Amino acid dipepetide frequency for Culex rhabdo-like virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.002AlaAla: 3.002 ± 1.189
0.273AlaCys: 0.273 ± 0.157
3.275AlaAsp: 3.275 ± 0.658
4.094AlaGlu: 4.094 ± 2.737
3.275AlaPhe: 3.275 ± 0.516
2.456AlaGly: 2.456 ± 0.8
1.91AlaHis: 1.91 ± 1.453
4.913AlaIle: 4.913 ± 0.726
3.002AlaLys: 3.002 ± 1.15
5.731AlaLeu: 5.731 ± 0.96
2.456AlaMet: 2.456 ± 0.788
1.365AlaAsn: 1.365 ± 0.834
3.002AlaPro: 3.002 ± 2.452
1.91AlaGln: 1.91 ± 0.685
2.729AlaArg: 2.729 ± 1.596
5.186AlaSer: 5.186 ± 1.421
3.275AlaThr: 3.275 ± 2.169
3.002AlaVal: 3.002 ± 1.15
0.819AlaTrp: 0.819 ± 0.426
1.638AlaTyr: 1.638 ± 0.684
0.0AlaXaa: 0.0 ± 0.0
Cys
1.092CysAla: 1.092 ± 0.928
0.0CysCys: 0.0 ± 0.0
1.638CysAsp: 1.638 ± 0.742
0.819CysGlu: 0.819 ± 0.749
0.819CysPhe: 0.819 ± 0.427
0.546CysGly: 0.546 ± 0.356
0.0CysHis: 0.0 ± 0.0
0.546CysIle: 0.546 ± 0.694
0.819CysLys: 0.819 ± 1.066
1.638CysLeu: 1.638 ± 0.283
0.0CysMet: 0.0 ± 0.0
0.273CysAsn: 0.273 ± 0.46
0.0CysPro: 0.0 ± 0.0
1.092CysGln: 1.092 ± 0.408
1.092CysArg: 1.092 ± 0.712
2.729CysSer: 2.729 ± 1.755
1.092CysThr: 1.092 ± 0.442
0.819CysVal: 0.819 ± 0.615
0.273CysTrp: 0.273 ± 0.157
0.546CysTyr: 0.546 ± 0.313
0.0CysXaa: 0.0 ± 0.0
Asp
4.094AspAla: 4.094 ± 0.45
1.365AspCys: 1.365 ± 0.871
2.456AspAsp: 2.456 ± 0.8
3.821AspGlu: 3.821 ± 0.905
2.456AspPhe: 2.456 ± 0.55
3.548AspGly: 3.548 ± 1.161
1.092AspHis: 1.092 ± 0.442
2.456AspIle: 2.456 ± 0.648
3.275AspLys: 3.275 ± 1.205
5.459AspLeu: 5.459 ± 0.868
1.092AspMet: 1.092 ± 0.477
2.456AspAsn: 2.456 ± 0.566
4.367AspPro: 4.367 ± 0.87
2.456AspGln: 2.456 ± 0.663
1.365AspArg: 1.365 ± 0.591
1.638AspSer: 1.638 ± 0.712
3.275AspThr: 3.275 ± 0.654
3.002AspVal: 3.002 ± 1.439
0.819AspTrp: 0.819 ± 0.426
2.456AspTyr: 2.456 ± 0.788
0.0AspXaa: 0.0 ± 0.0
Glu
3.275GluAla: 3.275 ± 0.501
0.546GluCys: 0.546 ± 0.92
4.367GluAsp: 4.367 ± 1.392
5.731GluGlu: 5.731 ± 1.87
3.548GluPhe: 3.548 ± 1.042
3.002GluGly: 3.002 ± 0.377
1.365GluHis: 1.365 ± 1.145
4.367GluIle: 4.367 ± 1.305
3.548GluLys: 3.548 ± 0.763
6.277GluLeu: 6.277 ± 0.683
2.729GluMet: 2.729 ± 1.388
2.183GluAsn: 2.183 ± 1.511
2.456GluPro: 2.456 ± 1.07
2.729GluGln: 2.729 ± 1.406
1.91GluArg: 1.91 ± 0.558
4.64GluSer: 4.64 ± 1.195
2.456GluThr: 2.456 ± 1.094
3.821GluVal: 3.821 ± 1.116
1.092GluTrp: 1.092 ± 0.802
2.729GluTyr: 2.729 ± 1.157
0.0GluXaa: 0.0 ± 0.0
Phe
3.275PheAla: 3.275 ± 1.469
0.546PheCys: 0.546 ± 0.815
1.638PheAsp: 1.638 ± 0.633
2.456PheGlu: 2.456 ± 0.663
1.91PhePhe: 1.91 ± 0.999
2.456PheGly: 2.456 ± 0.765
2.456PheHis: 2.456 ± 0.887
1.638PheIle: 1.638 ± 0.83
3.275PheLys: 3.275 ± 0.854
3.821PheLeu: 3.821 ± 1.048
0.819PheMet: 0.819 ± 0.902
1.91PheAsn: 1.91 ± 0.577
3.548PhePro: 3.548 ± 1.133
0.819PheGln: 0.819 ± 0.47
3.821PheArg: 3.821 ± 0.884
2.183PheSer: 2.183 ± 1.438
3.275PheThr: 3.275 ± 1.248
2.729PheVal: 2.729 ± 0.809
0.819PheTrp: 0.819 ± 0.47
1.365PheTyr: 1.365 ± 0.594
0.0PheXaa: 0.0 ± 0.0
Gly
2.456GlyAla: 2.456 ± 1.925
1.365GlyCys: 1.365 ± 0.668
3.548GlyAsp: 3.548 ± 1.352
4.094GlyGlu: 4.094 ± 1.312
2.183GlyPhe: 2.183 ± 1.046
4.64GlyGly: 4.64 ± 1.307
0.546GlyHis: 0.546 ± 0.356
3.275GlyIle: 3.275 ± 1.393
3.002GlyLys: 3.002 ± 0.792
8.188GlyLeu: 8.188 ± 1.075
1.365GlyMet: 1.365 ± 0.65
2.456GlyAsn: 2.456 ± 0.832
2.183GlyPro: 2.183 ± 2.126
2.456GlyGln: 2.456 ± 0.815
2.729GlyArg: 2.729 ± 1.597
3.821GlySer: 3.821 ± 1.252
4.367GlyThr: 4.367 ± 1.281
3.548GlyVal: 3.548 ± 1.535
1.092GlyTrp: 1.092 ± 0.627
0.819GlyTyr: 0.819 ± 1.066
0.0GlyXaa: 0.0 ± 0.0
His
1.092HisAla: 1.092 ± 0.477
0.0HisCys: 0.0 ± 0.0
0.546HisAsp: 0.546 ± 0.356
1.092HisGlu: 1.092 ± 0.831
1.638HisPhe: 1.638 ± 0.442
1.092HisGly: 1.092 ± 0.442
0.273HisHis: 0.273 ± 0.557
1.365HisIle: 1.365 ± 0.783
0.546HisLys: 0.546 ± 0.313
4.367HisLeu: 4.367 ± 1.488
0.819HisMet: 0.819 ± 1.015
1.092HisAsn: 1.092 ± 0.712
1.91HisPro: 1.91 ± 1.016
0.819HisGln: 0.819 ± 1.222
1.092HisArg: 1.092 ± 0.627
1.638HisSer: 1.638 ± 0.97
1.91HisThr: 1.91 ± 0.632
1.365HisVal: 1.365 ± 0.772
0.546HisTrp: 0.546 ± 0.313
1.365HisTyr: 1.365 ± 0.716
0.0HisXaa: 0.0 ± 0.0
Ile
4.64IleAla: 4.64 ± 1.225
1.092IleCys: 1.092 ± 0.442
3.275IleAsp: 3.275 ± 0.553
5.186IleGlu: 5.186 ± 1.328
3.548IlePhe: 3.548 ± 1.519
4.64IleGly: 4.64 ± 0.707
1.638IleHis: 1.638 ± 1.186
3.821IleIle: 3.821 ± 0.645
6.55IleLys: 6.55 ± 3.191
4.913IleLeu: 4.913 ± 1.23
0.819IleMet: 0.819 ± 0.497
3.002IleAsn: 3.002 ± 1.389
4.64IlePro: 4.64 ± 0.543
2.456IleGln: 2.456 ± 1.038
2.183IleArg: 2.183 ± 0.772
6.55IleSer: 6.55 ± 2.333
1.91IleThr: 1.91 ± 1.25
1.638IleVal: 1.638 ± 0.684
1.365IleTrp: 1.365 ± 0.716
2.183IleTyr: 2.183 ± 0.967
0.0IleXaa: 0.0 ± 0.0
Lys
3.275LysAla: 3.275 ± 0.916
1.092LysCys: 1.092 ± 0.425
4.367LysAsp: 4.367 ± 0.799
4.094LysGlu: 4.094 ± 1.145
1.092LysPhe: 1.092 ± 0.904
4.094LysGly: 4.094 ± 1.44
1.91LysHis: 1.91 ± 0.577
3.275LysIle: 3.275 ± 0.704
6.277LysLys: 6.277 ± 2.256
3.821LysLeu: 3.821 ± 1.633
1.91LysMet: 1.91 ± 0.219
2.729LysAsn: 2.729 ± 1.123
1.365LysPro: 1.365 ± 0.871
0.819LysGln: 0.819 ± 0.427
4.094LysArg: 4.094 ± 1.927
6.55LysSer: 6.55 ± 1.145
4.913LysThr: 4.913 ± 1.739
4.367LysVal: 4.367 ± 0.872
1.91LysTrp: 1.91 ± 0.58
2.456LysTyr: 2.456 ± 1.049
0.0LysXaa: 0.0 ± 0.0
Leu
4.913LeuAla: 4.913 ± 1.886
0.819LeuCys: 0.819 ± 0.37
2.456LeuAsp: 2.456 ± 1.61
5.186LeuGlu: 5.186 ± 0.895
3.275LeuPhe: 3.275 ± 0.553
5.731LeuGly: 5.731 ± 2.156
2.456LeuHis: 2.456 ± 1.642
7.642LeuIle: 7.642 ± 1.871
5.731LeuLys: 5.731 ± 1.227
7.096LeuLeu: 7.096 ± 1.128
3.821LeuMet: 3.821 ± 0.591
4.094LeuAsn: 4.094 ± 0.99
3.002LeuPro: 3.002 ± 0.498
3.548LeuGln: 3.548 ± 1.654
4.913LeuArg: 4.913 ± 1.849
10.917LeuSer: 10.917 ± 2.672
4.64LeuThr: 4.64 ± 1.626
5.731LeuVal: 5.731 ± 1.161
1.91LeuTrp: 1.91 ± 0.737
3.821LeuTyr: 3.821 ± 0.501
0.0LeuXaa: 0.0 ± 0.0
Met
1.365MetAla: 1.365 ± 0.834
0.819MetCys: 0.819 ± 0.644
1.638MetAsp: 1.638 ± 0.995
1.91MetGlu: 1.91 ± 0.763
1.365MetPhe: 1.365 ± 0.569
1.092MetGly: 1.092 ± 1.0
0.273MetHis: 0.273 ± 0.157
4.094MetIle: 4.094 ± 1.577
3.275MetLys: 3.275 ± 0.875
1.365MetLeu: 1.365 ± 0.569
1.092MetMet: 1.092 ± 0.916
1.365MetAsn: 1.365 ± 0.65
0.273MetPro: 0.273 ± 0.157
0.273MetGln: 0.273 ± 0.157
1.638MetArg: 1.638 ± 0.684
0.819MetSer: 0.819 ± 0.427
1.365MetThr: 1.365 ± 0.694
0.819MetVal: 0.819 ± 0.426
0.0MetTrp: 0.0 ± 0.0
1.638MetTyr: 1.638 ± 0.48
0.0MetXaa: 0.0 ± 0.0
Asn
3.002AsnAla: 3.002 ± 0.51
0.819AsnCys: 0.819 ± 0.37
1.365AsnAsp: 1.365 ± 0.783
1.91AsnGlu: 1.91 ± 0.884
1.91AsnPhe: 1.91 ± 0.674
2.456AsnGly: 2.456 ± 0.824
1.092AsnHis: 1.092 ± 0.491
1.638AsnIle: 1.638 ± 0.283
2.729AsnLys: 2.729 ± 1.032
5.459AsnLeu: 5.459 ± 0.994
1.638AsnMet: 1.638 ± 0.813
2.729AsnAsn: 2.729 ± 1.228
3.821AsnPro: 3.821 ± 0.547
2.456AsnGln: 2.456 ± 0.709
2.456AsnArg: 2.456 ± 0.943
3.275AsnSer: 3.275 ± 1.116
2.183AsnThr: 2.183 ± 0.984
3.275AsnVal: 3.275 ± 1.047
0.546AsnTrp: 0.546 ± 0.52
0.546AsnTyr: 0.546 ± 0.313
0.0AsnXaa: 0.0 ± 0.0
Pro
3.821ProAla: 3.821 ± 1.321
0.819ProCys: 0.819 ± 0.37
3.821ProAsp: 3.821 ± 0.576
2.183ProGlu: 2.183 ± 0.601
1.638ProPhe: 1.638 ± 0.854
1.638ProGly: 1.638 ± 1.223
1.092ProHis: 1.092 ± 0.491
1.638ProIle: 1.638 ± 1.346
3.821ProLys: 3.821 ± 1.379
5.186ProLeu: 5.186 ± 1.614
0.273ProMet: 0.273 ± 0.325
1.092ProAsn: 1.092 ± 0.442
1.91ProPro: 1.91 ± 1.19
1.91ProGln: 1.91 ± 0.542
3.002ProArg: 3.002 ± 0.407
4.64ProSer: 4.64 ± 0.823
3.275ProThr: 3.275 ± 1.951
3.002ProVal: 3.002 ± 0.979
0.819ProTrp: 0.819 ± 0.497
1.638ProTyr: 1.638 ± 0.995
0.0ProXaa: 0.0 ± 0.0
Gln
2.183GlnAla: 2.183 ± 1.185
0.546GlnCys: 0.546 ± 0.602
1.638GlnAsp: 1.638 ± 0.679
2.456GlnGlu: 2.456 ± 0.676
0.546GlnPhe: 0.546 ± 0.429
3.821GlnGly: 3.821 ± 0.813
1.092GlnHis: 1.092 ± 0.477
1.91GlnIle: 1.91 ± 0.506
1.365GlnLys: 1.365 ± 1.145
2.456GlnLeu: 2.456 ± 0.527
0.273GlnMet: 0.273 ± 0.46
3.548GlnAsn: 3.548 ± 0.675
0.819GlnPro: 0.819 ± 1.015
1.365GlnGln: 1.365 ± 0.848
1.365GlnArg: 1.365 ± 0.401
3.548GlnSer: 3.548 ± 0.999
1.91GlnThr: 1.91 ± 0.628
1.638GlnVal: 1.638 ± 0.679
0.273GlnTrp: 0.273 ± 0.157
0.819GlnTyr: 0.819 ± 0.426
0.0GlnXaa: 0.0 ± 0.0
Arg
2.456ArgAla: 2.456 ± 0.55
0.546ArgCys: 0.546 ± 0.429
3.275ArgAsp: 3.275 ± 0.791
3.275ArgGlu: 3.275 ± 1.16
4.094ArgPhe: 4.094 ± 0.844
2.183ArgGly: 2.183 ± 0.595
0.819ArgHis: 0.819 ± 0.37
4.367ArgIle: 4.367 ± 1.392
3.548ArgLys: 3.548 ± 1.395
4.094ArgLeu: 4.094 ± 0.95
1.638ArgMet: 1.638 ± 0.48
2.456ArgAsn: 2.456 ± 0.897
2.183ArgPro: 2.183 ± 0.256
0.546ArgGln: 0.546 ± 0.356
2.729ArgArg: 2.729 ± 1.126
3.821ArgSer: 3.821 ± 1.359
2.183ArgThr: 2.183 ± 0.956
4.913ArgVal: 4.913 ± 2.309
0.546ArgTrp: 0.546 ± 0.313
2.183ArgTyr: 2.183 ± 0.256
0.0ArgXaa: 0.0 ± 0.0
Ser
5.186SerAla: 5.186 ± 1.665
0.273SerCys: 0.273 ± 0.46
4.64SerAsp: 4.64 ± 1.483
5.186SerGlu: 5.186 ± 2.001
4.64SerPhe: 4.64 ± 1.54
5.731SerGly: 5.731 ± 1.717
1.91SerHis: 1.91 ± 0.8
4.094SerIle: 4.094 ± 1.408
6.004SerLys: 6.004 ± 1.665
8.461SerLeu: 8.461 ± 1.594
1.91SerMet: 1.91 ± 0.8
3.275SerAsn: 3.275 ± 0.744
5.186SerPro: 5.186 ± 1.347
1.638SerGln: 1.638 ± 0.283
6.277SerArg: 6.277 ± 1.307
8.734SerSer: 8.734 ± 3.232
5.731SerThr: 5.731 ± 0.924
2.729SerVal: 2.729 ± 0.952
2.456SerTrp: 2.456 ± 1.109
3.548SerTyr: 3.548 ± 0.675
0.0SerXaa: 0.0 ± 0.0
Thr
4.094ThrAla: 4.094 ± 2.204
3.275ThrCys: 3.275 ± 1.36
2.456ThrAsp: 2.456 ± 1.128
2.729ThrGlu: 2.729 ± 0.556
1.365ThrPhe: 1.365 ± 0.941
2.729ThrGly: 2.729 ± 0.872
1.638ThrHis: 1.638 ± 0.851
3.548ThrIle: 3.548 ± 1.747
3.002ThrLys: 3.002 ± 0.453
4.367ThrLeu: 4.367 ± 1.563
0.819ThrMet: 0.819 ± 0.565
3.275ThrAsn: 3.275 ± 0.791
2.183ThrPro: 2.183 ± 1.325
3.275ThrGln: 3.275 ± 0.75
1.638ThrArg: 1.638 ± 0.791
5.731ThrSer: 5.731 ± 1.277
3.002ThrThr: 3.002 ± 1.273
4.64ThrVal: 4.64 ± 1.011
1.092ThrTrp: 1.092 ± 0.627
2.183ThrTyr: 2.183 ± 0.974
0.0ThrXaa: 0.0 ± 0.0
Val
2.183ValAla: 2.183 ± 0.669
0.819ValCys: 0.819 ± 0.37
4.094ValAsp: 4.094 ± 0.703
3.275ValGlu: 3.275 ± 1.224
2.729ValPhe: 2.729 ± 1.165
3.548ValGly: 3.548 ± 0.948
0.546ValHis: 0.546 ± 0.52
7.642ValIle: 7.642 ± 1.258
2.456ValLys: 2.456 ± 0.647
5.186ValLeu: 5.186 ± 0.895
1.092ValMet: 1.092 ± 0.477
2.729ValAsn: 2.729 ± 1.15
2.456ValPro: 2.456 ± 1.076
1.365ValGln: 1.365 ± 0.591
3.002ValArg: 3.002 ± 2.061
5.459ValSer: 5.459 ± 1.183
2.456ValThr: 2.456 ± 1.719
4.913ValVal: 4.913 ± 1.18
0.273ValTrp: 0.273 ± 0.157
3.002ValTyr: 3.002 ± 1.061
0.0ValXaa: 0.0 ± 0.0
Trp
0.273TrpAla: 0.273 ± 0.157
0.273TrpCys: 0.273 ± 0.407
1.092TrpAsp: 1.092 ± 0.627
0.546TrpGlu: 0.546 ± 0.313
0.546TrpPhe: 0.546 ± 0.429
0.819TrpGly: 0.819 ± 1.066
0.819TrpHis: 0.819 ± 0.749
1.638TrpIle: 1.638 ± 0.776
1.365TrpLys: 1.365 ± 0.591
0.819TrpLeu: 0.819 ± 0.902
0.819TrpMet: 0.819 ± 0.37
1.092TrpAsn: 1.092 ± 0.627
0.546TrpPro: 0.546 ± 0.313
0.0TrpGln: 0.0 ± 0.0
0.546TrpArg: 0.546 ± 0.313
2.183TrpSer: 2.183 ± 0.96
1.91TrpThr: 1.91 ± 0.912
1.092TrpVal: 1.092 ± 1.152
0.0TrpTrp: 0.0 ± 0.0
0.546TrpTyr: 0.546 ± 0.52
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.638TyrAla: 1.638 ± 0.48
0.546TyrCys: 0.546 ± 0.356
1.365TyrAsp: 1.365 ± 0.551
2.729TyrGlu: 2.729 ± 0.731
2.183TyrPhe: 2.183 ± 0.638
1.91TyrGly: 1.91 ± 0.547
1.638TyrHis: 1.638 ± 0.442
2.183TyrIle: 2.183 ± 1.137
0.819TyrLys: 0.819 ± 0.47
3.002TyrLeu: 3.002 ± 0.961
0.819TyrMet: 0.819 ± 0.427
2.183TyrAsn: 2.183 ± 0.96
1.638TyrPro: 1.638 ± 0.442
1.638TyrGln: 1.638 ± 1.026
3.275TyrArg: 3.275 ± 1.503
3.548TyrSer: 3.548 ± 1.057
1.91TyrThr: 1.91 ± 0.577
2.183TyrVal: 2.183 ± 1.701
0.273TyrTrp: 0.273 ± 0.407
0.819TyrTyr: 0.819 ± 0.47
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (3665 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski