Amino acid dipepetide frequency for Mycoplasma phocirhinis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.177AlaAla: 3.177 ± 0.145
0.315AlaCys: 0.315 ± 0.036
2.448AlaAsp: 2.448 ± 0.112
2.44AlaGlu: 2.44 ± 0.12
2.601AlaPhe: 2.601 ± 0.109
2.417AlaGly: 2.417 ± 0.123
0.882AlaHis: 0.882 ± 0.064
5.118AlaIle: 5.118 ± 0.176
5.993AlaLys: 5.993 ± 0.258
5.349AlaLeu: 5.349 ± 0.182
1.024AlaMet: 1.024 ± 0.079
4.57AlaAsn: 4.57 ± 0.188
1.235AlaPro: 1.235 ± 0.076
2.92AlaGln: 2.92 ± 0.166
2.149AlaArg: 2.149 ± 0.104
3.396AlaSer: 3.396 ± 0.122
2.928AlaThr: 2.928 ± 0.096
2.513AlaVal: 2.513 ± 0.101
0.391AlaTrp: 0.391 ± 0.039
2.064AlaTyr: 2.064 ± 0.113
0.0AlaXaa: 0.0 ± 0.0
Cys
0.28CysAla: 0.28 ± 0.036
0.038CysCys: 0.038 ± 0.014
0.234CysAsp: 0.234 ± 0.029
0.345CysGlu: 0.345 ± 0.05
0.265CysPhe: 0.265 ± 0.039
0.299CysGly: 0.299 ± 0.038
0.088CysHis: 0.088 ± 0.02
0.173CysIle: 0.173 ± 0.029
0.269CysLys: 0.269 ± 0.033
0.437CysLeu: 0.437 ± 0.041
0.069CysMet: 0.069 ± 0.018
0.288CysAsn: 0.288 ± 0.034
0.146CysPro: 0.146 ± 0.025
0.176CysGln: 0.176 ± 0.028
0.161CysArg: 0.161 ± 0.026
0.365CysSer: 0.365 ± 0.037
0.123CysThr: 0.123 ± 0.021
0.253CysVal: 0.253 ± 0.032
0.046CysTrp: 0.046 ± 0.014
0.173CysTyr: 0.173 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.027AspAla: 3.027 ± 0.171
0.169AspCys: 0.169 ± 0.024
2.628AspAsp: 2.628 ± 0.133
4.324AspGlu: 4.324 ± 0.143
3.668AspPhe: 3.668 ± 0.142
2.26AspGly: 2.26 ± 0.106
0.694AspHis: 0.694 ± 0.049
4.838AspIle: 4.838 ± 0.143
5.345AspLys: 5.345 ± 0.184
5.725AspLeu: 5.725 ± 0.159
0.717AspMet: 0.717 ± 0.06
4.075AspAsn: 4.075 ± 0.149
1.42AspPro: 1.42 ± 0.074
1.93AspGln: 1.93 ± 0.112
1.316AspArg: 1.316 ± 0.067
3.146AspSer: 3.146 ± 0.119
2.521AspThr: 2.521 ± 0.11
3.284AspVal: 3.284 ± 0.133
0.533AspTrp: 0.533 ± 0.045
2.563AspTyr: 2.563 ± 0.104
0.0AspXaa: 0.0 ± 0.0
Glu
2.943GluAla: 2.943 ± 0.161
0.188GluCys: 0.188 ± 0.028
2.609GluAsp: 2.609 ± 0.108
3.269GluGlu: 3.269 ± 0.137
3.81GluPhe: 3.81 ± 0.13
2.03GluGly: 2.03 ± 0.121
1.032GluHis: 1.032 ± 0.069
6.392GluIle: 6.392 ± 0.188
5.89GluLys: 5.89 ± 0.172
6.803GluLeu: 6.803 ± 0.196
1.186GluMet: 1.186 ± 0.075
5.368GluAsn: 5.368 ± 0.156
1.178GluPro: 1.178 ± 0.072
4.079GluGln: 4.079 ± 0.152
1.542GluArg: 1.542 ± 0.115
2.49GluSer: 2.49 ± 0.111
2.858GluThr: 2.858 ± 0.116
3.058GluVal: 3.058 ± 0.11
0.583GluTrp: 0.583 ± 0.042
3.135GluTyr: 3.135 ± 0.122
0.0GluXaa: 0.0 ± 0.0
Phe
3.277PheAla: 3.277 ± 0.123
0.238PheCys: 0.238 ± 0.029
3.952PheAsp: 3.952 ± 0.115
3.434PheGlu: 3.434 ± 0.126
2.463PhePhe: 2.463 ± 0.115
2.617PheGly: 2.617 ± 0.123
0.622PheHis: 0.622 ± 0.045
5.337PheIle: 5.337 ± 0.221
5.491PheLys: 5.491 ± 0.179
4.324PheLeu: 4.324 ± 0.149
0.813PheMet: 0.813 ± 0.067
4.903PheAsn: 4.903 ± 0.162
1.047PhePro: 1.047 ± 0.064
1.305PheGln: 1.305 ± 0.078
1.473PheArg: 1.473 ± 0.071
4.221PheSer: 4.221 ± 0.14
2.413PheThr: 2.413 ± 0.112
2.962PheVal: 2.962 ± 0.111
0.529PheTrp: 0.529 ± 0.046
2.11PheTyr: 2.11 ± 0.096
0.0PheXaa: 0.0 ± 0.0
Gly
2.383GlyAla: 2.383 ± 0.112
0.196GlyCys: 0.196 ± 0.03
2.145GlyAsp: 2.145 ± 0.097
2.517GlyGlu: 2.517 ± 0.117
2.824GlyPhe: 2.824 ± 0.131
2.812GlyGly: 2.812 ± 0.138
0.833GlyHis: 0.833 ± 0.069
4.025GlyIle: 4.025 ± 0.139
3.645GlyLys: 3.645 ± 0.165
3.983GlyLeu: 3.983 ± 0.151
0.848GlyMet: 0.848 ± 0.063
2.314GlyAsn: 2.314 ± 0.093
0.921GlyPro: 0.921 ± 0.066
1.634GlyGln: 1.634 ± 0.089
1.646GlyArg: 1.646 ± 0.094
2.897GlySer: 2.897 ± 0.129
2.275GlyThr: 2.275 ± 0.108
3.027GlyVal: 3.027 ± 0.131
0.487GlyTrp: 0.487 ± 0.042
2.168GlyTyr: 2.168 ± 0.108
0.0GlyXaa: 0.0 ± 0.0
His
0.706HisAla: 0.706 ± 0.063
0.081HisCys: 0.081 ± 0.015
0.741HisAsp: 0.741 ± 0.051
0.875HisGlu: 0.875 ± 0.071
0.955HisPhe: 0.955 ± 0.056
0.902HisGly: 0.902 ± 0.079
0.33HisHis: 0.33 ± 0.034
1.408HisIle: 1.408 ± 0.081
1.435HisLys: 1.435 ± 0.084
1.389HisLeu: 1.389 ± 0.076
0.188HisMet: 0.188 ± 0.029
1.232HisAsn: 1.232 ± 0.075
0.61HisPro: 0.61 ± 0.051
0.602HisGln: 0.602 ± 0.043
0.495HisArg: 0.495 ± 0.048
1.155HisSer: 1.155 ± 0.072
0.771HisThr: 0.771 ± 0.06
0.595HisVal: 0.595 ± 0.052
0.15HisTrp: 0.15 ± 0.024
0.668HisTyr: 0.668 ± 0.052
0.0HisXaa: 0.0 ± 0.0
Ile
5.652IleAla: 5.652 ± 0.162
0.399IleCys: 0.399 ± 0.044
6.12IleAsp: 6.12 ± 0.161
6.799IleGlu: 6.799 ± 0.204
4.98IlePhe: 4.98 ± 0.249
4.171IleGly: 4.171 ± 0.173
1.235IleHis: 1.235 ± 0.065
8.407IleIle: 8.407 ± 0.273
9.396IleLys: 9.396 ± 0.217
8.011IleLeu: 8.011 ± 0.221
1.324IleMet: 1.324 ± 0.071
8.99IleAsn: 8.99 ± 0.281
2.858IlePro: 2.858 ± 0.117
3.357IleGln: 3.357 ± 0.112
2.525IleArg: 2.525 ± 0.112
7.083IleSer: 7.083 ± 0.174
4.773IleThr: 4.773 ± 0.141
5.276IleVal: 5.276 ± 0.176
0.698IleTrp: 0.698 ± 0.058
3.484IleTyr: 3.484 ± 0.132
0.0IleXaa: 0.0 ± 0.0
Lys
4.263LysAla: 4.263 ± 0.212
0.318LysCys: 0.318 ± 0.042
4.727LysAsp: 4.727 ± 0.176
5.425LysGlu: 5.425 ± 0.186
4.765LysPhe: 4.765 ± 0.124
3.046LysGly: 3.046 ± 0.129
1.623LysHis: 1.623 ± 0.078
10.54LysIle: 10.54 ± 0.225
8.786LysLys: 8.786 ± 0.224
8.994LysLeu: 8.994 ± 0.216
2.152LysMet: 2.152 ± 0.1
10.179LysAsn: 10.179 ± 0.254
2.74LysPro: 2.74 ± 0.151
4.965LysGln: 4.965 ± 0.17
2.851LysArg: 2.851 ± 0.125
5.41LysSer: 5.41 ± 0.151
5.997LysThr: 5.997 ± 0.167
4.174LysVal: 4.174 ± 0.127
1.044LysTrp: 1.044 ± 0.061
4.834LysTyr: 4.834 ± 0.126
0.0LysXaa: 0.0 ± 0.0
Leu
5.824LeuAla: 5.824 ± 0.159
0.541LeuCys: 0.541 ± 0.056
5.64LeuAsp: 5.64 ± 0.156
5.452LeuGlu: 5.452 ± 0.167
4.597LeuPhe: 4.597 ± 0.151
4.232LeuGly: 4.232 ± 0.14
1.324LeuHis: 1.324 ± 0.074
9.458LeuIle: 9.458 ± 0.262
9.304LeuLys: 9.304 ± 0.18
7.923LeuLeu: 7.923 ± 0.193
1.45LeuMet: 1.45 ± 0.081
9.784LeuAsn: 9.784 ± 0.286
2.64LeuPro: 2.64 ± 0.115
3.131LeuGln: 3.131 ± 0.112
2.801LeuArg: 2.801 ± 0.11
6.918LeuSer: 6.918 ± 0.188
5.184LeuThr: 5.184 ± 0.168
4.846LeuVal: 4.846 ± 0.14
0.775LeuTrp: 0.775 ± 0.063
3.119LeuTyr: 3.119 ± 0.108
0.0LeuXaa: 0.0 ± 0.0
Met
0.925MetAla: 0.925 ± 0.075
0.096MetCys: 0.096 ± 0.019
0.629MetAsp: 0.629 ± 0.051
0.687MetGlu: 0.687 ± 0.056
0.99MetPhe: 0.99 ± 0.073
0.633MetGly: 0.633 ± 0.048
0.238MetHis: 0.238 ± 0.029
1.473MetIle: 1.473 ± 0.091
1.661MetLys: 1.661 ± 0.085
1.65MetLeu: 1.65 ± 0.081
0.326MetMet: 0.326 ± 0.033
1.335MetAsn: 1.335 ± 0.074
0.625MetPro: 0.625 ± 0.053
0.652MetGln: 0.652 ± 0.053
0.664MetArg: 0.664 ± 0.054
1.37MetSer: 1.37 ± 0.09
0.694MetThr: 0.694 ± 0.061
0.798MetVal: 0.798 ± 0.064
0.134MetTrp: 0.134 ± 0.022
0.526MetTyr: 0.526 ± 0.048
0.0MetXaa: 0.0 ± 0.0
Asn
4.293AsnAla: 4.293 ± 0.194
0.265AsnCys: 0.265 ± 0.04
5.095AsnAsp: 5.095 ± 0.199
6.377AsnGlu: 6.377 ± 0.199
4.585AsnPhe: 4.585 ± 0.171
3.476AsnGly: 3.476 ± 0.121
1.27AsnHis: 1.27 ± 0.063
8.165AsnIle: 8.165 ± 0.231
8.882AsnLys: 8.882 ± 0.222
9.216AsnLeu: 9.216 ± 0.298
1.059AsnMet: 1.059 ± 0.065
8.518AsnAsn: 8.518 ± 0.345
2.387AsnPro: 2.387 ± 0.092
4.201AsnGln: 4.201 ± 0.171
2.08AsnArg: 2.08 ± 0.093
6.085AsnSer: 6.085 ± 0.234
4.834AsnThr: 4.834 ± 0.224
4.359AsnVal: 4.359 ± 0.128
0.821AsnTrp: 0.821 ± 0.056
3.649AsnTyr: 3.649 ± 0.126
0.0AsnXaa: 0.0 ± 0.0
Pro
1.22ProAla: 1.22 ± 0.077
0.104ProCys: 0.104 ± 0.02
1.546ProAsp: 1.546 ± 0.082
1.596ProGlu: 1.596 ± 0.087
1.458ProPhe: 1.458 ± 0.084
1.301ProGly: 1.301 ± 0.073
0.618ProHis: 0.618 ± 0.049
2.317ProIle: 2.317 ± 0.097
2.463ProLys: 2.463 ± 0.108
2.371ProLeu: 2.371 ± 0.091
0.414ProMet: 0.414 ± 0.041
2.306ProAsn: 2.306 ± 0.106
0.449ProPro: 0.449 ± 0.042
1.366ProGln: 1.366 ± 0.068
0.717ProArg: 0.717 ± 0.062
1.696ProSer: 1.696 ± 0.076
1.565ProThr: 1.565 ± 0.076
1.416ProVal: 1.416 ± 0.079
0.299ProTrp: 0.299 ± 0.037
1.051ProTyr: 1.051 ± 0.068
0.0ProXaa: 0.0 ± 0.0
Gln
2.494GlnAla: 2.494 ± 0.177
0.15GlnCys: 0.15 ± 0.027
2.041GlnAsp: 2.041 ± 0.095
1.938GlnGlu: 1.938 ± 0.098
1.849GlnPhe: 1.849 ± 0.082
1.446GlnGly: 1.446 ± 0.082
0.694GlnHis: 0.694 ± 0.052
4.616GlnIle: 4.616 ± 0.151
4.877GlnLys: 4.877 ± 0.14
3.729GlnLeu: 3.729 ± 0.146
0.771GlnMet: 0.771 ± 0.058
5.744GlnAsn: 5.744 ± 0.185
1.082GlnPro: 1.082 ± 0.063
2.275GlnGln: 2.275 ± 0.109
1.658GlnArg: 1.658 ± 0.08
2.479GlnSer: 2.479 ± 0.122
2.525GlnThr: 2.525 ± 0.111
1.481GlnVal: 1.481 ± 0.086
0.414GlnTrp: 0.414 ± 0.038
1.918GlnTyr: 1.918 ± 0.105
0.0GlnXaa: 0.0 ± 0.0
Arg
1.727ArgAla: 1.727 ± 0.09
0.107ArgCys: 0.107 ± 0.018
1.665ArgAsp: 1.665 ± 0.087
2.099ArgGlu: 2.099 ± 0.099
1.55ArgPhe: 1.55 ± 0.074
1.351ArgGly: 1.351 ± 0.084
0.491ArgHis: 0.491 ± 0.042
2.897ArgIle: 2.897 ± 0.11
2.77ArgLys: 2.77 ± 0.134
2.74ArgLeu: 2.74 ± 0.104
0.583ArgMet: 0.583 ± 0.057
2.187ArgAsn: 2.187 ± 0.087
0.821ArgPro: 0.821 ± 0.063
1.335ArgGln: 1.335 ± 0.077
1.147ArgArg: 1.147 ± 0.08
1.677ArgSer: 1.677 ± 0.091
1.308ArgThr: 1.308 ± 0.077
1.941ArgVal: 1.941 ± 0.087
0.269ArgTrp: 0.269 ± 0.033
1.404ArgTyr: 1.404 ± 0.073
0.0ArgXaa: 0.0 ± 0.0
Ser
3.33SerAla: 3.33 ± 0.12
0.345SerCys: 0.345 ± 0.044
3.211SerAsp: 3.211 ± 0.122
3.595SerGlu: 3.595 ± 0.122
3.549SerPhe: 3.549 ± 0.128
3.261SerGly: 3.261 ± 0.125
0.875SerHis: 0.875 ± 0.057
6.239SerIle: 6.239 ± 0.165
6.012SerLys: 6.012 ± 0.155
6.872SerLeu: 6.872 ± 0.174
0.902SerMet: 0.902 ± 0.059
5.279SerAsn: 5.279 ± 0.185
1.631SerPro: 1.631 ± 0.072
3.246SerGln: 3.246 ± 0.124
2.087SerArg: 2.087 ± 0.093
4.497SerSer: 4.497 ± 0.167
3.994SerThr: 3.994 ± 0.17
3.534SerVal: 3.534 ± 0.136
0.591SerTrp: 0.591 ± 0.048
2.621SerTyr: 2.621 ± 0.111
0.0SerXaa: 0.0 ± 0.0
Thr
2.252ThrAla: 2.252 ± 0.115
0.157ThrCys: 0.157 ± 0.026
2.544ThrAsp: 2.544 ± 0.147
2.456ThrGlu: 2.456 ± 0.098
2.851ThrPhe: 2.851 ± 0.111
2.448ThrGly: 2.448 ± 0.127
1.005ThrHis: 1.005 ± 0.06
4.93ThrIle: 4.93 ± 0.146
5.268ThrLys: 5.268 ± 0.167
5.609ThrLeu: 5.609 ± 0.156
0.771ThrMet: 0.771 ± 0.056
4.55ThrAsn: 4.55 ± 0.21
1.907ThrPro: 1.907 ± 0.086
2.843ThrGln: 2.843 ± 0.134
1.565ThrArg: 1.565 ± 0.086
3.495ThrSer: 3.495 ± 0.132
3.277ThrThr: 3.277 ± 0.124
2.363ThrVal: 2.363 ± 0.113
0.38ThrTrp: 0.38 ± 0.039
2.049ThrTyr: 2.049 ± 0.088
0.0ThrXaa: 0.0 ± 0.0
Val
3.522ValAla: 3.522 ± 0.134
0.246ValCys: 0.246 ± 0.034
3.181ValAsp: 3.181 ± 0.118
3.53ValGlu: 3.53 ± 0.138
2.847ValPhe: 2.847 ± 0.123
2.621ValGly: 2.621 ± 0.119
0.714ValHis: 0.714 ± 0.061
4.785ValIle: 4.785 ± 0.136
5.061ValLys: 5.061 ± 0.14
4.861ValLeu: 4.861 ± 0.157
0.81ValMet: 0.81 ± 0.067
3.81ValAsn: 3.81 ± 0.133
1.224ValPro: 1.224 ± 0.08
1.888ValGln: 1.888 ± 0.096
1.489ValArg: 1.489 ± 0.086
3.749ValSer: 3.749 ± 0.131
2.049ValThr: 2.049 ± 0.099
3.426ValVal: 3.426 ± 0.136
0.499ValTrp: 0.499 ± 0.05
1.865ValTyr: 1.865 ± 0.097
0.0ValXaa: 0.0 ± 0.0
Trp
0.395TrpAla: 0.395 ± 0.042
0.058TrpCys: 0.058 ± 0.017
0.549TrpAsp: 0.549 ± 0.042
0.549TrpGlu: 0.549 ± 0.046
0.572TrpPhe: 0.572 ± 0.048
0.353TrpGly: 0.353 ± 0.034
0.081TrpHis: 0.081 ± 0.018
0.875TrpIle: 0.875 ± 0.062
0.783TrpLys: 0.783 ± 0.054
0.844TrpLeu: 0.844 ± 0.068
0.169TrpMet: 0.169 ± 0.028
0.917TrpAsn: 0.917 ± 0.063
0.238TrpPro: 0.238 ± 0.03
0.341TrpGln: 0.341 ± 0.042
0.299TrpArg: 0.299 ± 0.039
0.591TrpSer: 0.591 ± 0.052
0.499TrpThr: 0.499 ± 0.041
0.526TrpVal: 0.526 ± 0.049
0.088TrpTrp: 0.088 ± 0.019
0.472TrpTyr: 0.472 ± 0.044
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.241TyrAla: 2.241 ± 0.097
0.219TyrCys: 0.219 ± 0.03
2.479TyrAsp: 2.479 ± 0.102
2.736TyrGlu: 2.736 ± 0.108
2.352TyrPhe: 2.352 ± 0.11
1.903TyrGly: 1.903 ± 0.089
0.637TyrHis: 0.637 ± 0.047
3.545TyrIle: 3.545 ± 0.134
3.503TyrLys: 3.503 ± 0.142
4.113TyrLeu: 4.113 ± 0.123
0.526TyrMet: 0.526 ± 0.047
3.269TyrAsn: 3.269 ± 0.128
1.117TyrPro: 1.117 ± 0.067
1.938TyrGln: 1.938 ± 0.091
1.404TyrArg: 1.404 ± 0.071
2.954TyrSer: 2.954 ± 0.103
2.133TyrThr: 2.133 ± 0.094
2.34TyrVal: 2.34 ± 0.116
0.464TyrTrp: 0.464 ± 0.048
1.619TyrTyr: 1.619 ± 0.083
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 676 proteins (260632 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski