Amino acid dipepetide frequency for Halomonas sp. 1513

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.683AlaAla: 14.683 ± 0.147	1.255AlaCys: 1.255 ± 0.036	6.256AlaAsp: 6.256 ± 0.08	8.346AlaGlu: 8.346 ± 0.104	3.979AlaPhe: 3.979 ± 0.059	9.789AlaGly: 9.789 ± 0.133	2.378AlaHis: 2.378 ± 0.051	5.475AlaIle: 5.475 ± 0.084	2.733AlaLys: 2.733 ± 0.068	15.3AlaLeu: 15.3 ± 0.168	3.435AlaMet: 3.435 ± 0.057	2.658AlaAsn: 2.658 ± 0.055	5.22AlaPro: 5.22 ± 0.106	4.223AlaGln: 4.223 ± 0.076	8.465AlaArg: 8.465 ± 0.101	6.837AlaSer: 6.837 ± 0.091	5.3AlaThr: 5.3 ± 0.062	7.916AlaVal: 7.916 ± 0.089	2.02AlaTrp: 2.02 ± 0.049	2.455AlaTyr: 2.455 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.919CysAla: 0.919 ± 0.031	0.126CysCys: 0.126 ± 0.011	0.613CysAsp: 0.613 ± 0.022	0.551CysGlu: 0.551 ± 0.026	0.333CysPhe: 0.333 ± 0.016	0.929CysGly: 0.929 ± 0.035	0.349CysHis: 0.349 ± 0.017	0.346CysIle: 0.346 ± 0.02	0.185CysLys: 0.185 ± 0.012	1.031CysLeu: 1.031 ± 0.03	0.171CysMet: 0.171 ± 0.014	0.207CysAsn: 0.207 ± 0.014	0.475CysPro: 0.475 ± 0.023	0.414CysGln: 0.414 ± 0.018	0.751CysArg: 0.751 ± 0.025	0.464CysSer: 0.464 ± 0.022	0.338CysThr: 0.338 ± 0.017	0.636CysVal: 0.636 ± 0.02	0.147CysTrp: 0.147 ± 0.011	0.248CysTyr: 0.248 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.562AspAla: 7.562 ± 0.123	0.479AspCys: 0.479 ± 0.022	4.586AspAsp: 4.586 ± 0.113	4.334AspGlu: 4.334 ± 0.075	2.131AspPhe: 2.131 ± 0.047	5.229AspGly: 5.229 ± 0.11	1.433AspHis: 1.433 ± 0.036	2.876AspIle: 2.876 ± 0.066	1.509AspLys: 1.509 ± 0.043	5.619AspLeu: 5.619 ± 0.085	1.326AspMet: 1.326 ± 0.036	1.504AspAsn: 1.504 ± 0.047	3.202AspPro: 3.202 ± 0.061	2.027AspGln: 2.027 ± 0.045	3.332AspArg: 3.332 ± 0.067	2.928AspSer: 2.928 ± 0.062	2.786AspThr: 2.786 ± 0.072	3.799AspVal: 3.799 ± 0.064	1.018AspTrp: 1.018 ± 0.026	1.759AspTyr: 1.759 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	8.675GluAla: 8.675 ± 0.094	0.477GluCys: 0.477 ± 0.022	2.833GluAsp: 2.833 ± 0.054	3.869GluGlu: 3.869 ± 0.083	1.67GluPhe: 1.67 ± 0.042	4.735GluGly: 4.735 ± 0.071	1.781GluHis: 1.781 ± 0.038	3.013GluIle: 3.013 ± 0.057	1.355GluLys: 1.355 ± 0.04	7.098GluLeu: 7.098 ± 0.095	1.552GluMet: 1.552 ± 0.04	1.269GluAsn: 1.269 ± 0.039	2.866GluPro: 2.866 ± 0.06	3.404GluGln: 3.404 ± 0.064	6.38GluArg: 6.38 ± 0.082	3.065GluSer: 3.065 ± 0.062	3.041GluThr: 3.041 ± 0.051	4.984GluVal: 4.984 ± 0.07	0.9GluTrp: 0.9 ± 0.029	1.24GluTyr: 1.24 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.769PheAla: 3.769 ± 0.068	0.367PheCys: 0.367 ± 0.015	2.481PheAsp: 2.481 ± 0.049	2.115PheGlu: 2.115 ± 0.047	1.329PhePhe: 1.329 ± 0.041	3.291PheGly: 3.291 ± 0.06	0.836PheHis: 0.836 ± 0.026	1.696PheIle: 1.696 ± 0.044	0.885PheLys: 0.885 ± 0.03	3.137PheLeu: 3.137 ± 0.057	0.889PheMet: 0.889 ± 0.031	1.026PheAsn: 1.026 ± 0.029	1.4PhePro: 1.4 ± 0.033	1.11PheGln: 1.11 ± 0.029	1.9PheArg: 1.9 ± 0.042	2.165PheSer: 2.165 ± 0.044	1.845PheThr: 1.845 ± 0.04	2.412PheVal: 2.412 ± 0.048	0.479PheTrp: 0.479 ± 0.023	0.884PheTyr: 0.884 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	7.876GlyAla: 7.876 ± 0.107	0.943GlyCys: 0.943 ± 0.032	4.897GlyAsp: 4.897 ± 0.121	6.025GlyGlu: 6.025 ± 0.079	3.192GlyPhe: 3.192 ± 0.045	6.779GlyGly: 6.779 ± 0.139	2.115GlyHis: 2.115 ± 0.048	4.379GlyIle: 4.379 ± 0.073	2.496GlyLys: 2.496 ± 0.054	9.551GlyLeu: 9.551 ± 0.097	2.483GlyMet: 2.483 ± 0.053	2.1GlyAsn: 2.1 ± 0.076	2.812GlyPro: 2.812 ± 0.056	3.287GlyGln: 3.287 ± 0.057	5.551GlyArg: 5.551 ± 0.068	4.577GlySer: 4.577 ± 0.094	3.529GlyThr: 3.529 ± 0.08	6.42GlyVal: 6.42 ± 0.079	1.392GlyTrp: 1.392 ± 0.04	2.398GlyTyr: 2.398 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.762HisAla: 2.762 ± 0.054	0.295HisCys: 0.295 ± 0.018	1.65HisAsp: 1.65 ± 0.037	1.283HisGlu: 1.283 ± 0.036	0.988HisPhe: 0.988 ± 0.027	2.337HisGly: 2.337 ± 0.046	0.802HisHis: 0.802 ± 0.03	0.923HisIle: 0.923 ± 0.028	0.532HisLys: 0.532 ± 0.021	2.639HisLeu: 2.639 ± 0.056	0.484HisMet: 0.484 ± 0.02	0.54HisAsn: 0.54 ± 0.024	1.559HisPro: 1.559 ± 0.037	0.994HisGln: 0.994 ± 0.031	1.742HisArg: 1.742 ± 0.043	1.153HisSer: 1.153 ± 0.032	0.973HisThr: 0.973 ± 0.031	1.434HisVal: 1.434 ± 0.04	0.432HisTrp: 0.432 ± 0.019	0.761HisTyr: 0.761 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.681IleAla: 5.681 ± 0.071	0.425IleCys: 0.425 ± 0.019	3.568IleAsp: 3.568 ± 0.071	3.453IleGlu: 3.453 ± 0.056	1.414IlePhe: 1.414 ± 0.038	4.427IleGly: 4.427 ± 0.08	1.028IleHis: 1.028 ± 0.032	2.03IleIle: 2.03 ± 0.049	1.232IleLys: 1.232 ± 0.036	3.952IleLeu: 3.952 ± 0.077	0.941IleMet: 0.941 ± 0.032	1.551IleAsn: 1.551 ± 0.045	2.142IlePro: 2.142 ± 0.051	1.375IleGln: 1.375 ± 0.038	2.836IleArg: 2.836 ± 0.049	2.641IleSer: 2.641 ± 0.052	2.521IleThr: 2.521 ± 0.059	3.293IleVal: 3.293 ± 0.06	0.497IleTrp: 0.497 ± 0.026	1.024IleTyr: 1.024 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	2.907LysAla: 2.907 ± 0.074	0.146LysCys: 0.146 ± 0.012	1.096LysAsp: 1.096 ± 0.037	1.278LysGlu: 1.278 ± 0.039	0.544LysPhe: 0.544 ± 0.025	1.889LysGly: 1.889 ± 0.049	0.579LysHis: 0.579 ± 0.02	1.056LysIle: 1.056 ± 0.033	0.802LysLys: 0.802 ± 0.033	2.535LysLeu: 2.535 ± 0.052	0.533LysMet: 0.533 ± 0.023	0.517LysAsn: 0.517 ± 0.026	1.389LysPro: 1.389 ± 0.039	1.074LysGln: 1.074 ± 0.035	2.206LysArg: 2.206 ± 0.049	1.286LysSer: 1.286 ± 0.04	1.189LysThr: 1.189 ± 0.035	1.98LysVal: 1.98 ± 0.046	0.232LysTrp: 0.232 ± 0.015	0.459LysTyr: 0.459 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	16.191LeuAla: 16.191 ± 0.162	1.114LeuCys: 1.114 ± 0.032	7.787LeuAsp: 7.787 ± 0.105	7.615LeuGlu: 7.615 ± 0.11	3.878LeuPhe: 3.878 ± 0.078	9.843LeuGly: 9.843 ± 0.111	2.328LeuHis: 2.328 ± 0.05	5.39LeuIle: 5.39 ± 0.09	3.027LeuLys: 3.027 ± 0.056	13.106LeuLeu: 13.106 ± 0.199	2.926LeuMet: 2.926 ± 0.057	2.69LeuAsn: 2.69 ± 0.051	6.324LeuPro: 6.324 ± 0.098	3.282LeuGln: 3.282 ± 0.058	7.23LeuArg: 7.23 ± 0.098	6.85LeuSer: 6.85 ± 0.071	5.806LeuThr: 5.806 ± 0.092	8.21LeuVal: 8.21 ± 0.116	1.542LeuTrp: 1.542 ± 0.055	2.34LeuTyr: 2.34 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.249MetAla: 3.249 ± 0.049	0.163MetCys: 0.163 ± 0.012	1.074MetAsp: 1.074 ± 0.03	1.104MetGlu: 1.104 ± 0.031	0.664MetPhe: 0.664 ± 0.026	1.83MetGly: 1.83 ± 0.048	0.523MetHis: 0.523 ± 0.02	1.25MetIle: 1.25 ± 0.036	0.686MetLys: 0.686 ± 0.026	2.998MetLeu: 2.998 ± 0.054	0.631MetMet: 0.631 ± 0.027	0.703MetAsn: 0.703 ± 0.025	1.488MetPro: 1.488 ± 0.036	1.064MetGln: 1.064 ± 0.031	1.724MetArg: 1.724 ± 0.039	1.709MetSer: 1.709 ± 0.041	1.603MetThr: 1.603 ± 0.036	1.708MetVal: 1.708 ± 0.043	0.204MetTrp: 0.204 ± 0.014	0.351MetTyr: 0.351 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.829AsnAla: 2.829 ± 0.057	0.207AsnCys: 0.207 ± 0.013	1.447AsnAsp: 1.447 ± 0.043	1.219AsnGlu: 1.219 ± 0.035	0.772AsnPhe: 0.772 ± 0.028	1.965AsnGly: 1.965 ± 0.058	0.558AsnHis: 0.558 ± 0.022	1.23AsnIle: 1.23 ± 0.036	0.553AsnLys: 0.553 ± 0.025	2.556AsnLeu: 2.556 ± 0.048	0.519AsnMet: 0.519 ± 0.023	0.625AsnAsn: 0.625 ± 0.026	1.557AsnPro: 1.557 ± 0.036	0.947AsnGln: 0.947 ± 0.025	1.843AsnArg: 1.843 ± 0.043	1.049AsnSer: 1.049 ± 0.034	1.161AsnThr: 1.161 ± 0.044	1.704AsnVal: 1.704 ± 0.045	0.347AsnTrp: 0.347 ± 0.017	0.624AsnTyr: 0.624 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	5.662ProAla: 5.662 ± 0.095	0.341ProCys: 0.341 ± 0.018	3.259ProAsp: 3.259 ± 0.057	3.742ProGlu: 3.742 ± 0.058	1.734ProPhe: 1.734 ± 0.037	4.363ProGly: 4.363 ± 0.07	1.172ProHis: 1.172 ± 0.033	1.954ProIle: 1.954 ± 0.041	1.039ProLys: 1.039 ± 0.038	6.087ProLeu: 6.087 ± 0.093	1.191ProMet: 1.191 ± 0.027	1.094ProAsn: 1.094 ± 0.029	2.413ProPro: 2.413 ± 0.06	1.91ProGln: 1.91 ± 0.043	3.261ProArg: 3.261 ± 0.055	2.689ProSer: 2.689 ± 0.044	2.134ProThr: 2.134 ± 0.042	3.552ProVal: 3.552 ± 0.059	0.834ProTrp: 0.834 ± 0.026	1.099ProTyr: 1.099 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	5.634GlnAla: 5.634 ± 0.07	0.297GlnCys: 0.297 ± 0.016	1.714GlnAsp: 1.714 ± 0.042	1.918GlnGlu: 1.918 ± 0.052	1.027GlnPhe: 1.027 ± 0.031	3.171GlnGly: 3.171 ± 0.059	1.083GlnHis: 1.083 ± 0.03	1.509GlnIle: 1.509 ± 0.037	0.691GlnLys: 0.691 ± 0.027	4.683GlnLeu: 4.683 ± 0.069	0.841GlnMet: 0.841 ± 0.028	0.664GlnAsn: 0.664 ± 0.024	2.068GlnPro: 2.068 ± 0.046	2.362GlnGln: 2.362 ± 0.062	4.143GlnArg: 4.143 ± 0.081	1.652GlnSer: 1.652 ± 0.039	1.56GlnThr: 1.56 ± 0.041	2.928GlnVal: 2.928 ± 0.056	0.598GlnTrp: 0.598 ± 0.021	0.658GlnTyr: 0.658 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	6.796ArgAla: 6.796 ± 0.087	0.657ArgCys: 0.657 ± 0.024	4.52ArgAsp: 4.52 ± 0.074	5.31ArgGlu: 5.31 ± 0.093	2.899ArgPhe: 2.899 ± 0.052	4.978ArgGly: 4.978 ± 0.07	2.377ArgHis: 2.377 ± 0.056	3.251ArgIle: 3.251 ± 0.053	1.523ArgLys: 1.523 ± 0.039	10.286ArgLeu: 10.286 ± 0.136	1.763ArgMet: 1.763 ± 0.041	1.522ArgAsn: 1.522 ± 0.04	3.062ArgPro: 3.062 ± 0.052	3.629ArgGln: 3.629 ± 0.073	6.079ArgArg: 6.079 ± 0.1	3.274ArgSer: 3.274 ± 0.06	2.593ArgThr: 2.593 ± 0.035	5.051ArgVal: 5.051 ± 0.068	1.188ArgTrp: 1.188 ± 0.034	2.171ArgTyr: 2.171 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.005SerAla: 6.005 ± 0.097	0.417SerCys: 0.417 ± 0.021	3.225SerAsp: 3.225 ± 0.065	3.144SerGlu: 3.144 ± 0.058	1.81SerPhe: 1.81 ± 0.045	5.177SerGly: 5.177 ± 0.081	1.27SerHis: 1.27 ± 0.031	2.341SerIle: 2.341 ± 0.047	1.073SerLys: 1.073 ± 0.033	6.743SerLeu: 6.743 ± 0.082	1.368SerMet: 1.368 ± 0.034	1.239SerAsn: 1.239 ± 0.037	2.845SerPro: 2.845 ± 0.048	2.081SerGln: 2.081 ± 0.045	4.11SerArg: 4.11 ± 0.068	2.857SerSer: 2.857 ± 0.059	2.361SerThr: 2.361 ± 0.048	3.962SerVal: 3.962 ± 0.103	0.732SerTrp: 0.732 ± 0.028	1.131SerTyr: 1.131 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	5.083ThrAla: 5.083 ± 0.115	0.409ThrCys: 0.409 ± 0.018	2.241ThrAsp: 2.241 ± 0.07	2.128ThrGlu: 2.128 ± 0.043	1.742ThrPhe: 1.742 ± 0.043	3.823ThrGly: 3.823 ± 0.07	1.112ThrHis: 1.112 ± 0.028	1.931ThrIle: 1.931 ± 0.055	0.825ThrLys: 0.825 ± 0.031	7.259ThrLeu: 7.259 ± 0.1	0.91ThrMet: 0.91 ± 0.033	1.042ThrAsn: 1.042 ± 0.031	3.365ThrPro: 3.365 ± 0.053	1.794ThrGln: 1.794 ± 0.043	3.527ThrArg: 3.527 ± 0.06	2.386ThrSer: 2.386 ± 0.05	2.416ThrThr: 2.416 ± 0.05	3.133ThrVal: 3.133 ± 0.081	0.618ThrTrp: 0.618 ± 0.031	0.971ThrTyr: 0.971 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	8.684ValAla: 8.684 ± 0.104	0.673ValCys: 0.673 ± 0.022	4.318ValAsp: 4.318 ± 0.073	5.006ValGlu: 5.006 ± 0.065	2.476ValPhe: 2.476 ± 0.056	5.466ValGly: 5.466 ± 0.077	1.479ValHis: 1.479 ± 0.038	3.936ValIle: 3.936 ± 0.072	1.801ValLys: 1.801 ± 0.051	7.498ValLeu: 7.498 ± 0.096	1.992ValMet: 1.992 ± 0.043	1.916ValAsn: 1.916 ± 0.047	3.341ValPro: 3.341 ± 0.055	2.056ValGln: 2.056 ± 0.04	4.317ValArg: 4.317 ± 0.063	4.317ValSer: 4.317 ± 0.064	3.944ValThr: 3.944 ± 0.096	6.025ValVal: 6.025 ± 0.116	0.899ValTrp: 0.899 ± 0.029	1.472ValTyr: 1.472 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.24TrpAla: 1.24 ± 0.036	0.182TrpCys: 0.182 ± 0.014	0.572TrpAsp: 0.572 ± 0.021	0.673TrpGlu: 0.673 ± 0.024	0.522TrpPhe: 0.522 ± 0.025	0.877TrpGly: 0.877 ± 0.027	0.447TrpHis: 0.447 ± 0.017	0.588TrpIle: 0.588 ± 0.025	0.31TrpLys: 0.31 ± 0.015	2.54TrpLeu: 2.54 ± 0.062	0.362TrpMet: 0.362 ± 0.015	0.328TrpAsn: 0.328 ± 0.018	0.74TrpPro: 0.74 ± 0.031	1.111TrpGln: 1.111 ± 0.03	1.309TrpArg: 1.309 ± 0.038	0.79TrpSer: 0.79 ± 0.026	0.555TrpThr: 0.555 ± 0.02	0.957TrpVal: 0.957 ± 0.029	0.317TrpTrp: 0.317 ± 0.018	0.319TrpTyr: 0.319 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.517TyrAla: 2.517 ± 0.047	0.26TyrCys: 0.26 ± 0.014	1.299TyrAsp: 1.299 ± 0.033	1.094TyrGlu: 1.094 ± 0.033	0.914TyrPhe: 0.914 ± 0.028	1.902TyrGly: 1.902 ± 0.042	0.631TyrHis: 0.631 ± 0.021	0.858TyrIle: 0.858 ± 0.029	0.442TyrLys: 0.442 ± 0.021	2.86TyrLeu: 2.86 ± 0.051	0.409TyrMet: 0.409 ± 0.02	0.516TyrAsn: 0.516 ± 0.026	1.261TyrPro: 1.261 ± 0.037	1.057TyrGln: 1.057 ± 0.028	2.224TyrArg: 2.224 ± 0.04	1.203TyrSer: 1.203 ± 0.032	1.056TyrThr: 1.056 ± 0.034	1.514TyrVal: 1.514 ± 0.035	0.347TyrTrp: 0.347 ± 0.02	0.673TyrTyr: 0.673 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3636 proteins (1211598 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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