Amino acid dipepetide frequency for Malikia spinosa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.293AlaAla: 17.293 ± 0.199	1.37AlaCys: 1.37 ± 0.044	6.477AlaAsp: 6.477 ± 0.085	6.9AlaGlu: 6.9 ± 0.091	3.696AlaPhe: 3.696 ± 0.054	10.724AlaGly: 10.724 ± 0.134	2.435AlaHis: 2.435 ± 0.054	5.224AlaIle: 5.224 ± 0.067	3.862AlaLys: 3.862 ± 0.078	15.506AlaLeu: 15.506 ± 0.182	3.275AlaMet: 3.275 ± 0.055	2.759AlaAsn: 2.759 ± 0.059	5.47AlaPro: 5.47 ± 0.097	6.649AlaGln: 6.649 ± 0.114	8.661AlaArg: 8.661 ± 0.108	6.997AlaSer: 6.997 ± 0.108	5.565AlaThr: 5.565 ± 0.079	8.436AlaVal: 8.436 ± 0.109	1.984AlaTrp: 1.984 ± 0.058	2.431AlaTyr: 2.431 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.137CysAla: 1.137 ± 0.038	0.157CysCys: 0.157 ± 0.012	0.545CysAsp: 0.545 ± 0.021	0.531CysGlu: 0.531 ± 0.023	0.314CysPhe: 0.314 ± 0.017	0.949CysGly: 0.949 ± 0.036	0.295CysHis: 0.295 ± 0.016	0.369CysIle: 0.369 ± 0.019	0.252CysLys: 0.252 ± 0.015	0.988CysLeu: 0.988 ± 0.03	0.183CysMet: 0.183 ± 0.011	0.242CysAsn: 0.242 ± 0.016	0.55CysPro: 0.55 ± 0.025	0.375CysGln: 0.375 ± 0.019	0.636CysArg: 0.636 ± 0.021	0.559CysSer: 0.559 ± 0.022	0.452CysThr: 0.452 ± 0.019	0.652CysVal: 0.652 ± 0.027	0.177CysTrp: 0.177 ± 0.013	0.234CysTyr: 0.234 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	6.606AspAla: 6.606 ± 0.081	0.545AspCys: 0.545 ± 0.023	2.531AspAsp: 2.531 ± 0.053	3.198AspGlu: 3.198 ± 0.06	2.11AspPhe: 2.11 ± 0.055	4.412AspGly: 4.412 ± 0.08	1.089AspHis: 1.089 ± 0.034	2.351AspIle: 2.351 ± 0.055	1.793AspLys: 1.793 ± 0.041	5.682AspLeu: 5.682 ± 0.079	1.134AspMet: 1.134 ± 0.032	1.182AspAsn: 1.182 ± 0.034	3.025AspPro: 3.025 ± 0.058	2.192AspGln: 2.192 ± 0.046	3.243AspArg: 3.243 ± 0.061	2.697AspSer: 2.697 ± 0.058	2.052AspThr: 2.052 ± 0.049	3.103AspVal: 3.103 ± 0.066	1.181AspTrp: 1.181 ± 0.038	1.474AspTyr: 1.474 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	6.975GluAla: 6.975 ± 0.104	0.394GluCys: 0.394 ± 0.019	2.116GluAsp: 2.116 ± 0.048	2.282GluGlu: 2.282 ± 0.059	1.95GluPhe: 1.95 ± 0.041	3.63GluGly: 3.63 ± 0.064	1.362GluHis: 1.362 ± 0.035	2.838GluIle: 2.838 ± 0.057	1.807GluLys: 1.807 ± 0.045	7.515GluLeu: 7.515 ± 0.109	1.151GluMet: 1.151 ± 0.036	1.198GluAsn: 1.198 ± 0.035	2.698GluPro: 2.698 ± 0.058	3.711GluGln: 3.711 ± 0.072	4.891GluArg: 4.891 ± 0.088	2.763GluSer: 2.763 ± 0.05	2.468GluThr: 2.468 ± 0.044	4.061GluVal: 4.061 ± 0.057	0.697GluTrp: 0.697 ± 0.027	0.899GluTyr: 0.899 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.786PheAla: 3.786 ± 0.057	0.382PheCys: 0.382 ± 0.02	2.4PheAsp: 2.4 ± 0.05	2.203PheGlu: 2.203 ± 0.048	1.179PhePhe: 1.179 ± 0.035	3.196PheGly: 3.196 ± 0.058	0.674PheHis: 0.674 ± 0.026	1.396PheIle: 1.396 ± 0.034	1.327PheLys: 1.327 ± 0.038	3.007PheLeu: 3.007 ± 0.058	0.754PheMet: 0.754 ± 0.028	1.05PheAsn: 1.05 ± 0.032	1.372PhePro: 1.372 ± 0.041	1.164PheGln: 1.164 ± 0.029	1.703PheArg: 1.703 ± 0.04	2.118PheSer: 2.118 ± 0.046	1.67PheThr: 1.67 ± 0.043	2.493PheVal: 2.493 ± 0.051	0.518PheTrp: 0.518 ± 0.028	0.829PheTyr: 0.829 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	8.647GlyAla: 8.647 ± 0.117	0.953GlyCys: 0.953 ± 0.032	3.696GlyAsp: 3.696 ± 0.072	4.183GlyGlu: 4.183 ± 0.063	3.05GlyPhe: 3.05 ± 0.049	6.472GlyGly: 6.472 ± 0.117	1.928GlyHis: 1.928 ± 0.043	3.886GlyIle: 3.886 ± 0.068	3.304GlyLys: 3.304 ± 0.072	10.182GlyLeu: 10.182 ± 0.118	2.242GlyMet: 2.242 ± 0.044	2.092GlyAsn: 2.092 ± 0.05	2.986GlyPro: 2.986 ± 0.057	4.575GlyGln: 4.575 ± 0.069	5.501GlyArg: 5.501 ± 0.074	4.954GlySer: 4.954 ± 0.111	3.656GlyThr: 3.656 ± 0.069	5.878GlyVal: 5.878 ± 0.077	1.563GlyTrp: 1.563 ± 0.039	2.294GlyTyr: 2.294 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.519HisAla: 2.519 ± 0.049	0.3HisCys: 0.3 ± 0.016	1.197HisAsp: 1.197 ± 0.037	1.315HisGlu: 1.315 ± 0.031	0.857HisPhe: 0.857 ± 0.026	2.021HisGly: 2.021 ± 0.046	0.591HisHis: 0.591 ± 0.028	0.853HisIle: 0.853 ± 0.027	0.593HisLys: 0.593 ± 0.025	2.299HisLeu: 2.299 ± 0.046	0.457HisMet: 0.457 ± 0.02	0.519HisAsn: 0.519 ± 0.023	1.481HisPro: 1.481 ± 0.038	1.009HisGln: 1.009 ± 0.032	1.414HisArg: 1.414 ± 0.038	1.094HisSer: 1.094 ± 0.033	0.883HisThr: 0.883 ± 0.024	1.446HisVal: 1.446 ± 0.041	0.484HisTrp: 0.484 ± 0.021	0.701HisTyr: 0.701 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.763IleAla: 5.763 ± 0.077	0.432IleCys: 0.432 ± 0.02	2.956IleAsp: 2.956 ± 0.061	3.446IleGlu: 3.446 ± 0.065	1.25IlePhe: 1.25 ± 0.034	4.047IleGly: 4.047 ± 0.067	0.876IleHis: 0.876 ± 0.029	1.446IleIle: 1.446 ± 0.051	1.722IleLys: 1.722 ± 0.054	3.369IleLeu: 3.369 ± 0.058	0.788IleMet: 0.788 ± 0.026	1.419IleAsn: 1.419 ± 0.048	1.939IlePro: 1.939 ± 0.046	1.491IleGln: 1.491 ± 0.04	2.595IleArg: 2.595 ± 0.049	2.479IleSer: 2.479 ± 0.053	2.317IleThr: 2.317 ± 0.063	3.136IleVal: 3.136 ± 0.056	0.485IleTrp: 0.485 ± 0.023	0.914IleTyr: 0.914 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.088LysAla: 4.088 ± 0.082	0.169LysCys: 0.169 ± 0.013	1.599LysAsp: 1.599 ± 0.046	1.418LysGlu: 1.418 ± 0.038	0.961LysPhe: 0.961 ± 0.033	2.495LysGly: 2.495 ± 0.054	0.657LysHis: 0.657 ± 0.028	1.485LysIle: 1.485 ± 0.042	1.421LysLys: 1.421 ± 0.051	3.82LysLeu: 3.82 ± 0.064	0.774LysMet: 0.774 ± 0.029	0.961LysAsn: 0.961 ± 0.031	2.103LysPro: 2.103 ± 0.048	1.315LysGln: 1.315 ± 0.032	2.223LysArg: 2.223 ± 0.054	1.93LysSer: 1.93 ± 0.052	2.012LysThr: 2.012 ± 0.05	2.449LysVal: 2.449 ± 0.058	0.348LysTrp: 0.348 ± 0.018	0.641LysTyr: 0.641 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	15.94LeuAla: 15.94 ± 0.194	1.151LeuCys: 1.151 ± 0.033	6.353LeuAsp: 6.353 ± 0.083	6.296LeuGlu: 6.296 ± 0.09	3.503LeuPhe: 3.503 ± 0.083	9.376LeuGly: 9.376 ± 0.111	2.5LeuHis: 2.5 ± 0.053	4.613LeuIle: 4.613 ± 0.071	3.927LeuLys: 3.927 ± 0.061	14.087LeuLeu: 14.087 ± 0.214	2.504LeuMet: 2.504 ± 0.055	2.857LeuAsn: 2.857 ± 0.053	6.716LeuPro: 6.716 ± 0.097	5.706LeuGln: 5.706 ± 0.093	8.191LeuArg: 8.191 ± 0.115	6.895LeuSer: 6.895 ± 0.1	5.444LeuThr: 5.444 ± 0.083	7.998LeuVal: 7.998 ± 0.099	1.379LeuTrp: 1.379 ± 0.044	2.139LeuTyr: 2.139 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.827MetAla: 2.827 ± 0.053	0.134MetCys: 0.134 ± 0.011	1.021MetAsp: 1.021 ± 0.034	0.994MetGlu: 0.994 ± 0.03	0.602MetPhe: 0.602 ± 0.027	1.733MetGly: 1.733 ± 0.04	0.438MetHis: 0.438 ± 0.017	0.927MetIle: 0.927 ± 0.028	1.039MetLys: 1.039 ± 0.035	2.541MetLeu: 2.541 ± 0.049	0.481MetMet: 0.481 ± 0.025	0.851MetAsn: 0.851 ± 0.027	1.362MetPro: 1.362 ± 0.039	1.049MetGln: 1.049 ± 0.034	1.508MetArg: 1.508 ± 0.034	1.624MetSer: 1.624 ± 0.037	1.453MetThr: 1.453 ± 0.036	1.63MetVal: 1.63 ± 0.041	0.181MetTrp: 0.181 ± 0.013	0.29MetTyr: 0.29 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.023AsnAla: 3.023 ± 0.058	0.262AsnCys: 0.262 ± 0.015	1.298AsnAsp: 1.298 ± 0.049	1.259AsnGlu: 1.259 ± 0.032	0.912AsnPhe: 0.912 ± 0.029	2.172AsnGly: 2.172 ± 0.053	0.519AsnHis: 0.519 ± 0.022	1.143AsnIle: 1.143 ± 0.042	0.793AsnLys: 0.793 ± 0.031	2.758AsnLeu: 2.758 ± 0.053	0.518AsnMet: 0.518 ± 0.023	0.654AsnAsn: 0.654 ± 0.027	1.822AsnPro: 1.822 ± 0.045	1.069AsnGln: 1.069 ± 0.034	1.622AsnArg: 1.622 ± 0.036	1.307AsnSer: 1.307 ± 0.044	1.184AsnThr: 1.184 ± 0.035	1.642AsnVal: 1.642 ± 0.048	0.435AsnTrp: 0.435 ± 0.02	0.648AsnTyr: 0.648 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.272ProAla: 7.272 ± 0.119	0.393ProCys: 0.393 ± 0.023	3.129ProAsp: 3.129 ± 0.057	3.625ProGlu: 3.625 ± 0.076	1.59ProPhe: 1.59 ± 0.038	4.585ProGly: 4.585 ± 0.077	1.121ProHis: 1.121 ± 0.034	1.852ProIle: 1.852 ± 0.045	1.438ProLys: 1.438 ± 0.039	5.357ProLeu: 5.357 ± 0.084	1.153ProMet: 1.153 ± 0.03	1.178ProAsn: 1.178 ± 0.036	2.243ProPro: 2.243 ± 0.059	2.27ProGln: 2.27 ± 0.052	2.825ProArg: 2.825 ± 0.059	2.583ProSer: 2.583 ± 0.051	2.375ProThr: 2.375 ± 0.05	4.136ProVal: 4.136 ± 0.07	0.783ProTrp: 0.783 ± 0.028	1.141ProTyr: 1.141 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	7.644GlnAla: 7.644 ± 0.124	0.309GlnCys: 0.309 ± 0.018	2.16GlnAsp: 2.16 ± 0.043	1.961GlnGlu: 1.961 ± 0.054	1.32GlnPhe: 1.32 ± 0.038	3.861GlnGly: 3.861 ± 0.055	1.091GlnHis: 1.091 ± 0.033	2.14GlnIle: 2.14 ± 0.052	1.129GlnLys: 1.129 ± 0.035	5.814GlnLeu: 5.814 ± 0.101	0.994GlnMet: 0.994 ± 0.032	0.895GlnAsn: 0.895 ± 0.033	2.89GlnPro: 2.89 ± 0.062	3.085GlnGln: 3.085 ± 0.083	4.091GlnArg: 4.091 ± 0.078	2.434GlnSer: 2.434 ± 0.057	2.202GlnThr: 2.202 ± 0.05	3.559GlnVal: 3.559 ± 0.062	0.695GlnTrp: 0.695 ± 0.023	0.824GlnTyr: 0.824 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	7.466ArgAla: 7.466 ± 0.107	0.637ArgCys: 0.637 ± 0.023	3.354ArgAsp: 3.354 ± 0.059	4.361ArgGlu: 4.361 ± 0.074	2.639ArgPhe: 2.639 ± 0.048	4.261ArgGly: 4.261 ± 0.072	1.857ArgHis: 1.857 ± 0.044	3.328ArgIle: 3.328 ± 0.057	2.026ArgLys: 2.026 ± 0.046	8.739ArgLeu: 8.739 ± 0.111	1.565ArgMet: 1.565 ± 0.038	1.64ArgAsn: 1.64 ± 0.038	3.189ArgPro: 3.189 ± 0.052	3.913ArgGln: 3.913 ± 0.069	4.772ArgArg: 4.772 ± 0.094	3.719ArgSer: 3.719 ± 0.057	2.713ArgThr: 2.713 ± 0.047	4.751ArgVal: 4.751 ± 0.077	1.266ArgTrp: 1.266 ± 0.041	1.861ArgTyr: 1.861 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.889SerAla: 6.889 ± 0.078	0.527SerCys: 0.527 ± 0.021	2.831SerAsp: 2.831 ± 0.058	2.816SerGlu: 2.816 ± 0.052	2.046SerPhe: 2.046 ± 0.044	5.498SerGly: 5.498 ± 0.123	1.312SerHis: 1.312 ± 0.032	2.341SerIle: 2.341 ± 0.06	1.648SerLys: 1.648 ± 0.044	6.234SerLeu: 6.234 ± 0.088	1.258SerMet: 1.258 ± 0.037	1.492SerAsn: 1.492 ± 0.051	2.857SerPro: 2.857 ± 0.053	2.44SerGln: 2.44 ± 0.049	3.641SerArg: 3.641 ± 0.058	3.346SerSer: 3.346 ± 0.065	2.689SerThr: 2.689 ± 0.058	3.988SerVal: 3.988 ± 0.084	0.888SerTrp: 0.888 ± 0.029	1.34SerTyr: 1.34 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.317ThrAla: 5.317 ± 0.085	0.358ThrCys: 0.358 ± 0.017	2.332ThrAsp: 2.332 ± 0.05	2.545ThrGlu: 2.545 ± 0.044	1.456ThrPhe: 1.456 ± 0.044	4.403ThrGly: 4.403 ± 0.083	1.036ThrHis: 1.036 ± 0.029	1.867ThrIle: 1.867 ± 0.052	1.1ThrLys: 1.1 ± 0.039	6.562ThrLeu: 6.562 ± 0.111	0.936ThrMet: 0.936 ± 0.023	0.997ThrAsn: 0.997 ± 0.033	3.097ThrPro: 3.097 ± 0.054	2.011ThrGln: 2.011 ± 0.046	3.039ThrArg: 3.039 ± 0.059	2.44ThrSer: 2.44 ± 0.049	2.294ThrThr: 2.294 ± 0.052	3.766ThrVal: 3.766 ± 0.068	0.548ThrTrp: 0.548 ± 0.026	0.868ThrTyr: 0.868 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	8.661ValAla: 8.661 ± 0.11	0.664ValCys: 0.664 ± 0.025	3.719ValAsp: 3.719 ± 0.062	4.359ValGlu: 4.359 ± 0.069	2.392ValPhe: 2.392 ± 0.052	5.353ValGly: 5.353 ± 0.085	1.431ValHis: 1.431 ± 0.039	3.407ValIle: 3.407 ± 0.056	2.583ValLys: 2.583 ± 0.052	8.076ValLeu: 8.076 ± 0.102	1.77ValMet: 1.77 ± 0.039	2.033ValAsn: 2.033 ± 0.05	3.391ValPro: 3.391 ± 0.054	2.992ValGln: 2.992 ± 0.062	4.588ValArg: 4.588 ± 0.065	3.975ValSer: 3.975 ± 0.086	3.81ValThr: 3.81 ± 0.071	5.454ValVal: 5.454 ± 0.092	0.962ValTrp: 0.962 ± 0.03	1.435ValTyr: 1.435 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.392TrpAla: 1.392 ± 0.04	0.202TrpCys: 0.202 ± 0.014	0.663TrpAsp: 0.663 ± 0.027	0.54TrpGlu: 0.54 ± 0.024	0.531TrpPhe: 0.531 ± 0.022	0.944TrpGly: 0.944 ± 0.029	0.352TrpHis: 0.352 ± 0.02	0.681TrpIle: 0.681 ± 0.025	0.462TrpLys: 0.462 ± 0.022	2.451TrpLeu: 2.451 ± 0.065	0.363TrpMet: 0.363 ± 0.019	0.447TrpAsn: 0.447 ± 0.021	0.768TrpPro: 0.768 ± 0.03	0.995TrpGln: 0.995 ± 0.03	1.248TrpArg: 1.248 ± 0.036	0.905TrpSer: 0.905 ± 0.028	0.727TrpThr: 0.727 ± 0.03	0.993TrpVal: 0.993 ± 0.036	0.288TrpTrp: 0.288 ± 0.017	0.273TrpTyr: 0.273 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.47TyrAla: 2.47 ± 0.05	0.256TyrCys: 0.256 ± 0.016	1.221TyrAsp: 1.221 ± 0.035	1.175TyrGlu: 1.175 ± 0.034	0.865TyrPhe: 0.865 ± 0.023	1.908TyrGly: 1.908 ± 0.042	0.469TyrHis: 0.469 ± 0.022	0.725TyrIle: 0.725 ± 0.027	0.643TyrLys: 0.643 ± 0.027	2.589TyrLeu: 2.589 ± 0.049	0.384TyrMet: 0.384 ± 0.019	0.575TyrAsn: 0.575 ± 0.024	1.089TyrPro: 1.089 ± 0.035	1.085TyrGln: 1.085 ± 0.031	1.664TyrArg: 1.664 ± 0.041	1.264TyrSer: 1.264 ± 0.04	1.008TyrThr: 1.008 ± 0.032	1.483TyrVal: 1.483 ± 0.033	0.364TyrTrp: 0.364 ± 0.018	0.567TyrTyr: 0.567 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3366 proteins (1124414 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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