Amino acid dipepetide frequency for Streptococcus phage Javan570

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.037AlaAla: 4.037 ± 1.204
0.263AlaCys: 0.263 ± 0.177
5.792AlaAsp: 5.792 ± 0.641
7.02AlaGlu: 7.02 ± 1.016
2.545AlaPhe: 2.545 ± 0.593
5.177AlaGly: 5.177 ± 1.392
0.527AlaHis: 0.527 ± 0.219
5.441AlaIle: 5.441 ± 0.6
6.581AlaLys: 6.581 ± 0.756
6.055AlaLeu: 6.055 ± 0.965
2.282AlaMet: 2.282 ± 0.66
4.475AlaAsn: 4.475 ± 1.023
1.58AlaPro: 1.58 ± 0.39
3.598AlaGln: 3.598 ± 0.755
2.282AlaArg: 2.282 ± 0.506
4.914AlaSer: 4.914 ± 1.383
5.265AlaThr: 5.265 ± 0.817
5.353AlaVal: 5.353 ± 0.726
0.702AlaTrp: 0.702 ± 0.272
1.755AlaTyr: 1.755 ± 0.467
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.088CysCys: 0.088 ± 0.106
0.439CysAsp: 0.439 ± 0.243
0.439CysGlu: 0.439 ± 0.217
0.351CysPhe: 0.351 ± 0.181
0.702CysGly: 0.702 ± 0.298
0.088CysHis: 0.088 ± 0.09
0.176CysIle: 0.176 ± 0.126
0.439CysLys: 0.439 ± 0.211
0.351CysLeu: 0.351 ± 0.205
0.176CysMet: 0.176 ± 0.17
0.088CysAsn: 0.088 ± 0.073
0.263CysPro: 0.263 ± 0.14
0.088CysGln: 0.088 ± 0.081
0.351CysArg: 0.351 ± 0.236
0.263CysSer: 0.263 ± 0.176
0.088CysThr: 0.088 ± 0.083
0.176CysVal: 0.176 ± 0.12
0.0CysTrp: 0.0 ± 0.0
0.176CysTyr: 0.176 ± 0.104
0.0CysXaa: 0.0 ± 0.0
Asp
4.388AspAla: 4.388 ± 0.543
0.878AspCys: 0.878 ± 0.36
2.545AspAsp: 2.545 ± 0.805
6.143AspGlu: 6.143 ± 0.911
2.457AspPhe: 2.457 ± 0.473
4.212AspGly: 4.212 ± 0.633
0.702AspHis: 0.702 ± 0.281
4.212AspIle: 4.212 ± 0.558
4.826AspLys: 4.826 ± 1.021
4.739AspLeu: 4.739 ± 0.669
1.58AspMet: 1.58 ± 0.518
3.686AspAsn: 3.686 ± 0.814
0.965AspPro: 0.965 ± 0.261
1.053AspGln: 1.053 ± 0.275
2.194AspArg: 2.194 ± 0.493
3.51AspSer: 3.51 ± 0.643
3.247AspThr: 3.247 ± 0.699
3.51AspVal: 3.51 ± 0.629
0.965AspTrp: 0.965 ± 0.28
3.422AspTyr: 3.422 ± 0.663
0.0AspXaa: 0.0 ± 0.0
Glu
4.826GluAla: 4.826 ± 0.688
0.176GluCys: 0.176 ± 0.114
3.861GluAsp: 3.861 ± 0.854
6.23GluGlu: 6.23 ± 1.237
2.369GluPhe: 2.369 ± 0.5
3.335GluGly: 3.335 ± 0.461
0.79GluHis: 0.79 ± 0.319
6.757GluIle: 6.757 ± 0.864
5.792GluLys: 5.792 ± 1.034
9.477GluLeu: 9.477 ± 1.585
1.843GluMet: 1.843 ± 0.576
3.861GluAsn: 3.861 ± 0.795
2.194GluPro: 2.194 ± 0.431
4.124GluGln: 4.124 ± 1.066
3.686GluArg: 3.686 ± 0.925
4.388GluSer: 4.388 ± 0.485
4.212GluThr: 4.212 ± 0.545
4.826GluVal: 4.826 ± 0.787
1.053GluTrp: 1.053 ± 0.32
3.51GluTyr: 3.51 ± 0.742
0.0GluXaa: 0.0 ± 0.0
Phe
2.633PheAla: 2.633 ± 0.611
0.088PheCys: 0.088 ± 0.083
2.984PheAsp: 2.984 ± 0.536
4.037PheGlu: 4.037 ± 0.756
1.667PhePhe: 1.667 ± 0.317
2.72PheGly: 2.72 ± 0.648
0.263PheHis: 0.263 ± 0.187
2.194PheIle: 2.194 ± 0.409
2.72PheLys: 2.72 ± 0.337
2.633PheLeu: 2.633 ± 0.449
0.527PheMet: 0.527 ± 0.191
2.369PheAsn: 2.369 ± 0.48
0.965PhePro: 0.965 ± 0.205
0.965PheGln: 0.965 ± 0.224
1.667PheArg: 1.667 ± 0.36
1.58PheSer: 1.58 ± 0.405
2.633PheThr: 2.633 ± 0.578
2.896PheVal: 2.896 ± 0.596
0.176PheTrp: 0.176 ± 0.146
1.316PheTyr: 1.316 ± 0.38
0.0PheXaa: 0.0 ± 0.0
Gly
4.212GlyAla: 4.212 ± 0.818
0.088GlyCys: 0.088 ± 0.088
2.633GlyAsp: 2.633 ± 0.606
4.388GlyGlu: 4.388 ± 0.622
1.931GlyPhe: 1.931 ± 0.486
3.686GlyGly: 3.686 ± 0.567
0.878GlyHis: 0.878 ± 0.207
3.686GlyIle: 3.686 ± 0.538
5.353GlyLys: 5.353 ± 0.766
5.616GlyLeu: 5.616 ± 1.619
2.194GlyMet: 2.194 ± 0.514
3.773GlyAsn: 3.773 ± 0.54
0.965GlyPro: 0.965 ± 0.328
3.159GlyGln: 3.159 ± 0.532
2.896GlyArg: 2.896 ± 0.662
3.335GlySer: 3.335 ± 1.033
3.861GlyThr: 3.861 ± 0.759
4.388GlyVal: 4.388 ± 0.599
0.878GlyTrp: 0.878 ± 0.341
3.159GlyTyr: 3.159 ± 0.42
0.0GlyXaa: 0.0 ± 0.0
His
0.614HisAla: 0.614 ± 0.261
0.088HisCys: 0.088 ± 0.081
0.702HisAsp: 0.702 ± 0.231
0.79HisGlu: 0.79 ± 0.361
0.614HisPhe: 0.614 ± 0.216
0.79HisGly: 0.79 ± 0.291
0.439HisHis: 0.439 ± 0.222
0.878HisIle: 0.878 ± 0.303
0.965HisLys: 0.965 ± 0.293
1.404HisLeu: 1.404 ± 0.335
0.439HisMet: 0.439 ± 0.181
0.527HisAsn: 0.527 ± 0.24
0.351HisPro: 0.351 ± 0.159
0.614HisGln: 0.614 ± 0.243
0.527HisArg: 0.527 ± 0.233
0.527HisSer: 0.527 ± 0.159
0.702HisThr: 0.702 ± 0.258
0.702HisVal: 0.702 ± 0.326
0.088HisTrp: 0.088 ± 0.097
0.527HisTyr: 0.527 ± 0.231
0.0HisXaa: 0.0 ± 0.0
Ile
6.055IleAla: 6.055 ± 1.103
0.439IleCys: 0.439 ± 0.277
3.598IleAsp: 3.598 ± 0.461
5.09IleGlu: 5.09 ± 0.873
2.545IlePhe: 2.545 ± 0.414
3.51IleGly: 3.51 ± 0.604
0.965IleHis: 0.965 ± 0.293
3.422IleIle: 3.422 ± 0.632
5.704IleLys: 5.704 ± 0.85
4.212IleLeu: 4.212 ± 0.527
0.878IleMet: 0.878 ± 0.319
3.949IleAsn: 3.949 ± 0.576
2.545IlePro: 2.545 ± 0.533
2.896IleGln: 2.896 ± 0.713
1.931IleArg: 1.931 ± 0.366
4.914IleSer: 4.914 ± 0.818
4.037IleThr: 4.037 ± 0.533
3.861IleVal: 3.861 ± 0.595
0.439IleTrp: 0.439 ± 0.199
2.984IleTyr: 2.984 ± 0.531
0.0IleXaa: 0.0 ± 0.0
Lys
6.23LysAla: 6.23 ± 0.78
0.088LysCys: 0.088 ± 0.081
4.124LysAsp: 4.124 ± 0.809
5.792LysGlu: 5.792 ± 1.131
2.72LysPhe: 2.72 ± 0.457
3.949LysGly: 3.949 ± 0.64
1.316LysHis: 1.316 ± 0.413
4.914LysIle: 4.914 ± 0.874
5.002LysLys: 5.002 ± 0.895
6.581LysLeu: 6.581 ± 1.11
2.194LysMet: 2.194 ± 0.586
4.212LysAsn: 4.212 ± 0.888
2.106LysPro: 2.106 ± 0.581
4.124LysGln: 4.124 ± 0.744
4.212LysArg: 4.212 ± 1.041
4.651LysSer: 4.651 ± 0.659
5.09LysThr: 5.09 ± 1.093
6.055LysVal: 6.055 ± 0.831
0.702LysTrp: 0.702 ± 0.336
3.422LysTyr: 3.422 ± 0.611
0.0LysXaa: 0.0 ± 0.0
Leu
6.581LeuAla: 6.581 ± 1.058
0.263LeuCys: 0.263 ± 0.176
6.23LeuAsp: 6.23 ± 0.971
6.23LeuGlu: 6.23 ± 1.169
2.896LeuPhe: 2.896 ± 0.584
6.143LeuGly: 6.143 ± 1.046
0.614LeuHis: 0.614 ± 0.262
5.002LeuIle: 5.002 ± 1.008
6.055LeuLys: 6.055 ± 0.684
4.739LeuLeu: 4.739 ± 0.86
1.316LeuMet: 1.316 ± 0.372
5.177LeuAsn: 5.177 ± 0.693
2.984LeuPro: 2.984 ± 0.707
4.037LeuGln: 4.037 ± 0.592
3.598LeuArg: 3.598 ± 0.766
7.196LeuSer: 7.196 ± 0.893
6.055LeuThr: 6.055 ± 0.715
5.002LeuVal: 5.002 ± 0.972
0.527LeuTrp: 0.527 ± 0.24
2.018LeuTyr: 2.018 ± 0.557
0.0LeuXaa: 0.0 ± 0.0
Met
1.931MetAla: 1.931 ± 0.546
0.088MetCys: 0.088 ± 0.094
1.053MetAsp: 1.053 ± 0.368
1.931MetGlu: 1.931 ± 0.507
0.79MetPhe: 0.79 ± 0.273
1.141MetGly: 1.141 ± 0.398
0.0MetHis: 0.0 ± 0.0
1.053MetIle: 1.053 ± 0.364
2.018MetLys: 2.018 ± 0.585
1.667MetLeu: 1.667 ± 0.427
0.351MetMet: 0.351 ± 0.203
1.667MetAsn: 1.667 ± 0.627
0.527MetPro: 0.527 ± 0.252
1.053MetGln: 1.053 ± 0.273
1.053MetArg: 1.053 ± 0.301
2.282MetSer: 2.282 ± 0.681
2.633MetThr: 2.633 ± 0.55
1.58MetVal: 1.58 ± 0.471
0.176MetTrp: 0.176 ± 0.135
0.439MetTyr: 0.439 ± 0.224
0.0MetXaa: 0.0 ± 0.0
Asn
5.616AsnAla: 5.616 ± 0.879
0.263AsnCys: 0.263 ± 0.142
3.335AsnAsp: 3.335 ± 0.562
3.773AsnGlu: 3.773 ± 0.728
2.018AsnPhe: 2.018 ± 0.414
4.037AsnGly: 4.037 ± 0.712
1.229AsnHis: 1.229 ± 0.287
3.949AsnIle: 3.949 ± 0.615
3.773AsnLys: 3.773 ± 0.689
6.23AsnLeu: 6.23 ± 0.577
1.141AsnMet: 1.141 ± 0.37
2.545AsnAsn: 2.545 ± 0.518
1.843AsnPro: 1.843 ± 0.673
2.984AsnGln: 2.984 ± 0.522
3.159AsnArg: 3.159 ± 0.533
3.686AsnSer: 3.686 ± 0.749
2.545AsnThr: 2.545 ± 0.696
3.949AsnVal: 3.949 ± 0.624
0.702AsnTrp: 0.702 ± 0.35
2.194AsnTyr: 2.194 ± 0.604
0.0AsnXaa: 0.0 ± 0.0
Pro
2.106ProAla: 2.106 ± 0.454
0.088ProCys: 0.088 ± 0.08
1.492ProAsp: 1.492 ± 0.333
1.755ProGlu: 1.755 ± 0.309
1.316ProPhe: 1.316 ± 0.316
1.404ProGly: 1.404 ± 0.374
0.351ProHis: 0.351 ± 0.237
1.58ProIle: 1.58 ± 0.39
2.106ProLys: 2.106 ± 0.657
1.58ProLeu: 1.58 ± 0.509
0.351ProMet: 0.351 ± 0.148
1.931ProAsn: 1.931 ± 0.451
0.527ProPro: 0.527 ± 0.178
1.404ProGln: 1.404 ± 0.394
1.229ProArg: 1.229 ± 0.456
1.229ProSer: 1.229 ± 0.354
1.053ProThr: 1.053 ± 0.287
1.667ProVal: 1.667 ± 0.358
0.439ProTrp: 0.439 ± 0.213
0.965ProTyr: 0.965 ± 0.272
0.0ProXaa: 0.0 ± 0.0
Gln
3.861GlnAla: 3.861 ± 0.984
0.351GlnCys: 0.351 ± 0.206
2.106GlnAsp: 2.106 ± 0.429
2.984GlnGlu: 2.984 ± 0.951
1.492GlnPhe: 1.492 ± 0.343
2.545GlnGly: 2.545 ± 0.308
0.527GlnHis: 0.527 ± 0.289
3.159GlnIle: 3.159 ± 0.403
3.422GlnLys: 3.422 ± 0.506
4.388GlnLeu: 4.388 ± 0.773
1.053GlnMet: 1.053 ± 0.378
3.335GlnAsn: 3.335 ± 0.414
0.79GlnPro: 0.79 ± 0.371
2.369GlnGln: 2.369 ± 0.496
1.843GlnArg: 1.843 ± 0.616
3.686GlnSer: 3.686 ± 0.616
3.949GlnThr: 3.949 ± 0.896
3.159GlnVal: 3.159 ± 0.529
0.614GlnTrp: 0.614 ± 0.267
1.58GlnTyr: 1.58 ± 0.418
0.0GlnXaa: 0.0 ± 0.0
Arg
3.071ArgAla: 3.071 ± 0.54
0.351ArgCys: 0.351 ± 0.197
2.194ArgAsp: 2.194 ± 0.561
2.282ArgGlu: 2.282 ± 0.682
1.58ArgPhe: 1.58 ± 0.338
2.545ArgGly: 2.545 ± 0.588
0.351ArgHis: 0.351 ± 0.158
3.773ArgIle: 3.773 ± 0.631
5.09ArgLys: 5.09 ± 0.997
5.353ArgLeu: 5.353 ± 0.739
1.404ArgMet: 1.404 ± 0.358
3.247ArgAsn: 3.247 ± 0.553
1.229ArgPro: 1.229 ± 0.433
1.316ArgGln: 1.316 ± 0.386
2.808ArgArg: 2.808 ± 0.626
1.843ArgSer: 1.843 ± 0.497
2.984ArgThr: 2.984 ± 0.845
2.282ArgVal: 2.282 ± 0.452
0.0ArgTrp: 0.0 ± 0.0
2.369ArgTyr: 2.369 ± 0.584
0.0ArgXaa: 0.0 ± 0.0
Ser
5.792SerAla: 5.792 ± 1.399
0.088SerCys: 0.088 ± 0.088
3.949SerAsp: 3.949 ± 0.472
5.528SerGlu: 5.528 ± 0.579
2.369SerPhe: 2.369 ± 0.652
3.686SerGly: 3.686 ± 0.602
0.702SerHis: 0.702 ± 0.258
4.388SerIle: 4.388 ± 0.664
4.388SerLys: 4.388 ± 0.576
4.739SerLeu: 4.739 ± 0.925
1.404SerMet: 1.404 ± 0.47
4.3SerAsn: 4.3 ± 0.766
1.492SerPro: 1.492 ± 0.413
3.335SerGln: 3.335 ± 0.706
3.422SerArg: 3.422 ± 0.672
5.792SerSer: 5.792 ± 1.604
4.475SerThr: 4.475 ± 0.822
5.177SerVal: 5.177 ± 1.047
0.702SerTrp: 0.702 ± 0.196
1.843SerTyr: 1.843 ± 0.464
0.0SerXaa: 0.0 ± 0.0
Thr
6.23ThrAla: 6.23 ± 1.097
0.263ThrCys: 0.263 ± 0.127
3.247ThrAsp: 3.247 ± 0.567
3.861ThrGlu: 3.861 ± 0.864
2.72ThrPhe: 2.72 ± 0.536
4.563ThrGly: 4.563 ± 0.704
0.351ThrHis: 0.351 ± 0.188
3.335ThrIle: 3.335 ± 0.535
4.651ThrLys: 4.651 ± 0.684
5.704ThrLeu: 5.704 ± 0.694
1.141ThrMet: 1.141 ± 0.466
3.422ThrAsn: 3.422 ± 0.555
1.053ThrPro: 1.053 ± 0.375
5.002ThrGln: 5.002 ± 0.92
2.457ThrArg: 2.457 ± 0.684
4.475ThrSer: 4.475 ± 0.848
4.3ThrThr: 4.3 ± 0.626
5.879ThrVal: 5.879 ± 1.427
0.702ThrTrp: 0.702 ± 0.27
1.931ThrTyr: 1.931 ± 0.727
0.0ThrXaa: 0.0 ± 0.0
Val
4.388ValAla: 4.388 ± 0.618
0.351ValCys: 0.351 ± 0.214
4.914ValAsp: 4.914 ± 0.601
6.581ValGlu: 6.581 ± 1.211
2.194ValPhe: 2.194 ± 0.423
4.475ValGly: 4.475 ± 0.725
0.965ValHis: 0.965 ± 0.294
3.422ValIle: 3.422 ± 0.382
5.616ValLys: 5.616 ± 0.868
3.861ValLeu: 3.861 ± 0.781
1.58ValMet: 1.58 ± 0.434
3.598ValAsn: 3.598 ± 0.444
1.316ValPro: 1.316 ± 0.355
2.457ValGln: 2.457 ± 0.612
3.861ValArg: 3.861 ± 0.796
5.528ValSer: 5.528 ± 0.81
5.002ValThr: 5.002 ± 1.056
4.826ValVal: 4.826 ± 0.77
0.878ValTrp: 0.878 ± 0.325
2.282ValTyr: 2.282 ± 0.45
0.0ValXaa: 0.0 ± 0.0
Trp
0.702TrpAla: 0.702 ± 0.31
0.0TrpCys: 0.0 ± 0.0
0.965TrpAsp: 0.965 ± 0.278
0.702TrpGlu: 0.702 ± 0.189
0.351TrpPhe: 0.351 ± 0.199
0.439TrpGly: 0.439 ± 0.198
0.439TrpHis: 0.439 ± 0.198
0.614TrpIle: 0.614 ± 0.242
0.79TrpLys: 0.79 ± 0.279
0.614TrpLeu: 0.614 ± 0.165
0.263TrpMet: 0.263 ± 0.197
0.351TrpAsn: 0.351 ± 0.293
0.088TrpPro: 0.088 ± 0.088
1.141TrpGln: 1.141 ± 0.362
0.527TrpArg: 0.527 ± 0.307
0.79TrpSer: 0.79 ± 0.269
0.527TrpThr: 0.527 ± 0.294
0.965TrpVal: 0.965 ± 0.347
0.0TrpTrp: 0.0 ± 0.0
0.088TrpTyr: 0.088 ± 0.088
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.369TyrAla: 2.369 ± 0.372
0.527TyrCys: 0.527 ± 0.237
3.071TyrAsp: 3.071 ± 0.797
1.755TyrGlu: 1.755 ± 0.36
2.106TyrPhe: 2.106 ± 0.481
2.018TyrGly: 2.018 ± 0.447
0.79TyrHis: 0.79 ± 0.263
2.018TyrIle: 2.018 ± 0.412
2.194TyrLys: 2.194 ± 0.514
2.72TyrLeu: 2.72 ± 0.706
1.229TyrMet: 1.229 ± 0.426
2.457TyrAsn: 2.457 ± 0.819
0.79TyrPro: 0.79 ± 0.227
1.492TyrGln: 1.492 ± 0.404
2.369TyrArg: 2.369 ± 0.777
2.984TyrSer: 2.984 ± 0.53
2.633TyrThr: 2.633 ± 0.525
1.843TyrVal: 1.843 ± 0.448
0.614TyrTrp: 0.614 ± 0.258
1.053TyrTyr: 1.053 ± 0.272
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 56 proteins (11397 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski