Amino acid dipepetide frequency for Simplicispira suum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.331AlaAla: 18.331 ± 0.226	1.436AlaCys: 1.436 ± 0.036	6.09AlaAsp: 6.09 ± 0.077	6.551AlaGlu: 6.551 ± 0.095	4.197AlaPhe: 4.197 ± 0.056	10.765AlaGly: 10.765 ± 0.112	2.966AlaHis: 2.966 ± 0.061	5.246AlaIle: 5.246 ± 0.074	3.876AlaLys: 3.876 ± 0.094	16.602AlaLeu: 16.602 ± 0.155	3.588AlaMet: 3.588 ± 0.057	2.727AlaAsn: 2.727 ± 0.05	6.814AlaPro: 6.814 ± 0.112	6.93AlaGln: 6.93 ± 0.096	9.367AlaArg: 9.367 ± 0.112	7.152AlaSer: 7.152 ± 0.09	5.899AlaThr: 5.899 ± 0.088	9.167AlaVal: 9.167 ± 0.096	2.056AlaTrp: 2.056 ± 0.047	2.391AlaTyr: 2.391 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.302CysAla: 1.302 ± 0.035	0.132CysCys: 0.132 ± 0.012	0.537CysAsp: 0.537 ± 0.022	0.542CysGlu: 0.542 ± 0.023	0.336CysPhe: 0.336 ± 0.017	0.956CysGly: 0.956 ± 0.032	0.265CysHis: 0.265 ± 0.013	0.44CysIle: 0.44 ± 0.019	0.262CysLys: 0.262 ± 0.017	0.89CysLeu: 0.89 ± 0.028	0.247CysMet: 0.247 ± 0.013	0.241CysAsn: 0.241 ± 0.015	0.524CysPro: 0.524 ± 0.022	0.309CysGln: 0.309 ± 0.017	0.555CysArg: 0.555 ± 0.023	0.564CysSer: 0.564 ± 0.025	0.55CysThr: 0.55 ± 0.023	0.779CysVal: 0.779 ± 0.027	0.138CysTrp: 0.138 ± 0.012	0.174CysTyr: 0.174 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.402AspAla: 7.402 ± 0.095	0.452AspCys: 0.452 ± 0.019	2.42AspAsp: 2.42 ± 0.053	3.009AspGlu: 3.009 ± 0.061	1.975AspPhe: 1.975 ± 0.04	4.21AspGly: 4.21 ± 0.07	1.088AspHis: 1.088 ± 0.032	2.374AspIle: 2.374 ± 0.045	1.688AspLys: 1.688 ± 0.042	5.21AspLeu: 5.21 ± 0.077	1.271AspMet: 1.271 ± 0.032	1.077AspAsn: 1.077 ± 0.032	2.707AspPro: 2.707 ± 0.05	1.572AspGln: 1.572 ± 0.035	2.904AspArg: 2.904 ± 0.055	2.26AspSer: 2.26 ± 0.037	2.461AspThr: 2.461 ± 0.043	3.796AspVal: 3.796 ± 0.059	0.913AspTrp: 0.913 ± 0.029	1.319AspTyr: 1.319 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.808GluAla: 6.808 ± 0.083	0.426GluCys: 0.426 ± 0.019	2.241GluAsp: 2.241 ± 0.048	2.453GluGlu: 2.453 ± 0.058	1.788GluPhe: 1.788 ± 0.041	3.723GluGly: 3.723 ± 0.058	1.433GluHis: 1.433 ± 0.036	2.702GluIle: 2.702 ± 0.054	1.943GluLys: 1.943 ± 0.05	5.85GluLeu: 5.85 ± 0.071	1.341GluMet: 1.341 ± 0.035	1.283GluAsn: 1.283 ± 0.036	2.594GluPro: 2.594 ± 0.047	2.766GluGln: 2.766 ± 0.061	5.164GluArg: 5.164 ± 0.076	2.677GluSer: 2.677 ± 0.052	2.563GluThr: 2.563 ± 0.048	4.034GluVal: 4.034 ± 0.069	0.715GluTrp: 0.715 ± 0.023	1.01GluTyr: 1.01 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.432PheAla: 4.432 ± 0.063	0.413PheCys: 0.413 ± 0.018	2.442PheAsp: 2.442 ± 0.048	2.091PheGlu: 2.091 ± 0.037	1.389PhePhe: 1.389 ± 0.045	3.343PheGly: 3.343 ± 0.059	0.727PheHis: 0.727 ± 0.021	1.443PheIle: 1.443 ± 0.038	1.161PheLys: 1.161 ± 0.034	3.071PheLeu: 3.071 ± 0.052	0.778PheMet: 0.778 ± 0.029	0.997PheAsn: 0.997 ± 0.035	1.488PhePro: 1.488 ± 0.038	1.088PheGln: 1.088 ± 0.028	1.747PheArg: 1.747 ± 0.035	2.206PheSer: 2.206 ± 0.045	1.807PheThr: 1.807 ± 0.041	2.846PheVal: 2.846 ± 0.05	0.538PheTrp: 0.538 ± 0.022	0.872PheTyr: 0.872 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.89GlyAla: 9.89 ± 0.102	0.905GlyCys: 0.905 ± 0.03	3.864GlyAsp: 3.864 ± 0.063	4.52GlyGlu: 4.52 ± 0.064	3.186GlyPhe: 3.186 ± 0.057	6.778GlyGly: 6.778 ± 0.096	1.97GlyHis: 1.97 ± 0.046	3.875GlyIle: 3.875 ± 0.066	3.33GlyLys: 3.33 ± 0.06	8.943GlyLeu: 8.943 ± 0.089	2.473GlyMet: 2.473 ± 0.051	2.023GlyAsn: 2.023 ± 0.048	2.977GlyPro: 2.977 ± 0.052	3.398GlyGln: 3.398 ± 0.052	5.24GlyArg: 5.24 ± 0.074	4.694GlySer: 4.694 ± 0.056	4.167GlyThr: 4.167 ± 0.064	6.564GlyVal: 6.564 ± 0.085	1.406GlyTrp: 1.406 ± 0.038	2.172GlyTyr: 2.172 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	3.102HisAla: 3.102 ± 0.058	0.346HisCys: 0.346 ± 0.019	1.162HisAsp: 1.162 ± 0.031	1.168HisGlu: 1.168 ± 0.033	0.92HisPhe: 0.92 ± 0.031	2.096HisGly: 2.096 ± 0.043	0.588HisHis: 0.588 ± 0.023	1.017HisIle: 1.017 ± 0.034	0.596HisLys: 0.596 ± 0.019	2.268HisLeu: 2.268 ± 0.048	0.515HisMet: 0.515 ± 0.021	0.492HisAsn: 0.492 ± 0.02	1.504HisPro: 1.504 ± 0.039	0.82HisGln: 0.82 ± 0.027	1.395HisArg: 1.395 ± 0.036	1.207HisSer: 1.207 ± 0.035	1.147HisThr: 1.147 ± 0.031	1.509HisVal: 1.509 ± 0.038	0.48HisTrp: 0.48 ± 0.018	0.605HisTyr: 0.605 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.122IleAla: 6.122 ± 0.082	0.407IleCys: 0.407 ± 0.022	2.919IleAsp: 2.919 ± 0.044	3.095IleGlu: 3.095 ± 0.057	1.297IlePhe: 1.297 ± 0.039	3.953IleGly: 3.953 ± 0.068	0.83IleHis: 0.83 ± 0.029	1.43IleIle: 1.43 ± 0.04	1.459IleLys: 1.459 ± 0.038	3.22IleLeu: 3.22 ± 0.064	0.749IleMet: 0.749 ± 0.027	1.348IleAsn: 1.348 ± 0.035	1.901IlePro: 1.901 ± 0.041	1.213IleGln: 1.213 ± 0.032	2.374IleArg: 2.374 ± 0.047	2.394IleSer: 2.394 ± 0.047	2.429IleThr: 2.429 ± 0.049	3.468IleVal: 3.468 ± 0.062	0.454IleTrp: 0.454 ± 0.021	0.987IleTyr: 0.987 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.91LysAla: 3.91 ± 0.085	0.173LysCys: 0.173 ± 0.012	1.679LysAsp: 1.679 ± 0.042	1.583LysGlu: 1.583 ± 0.043	0.896LysPhe: 0.896 ± 0.028	2.434LysGly: 2.434 ± 0.05	0.647LysHis: 0.647 ± 0.027	1.503LysIle: 1.503 ± 0.042	1.434LysLys: 1.434 ± 0.051	3.342LysLeu: 3.342 ± 0.066	0.856LysMet: 0.856 ± 0.03	0.991LysAsn: 0.991 ± 0.035	1.871LysPro: 1.871 ± 0.046	1.203LysGln: 1.203 ± 0.034	2.231LysArg: 2.231 ± 0.047	1.864LysSer: 1.864 ± 0.04	1.88LysThr: 1.88 ± 0.046	2.387LysVal: 2.387 ± 0.054	0.327LysTrp: 0.327 ± 0.018	0.656LysTyr: 0.656 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	16.181LeuAla: 16.181 ± 0.152	1.13LeuCys: 1.13 ± 0.033	5.618LeuAsp: 5.618 ± 0.065	5.434LeuGlu: 5.434 ± 0.076	3.417LeuPhe: 3.417 ± 0.067	9.052LeuGly: 9.052 ± 0.105	2.54LeuHis: 2.54 ± 0.054	4.212LeuIle: 4.212 ± 0.064	3.335LeuLys: 3.335 ± 0.063	12.081LeuLeu: 12.081 ± 0.158	2.567LeuMet: 2.567 ± 0.054	2.543LeuAsn: 2.543 ± 0.042	6.248LeuPro: 6.248 ± 0.084	4.727LeuGln: 4.727 ± 0.073	8.041LeuArg: 8.041 ± 0.101	6.188LeuSer: 6.188 ± 0.067	5.211LeuThr: 5.211 ± 0.062	8.224LeuVal: 8.224 ± 0.104	1.45LeuTrp: 1.45 ± 0.042	2.046LeuTyr: 2.046 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.312MetAla: 3.312 ± 0.055	0.173MetCys: 0.173 ± 0.011	1.222MetAsp: 1.222 ± 0.032	1.249MetGlu: 1.249 ± 0.032	0.732MetPhe: 0.732 ± 0.027	2.059MetGly: 2.059 ± 0.049	0.6MetHis: 0.6 ± 0.021	0.831MetIle: 0.831 ± 0.029	1.007MetLys: 1.007 ± 0.033	2.776MetLeu: 2.776 ± 0.053	0.564MetMet: 0.564 ± 0.026	0.828MetAsn: 0.828 ± 0.026	1.486MetPro: 1.486 ± 0.037	1.258MetGln: 1.258 ± 0.031	1.715MetArg: 1.715 ± 0.038	1.433MetSer: 1.433 ± 0.04	1.388MetThr: 1.388 ± 0.036	1.935MetVal: 1.935 ± 0.043	0.204MetTrp: 0.204 ± 0.012	0.412MetTyr: 0.412 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.225AsnAla: 3.225 ± 0.051	0.241AsnCys: 0.241 ± 0.014	1.205AsnAsp: 1.205 ± 0.031	1.192AsnGlu: 1.192 ± 0.033	0.985AsnPhe: 0.985 ± 0.029	1.97AsnGly: 1.97 ± 0.042	0.502AsnHis: 0.502 ± 0.019	1.127AsnIle: 1.127 ± 0.031	0.799AsnLys: 0.799 ± 0.026	2.575AsnLeu: 2.575 ± 0.054	0.599AsnMet: 0.599 ± 0.024	0.644AsnAsn: 0.644 ± 0.025	1.75AsnPro: 1.75 ± 0.037	0.89AsnGln: 0.89 ± 0.03	1.536AsnArg: 1.536 ± 0.033	1.144AsnSer: 1.144 ± 0.03	1.332AsnThr: 1.332 ± 0.033	1.8AsnVal: 1.8 ± 0.043	0.412AsnTrp: 0.412 ± 0.019	0.649AsnTyr: 0.649 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.86ProAla: 6.86 ± 0.098	0.406ProCys: 0.406 ± 0.018	2.88ProAsp: 2.88 ± 0.054	3.552ProGlu: 3.552 ± 0.056	1.718ProPhe: 1.718 ± 0.036	4.566ProGly: 4.566 ± 0.064	1.144ProHis: 1.144 ± 0.035	1.778ProIle: 1.778 ± 0.036	1.503ProLys: 1.503 ± 0.041	5.371ProLeu: 5.371 ± 0.077	1.31ProMet: 1.31 ± 0.032	1.167ProAsn: 1.167 ± 0.033	2.675ProPro: 2.675 ± 0.061	2.323ProGln: 2.323 ± 0.044	2.978ProArg: 2.978 ± 0.051	2.795ProSer: 2.795 ± 0.049	2.543ProThr: 2.543 ± 0.052	4.279ProVal: 4.279 ± 0.068	0.857ProTrp: 0.857 ± 0.027	1.097ProTyr: 1.097 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	6.264GlnAla: 6.264 ± 0.094	0.331GlnCys: 0.331 ± 0.016	1.919GlnAsp: 1.919 ± 0.043	1.961GlnGlu: 1.961 ± 0.046	1.414GlnPhe: 1.414 ± 0.037	3.302GlnGly: 3.302 ± 0.06	1.06GlnHis: 1.06 ± 0.037	1.832GlnIle: 1.832 ± 0.045	1.202GlnLys: 1.202 ± 0.037	4.573GlnLeu: 4.573 ± 0.061	1.037GlnMet: 1.037 ± 0.035	0.957GlnAsn: 0.957 ± 0.029	2.193GlnPro: 2.193 ± 0.043	2.077GlnGln: 2.077 ± 0.058	3.639GlnArg: 3.639 ± 0.065	2.298GlnSer: 2.298 ± 0.045	2.039GlnThr: 2.039 ± 0.041	3.218GlnVal: 3.218 ± 0.056	0.737GlnTrp: 0.737 ± 0.026	0.77GlnTyr: 0.77 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.362ArgAla: 8.362 ± 0.087	0.648ArgCys: 0.648 ± 0.029	3.203ArgAsp: 3.203 ± 0.061	4.095ArgGlu: 4.095 ± 0.067	2.722ArgPhe: 2.722 ± 0.046	4.589ArgGly: 4.589 ± 0.071	1.662ArgHis: 1.662 ± 0.046	3.367ArgIle: 3.367 ± 0.045	2.118ArgLys: 2.118 ± 0.042	7.845ArgLeu: 7.845 ± 0.101	2.005ArgMet: 2.005 ± 0.039	1.764ArgAsn: 1.764 ± 0.043	3.101ArgPro: 3.101 ± 0.053	2.862ArgGln: 2.862 ± 0.054	4.874ArgArg: 4.874 ± 0.072	4.016ArgSer: 4.016 ± 0.068	3.284ArgThr: 3.284 ± 0.057	5.022ArgVal: 5.022 ± 0.07	1.213ArgTrp: 1.213 ± 0.037	1.778ArgTyr: 1.778 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	7.033SerAla: 7.033 ± 0.081	0.48SerCys: 0.48 ± 0.022	2.798SerAsp: 2.798 ± 0.046	2.858SerGlu: 2.858 ± 0.052	2.045SerPhe: 2.045 ± 0.04	5.273SerGly: 5.273 ± 0.07	1.172SerHis: 1.172 ± 0.031	2.459SerIle: 2.459 ± 0.049	1.642SerLys: 1.642 ± 0.042	5.748SerLeu: 5.748 ± 0.087	1.462SerMet: 1.462 ± 0.032	1.381SerAsn: 1.381 ± 0.039	2.803SerPro: 2.803 ± 0.051	2.052SerGln: 2.052 ± 0.04	3.374SerArg: 3.374 ± 0.055	3.149SerSer: 3.149 ± 0.066	2.895SerThr: 2.895 ± 0.051	4.175SerVal: 4.175 ± 0.065	0.724SerTrp: 0.724 ± 0.026	1.221SerTyr: 1.221 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.89ThrAla: 5.89 ± 0.073	0.388ThrCys: 0.388 ± 0.018	2.407ThrAsp: 2.407 ± 0.051	2.456ThrGlu: 2.456 ± 0.049	1.535ThrPhe: 1.535 ± 0.038	4.565ThrGly: 4.565 ± 0.066	1.143ThrHis: 1.143 ± 0.031	1.918ThrIle: 1.918 ± 0.042	1.246ThrLys: 1.246 ± 0.035	6.247ThrLeu: 6.247 ± 0.08	1.062ThrMet: 1.062 ± 0.03	1.153ThrAsn: 1.153 ± 0.032	3.377ThrPro: 3.377 ± 0.059	2.165ThrGln: 2.165 ± 0.042	3.204ThrArg: 3.204 ± 0.058	2.686ThrSer: 2.686 ± 0.049	2.571ThrThr: 2.571 ± 0.049	4.05ThrVal: 4.05 ± 0.052	0.669ThrTrp: 0.669 ± 0.027	0.981ThrTyr: 0.981 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.702ValAla: 9.702 ± 0.103	0.79ValCys: 0.79 ± 0.027	3.815ValAsp: 3.815 ± 0.054	3.934ValGlu: 3.934 ± 0.066	2.856ValPhe: 2.856 ± 0.058	5.769ValGly: 5.769 ± 0.074	1.819ValHis: 1.819 ± 0.038	3.057ValIle: 3.057 ± 0.055	2.175ValLys: 2.175 ± 0.05	9.053ValLeu: 9.053 ± 0.107	1.877ValMet: 1.877 ± 0.044	1.982ValAsn: 1.982 ± 0.045	3.982ValPro: 3.982 ± 0.05	3.47ValGln: 3.47 ± 0.058	5.31ValArg: 5.31 ± 0.081	4.007ValSer: 4.007 ± 0.059	3.728ValThr: 3.728 ± 0.059	6.425ValVal: 6.425 ± 0.083	1.007ValTrp: 1.007 ± 0.028	1.515ValTyr: 1.515 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.466TrpAla: 1.466 ± 0.04	0.201TrpCys: 0.201 ± 0.014	0.595TrpAsp: 0.595 ± 0.024	0.625TrpGlu: 0.625 ± 0.024	0.576TrpPhe: 0.576 ± 0.02	1.004TrpGly: 1.004 ± 0.036	0.367TrpHis: 0.367 ± 0.02	0.693TrpIle: 0.693 ± 0.026	0.465TrpLys: 0.465 ± 0.021	2.176TrpLeu: 2.176 ± 0.058	0.46TrpMet: 0.46 ± 0.018	0.442TrpAsn: 0.442 ± 0.021	0.734TrpPro: 0.734 ± 0.028	0.788TrpGln: 0.788 ± 0.028	1.213TrpArg: 1.213 ± 0.036	0.82TrpSer: 0.82 ± 0.025	0.721TrpThr: 0.721 ± 0.022	1.03TrpVal: 1.03 ± 0.029	0.304TrpTrp: 0.304 ± 0.015	0.28TrpTyr: 0.28 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.561TyrAla: 2.561 ± 0.053	0.263TyrCys: 0.263 ± 0.014	1.092TyrAsp: 1.092 ± 0.03	1.144TyrGlu: 1.144 ± 0.033	0.899TyrPhe: 0.899 ± 0.027	1.966TyrGly: 1.966 ± 0.045	0.41TyrHis: 0.41 ± 0.017	0.747TyrIle: 0.747 ± 0.028	0.629TyrLys: 0.629 ± 0.027	2.405TyrLeu: 2.405 ± 0.052	0.421TyrMet: 0.421 ± 0.02	0.537TyrAsn: 0.537 ± 0.024	1.074TyrPro: 1.074 ± 0.026	0.913TyrGln: 0.913 ± 0.028	1.67TyrArg: 1.67 ± 0.036	1.188TyrSer: 1.188 ± 0.029	1.097TyrThr: 1.097 ± 0.029	1.567TyrVal: 1.567 ± 0.037	0.355TyrTrp: 0.355 ± 0.02	0.583TyrTyr: 0.583 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3677 proteins (1198209 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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