Amino acid dipepetide frequency for Marinobacter confluentis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.678AlaAla: 9.678 ± 0.111
0.957AlaCys: 0.957 ± 0.033
5.973AlaAsp: 5.973 ± 0.079
6.657AlaGlu: 6.657 ± 0.089
3.659AlaPhe: 3.659 ± 0.057
8.302AlaGly: 8.302 ± 0.106
1.693AlaHis: 1.693 ± 0.039
5.405AlaIle: 5.405 ± 0.082
3.17AlaLys: 3.17 ± 0.052
11.04AlaLeu: 11.04 ± 0.112
2.993AlaMet: 2.993 ± 0.053
3.023AlaAsn: 3.023 ± 0.06
3.831AlaPro: 3.831 ± 0.067
3.377AlaGln: 3.377 ± 0.063
6.422AlaArg: 6.422 ± 0.086
6.051AlaSer: 6.051 ± 0.077
4.717AlaThr: 4.717 ± 0.073
6.944AlaVal: 6.944 ± 0.096
1.285AlaTrp: 1.285 ± 0.038
2.263AlaTyr: 2.263 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.759CysAla: 0.759 ± 0.029
0.12CysCys: 0.12 ± 0.011
0.566CysAsp: 0.566 ± 0.024
0.553CysGlu: 0.553 ± 0.022
0.386CysPhe: 0.386 ± 0.019
0.891CysGly: 0.891 ± 0.031
0.284CysHis: 0.284 ± 0.017
0.421CysIle: 0.421 ± 0.021
0.295CysLys: 0.295 ± 0.018
0.929CysLeu: 0.929 ± 0.031
0.182CysMet: 0.182 ± 0.014
0.256CysAsn: 0.256 ± 0.015
0.473CysPro: 0.473 ± 0.024
0.384CysGln: 0.384 ± 0.019
0.619CysArg: 0.619 ± 0.028
0.552CysSer: 0.552 ± 0.026
0.4CysThr: 0.4 ± 0.018
0.598CysVal: 0.598 ± 0.022
0.113CysTrp: 0.113 ± 0.01
0.224CysTyr: 0.224 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
5.309AspAla: 5.309 ± 0.073
0.493AspCys: 0.493 ± 0.019
3.681AspAsp: 3.681 ± 0.077
4.206AspGlu: 4.206 ± 0.067
2.388AspPhe: 2.388 ± 0.047
4.706AspGly: 4.706 ± 0.077
1.349AspHis: 1.349 ± 0.037
3.377AspIle: 3.377 ± 0.062
1.894AspLys: 1.894 ± 0.046
6.225AspLeu: 6.225 ± 0.082
1.487AspMet: 1.487 ± 0.038
1.965AspAsn: 1.965 ± 0.045
2.878AspPro: 2.878 ± 0.061
2.756AspGln: 2.756 ± 0.048
4.072AspArg: 4.072 ± 0.073
3.469AspSer: 3.469 ± 0.062
3.034AspThr: 3.034 ± 0.054
4.006AspVal: 4.006 ± 0.061
0.988AspTrp: 0.988 ± 0.031
1.874AspTyr: 1.874 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
6.646GluAla: 6.646 ± 0.083
0.424GluCys: 0.424 ± 0.018
3.562GluAsp: 3.562 ± 0.065
4.218GluGlu: 4.218 ± 0.073
2.266GluPhe: 2.266 ± 0.048
4.414GluGly: 4.414 ± 0.063
1.466GluHis: 1.466 ± 0.041
3.472GluIle: 3.472 ± 0.06
3.07GluLys: 3.07 ± 0.059
6.856GluLeu: 6.856 ± 0.073
1.629GluMet: 1.629 ± 0.044
2.37GluAsn: 2.37 ± 0.052
3.152GluPro: 3.152 ± 0.071
3.529GluGln: 3.529 ± 0.066
4.553GluArg: 4.553 ± 0.072
3.862GluSer: 3.862 ± 0.067
3.726GluThr: 3.726 ± 0.059
4.326GluVal: 4.326 ± 0.064
0.788GluTrp: 0.788 ± 0.031
1.447GluTyr: 1.447 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.47PheAla: 3.47 ± 0.061
0.439PheCys: 0.439 ± 0.018
2.59PheAsp: 2.59 ± 0.052
2.468PheGlu: 2.468 ± 0.05
1.671PhePhe: 1.671 ± 0.049
3.252PheGly: 3.252 ± 0.068
0.819PheHis: 0.819 ± 0.026
2.021PheIle: 2.021 ± 0.048
1.148PheLys: 1.148 ± 0.033
3.614PheLeu: 3.614 ± 0.073
0.96PheMet: 0.96 ± 0.03
1.423PheAsn: 1.423 ± 0.036
1.662PhePro: 1.662 ± 0.036
1.331PheGln: 1.331 ± 0.03
2.503PheArg: 2.503 ± 0.048
2.817PheSer: 2.817 ± 0.051
2.07PheThr: 2.07 ± 0.043
2.654PheVal: 2.654 ± 0.047
0.555PheTrp: 0.555 ± 0.02
1.163PheTyr: 1.163 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
6.697GlyAla: 6.697 ± 0.082
0.878GlyCys: 0.878 ± 0.027
4.566GlyAsp: 4.566 ± 0.068
5.057GlyGlu: 5.057 ± 0.077
3.518GlyPhe: 3.518 ± 0.056
6.009GlyGly: 6.009 ± 0.088
1.796GlyHis: 1.796 ± 0.043
4.577GlyIle: 4.577 ± 0.07
3.374GlyLys: 3.374 ± 0.057
8.449GlyLeu: 8.449 ± 0.092
2.244GlyMet: 2.244 ± 0.046
2.561GlyAsn: 2.561 ± 0.051
2.568GlyPro: 2.568 ± 0.047
3.459GlyGln: 3.459 ± 0.063
4.701GlyArg: 4.701 ± 0.074
4.669GlySer: 4.669 ± 0.078
3.904GlyThr: 3.904 ± 0.072
5.751GlyVal: 5.751 ± 0.072
1.189GlyTrp: 1.189 ± 0.029
2.446GlyTyr: 2.446 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
1.705HisAla: 1.705 ± 0.033
0.287HisCys: 0.287 ± 0.015
1.075HisAsp: 1.075 ± 0.034
1.195HisGlu: 1.195 ± 0.033
0.924HisPhe: 0.924 ± 0.029
1.702HisGly: 1.702 ± 0.043
0.618HisHis: 0.618 ± 0.03
1.03HisIle: 1.03 ± 0.032
0.69HisLys: 0.69 ± 0.027
2.196HisLeu: 2.196 ± 0.05
0.485HisMet: 0.485 ± 0.022
0.672HisAsn: 0.672 ± 0.028
1.311HisPro: 1.311 ± 0.041
1.025HisGln: 1.025 ± 0.032
1.533HisArg: 1.533 ± 0.04
1.289HisSer: 1.289 ± 0.035
0.942HisThr: 0.942 ± 0.031
1.235HisVal: 1.235 ± 0.031
0.373HisTrp: 0.373 ± 0.019
0.736HisTyr: 0.736 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
5.521IleAla: 5.521 ± 0.074
0.501IleCys: 0.501 ± 0.023
3.497IleAsp: 3.497 ± 0.048
3.744IleGlu: 3.744 ± 0.057
1.755IlePhe: 1.755 ± 0.047
4.344IleGly: 4.344 ± 0.073
1.098IleHis: 1.098 ± 0.032
2.595IleIle: 2.595 ± 0.055
1.824IleLys: 1.824 ± 0.048
4.743IleLeu: 4.743 ± 0.069
1.113IleMet: 1.113 ± 0.031
2.06IleAsn: 2.06 ± 0.049
2.539IlePro: 2.539 ± 0.053
1.91IleGln: 1.91 ± 0.04
3.65IleArg: 3.65 ± 0.062
3.503IleSer: 3.503 ± 0.062
3.041IleThr: 3.041 ± 0.062
3.545IleVal: 3.545 ± 0.06
0.553IleTrp: 0.553 ± 0.022
1.228IleTyr: 1.228 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
3.94LysAla: 3.94 ± 0.067
0.195LysCys: 0.195 ± 0.012
2.061LysAsp: 2.061 ± 0.042
2.207LysGlu: 2.207 ± 0.048
0.958LysPhe: 0.958 ± 0.028
2.767LysGly: 2.767 ± 0.056
0.785LysHis: 0.785 ± 0.029
1.64LysIle: 1.64 ± 0.044
1.723LysLys: 1.723 ± 0.047
3.6LysLeu: 3.6 ± 0.066
0.832LysMet: 0.832 ± 0.023
1.168LysAsn: 1.168 ± 0.034
2.052LysPro: 2.052 ± 0.051
1.715LysGln: 1.715 ± 0.044
2.318LysArg: 2.318 ± 0.046
2.127LysSer: 2.127 ± 0.042
2.07LysThr: 2.07 ± 0.042
2.749LysVal: 2.749 ± 0.053
0.354LysTrp: 0.354 ± 0.018
0.743LysTyr: 0.743 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
11.64LeuAla: 11.64 ± 0.129
0.965LeuCys: 0.965 ± 0.031
6.274LeuAsp: 6.274 ± 0.08
6.909LeuGlu: 6.909 ± 0.091
3.946LeuPhe: 3.946 ± 0.068
7.937LeuGly: 7.937 ± 0.096
1.933LeuHis: 1.933 ± 0.041
5.544LeuIle: 5.544 ± 0.071
4.219LeuLys: 4.219 ± 0.071
10.4LeuLeu: 10.4 ± 0.151
2.85LeuMet: 2.85 ± 0.055
3.762LeuAsn: 3.762 ± 0.062
5.256LeuPro: 5.256 ± 0.079
3.638LeuGln: 3.638 ± 0.053
6.137LeuArg: 6.137 ± 0.079
7.009LeuSer: 7.009 ± 0.087
5.895LeuThr: 5.895 ± 0.07
7.498LeuVal: 7.498 ± 0.094
1.246LeuTrp: 1.246 ± 0.038
2.308LeuTyr: 2.308 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
3.126MetAla: 3.126 ± 0.056
0.174MetCys: 0.174 ± 0.012
1.433MetAsp: 1.433 ± 0.032
1.459MetGlu: 1.459 ± 0.031
0.8MetPhe: 0.8 ± 0.033
1.983MetGly: 1.983 ± 0.046
0.43MetHis: 0.43 ± 0.02
1.333MetIle: 1.333 ± 0.043
1.174MetLys: 1.174 ± 0.031
2.551MetLeu: 2.551 ± 0.052
0.692MetMet: 0.692 ± 0.03
1.023MetAsn: 1.023 ± 0.03
1.401MetPro: 1.401 ± 0.032
0.904MetGln: 0.904 ± 0.026
1.398MetArg: 1.398 ± 0.04
1.773MetSer: 1.773 ± 0.036
1.684MetThr: 1.684 ± 0.039
1.878MetVal: 1.878 ± 0.041
0.157MetTrp: 0.157 ± 0.011
0.425MetTyr: 0.425 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.175AsnAla: 3.175 ± 0.06
0.298AsnCys: 0.298 ± 0.016
1.897AsnAsp: 1.897 ± 0.044
1.956AsnGlu: 1.956 ± 0.045
1.148AsnPhe: 1.148 ± 0.033
2.735AsnGly: 2.735 ± 0.054
0.776AsnHis: 0.776 ± 0.025
1.749AsnIle: 1.749 ± 0.043
1.01AsnLys: 1.01 ± 0.03
3.51AsnLeu: 3.51 ± 0.068
0.768AsnMet: 0.768 ± 0.025
1.178AsnAsn: 1.178 ± 0.037
2.152AsnPro: 2.152 ± 0.044
1.514AsnGln: 1.514 ± 0.039
2.445AsnArg: 2.445 ± 0.043
1.738AsnSer: 1.738 ± 0.043
1.763AsnThr: 1.763 ± 0.04
2.113AsnVal: 2.113 ± 0.043
0.494AsnTrp: 0.494 ± 0.024
0.897AsnTyr: 0.897 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
4.703ProAla: 4.703 ± 0.072
0.315ProCys: 0.315 ± 0.017
3.806ProAsp: 3.806 ± 0.053
4.492ProGlu: 4.492 ± 0.075
1.81ProPhe: 1.81 ± 0.042
4.106ProGly: 4.106 ± 0.059
0.874ProHis: 0.874 ± 0.026
2.057ProIle: 2.057 ± 0.045
1.418ProLys: 1.418 ± 0.039
4.58ProLeu: 4.58 ± 0.074
1.182ProMet: 1.182 ± 0.033
1.297ProAsn: 1.297 ± 0.032
1.833ProPro: 1.833 ± 0.045
1.622ProGln: 1.622 ± 0.038
2.222ProArg: 2.222 ± 0.043
2.572ProSer: 2.572 ± 0.05
2.05ProThr: 2.05 ± 0.042
4.157ProVal: 4.157 ± 0.065
0.689ProTrp: 0.689 ± 0.027
1.102ProTyr: 1.102 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
4.542GlnAla: 4.542 ± 0.076
0.336GlnCys: 0.336 ± 0.018
1.911GlnAsp: 1.911 ± 0.041
2.323GlnGlu: 2.323 ± 0.046
1.472GlnPhe: 1.472 ± 0.037
2.984GlnGly: 2.984 ± 0.054
0.842GlnHis: 0.842 ± 0.031
2.07GlnIle: 2.07 ± 0.045
1.568GlnLys: 1.568 ± 0.039
4.162GlnLeu: 4.162 ± 0.066
1.088GlnMet: 1.088 ± 0.028
1.33GlnAsn: 1.33 ± 0.033
2.138GlnPro: 2.138 ± 0.043
2.204GlnGln: 2.204 ± 0.053
2.843GlnArg: 2.843 ± 0.053
2.503GlnSer: 2.503 ± 0.049
2.066GlnThr: 2.066 ± 0.046
2.969GlnVal: 2.969 ± 0.055
0.742GlnTrp: 0.742 ± 0.022
0.955GlnTyr: 0.955 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
5.389ArgAla: 5.389 ± 0.068
0.545ArgCys: 0.545 ± 0.021
3.674ArgAsp: 3.674 ± 0.06
4.497ArgGlu: 4.497 ± 0.075
2.9ArgPhe: 2.9 ± 0.058
3.659ArgGly: 3.659 ± 0.061
1.534ArgHis: 1.534 ± 0.045
3.76ArgIle: 3.76 ± 0.062
2.77ArgLys: 2.77 ± 0.052
7.428ArgLeu: 7.428 ± 0.098
1.72ArgMet: 1.72 ± 0.041
2.214ArgAsn: 2.214 ± 0.044
2.75ArgPro: 2.75 ± 0.059
3.211ArgGln: 3.211 ± 0.065
4.343ArgArg: 4.343 ± 0.075
3.576ArgSer: 3.576 ± 0.062
2.934ArgThr: 2.934 ± 0.048
4.578ArgVal: 4.578 ± 0.066
0.982ArgTrp: 0.982 ± 0.033
1.982ArgTyr: 1.982 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
6.024SerAla: 6.024 ± 0.086
0.444SerCys: 0.444 ± 0.021
3.898SerAsp: 3.898 ± 0.068
3.998SerGlu: 3.998 ± 0.057
2.379SerPhe: 2.379 ± 0.054
5.715SerGly: 5.715 ± 0.082
1.337SerHis: 1.337 ± 0.038
2.976SerIle: 2.976 ± 0.052
1.868SerLys: 1.868 ± 0.044
6.797SerLeu: 6.797 ± 0.089
1.551SerMet: 1.551 ± 0.037
1.811SerAsn: 1.811 ± 0.042
2.847SerPro: 2.847 ± 0.051
2.464SerGln: 2.464 ± 0.045
4.067SerArg: 4.067 ± 0.059
3.904SerSer: 3.904 ± 0.07
2.818SerThr: 2.818 ± 0.046
4.529SerVal: 4.529 ± 0.069
0.791SerTrp: 0.791 ± 0.031
1.463SerTyr: 1.463 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
5.002ThrAla: 5.002 ± 0.069
0.471ThrCys: 0.471 ± 0.023
3.247ThrAsp: 3.247 ± 0.062
3.107ThrGlu: 3.107 ± 0.062
1.998ThrPhe: 1.998 ± 0.047
5.025ThrGly: 5.025 ± 0.076
1.034ThrHis: 1.034 ± 0.031
2.635ThrIle: 2.635 ± 0.052
1.174ThrLys: 1.174 ± 0.031
6.353ThrLeu: 6.353 ± 0.074
1.101ThrMet: 1.101 ± 0.034
1.453ThrAsn: 1.453 ± 0.038
2.815ThrPro: 2.815 ± 0.055
1.577ThrGln: 1.577 ± 0.037
3.319ThrArg: 3.319 ± 0.055
3.029ThrSer: 3.029 ± 0.045
2.674ThrThr: 2.674 ± 0.054
4.016ThrVal: 4.016 ± 0.078
0.673ThrTrp: 0.673 ± 0.025
1.212ThrTyr: 1.212 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
7.036ValAla: 7.036 ± 0.091
0.71ValCys: 0.71 ± 0.028
4.283ValAsp: 4.283 ± 0.064
4.506ValGlu: 4.506 ± 0.066
2.97ValPhe: 2.97 ± 0.053
4.976ValGly: 4.976 ± 0.065
1.392ValHis: 1.392 ± 0.036
4.281ValIle: 4.281 ± 0.063
2.473ValLys: 2.473 ± 0.055
7.142ValLeu: 7.142 ± 0.086
2.053ValMet: 2.053 ± 0.047
2.478ValAsn: 2.478 ± 0.049
3.34ValPro: 3.34 ± 0.053
2.266ValGln: 2.266 ± 0.041
4.328ValArg: 4.328 ± 0.06
4.92ValSer: 4.92 ± 0.073
4.261ValThr: 4.261 ± 0.062
5.637ValVal: 5.637 ± 0.075
0.875ValTrp: 0.875 ± 0.034
1.702ValTyr: 1.702 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.984TrpAla: 0.984 ± 0.032
0.15TrpCys: 0.15 ± 0.011
0.627TrpAsp: 0.627 ± 0.026
0.68TrpGlu: 0.68 ± 0.024
0.598TrpPhe: 0.598 ± 0.021
0.852TrpGly: 0.852 ± 0.029
0.36TrpHis: 0.36 ± 0.016
0.702TrpIle: 0.702 ± 0.025
0.457TrpLys: 0.457 ± 0.023
1.888TrpLeu: 1.888 ± 0.045
0.378TrpMet: 0.378 ± 0.016
0.453TrpAsn: 0.453 ± 0.018
0.61TrpPro: 0.61 ± 0.026
0.868TrpGln: 0.868 ± 0.03
0.957TrpArg: 0.957 ± 0.033
0.773TrpSer: 0.773 ± 0.027
0.637TrpThr: 0.637 ± 0.026
0.921TrpVal: 0.921 ± 0.032
0.224TrpTrp: 0.224 ± 0.017
0.346TrpTyr: 0.346 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.093TyrAla: 2.093 ± 0.043
0.3TyrCys: 0.3 ± 0.016
1.537TyrAsp: 1.537 ± 0.043
1.545TyrGlu: 1.545 ± 0.042
1.082TyrPhe: 1.082 ± 0.034
2.057TyrGly: 2.057 ± 0.043
0.604TyrHis: 0.604 ± 0.024
1.118TyrIle: 1.118 ± 0.034
0.686TyrLys: 0.686 ± 0.025
2.901TyrLeu: 2.901 ± 0.051
0.488TyrMet: 0.488 ± 0.024
0.82TyrAsn: 0.82 ± 0.029
1.281TyrPro: 1.281 ± 0.04
1.293TyrGln: 1.293 ± 0.036
2.018TyrArg: 2.018 ± 0.044
1.546TyrSer: 1.546 ± 0.036
1.229TyrThr: 1.229 ± 0.031
1.524TyrVal: 1.524 ± 0.037
0.392TyrTrp: 0.392 ± 0.019
0.733TyrTyr: 0.733 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3435 proteins (1138417 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski