Amino acid dipepetide frequency for Vibrio diazotrophicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.432AlaAla: 7.432 ± 0.101
0.919AlaCys: 0.919 ± 0.03
4.377AlaAsp: 4.377 ± 0.062
5.405AlaGlu: 5.405 ± 0.069
3.351AlaPhe: 3.351 ± 0.056
5.789AlaGly: 5.789 ± 0.079
1.653AlaHis: 1.653 ± 0.036
5.921AlaIle: 5.921 ± 0.074
5.083AlaLys: 5.083 ± 0.067
9.676AlaLeu: 9.676 ± 0.103
2.771AlaMet: 2.771 ± 0.048
3.523AlaAsn: 3.523 ± 0.054
2.703AlaPro: 2.703 ± 0.051
3.877AlaGln: 3.877 ± 0.063
3.557AlaArg: 3.557 ± 0.059
5.309AlaSer: 5.309 ± 0.07
4.363AlaThr: 4.363 ± 0.07
5.847AlaVal: 5.847 ± 0.079
0.965AlaTrp: 0.965 ± 0.026
2.259AlaTyr: 2.259 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.768CysAla: 0.768 ± 0.028
0.172CysCys: 0.172 ± 0.011
0.567CysAsp: 0.567 ± 0.023
0.646CysGlu: 0.646 ± 0.024
0.477CysPhe: 0.477 ± 0.02
0.93CysGly: 0.93 ± 0.031
0.357CysHis: 0.357 ± 0.018
0.617CysIle: 0.617 ± 0.023
0.454CysLys: 0.454 ± 0.02
0.974CysLeu: 0.974 ± 0.032
0.24CysMet: 0.24 ± 0.014
0.375CysAsn: 0.375 ± 0.015
0.435CysPro: 0.435 ± 0.021
0.487CysGln: 0.487 ± 0.023
0.472CysArg: 0.472 ± 0.02
0.784CysSer: 0.784 ± 0.026
0.473CysThr: 0.473 ± 0.02
0.679CysVal: 0.679 ± 0.023
0.138CysTrp: 0.138 ± 0.01
0.349CysTyr: 0.349 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.188AspAla: 4.188 ± 0.072
0.529AspCys: 0.529 ± 0.02
2.844AspAsp: 2.844 ± 0.056
3.922AspGlu: 3.922 ± 0.056
2.343AspPhe: 2.343 ± 0.045
3.554AspGly: 3.554 ± 0.057
1.073AspHis: 1.073 ± 0.031
4.026AspIle: 4.026 ± 0.061
3.344AspLys: 3.344 ± 0.051
5.1AspLeu: 5.1 ± 0.071
1.397AspMet: 1.397 ± 0.032
2.344AspAsn: 2.344 ± 0.045
1.947AspPro: 1.947 ± 0.047
1.92AspGln: 1.92 ± 0.038
2.215AspArg: 2.215 ± 0.045
3.356AspSer: 3.356 ± 0.052
2.594AspThr: 2.594 ± 0.046
4.082AspVal: 4.082 ± 0.064
0.88AspTrp: 0.88 ± 0.029
2.005AspTyr: 2.005 ± 0.046
0.0AspXaa: 0.0 ± 0.0
Glu
5.28GluAla: 5.28 ± 0.082
0.617GluCys: 0.617 ± 0.024
2.904GluAsp: 2.904 ± 0.054
4.09GluGlu: 4.09 ± 0.07
2.531GluPhe: 2.531 ± 0.041
3.526GluGly: 3.526 ± 0.052
1.661GluHis: 1.661 ± 0.038
3.895GluIle: 3.895 ± 0.052
4.046GluLys: 4.046 ± 0.064
7.374GluLeu: 7.374 ± 0.079
1.872GluMet: 1.872 ± 0.039
2.836GluAsn: 2.836 ± 0.043
2.068GluPro: 2.068 ± 0.046
4.096GluGln: 4.096 ± 0.069
3.469GluArg: 3.469 ± 0.062
3.923GluSer: 3.923 ± 0.059
3.217GluThr: 3.217 ± 0.052
4.496GluVal: 4.496 ± 0.056
0.833GluTrp: 0.833 ± 0.028
1.83GluTyr: 1.83 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.634PheAla: 3.634 ± 0.058
0.529PheCys: 0.529 ± 0.022
2.638PheAsp: 2.638 ± 0.052
2.548PheGlu: 2.548 ± 0.045
1.701PhePhe: 1.701 ± 0.045
3.284PheGly: 3.284 ± 0.062
0.86PheHis: 0.86 ± 0.027
2.823PheIle: 2.823 ± 0.048
1.987PheLys: 1.987 ± 0.042
3.417PheLeu: 3.417 ± 0.061
1.007PheMet: 1.007 ± 0.03
2.016PheAsn: 2.016 ± 0.04
1.464PhePro: 1.464 ± 0.033
1.301PheGln: 1.301 ± 0.034
1.513PheArg: 1.513 ± 0.037
3.301PheSer: 3.301 ± 0.061
2.338PheThr: 2.338 ± 0.046
2.899PheVal: 2.899 ± 0.051
0.544PheTrp: 0.544 ± 0.022
1.314PheTyr: 1.314 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
5.08GlyAla: 5.08 ± 0.083
0.885GlyCys: 0.885 ± 0.03
3.491GlyAsp: 3.491 ± 0.063
4.449GlyGlu: 4.449 ± 0.056
3.248GlyPhe: 3.248 ± 0.059
4.611GlyGly: 4.611 ± 0.081
1.519GlyHis: 1.519 ± 0.032
4.833GlyIle: 4.833 ± 0.063
4.084GlyLys: 4.084 ± 0.056
6.867GlyLeu: 6.867 ± 0.079
2.043GlyMet: 2.043 ± 0.041
2.565GlyAsn: 2.565 ± 0.049
1.548GlyPro: 1.548 ± 0.038
2.725GlyGln: 2.725 ± 0.049
2.972GlyArg: 2.972 ± 0.052
4.152GlySer: 4.152 ± 0.064
3.352GlyThr: 3.352 ± 0.056
5.255GlyVal: 5.255 ± 0.073
0.974GlyTrp: 0.974 ± 0.028
2.605GlyTyr: 2.605 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.587HisAla: 1.587 ± 0.035
0.322HisCys: 0.322 ± 0.015
1.123HisAsp: 1.123 ± 0.035
1.151HisGlu: 1.151 ± 0.032
1.117HisPhe: 1.117 ± 0.031
1.577HisGly: 1.577 ± 0.036
0.723HisHis: 0.723 ± 0.027
1.503HisIle: 1.503 ± 0.038
1.081HisLys: 1.081 ± 0.028
2.308HisLeu: 2.308 ± 0.04
0.542HisMet: 0.542 ± 0.019
0.907HisAsn: 0.907 ± 0.033
1.143HisPro: 1.143 ± 0.03
1.239HisGln: 1.239 ± 0.03
1.024HisArg: 1.024 ± 0.026
1.508HisSer: 1.508 ± 0.033
1.098HisThr: 1.098 ± 0.033
1.277HisVal: 1.277 ± 0.037
0.375HisTrp: 0.375 ± 0.017
0.888HisTyr: 0.888 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.467IleAla: 6.467 ± 0.071
0.705IleCys: 0.705 ± 0.026
4.137IleAsp: 4.137 ± 0.055
4.948IleGlu: 4.948 ± 0.068
2.206IlePhe: 2.206 ± 0.054
4.792IleGly: 4.792 ± 0.069
1.355IleHis: 1.355 ± 0.037
3.64IleIle: 3.64 ± 0.067
3.348IleLys: 3.348 ± 0.052
5.348IleLeu: 5.348 ± 0.078
1.361IleMet: 1.361 ± 0.034
2.927IleAsn: 2.927 ± 0.046
2.69IlePro: 2.69 ± 0.047
2.432IleGln: 2.432 ± 0.046
2.834IleArg: 2.834 ± 0.047
4.691IleSer: 4.691 ± 0.07
3.748IleThr: 3.748 ± 0.062
4.39IleVal: 4.39 ± 0.058
0.669IleTrp: 0.669 ± 0.023
1.773IleTyr: 1.773 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
4.998LysAla: 4.998 ± 0.076
0.366LysCys: 0.366 ± 0.015
2.839LysAsp: 2.839 ± 0.054
3.632LysGlu: 3.632 ± 0.056
1.675LysPhe: 1.675 ± 0.034
3.482LysGly: 3.482 ± 0.056
1.331LysHis: 1.331 ± 0.031
2.978LysIle: 2.978 ± 0.048
3.022LysLys: 3.022 ± 0.051
5.605LysLeu: 5.605 ± 0.069
1.449LysMet: 1.449 ± 0.035
2.204LysAsn: 2.204 ± 0.05
2.474LysPro: 2.474 ± 0.053
3.093LysGln: 3.093 ± 0.054
2.765LysArg: 2.765 ± 0.055
3.392LysSer: 3.392 ± 0.052
2.873LysThr: 2.873 ± 0.052
4.065LysVal: 4.065 ± 0.062
0.584LysTrp: 0.584 ± 0.021
1.495LysTyr: 1.495 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
9.555LeuAla: 9.555 ± 0.09
1.117LeuCys: 1.117 ± 0.028
5.69LeuAsp: 5.69 ± 0.071
6.444LeuGlu: 6.444 ± 0.081
4.234LeuPhe: 4.234 ± 0.075
6.884LeuGly: 6.884 ± 0.091
2.049LeuHis: 2.049 ± 0.045
6.342LeuIle: 6.342 ± 0.082
5.45LeuLys: 5.45 ± 0.072
10.377LeuLeu: 10.377 ± 0.127
2.81LeuMet: 2.81 ± 0.047
4.786LeuAsn: 4.786 ± 0.069
4.617LeuPro: 4.617 ± 0.073
3.551LeuGln: 3.551 ± 0.051
4.349LeuArg: 4.349 ± 0.062
8.089LeuSer: 8.089 ± 0.084
5.892LeuThr: 5.892 ± 0.065
7.232LeuVal: 7.232 ± 0.071
1.104LeuTrp: 1.104 ± 0.033
2.701LeuTyr: 2.701 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
2.581MetAla: 2.581 ± 0.047
0.209MetCys: 0.209 ± 0.012
1.325MetAsp: 1.325 ± 0.029
1.417MetGlu: 1.417 ± 0.03
1.018MetPhe: 1.018 ± 0.03
1.838MetGly: 1.838 ± 0.043
0.492MetHis: 0.492 ± 0.02
1.585MetIle: 1.585 ± 0.037
1.592MetLys: 1.592 ± 0.029
2.831MetLeu: 2.831 ± 0.048
0.888MetMet: 0.888 ± 0.027
1.223MetAsn: 1.223 ± 0.031
1.217MetPro: 1.217 ± 0.035
1.108MetGln: 1.108 ± 0.03
1.241MetArg: 1.241 ± 0.03
2.123MetSer: 2.123 ± 0.039
1.674MetThr: 1.674 ± 0.033
1.928MetVal: 1.928 ± 0.04
0.245MetTrp: 0.245 ± 0.014
0.599MetTyr: 0.599 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.5AsnAla: 3.5 ± 0.062
0.433AsnCys: 0.433 ± 0.017
2.303AsnAsp: 2.303 ± 0.047
2.56AsnGlu: 2.56 ± 0.051
1.539AsnPhe: 1.539 ± 0.035
2.97AsnGly: 2.97 ± 0.053
1.049AsnHis: 1.049 ± 0.028
2.856AsnIle: 2.856 ± 0.053
2.39AsnLys: 2.39 ± 0.048
4.158AsnLeu: 4.158 ± 0.062
1.072AsnMet: 1.072 ± 0.034
1.947AsnAsn: 1.947 ± 0.048
2.13AsnPro: 2.13 ± 0.04
2.22AsnGln: 2.22 ± 0.043
1.968AsnArg: 1.968 ± 0.037
2.758AsnSer: 2.758 ± 0.04
2.168AsnThr: 2.168 ± 0.047
2.873AsnVal: 2.873 ± 0.052
0.574AsnTrp: 0.574 ± 0.025
1.383AsnTyr: 1.383 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
2.907ProAla: 2.907 ± 0.055
0.33ProCys: 0.33 ± 0.016
2.194ProAsp: 2.194 ± 0.044
3.167ProGlu: 3.167 ± 0.058
1.721ProPhe: 1.721 ± 0.038
1.973ProGly: 1.973 ± 0.045
0.866ProHis: 0.866 ± 0.025
2.471ProIle: 2.471 ± 0.042
2.099ProLys: 2.099 ± 0.041
3.963ProLeu: 3.963 ± 0.055
1.091ProMet: 1.091 ± 0.031
1.729ProAsn: 1.729 ± 0.037
1.058ProPro: 1.058 ± 0.031
1.712ProGln: 1.712 ± 0.034
1.354ProArg: 1.354 ± 0.036
2.487ProSer: 2.487 ± 0.042
2.158ProThr: 2.158 ± 0.046
3.093ProVal: 3.093 ± 0.047
0.518ProTrp: 0.518 ± 0.019
1.321ProTyr: 1.321 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
4.201GlnAla: 4.201 ± 0.061
0.415GlnCys: 0.415 ± 0.017
2.011GlnAsp: 2.011 ± 0.042
2.558GlnGlu: 2.558 ± 0.045
1.765GlnPhe: 1.765 ± 0.035
2.909GlnGly: 2.909 ± 0.046
1.123GlnHis: 1.123 ± 0.032
2.597GlnIle: 2.597 ± 0.047
2.216GlnLys: 2.216 ± 0.048
5.096GlnLeu: 5.096 ± 0.075
1.23GlnMet: 1.23 ± 0.031
1.746GlnAsn: 1.746 ± 0.037
1.636GlnPro: 1.636 ± 0.035
2.811GlnGln: 2.811 ± 0.067
2.315GlnArg: 2.315 ± 0.044
2.876GlnSer: 2.876 ± 0.058
2.377GlnThr: 2.377 ± 0.045
3.178GlnVal: 3.178 ± 0.047
0.689GlnTrp: 0.689 ± 0.025
1.482GlnTyr: 1.482 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
3.269ArgAla: 3.269 ± 0.051
0.473ArgCys: 0.473 ± 0.018
2.426ArgAsp: 2.426 ± 0.047
3.033ArgGlu: 3.033 ± 0.051
2.139ArgPhe: 2.139 ± 0.04
2.572ArgGly: 2.572 ± 0.045
1.09ArgHis: 1.09 ± 0.031
3.106ArgIle: 3.106 ± 0.053
2.421ArgLys: 2.421 ± 0.048
4.804ArgLeu: 4.804 ± 0.065
1.235ArgMet: 1.235 ± 0.031
1.959ArgAsn: 1.959 ± 0.034
1.535ArgPro: 1.535 ± 0.032
2.04ArgGln: 2.04 ± 0.044
2.27ArgArg: 2.27 ± 0.05
2.76ArgSer: 2.76 ± 0.043
2.118ArgThr: 2.118 ± 0.042
3.164ArgVal: 3.164 ± 0.049
0.63ArgTrp: 0.63 ± 0.026
1.736ArgTyr: 1.736 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
5.451SerAla: 5.451 ± 0.072
0.587SerCys: 0.587 ± 0.021
3.757SerAsp: 3.757 ± 0.06
4.283SerGlu: 4.283 ± 0.066
2.916SerPhe: 2.916 ± 0.049
4.988SerGly: 4.988 ± 0.063
1.587SerHis: 1.587 ± 0.04
4.376SerIle: 4.376 ± 0.059
3.425SerLys: 3.425 ± 0.057
7.197SerLeu: 7.197 ± 0.084
1.815SerMet: 1.815 ± 0.04
2.853SerAsn: 2.853 ± 0.053
2.467SerPro: 2.467 ± 0.042
3.039SerGln: 3.039 ± 0.049
2.915SerArg: 2.915 ± 0.048
4.63SerSer: 4.63 ± 0.083
3.328SerThr: 3.328 ± 0.058
4.874SerVal: 4.874 ± 0.07
0.83SerTrp: 0.83 ± 0.025
2.212SerTyr: 2.212 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
4.298ThrAla: 4.298 ± 0.068
0.474ThrCys: 0.474 ± 0.02
2.721ThrAsp: 2.721 ± 0.047
3.155ThrGlu: 3.155 ± 0.05
2.126ThrPhe: 2.126 ± 0.04
3.935ThrGly: 3.935 ± 0.057
1.247ThrHis: 1.247 ± 0.034
3.427ThrIle: 3.427 ± 0.055
2.411ThrLys: 2.411 ± 0.046
6.153ThrLeu: 6.153 ± 0.073
1.228ThrMet: 1.228 ± 0.032
2.111ThrAsn: 2.111 ± 0.05
2.551ThrPro: 2.551 ± 0.044
2.467ThrGln: 2.467 ± 0.043
2.198ThrArg: 2.198 ± 0.046
3.402ThrSer: 3.402 ± 0.055
2.867ThrThr: 2.867 ± 0.057
3.867ThrVal: 3.867 ± 0.064
0.586ThrTrp: 0.586 ± 0.023
1.557ThrTyr: 1.557 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
6.385ValAla: 6.385 ± 0.074
0.791ValCys: 0.791 ± 0.025
4.098ValAsp: 4.098 ± 0.066
4.948ValGlu: 4.948 ± 0.075
2.954ValPhe: 2.954 ± 0.048
4.79ValGly: 4.79 ± 0.066
1.307ValHis: 1.307 ± 0.033
4.992ValIle: 4.992 ± 0.076
3.83ValLys: 3.83 ± 0.059
6.891ValLeu: 6.891 ± 0.074
2.053ValMet: 2.053 ± 0.041
3.044ValAsn: 3.044 ± 0.049
2.723ValPro: 2.723 ± 0.041
2.303ValGln: 2.303 ± 0.042
2.99ValArg: 2.99 ± 0.048
5.167ValSer: 5.167 ± 0.064
4.128ValThr: 4.128 ± 0.055
5.695ValVal: 5.695 ± 0.089
0.785ValTrp: 0.785 ± 0.025
1.888ValTyr: 1.888 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
0.879TrpAla: 0.879 ± 0.026
0.151TrpCys: 0.151 ± 0.011
0.606TrpAsp: 0.606 ± 0.024
0.588TrpGlu: 0.588 ± 0.022
0.627TrpPhe: 0.627 ± 0.022
0.783TrpGly: 0.783 ± 0.025
0.347TrpHis: 0.347 ± 0.016
0.758TrpIle: 0.758 ± 0.025
0.599TrpLys: 0.599 ± 0.02
1.739TrpLeu: 1.739 ± 0.043
0.342TrpMet: 0.342 ± 0.016
0.568TrpAsn: 0.568 ± 0.022
0.434TrpPro: 0.434 ± 0.018
0.887TrpGln: 0.887 ± 0.025
0.62TrpArg: 0.62 ± 0.024
0.729TrpSer: 0.729 ± 0.025
0.508TrpThr: 0.508 ± 0.021
0.886TrpVal: 0.886 ± 0.03
0.221TrpTrp: 0.221 ± 0.015
0.367TrpTyr: 0.367 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.321TyrAla: 2.321 ± 0.039
0.369TyrCys: 0.369 ± 0.017
1.613TyrAsp: 1.613 ± 0.038
1.621TyrGlu: 1.621 ± 0.031
1.428TyrPhe: 1.428 ± 0.036
2.071TyrGly: 2.071 ± 0.045
0.804TyrHis: 0.804 ± 0.025
1.715TyrIle: 1.715 ± 0.038
1.443TyrLys: 1.443 ± 0.034
3.394TyrLeu: 3.394 ± 0.058
0.687TyrMet: 0.687 ± 0.023
1.189TyrAsn: 1.189 ± 0.027
1.373TyrPro: 1.373 ± 0.035
1.92TyrGln: 1.92 ± 0.036
1.741TyrArg: 1.741 ± 0.037
2.095TyrSer: 2.095 ± 0.043
1.505TyrThr: 1.505 ± 0.04
1.98TyrVal: 1.98 ± 0.04
0.497TyrTrp: 0.497 ± 0.018
0.986TyrTyr: 0.986 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4064 proteins (1322842 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski