Amino acid dipepetide frequency for Bacteroidetes bacterium B1(2017)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.702AlaAla: 4.702 ± 0.082	0.739AlaCys: 0.739 ± 0.026	3.308AlaAsp: 3.308 ± 0.053	3.623AlaGlu: 3.623 ± 0.059	3.366AlaPhe: 3.366 ± 0.05	4.913AlaGly: 4.913 ± 0.08	1.102AlaHis: 1.102 ± 0.03	5.211AlaIle: 5.211 ± 0.073	4.642AlaLys: 4.642 ± 0.058	6.058AlaLeu: 6.058 ± 0.072	1.596AlaMet: 1.596 ± 0.031	4.187AlaAsn: 4.187 ± 0.075	2.268AlaPro: 2.268 ± 0.057	2.763AlaGln: 2.763 ± 0.046	2.076AlaArg: 2.076 ± 0.043	4.866AlaSer: 4.866 ± 0.081	4.122AlaThr: 4.122 ± 0.091	3.608AlaVal: 3.608 ± 0.055	0.731AlaTrp: 0.731 ± 0.024	2.783AlaTyr: 2.783 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.625CysAla: 0.625 ± 0.028	0.132CysCys: 0.132 ± 0.011	0.506CysAsp: 0.506 ± 0.024	0.49CysGlu: 0.49 ± 0.018	0.504CysPhe: 0.504 ± 0.02	0.747CysGly: 0.747 ± 0.031	0.216CysHis: 0.216 ± 0.015	0.681CysIle: 0.681 ± 0.019	0.707CysLys: 0.707 ± 0.027	0.949CysLeu: 0.949 ± 0.027	0.188CysMet: 0.188 ± 0.01	0.522CysAsn: 0.522 ± 0.022	0.417CysPro: 0.417 ± 0.023	0.297CysGln: 0.297 ± 0.014	0.316CysArg: 0.316 ± 0.016	0.726CysSer: 0.726 ± 0.029	0.595CysThr: 0.595 ± 0.025	0.548CysVal: 0.548 ± 0.023	0.113CysTrp: 0.113 ± 0.009	0.392CysTyr: 0.392 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.342AspAla: 3.342 ± 0.054	0.403AspCys: 0.403 ± 0.016	1.96AspAsp: 1.96 ± 0.046	2.939AspGlu: 2.939 ± 0.049	3.093AspPhe: 3.093 ± 0.048	3.403AspGly: 3.403 ± 0.064	0.726AspHis: 0.726 ± 0.024	3.609AspIle: 3.609 ± 0.055	3.455AspLys: 3.455 ± 0.053	4.877AspLeu: 4.877 ± 0.058	1.077AspMet: 1.077 ± 0.027	2.467AspAsn: 2.467 ± 0.048	1.842AspPro: 1.842 ± 0.043	1.495AspGln: 1.495 ± 0.031	1.537AspArg: 1.537 ± 0.032	3.669AspSer: 3.669 ± 0.066	2.897AspThr: 2.897 ± 0.067	2.81AspVal: 2.81 ± 0.042	0.667AspTrp: 0.667 ± 0.022	2.245AspTyr: 2.245 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	3.818GluAla: 3.818 ± 0.057	0.38GluCys: 0.38 ± 0.016	2.547GluAsp: 2.547 ± 0.043	3.729GluGlu: 3.729 ± 0.071	2.784GluPhe: 2.784 ± 0.042	3.329GluGly: 3.329 ± 0.057	1.01GluHis: 1.01 ± 0.029	4.779GluIle: 4.779 ± 0.078	5.008GluLys: 5.008 ± 0.084	5.908GluLeu: 5.908 ± 0.082	1.557GluMet: 1.557 ± 0.039	3.828GluAsn: 3.828 ± 0.062	1.816GluPro: 1.816 ± 0.042	2.07GluGln: 2.07 ± 0.046	2.098GluArg: 2.098 ± 0.047	3.007GluSer: 3.007 ± 0.053	3.049GluThr: 3.049 ± 0.05	3.575GluVal: 3.575 ± 0.051	0.623GluTrp: 0.623 ± 0.017	2.162GluTyr: 2.162 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.443PheAla: 3.443 ± 0.054	0.545PheCys: 0.545 ± 0.02	2.997PheAsp: 2.997 ± 0.046	3.417PheGlu: 3.417 ± 0.049	2.698PhePhe: 2.698 ± 0.058	3.874PheGly: 3.874 ± 0.056	0.815PheHis: 0.815 ± 0.022	3.75PheIle: 3.75 ± 0.063	3.559PheLys: 3.559 ± 0.055	4.769PheLeu: 4.769 ± 0.078	1.184PheMet: 1.184 ± 0.028	3.226PheAsn: 3.226 ± 0.048	1.782PhePro: 1.782 ± 0.032	1.598PheGln: 1.598 ± 0.033	1.669PheArg: 1.669 ± 0.036	4.143PheSer: 4.143 ± 0.053	3.402PheThr: 3.402 ± 0.053	3.301PheVal: 3.301 ± 0.048	0.662PheTrp: 0.662 ± 0.022	2.309PheTyr: 2.309 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.451GlyAla: 4.451 ± 0.082	0.799GlyCys: 0.799 ± 0.035	3.093GlyAsp: 3.093 ± 0.05	3.184GlyGlu: 3.184 ± 0.047	3.882GlyPhe: 3.882 ± 0.052	4.913GlyGly: 4.913 ± 0.077	1.06GlyHis: 1.06 ± 0.028	5.47GlyIle: 5.47 ± 0.065	5.15GlyLys: 5.15 ± 0.066	6.261GlyLeu: 6.261 ± 0.075	1.673GlyMet: 1.673 ± 0.036	4.239GlyAsn: 4.239 ± 0.08	1.578GlyPro: 1.578 ± 0.037	2.129GlyGln: 2.129 ± 0.038	2.134GlyArg: 2.134 ± 0.041	5.183GlySer: 5.183 ± 0.089	4.826GlyThr: 4.826 ± 0.127	4.312GlyVal: 4.312 ± 0.055	0.779GlyTrp: 0.779 ± 0.022	2.892GlyTyr: 2.892 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.009HisAla: 1.009 ± 0.03	0.197HisCys: 0.197 ± 0.011	0.731HisAsp: 0.731 ± 0.024	0.944HisGlu: 0.944 ± 0.026	1.108HisPhe: 1.108 ± 0.028	1.026HisGly: 1.026 ± 0.028	0.439HisHis: 0.439 ± 0.018	1.214HisIle: 1.214 ± 0.028	1.099HisLys: 1.099 ± 0.026	1.783HisLeu: 1.783 ± 0.039	0.325HisMet: 0.325 ± 0.016	0.81HisAsn: 0.81 ± 0.021	0.868HisPro: 0.868 ± 0.027	0.704HisGln: 0.704 ± 0.022	0.59HisArg: 0.59 ± 0.019	1.138HisSer: 1.138 ± 0.028	0.987HisThr: 0.987 ± 0.024	0.882HisVal: 0.882 ± 0.026	0.233HisTrp: 0.233 ± 0.012	0.763HisTyr: 0.763 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.097IleAla: 5.097 ± 0.062	0.869IleCys: 0.869 ± 0.029	4.132IleAsp: 4.132 ± 0.05	4.913IleGlu: 4.913 ± 0.067	3.31IlePhe: 3.31 ± 0.057	5.335IleGly: 5.335 ± 0.067	1.356IleHis: 1.356 ± 0.033	5.038IleIle: 5.038 ± 0.073	5.338IleLys: 5.338 ± 0.067	6.993IleLeu: 6.993 ± 0.099	1.269IleMet: 1.269 ± 0.028	4.635IleAsn: 4.635 ± 0.058	3.126IlePro: 3.126 ± 0.05	2.628IleGln: 2.628 ± 0.044	2.594IleArg: 2.594 ± 0.042	6.026IleSer: 6.026 ± 0.077	4.4IleThr: 4.4 ± 0.082	4.165IleVal: 4.165 ± 0.049	0.799IleTrp: 0.799 ± 0.025	2.918IleTyr: 2.918 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.774LysAla: 4.774 ± 0.067	0.441LysCys: 0.441 ± 0.017	3.867LysAsp: 3.867 ± 0.064	5.147LysGlu: 5.147 ± 0.082	2.985LysPhe: 2.985 ± 0.052	4.493LysGly: 4.493 ± 0.064	1.27LysHis: 1.27 ± 0.033	5.711LysIle: 5.711 ± 0.078	5.707LysLys: 5.707 ± 0.092	6.577LysLeu: 6.577 ± 0.091	1.973LysMet: 1.973 ± 0.041	4.78LysAsn: 4.78 ± 0.052	2.739LysPro: 2.739 ± 0.047	2.72LysGln: 2.72 ± 0.056	2.515LysArg: 2.515 ± 0.045	4.434LysSer: 4.434 ± 0.059	4.459LysThr: 4.459 ± 0.056	4.607LysVal: 4.607 ± 0.063	0.832LysTrp: 0.832 ± 0.023	2.919LysTyr: 2.919 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	6.57LeuAla: 6.57 ± 0.076	0.906LeuCys: 0.906 ± 0.027	4.584LeuAsp: 4.584 ± 0.06	5.29LeuGlu: 5.29 ± 0.084	5.181LeuPhe: 5.181 ± 0.081	6.148LeuGly: 6.148 ± 0.07	1.527LeuHis: 1.527 ± 0.035	6.769LeuIle: 6.769 ± 0.096	7.344LeuLys: 7.344 ± 0.102	9.325LeuLeu: 9.325 ± 0.133	2.104LeuMet: 2.104 ± 0.043	6.434LeuAsn: 6.434 ± 0.071	3.91LeuPro: 3.91 ± 0.052	3.254LeuGln: 3.254 ± 0.053	3.154LeuArg: 3.154 ± 0.049	7.318LeuSer: 7.318 ± 0.079	5.292LeuThr: 5.292 ± 0.079	6.163LeuVal: 6.163 ± 0.075	0.893LeuTrp: 0.893 ± 0.025	3.194LeuTyr: 3.194 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	1.788MetAla: 1.788 ± 0.037	0.152MetCys: 0.152 ± 0.009	1.231MetAsp: 1.231 ± 0.027	1.35MetGlu: 1.35 ± 0.034	0.882MetPhe: 0.882 ± 0.026	1.635MetGly: 1.635 ± 0.031	0.441MetHis: 0.441 ± 0.017	1.367MetIle: 1.367 ± 0.033	2.031MetLys: 2.031 ± 0.042	2.076MetLeu: 2.076 ± 0.035	0.579MetMet: 0.579 ± 0.018	1.389MetAsn: 1.389 ± 0.027	1.067MetPro: 1.067 ± 0.028	0.862MetGln: 0.862 ± 0.023	0.9MetArg: 0.9 ± 0.027	1.344MetSer: 1.344 ± 0.031	0.96MetThr: 0.96 ± 0.026	1.518MetVal: 1.518 ± 0.029	0.185MetTrp: 0.185 ± 0.01	0.732MetTyr: 0.732 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	4.089AsnAla: 4.089 ± 0.071	0.665AsnCys: 0.665 ± 0.03	2.641AsnAsp: 2.641 ± 0.055	3.284AsnGlu: 3.284 ± 0.046	3.375AsnPhe: 3.375 ± 0.049	4.718AsnGly: 4.718 ± 0.085	1.042AsnHis: 1.042 ± 0.024	4.355AsnIle: 4.355 ± 0.068	4.174AsnLys: 4.174 ± 0.055	6.199AsnLeu: 6.199 ± 0.069	1.339AsnMet: 1.339 ± 0.03	3.868AsnAsn: 3.868 ± 0.099	3.151AsnPro: 3.151 ± 0.044	2.589AsnGln: 2.589 ± 0.044	2.072AsnArg: 2.072 ± 0.044	4.436AsnSer: 4.436 ± 0.081	3.998AsnThr: 3.998 ± 0.086	3.222AsnVal: 3.222 ± 0.063	0.897AsnTrp: 0.897 ± 0.028	3.006AsnTyr: 3.006 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	2.48ProAla: 2.48 ± 0.047	0.292ProCys: 0.292 ± 0.014	1.94ProAsp: 1.94 ± 0.037	2.363ProGlu: 2.363 ± 0.045	2.044ProPhe: 2.044 ± 0.038	2.217ProGly: 2.217 ± 0.045	0.563ProHis: 0.563 ± 0.018	3.009ProIle: 3.009 ± 0.047	2.65ProLys: 2.65 ± 0.048	3.137ProLeu: 3.137 ± 0.05	0.834ProMet: 0.834 ± 0.026	2.665ProAsn: 2.665 ± 0.046	0.968ProPro: 0.968 ± 0.031	1.173ProGln: 1.173 ± 0.028	0.999ProArg: 0.999 ± 0.026	2.85ProSer: 2.85 ± 0.054	2.413ProThr: 2.413 ± 0.052	2.462ProVal: 2.462 ± 0.053	0.377ProTrp: 0.377 ± 0.015	1.57ProTyr: 1.57 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	2.333GlnAla: 2.333 ± 0.043	0.226GlnCys: 0.226 ± 0.015	1.484GlnAsp: 1.484 ± 0.026	2.06GlnGlu: 2.06 ± 0.044	1.774GlnPhe: 1.774 ± 0.035	1.935GlnGly: 1.935 ± 0.04	0.596GlnHis: 0.596 ± 0.018	2.85GlnIle: 2.85 ± 0.04	2.939GlnLys: 2.939 ± 0.049	3.497GlnLeu: 3.497 ± 0.053	0.871GlnMet: 0.871 ± 0.024	2.485GlnAsn: 2.485 ± 0.037	1.05GlnPro: 1.05 ± 0.025	1.382GlnGln: 1.382 ± 0.032	1.142GlnArg: 1.142 ± 0.028	2.268GlnSer: 2.268 ± 0.041	2.454GlnThr: 2.454 ± 0.037	2.228GlnVal: 2.228 ± 0.039	0.392GlnTrp: 0.392 ± 0.016	1.372GlnTyr: 1.372 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	1.927ArgAla: 1.927 ± 0.037	0.241ArgCys: 0.241 ± 0.012	1.507ArgAsp: 1.507 ± 0.031	1.835ArgGlu: 1.835 ± 0.039	1.913ArgPhe: 1.913 ± 0.039	1.865ArgGly: 1.865 ± 0.037	0.526ArgHis: 0.526 ± 0.02	2.951ArgIle: 2.951 ± 0.046	2.606ArgLys: 2.606 ± 0.045	3.127ArgLeu: 3.127 ± 0.052	0.96ArgMet: 0.96 ± 0.025	2.24ArgAsn: 2.24 ± 0.035	1.13ArgPro: 1.13 ± 0.03	1.065ArgGln: 1.065 ± 0.027	1.154ArgArg: 1.154 ± 0.032	1.846ArgSer: 1.846 ± 0.035	1.8ArgThr: 1.8 ± 0.033	2.147ArgVal: 2.147 ± 0.037	0.409ArgTrp: 0.409 ± 0.018	1.442ArgTyr: 1.442 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	4.648SerAla: 4.648 ± 0.088	0.807SerCys: 0.807 ± 0.029	3.235SerAsp: 3.235 ± 0.048	3.536SerGlu: 3.536 ± 0.052	4.127SerPhe: 4.127 ± 0.06	5.319SerGly: 5.319 ± 0.114	1.075SerHis: 1.075 ± 0.028	5.989SerIle: 5.989 ± 0.074	4.984SerLys: 4.984 ± 0.062	6.775SerLeu: 6.775 ± 0.074	1.524SerMet: 1.524 ± 0.031	4.701SerAsn: 4.701 ± 0.088	2.417SerPro: 2.417 ± 0.049	2.329SerGln: 2.329 ± 0.043	1.987SerArg: 1.987 ± 0.034	5.434SerSer: 5.434 ± 0.106	4.551SerThr: 4.551 ± 0.115	4.302SerVal: 4.302 ± 0.064	0.749SerTrp: 0.749 ± 0.021	3.088SerTyr: 3.088 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.176ThrAla: 4.176 ± 0.101	0.592ThrCys: 0.592 ± 0.024	2.952ThrAsp: 2.952 ± 0.048	2.911ThrGlu: 2.911 ± 0.049	3.258ThrPhe: 3.258 ± 0.05	4.745ThrGly: 4.745 ± 0.112	1.069ThrHis: 1.069 ± 0.026	4.82ThrIle: 4.82 ± 0.1	3.706ThrLys: 3.706 ± 0.052	5.95ThrLeu: 5.95 ± 0.076	1.016ThrMet: 1.016 ± 0.028	3.703ThrAsn: 3.703 ± 0.08	2.702ThrPro: 2.702 ± 0.053	2.108ThrGln: 2.108 ± 0.04	1.742ThrArg: 1.742 ± 0.038	4.365ThrSer: 4.365 ± 0.117	3.832ThrThr: 3.832 ± 0.121	3.564ThrVal: 3.564 ± 0.086	0.731ThrTrp: 0.731 ± 0.026	2.866ThrTyr: 2.866 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	4.076ValAla: 4.076 ± 0.063	0.715ValCys: 0.715 ± 0.025	3.04ValAsp: 3.04 ± 0.051	3.319ValGlu: 3.319 ± 0.05	3.572ValPhe: 3.572 ± 0.046	3.887ValGly: 3.887 ± 0.059	0.958ValHis: 0.958 ± 0.023	4.099ValIle: 4.099 ± 0.059	4.236ValLys: 4.236 ± 0.058	5.911ValLeu: 5.911 ± 0.07	1.324ValMet: 1.324 ± 0.032	3.79ValAsn: 3.79 ± 0.073	2.168ValPro: 2.168 ± 0.046	1.994ValGln: 1.994 ± 0.035	1.993ValArg: 1.993 ± 0.037	4.654ValSer: 4.654 ± 0.072	3.322ValThr: 3.322 ± 0.092	3.826ValVal: 3.826 ± 0.054	0.721ValTrp: 0.721 ± 0.022	2.691ValTyr: 2.691 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.734TrpAla: 0.734 ± 0.023	0.112TrpCys: 0.112 ± 0.008	0.599TrpAsp: 0.599 ± 0.022	0.613TrpGlu: 0.613 ± 0.022	0.636TrpPhe: 0.636 ± 0.024	0.763TrpGly: 0.763 ± 0.026	0.246TrpHis: 0.246 ± 0.013	0.825TrpIle: 0.825 ± 0.024	0.794TrpLys: 0.794 ± 0.026	1.008TrpLeu: 1.008 ± 0.031	0.329TrpMet: 0.329 ± 0.014	0.774TrpAsn: 0.774 ± 0.024	0.319TrpPro: 0.319 ± 0.016	0.525TrpGln: 0.525 ± 0.017	0.425TrpArg: 0.425 ± 0.019	0.695TrpSer: 0.695 ± 0.024	0.674TrpThr: 0.674 ± 0.027	0.785TrpVal: 0.785 ± 0.022	0.15TrpTrp: 0.15 ± 0.009	0.499TrpTyr: 0.499 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.582TyrAla: 2.582 ± 0.045	0.46TyrCys: 0.46 ± 0.016	2.157TyrAsp: 2.157 ± 0.039	2.13TyrGlu: 2.13 ± 0.044	2.651TyrPhe: 2.651 ± 0.043	2.742TyrGly: 2.742 ± 0.047	0.813TyrHis: 0.813 ± 0.025	2.445TyrIle: 2.445 ± 0.041	2.823TyrLys: 2.823 ± 0.051	4.179TyrLeu: 4.179 ± 0.055	0.765TyrMet: 0.765 ± 0.021	2.374TyrAsn: 2.374 ± 0.048	1.688TyrPro: 1.688 ± 0.034	1.653TyrGln: 1.653 ± 0.034	1.596TyrArg: 1.596 ± 0.037	3.177TyrSer: 3.177 ± 0.052	2.777TyrThr: 2.777 ± 0.051	2.27TyrVal: 2.27 ± 0.042	0.561TyrTrp: 0.561 ± 0.022	2.151TyrTyr: 2.151 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4556 proteins (1641265 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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