AlaPhe: 3.04 ± 0.051	8.673AlaGly: 8.673 ± 0.132	1.302AlaHis: 1.302 ± 0.032	5.273AlaIle: 5.273 ± 0.065	4.258AlaLys: 4.258 ± 0.064	8.993AlaLeu: 8.993 ± 0.092	2.303AlaMet: 2.303 ± 0.053	2.692AlaAsn: 2.692 ± 0.052	3.013AlaPro: 3.013 ± 0.06	2.621AlaGln: 2.621 ± 0.053	4.853AlaArg: 4.853 ± 0.072	4.293AlaSer: 4.293 ± 0.062	3.92AlaThr: 3.92 ± 0.069	7.51AlaVal: 7.51 ± 0.104	0.843AlaTrp: 0.843 ± 0.03	2.503AlaTyr: 2.503 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.981CysAla: 0.981 ± 0.027	0.294CysCys: 0.294 ± 0.018	0.624CysAsp: 0.624 ± 0.027	0.611CysGlu: 0.611 ± 0.024	0.484CysPhe: 0.484 ± 0.021	1.396CysGly: 1.396 ± 0.046	0.253CysHis: 0.253 ± 0.015	0.744CysIle: 0.744 ± 0.026	0.55CysLys: 0.55 ± 0.022	1.211CysLeu: 1.211 ± 0.03	0.332CysMet: 0.332 ± 0.017	0.495CysAsn: 0.495 ± 0.022	0.778CysPro: 0.778 ± 0.028	0.366CysGln: 0.366 ± 0.018	0.872CysArg: 0.872 ± 0.029	0.846CysSer: 0.846 ± 0.028	0.617CysThr: 0.617 ± 0.027	0.738CysVal: 0.738 ± 0.025	0.119CysTrp: 0.119 ± 0.01	0.431CysTyr: 0.431 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	3.655AspAla: 3.655 ± 0.061	0.64AspCys: 0.64 ± 0.024	2.278AspAsp: 2.278 ± 0.057	3.407AspGlu: 3.407 ± 0.059	2.247AspPhe: 2.247 ± 0.037	3.902AspGly: 3.902 ± 0.077	0.834AspHis: 0.834 ± 0.024	3.942AspIle: 3.942 ± 0.069	2.761AspLys: 2.761 ± 0.055	5.355AspLeu: 5.355 ± 0.068	1.321AspMet: 1.321 ± 0.035	2.083AspAsn: 2.083 ± 0.052	2.373AspPro: 2.373 ± 0.045	1.555AspGln: 1.555 ± 0.037	2.704AspArg: 2.704 ± 0.056	2.574AspSer: 2.574 ± 0.059	2.537AspThr: 2.537 ± 0.051	3.47AspVal: 3.47 ± 0.056	0.597AspTrp: 0.597 ± 0.023	2.038AspTyr: 2.038 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	5.817GluAla: 5.817 ± 0.076	0.564GluCys: 0.564 ± 0.022	3.078GluAsp: 3.078 ± 0.063	5.204GluGlu: 5.204 ± 0.085	2.228GluPhe: 2.228 ± 0.049	4.236GluGly: 4.236 ± 0.061	1.157GluHis: 1.157 ± 0.029	5.151GluIle: 5.151 ± 0.077	4.95GluLys: 4.95 ± 0.083	6.743GluLeu: 6.743 ± 0.093	1.914GluMet: 1.914 ± 0.042	2.932GluAsn: 2.932 ± 0.058	2.224GluPro: 2.224 ± 0.052	2.795GluGln: 2.795 ± 0.053	3.664GluArg: 3.664 ± 0.061	3.0GluSer: 3.0 ± 0.048	3.21GluThr: 3.21 ± 0.049	4.803GluVal: 4.803 ± 0.069	0.616GluTrp: 0.616 ± 0.024	2.1GluTyr: 2.1 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.014PheAla: 3.014 ± 0.053	0.561PheCys: 0.561 ± 0.023	2.102PheAsp: 2.102 ± 0.043	2.17PheGlu: 2.17 ± 0.051	1.81PhePhe: 1.81 ± 0.045	2.955PheGly: 2.955 ± 0.053	0.697PheHis: 0.697 ± 0.023	2.811PheIle: 2.811 ± 0.062	2.115PheLys: 2.115 ± 0.046	3.839PheLeu: 3.839 ± 0.065	0.959PheMet: 0.959 ± 0.027	1.757PheAsn: 1.757 ± 0.039	1.594PhePro: 1.594 ± 0.038	1.218PheGln: 1.218 ± 0.03	1.747PheArg: 1.747 ± 0.039	2.613PheSer: 2.613 ± 0.05	2.366PheThr: 2.366 ± 0.048	2.471PheVal: 2.471 ± 0.045	0.451PheTrp: 0.451 ± 0.021	1.425PheTyr: 1.425 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	6.504GlyAla: 6.504 ± 0.094	1.224GlyCys: 1.224 ± 0.037	3.695GlyAsp: 3.695 ± 0.068	4.833GlyGlu: 4.833 ± 0.065	3.262GlyPhe: 3.262 ± 0.05	6.219GlyGly: 6.219 ± 0.115	1.405GlyHis: 1.405 ± 0.037	5.719GlyIle: 5.719 ± 0.081	4.782GlyLys: 4.782 ± 0.068	8.094GlyLeu: 8.094 ± 0.108	2.237GlyMet: 2.237 ± 0.05	2.833GlyAsn: 2.833 ± 0.067	2.419GlyPro: 2.419 ± 0.051	2.803GlyGln: 2.803 ± 0.058	4.323GlyArg: 4.323 ± 0.077	4.787GlySer: 4.787 ± 0.076	4.193GlyThr: 4.193 ± 0.08	5.899GlyVal: 5.899 ± 0.074	0.866GlyTrp: 0.866 ± 0.027	2.984GlyTyr: 2.984 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.27HisAla: 1.27 ± 0.031	0.305HisCys: 0.305 ± 0.017	0.846HisAsp: 0.846 ± 0.03	0.961HisGlu: 0.961 ± 0.032	0.79HisPhe: 0.79 ± 0.025	1.382HisGly: 1.382 ± 0.038	0.397HisHis: 0.397 ± 0.02	1.181HisIle: 1.181 ± 0.034	0.829HisLys: 0.829 ± 0.027	1.751HisLeu: 1.751 ± 0.039	0.4HisMet: 0.4 ± 0.018	0.687HisAsn: 0.687 ± 0.024	0.968HisPro: 0.968 ± 0.034	0.568HisGln: 0.568 ± 0.021	1.003HisArg: 1.003 ± 0.027	0.98HisSer: 0.98 ± 0.034	0.934HisThr: 0.934 ± 0.027	1.056HisVal: 1.056 ± 0.035	0.236HisTrp: 0.236 ± 0.014	0.703HisTyr: 0.703 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.629IleAla: 5.629 ± 0.064	0.907IleCys: 0.907 ± 0.029	3.595IleAsp: 3.595 ± 0.062	4.384IleGlu: 4.384 ± 0.072	2.654IlePhe: 2.654 ± 0.049	4.752IleGly: 4.752 ± 0.069	1.143IleHis: 1.143 ± 0.033	4.994IleIle: 4.994 ± 0.073	4.145IleLys: 4.145 ± 0.074	6.461IleLeu: 6.461 ± 0.084	1.653IleMet: 1.653 ± 0.04	3.189IleAsn: 3.189 ± 0.057	3.186IlePro: 3.186 ± 0.055	1.987IleGln: 1.987 ± 0.044	3.342IleArg: 3.342 ± 0.055	4.391IleSer: 4.391 ± 0.068	4.305IleThr: 4.305 ± 0.071	4.517IleVal: 4.517 ± 0.073	0.589IleTrp: 0.589 ± 0.022	2.119IleTyr: 2.119 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.805LysAla: 4.805 ± 0.063	0.554LysCys: 0.554 ± 0.025	3.156LysAsp: 3.156 ± 0.053	4.707LysGlu: 4.707 ± 0.085	1.711LysPhe: 1.711 ± 0.038	3.787LysGly: 3.787 ± 0.064	0.975LysHis: 0.975 ± 0.03	4.338LysIle: 4.338 ± 0.07	4.274LysLys: 4.274 ± 0.075	5.205LysLeu: 5.205 ± 0.076	1.677LysMet: 1.677 ± 0.044	2.758LysAsn: 2.758 ± 0.054	2.349LysPro: 2.349 ± 0.047	1.985LysGln: 1.985 ± 0.04	2.84LysArg: 2.84 ± 0.051	2.968LysSer: 2.968 ± 0.055	3.186LysThr: 3.186 ± 0.044	4.158LysVal: 4.158 ± 0.068	0.511LysTrp: 0.511 ± 0.022	1.992LysTyr: 1.992 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	9.978LeuAla: 9.978 ± 0.121	1.162LeuCys: 1.162 ± 0.037	5.121LeuAsp: 5.121 ± 0.062	6.88LeuGlu: 6.88 ± 0.091	3.73LeuPhe: 3.73 ± 0.068	7.399LeuGly: 7.399 ± 0.097	1.655LeuHis: 1.655 ± 0.038	6.063LeuIle: 6.063 ± 0.09	6.243LeuLys: 6.243 ± 0.087	10.477LeuLeu: 10.477 ± 0.131	2.275LeuMet: 2.275 ± 0.043	4.124LeuAsn: 4.124 ± 0.064	4.735LeuPro: 4.735 ± 0.068	3.362LeuGln: 3.362 ± 0.06	4.955LeuArg: 4.955 ± 0.079	6.519LeuSer: 6.519 ± 0.077	5.717LeuThr: 5.717 ± 0.073	7.14LeuVal: 7.14 ± 0.081	0.935LeuTrp: 0.935 ± 0.032	2.919LeuTyr: 2.919 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.502MetAla: 2.502 ± 0.046	0.225MetCys: 0.225 ± 0.015	1.391MetAsp: 1.391 ± 0.038	1.826MetGlu: 1.826 ± 0.044	0.819MetPhe: 0.819 ± 0.03	1.962MetGly: 1.962 ± 0.047	0.419MetHis: 0.419 ± 0.02	1.545MetIle: 1.545 ± 0.042	1.685MetLys: 1.685 ± 0.038	2.543MetLeu: 2.543 ± 0.046	0.638MetMet: 0.638 ± 0.025	1.0MetAsn: 1.0 ± 0.029	1.257MetPro: 1.257 ± 0.036	0.915MetGln: 0.915 ± 0.029	1.24MetArg: 1.24 ± 0.03	1.522MetSer: 1.522 ± 0.03	1.304MetThr: 1.304 ± 0.032	2.044MetVal: 2.044 ± 0.045	0.186MetTrp: 0.186 ± 0.013	0.574MetTyr: 0.574 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.818AsnAla: 2.818 ± 0.052	0.629AsnCys: 0.629 ± 0.024	1.695AsnAsp: 1.695 ± 0.038	2.254AsnGlu: 2.254 ± 0.042	1.425AsnPhe: 1.425 ± 0.037	3.164AsnGly: 3.164 ± 0.058	0.728AsnHis: 0.728 ± 0.024	3.299AsnIle: 3.299 ± 0.059	2.396AsnLys: 2.396 ± 0.051	4.105AsnLeu: 4.105 ± 0.062	1.054AsnMet: 1.054 ± 0.029	1.954AsnAsn: 1.954 ± 0.054	2.239AsnPro: 2.239 ± 0.049	1.427AsnGln: 1.427 ± 0.036	2.121AsnArg: 2.121 ± 0.042	2.332AsnSer: 2.332 ± 0.057	2.14AsnThr: 2.14 ± 0.047	2.498AsnVal: 2.498 ± 0.051	0.457AsnTrp: 0.457 ± 0.02	1.511AsnTyr: 1.511 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	4.13ProAla: 4.13 ± 0.086	0.484ProCys: 0.484 ± 0.025	2.739ProAsp: 2.739 ± 0.051	3.53ProGlu: 3.53 ± 0.056	1.765ProPhe: 1.765 ± 0.04	4.038ProGly: 4.038 ± 0.068	0.713ProHis: 0.713 ± 0.026	1.971ProIle: 1.971 ± 0.043	1.898ProLys: 1.898 ± 0.045	3.977ProLeu: 3.977 ± 0.052	0.868ProMet: 0.868 ± 0.03	1.371ProAsn: 1.371 ± 0.033	1.639ProPro: 1.639 ± 0.051	1.455ProGln: 1.455 ± 0.035	1.823ProArg: 1.823 ± 0.042	2.23ProSer: 2.23 ± 0.044	1.764ProThr: 1.764 ± 0.045	4.137ProVal: 4.137 ± 0.07	0.472ProTrp: 0.472 ± 0.023	1.417ProTyr: 1.417 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.237GlnAla: 3.237 ± 0.061	0.357GlnCys: 0.357 ± 0.021	1.649GlnAsp: 1.649 ± 0.038	2.532GlnGlu: 2.532 ± 0.043	1.151GlnPhe: 1.151 ± 0.035	2.427GlnGly: 2.427 ± 0.047	0.564GlnHis: 0.564 ± 0.02	2.203GlnIle: 2.203 ± 0.046	2.244GlnLys: 2.244 ± 0.046	3.12GlnLeu: 3.12 ± 0.05	0.938GlnMet: 0.938 ± 0.031	1.408GlnAsn: 1.408 ± 0.035	1.359GlnPro: 1.359 ± 0.035	1.424GlnGln: 1.424 ± 0.041	1.688GlnArg: 1.688 ± 0.04	1.775GlnSer: 1.775 ± 0.043	1.668GlnThr: 1.668 ± 0.037	2.752GlnVal: 2.752 ± 0.043	0.356GlnTrp: 0.356 ± 0.017	1.08GlnTyr: 1.08 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	3.816ArgAla: 3.816 ± 0.055	0.652ArgCys: 0.652 ± 0.024	2.627ArgAsp: 2.627 ± 0.052	4.156ArgGlu: 4.156 ± 0.066	2.06ArgPhe: 2.06 ± 0.041	3.471ArgGly: 3.471 ± 0.06	0.955ArgHis: 0.955 ± 0.03	3.508ArgIle: 3.508 ± 0.06	2.985ArgLys: 2.985 ± 0.054	5.923ArgLeu: 5.923 ± 0.095	1.44ArgMet: 1.44 ± 0.031	1.974ArgAsn: 1.974 ± 0.041	2.06ArgPro: 2.06 ± 0.048	2.17ArgGln: 2.17 ± 0.044	3.29ArgArg: 3.29 ± 0.063	2.651ArgSer: 2.651 ± 0.042	2.425ArgThr: 2.425 ± 0.044	3.762ArgVal: 3.762 ± 0.063	0.558ArgTrp: 0.558 ± 0.02	1.951ArgTyr: 1.951 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.333SerAla: 4.333 ± 0.067	0.823SerCys: 0.823 ± 0.029	2.732SerAsp: 2.732 ± 0.053	3.26SerGlu: 3.26 ± 0.057	2.59SerPhe: 2.59 ± 0.044	5.326SerGly: 5.326 ± 0.09	1.061SerHis: 1.061 ± 0.028	3.734SerIle: 3.734 ± 0.064	2.881SerLys: 2.881 ± 0.058	6.07SerLeu: 6.07 ± 0.07	1.515SerMet: 1.515 ± 0.04	2.123SerAsn: 2.123 ± 0.052	2.579SerPro: 2.579 ± 0.053	1.83SerGln: 1.83 ± 0.039	3.068SerArg: 3.068 ± 0.053	3.486SerSer: 3.486 ± 0.065	2.795SerThr: 2.795 ± 0.047	4.065SerVal: 4.065 ± 0.074	0.646SerTrp: 0.646 ± 0.026	2.069SerTyr: 2.069 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.845ThrAla: 4.845 ± 0.085	0.633ThrCys: 0.633 ± 0.025	2.49ThrAsp: 2.49 ± 0.054	2.892ThrGlu: 2.892 ± 0.048	1.991ThrPhe: 1.991 ± 0.043	5.612ThrGly: 5.612 ± 0.079	0.846ThrHis: 0.846 ± 0.028	3.615ThrIle: 3.615 ± 0.058	2.361ThrLys: 2.361 ± 0.044	5.155ThrLeu: 5.155 ± 0.08	1.209ThrMet: 1.209 ± 0.028	1.826ThrAsn: 1.826 ± 0.046	2.62ThrPro: 2.62 ± 0.05	1.357ThrGln: 1.357 ± 0.037	2.589ThrArg: 2.589 ± 0.047	2.854ThrSer: 2.854 ± 0.055	2.812ThrThr: 2.812 ± 0.066	4.651ThrVal: 4.651 ± 0.106	0.573ThrTrp: 0.573 ± 0.027	1.639ThrTyr: 1.639 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	6.243ValAla: 6.243 ± 0.095	0.946ValCys: 0.946 ± 0.032	3.937ValAsp: 3.937 ± 0.065	4.852ValGlu: 4.852 ± 0.071	3.037ValPhe: 3.037 ± 0.054	4.901ValGly: 4.901 ± 0.077	1.183ValHis: 1.183 ± 0.032	5.11ValIle: 5.11 ± 0.067	4.324ValLys: 4.324 ± 0.061	7.605ValLeu: 7.605 ± 0.09	1.937ValMet: 1.937 ± 0.04	3.128ValAsn: 3.128 ± 0.053	3.112ValPro: 3.112 ± 0.058	2.279ValGln: 2.279 ± 0.044	3.719ValArg: 3.719 ± 0.059	4.603ValSer: 4.603 ± 0.07	4.408ValThr: 4.408 ± 0.099	5.946ValVal: 5.946 ± 0.086	0.68ValTrp: 0.68 ± 0.029	2.276ValTyr: 2.276 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.765TrpAla: 0.765 ± 0.027	0.121TrpCys: 0.121 ± 0.01	0.558TrpAsp: 0.558 ± 0.023	0.695TrpGlu: 0.695 ± 0.024	0.404TrpPhe: 0.404 ± 0.021	0.864TrpGly: 0.864 ± 0.036	0.197TrpHis: 0.197 ± 0.012	0.574TrpIle: 0.574 ± 0.023	0.538TrpLys: 0.538 ± 0.022	1.174TrpLeu: 1.174 ± 0.037	0.237TrpMet: 0.237 ± 0.013	0.436TrpAsn: 0.436 ± 0.018	0.401TrpPro: 0.401 ± 0.022	0.447TrpGln: 0.447 ± 0.018	0.565TrpArg: 0.565 ± 0.02	0.617TrpSer: 0.617 ± 0.03	0.438TrpThr: 0.438 ± 0.022	0.682TrpVal: 0.682 ± 0.026	0.142TrpTrp: 0.142 ± 0.012	0.324TrpTyr: 0.324 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.405TyrAla: 2.405 ± 0.056	0.485TyrCys: 0.485 ± 0.02	1.854TyrAsp: 1.854 ± 0.057	1.86TyrGlu: 1.86 ± 0.045	1.477TyrPhe: 1.477 ± 0.031	2.614TyrGly: 2.614 ± 0.047	0.76TyrHis: 0.76 ± 0.025	2.167TyrIle: 2.167 ± 0.039	1.719TyrLys: 1.719 ± 0.041	3.589TyrLeu: 3.589 ± 0.067	0.685TyrMet: 0.685 ± 0.022	1.475TyrAsn: 1.475 ± 0.05	1.518TyrPro: 1.518 ± 0.038	1.37TyrGln: 1.37 ± 0.038	2.029TyrArg: 2.029 ± 0.038	1.945TyrSer: 1.945 ± 0.043	1.831TyrThr: 1.831 ± 0.042	1.928TyrVal: 1.928 ± 0.043	0.344TyrTrp: 0.344 ± 0.018	1.335TyrTyr: 1.335 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4132 proteins (1213829 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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