Amino acid dipepetide frequency for Leptolyngbyaceae cyanobacterium JSC-12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.466AlaAla: 8.466 ± 0.109	0.939AlaCys: 0.939 ± 0.026	4.41AlaAsp: 4.41 ± 0.053	5.669AlaGlu: 5.669 ± 0.074	3.136AlaPhe: 3.136 ± 0.045	6.077AlaGly: 6.077 ± 0.095	1.562AlaHis: 1.562 ± 0.035	7.722AlaIle: 7.722 ± 0.076	3.618AlaLys: 3.618 ± 0.056	9.464AlaLeu: 9.464 ± 0.101	1.946AlaMet: 1.946 ± 0.033	3.394AlaAsn: 3.394 ± 0.072	3.624AlaPro: 3.624 ± 0.068	4.689AlaGln: 4.689 ± 0.071	4.282AlaArg: 4.282 ± 0.054	5.25AlaSer: 5.25 ± 0.068	5.36AlaThr: 5.36 ± 0.065	6.046AlaVal: 6.046 ± 0.065	1.106AlaTrp: 1.106 ± 0.03	2.466AlaTyr: 2.466 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.675CysAla: 0.675 ± 0.02	0.152CysCys: 0.152 ± 0.011	0.605CysAsp: 0.605 ± 0.021	0.516CysGlu: 0.516 ± 0.02	0.413CysPhe: 0.413 ± 0.015	0.75CysGly: 0.75 ± 0.025	0.287CysHis: 0.287 ± 0.014	0.535CysIle: 0.535 ± 0.019	0.347CysLys: 0.347 ± 0.015	1.129CysLeu: 1.129 ± 0.026	0.175CysMet: 0.175 ± 0.011	0.348CysAsn: 0.348 ± 0.016	0.577CysPro: 0.577 ± 0.02	0.545CysGln: 0.545 ± 0.022	0.604CysArg: 0.604 ± 0.023	0.628CysSer: 0.628 ± 0.023	0.482CysThr: 0.482 ± 0.016	0.611CysVal: 0.611 ± 0.024	0.16CysTrp: 0.16 ± 0.009	0.349CysTyr: 0.349 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.124AspAla: 4.124 ± 0.056	0.55AspCys: 0.55 ± 0.019	2.294AspAsp: 2.294 ± 0.045	2.954AspGlu: 2.954 ± 0.052	2.13AspPhe: 2.13 ± 0.044	3.424AspGly: 3.424 ± 0.063	0.897AspHis: 0.897 ± 0.026	2.772AspIle: 2.772 ± 0.044	1.558AspLys: 1.558 ± 0.032	5.975AspLeu: 5.975 ± 0.078	0.797AspMet: 0.797 ± 0.024	1.549AspAsn: 1.549 ± 0.035	2.802AspPro: 2.802 ± 0.047	2.215AspGln: 2.215 ± 0.038	4.007AspArg: 4.007 ± 0.055	2.765AspSer: 2.765 ± 0.049	2.489AspThr: 2.489 ± 0.051	3.308AspVal: 3.308 ± 0.044	0.922AspTrp: 0.922 ± 0.028	1.695AspTyr: 1.695 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.775GluAla: 5.775 ± 0.079	0.466GluCys: 0.466 ± 0.019	2.535GluAsp: 2.535 ± 0.041	3.486GluGlu: 3.486 ± 0.064	2.347GluPhe: 2.347 ± 0.046	3.212GluGly: 3.212 ± 0.047	1.105GluHis: 1.105 ± 0.029	3.836GluIle: 3.836 ± 0.056	2.504GluLys: 2.504 ± 0.047	6.696GluLeu: 6.696 ± 0.083	1.369GluMet: 1.369 ± 0.031	1.962GluAsn: 1.962 ± 0.036	2.595GluPro: 2.595 ± 0.045	3.515GluGln: 3.515 ± 0.052	3.598GluArg: 3.598 ± 0.06	3.168GluSer: 3.168 ± 0.053	3.514GluThr: 3.514 ± 0.05	4.273GluVal: 4.273 ± 0.057	0.824GluTrp: 0.824 ± 0.026	1.557GluTyr: 1.557 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.197PheAla: 3.197 ± 0.054	0.514PheCys: 0.514 ± 0.021	2.128PheAsp: 2.128 ± 0.042	2.157PheGlu: 2.157 ± 0.039	1.58PhePhe: 1.58 ± 0.037	2.975PheGly: 2.975 ± 0.051	0.782PheHis: 0.782 ± 0.027	2.075PheIle: 2.075 ± 0.041	1.37PheLys: 1.37 ± 0.032	4.102PheLeu: 4.102 ± 0.059	0.704PheMet: 0.704 ± 0.02	1.678PheAsn: 1.678 ± 0.042	1.917PhePro: 1.917 ± 0.035	1.869PheGln: 1.869 ± 0.04	2.044PheArg: 2.044 ± 0.038	2.839PheSer: 2.839 ± 0.053	2.324PheThr: 2.324 ± 0.048	2.629PheVal: 2.629 ± 0.044	0.717PheTrp: 0.717 ± 0.021	1.247PheTyr: 1.247 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	5.419GlyAla: 5.419 ± 0.082	0.793GlyCys: 0.793 ± 0.025	3.518GlyAsp: 3.518 ± 0.068	3.653GlyGlu: 3.653 ± 0.062	3.149GlyPhe: 3.149 ± 0.047	4.883GlyGly: 4.883 ± 0.116	1.28GlyHis: 1.28 ± 0.034	4.892GlyIle: 4.892 ± 0.067	3.452GlyLys: 3.452 ± 0.056	7.182GlyLeu: 7.182 ± 0.07	1.665GlyMet: 1.665 ± 0.037	2.959GlyAsn: 2.959 ± 0.087	1.524GlyPro: 1.524 ± 0.035	3.144GlyGln: 3.144 ± 0.049	3.726GlyArg: 3.726 ± 0.057	4.346GlySer: 4.346 ± 0.071	4.24GlyThr: 4.24 ± 0.079	4.927GlyVal: 4.927 ± 0.062	1.253GlyTrp: 1.253 ± 0.029	2.313GlyTyr: 2.313 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	1.37HisAla: 1.37 ± 0.03	0.27HisCys: 0.27 ± 0.013	0.849HisAsp: 0.849 ± 0.024	0.931HisGlu: 0.931 ± 0.025	0.789HisPhe: 0.789 ± 0.022	1.185HisGly: 1.185 ± 0.027	0.671HisHis: 0.671 ± 0.024	0.98HisIle: 0.98 ± 0.023	0.578HisLys: 0.578 ± 0.019	2.494HisLeu: 2.494 ± 0.045	0.305HisMet: 0.305 ± 0.017	0.672HisAsn: 0.672 ± 0.019	1.588HisPro: 1.588 ± 0.034	1.214HisGln: 1.214 ± 0.028	1.296HisArg: 1.296 ± 0.03	1.244HisSer: 1.244 ± 0.035	1.01HisThr: 1.01 ± 0.026	1.026HisVal: 1.026 ± 0.028	0.417HisTrp: 0.417 ± 0.019	0.771HisTyr: 0.771 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.691IleAla: 7.691 ± 0.086	0.654IleCys: 0.654 ± 0.021	3.177IleAsp: 3.177 ± 0.049	3.499IleGlu: 3.499 ± 0.052	2.101IlePhe: 2.101 ± 0.042	4.34IleGly: 4.34 ± 0.059	1.246IleHis: 1.246 ± 0.031	2.668IleIle: 2.668 ± 0.049	1.87IleLys: 1.87 ± 0.039	6.25IleLeu: 6.25 ± 0.071	0.808IleMet: 0.808 ± 0.025	2.219IleAsn: 2.219 ± 0.047	3.486IlePro: 3.486 ± 0.047	3.176IleGln: 3.176 ± 0.051	3.313IleArg: 3.313 ± 0.056	3.93IleSer: 3.93 ± 0.049	3.503IleThr: 3.503 ± 0.057	4.162IleVal: 4.162 ± 0.06	0.819IleTrp: 0.819 ± 0.025	1.598IleTyr: 1.598 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.588LysAla: 3.588 ± 0.055	0.235LysCys: 0.235 ± 0.013	1.791LysAsp: 1.791 ± 0.039	2.129LysGlu: 2.129 ± 0.043	1.312LysPhe: 1.312 ± 0.029	2.332LysGly: 2.332 ± 0.044	0.779LysHis: 0.779 ± 0.02	2.246LysIle: 2.246 ± 0.041	1.502LysLys: 1.502 ± 0.033	4.345LysLeu: 4.345 ± 0.067	0.755LysMet: 0.755 ± 0.024	1.292LysAsn: 1.292 ± 0.033	2.457LysPro: 2.457 ± 0.045	2.358LysGln: 2.358 ± 0.04	2.296LysArg: 2.296 ± 0.044	2.281LysSer: 2.281 ± 0.04	2.469LysThr: 2.469 ± 0.039	2.675LysVal: 2.675 ± 0.046	0.363LysTrp: 0.363 ± 0.015	0.973LysTyr: 0.973 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	10.14LeuAla: 10.14 ± 0.095	1.038LeuCys: 1.038 ± 0.026	5.44LeuAsp: 5.44 ± 0.063	7.095LeuGlu: 7.095 ± 0.09	3.91LeuPhe: 3.91 ± 0.06	7.755LeuGly: 7.755 ± 0.076	2.077LeuHis: 2.077 ± 0.044	6.294LeuIle: 6.294 ± 0.069	4.982LeuLys: 4.982 ± 0.058	11.852LeuLeu: 11.852 ± 0.121	2.291LeuMet: 2.291 ± 0.037	4.381LeuAsn: 4.381 ± 0.055	6.117LeuPro: 6.117 ± 0.068	5.949LeuGln: 5.949 ± 0.082	6.174LeuArg: 6.174 ± 0.076	7.491LeuSer: 7.491 ± 0.09	6.677LeuThr: 6.677 ± 0.066	7.678LeuVal: 7.678 ± 0.075	1.451LeuTrp: 1.451 ± 0.032	2.738LeuTyr: 2.738 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	1.906MetAla: 1.906 ± 0.034	0.126MetCys: 0.126 ± 0.011	0.849MetAsp: 0.849 ± 0.026	0.992MetGlu: 0.992 ± 0.024	0.578MetPhe: 0.578 ± 0.018	1.432MetGly: 1.432 ± 0.035	0.361MetHis: 0.361 ± 0.015	1.079MetIle: 1.079 ± 0.027	0.864MetLys: 0.864 ± 0.025	2.107MetLeu: 2.107 ± 0.039	0.515MetMet: 0.515 ± 0.019	0.847MetAsn: 0.847 ± 0.021	1.106MetPro: 1.106 ± 0.03	1.07MetGln: 1.07 ± 0.024	1.076MetArg: 1.076 ± 0.029	1.351MetSer: 1.351 ± 0.036	1.38MetThr: 1.38 ± 0.03	1.463MetVal: 1.463 ± 0.033	0.156MetTrp: 0.156 ± 0.009	0.355MetTyr: 0.355 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.035AsnAla: 3.035 ± 0.054	0.383AsnCys: 0.383 ± 0.016	1.687AsnAsp: 1.687 ± 0.063	1.638AsnGlu: 1.638 ± 0.037	1.487AsnPhe: 1.487 ± 0.035	2.709AsnGly: 2.709 ± 0.071	0.827AsnHis: 0.827 ± 0.023	1.876AsnIle: 1.876 ± 0.041	1.101AsnLys: 1.101 ± 0.03	4.836AsnLeu: 4.836 ± 0.069	0.518AsnMet: 0.518 ± 0.017	1.381AsnAsn: 1.381 ± 0.039	2.848AsnPro: 2.848 ± 0.052	2.397AsnGln: 2.397 ± 0.045	2.454AsnArg: 2.454 ± 0.042	2.362AsnSer: 2.362 ± 0.045	2.023AsnThr: 2.023 ± 0.038	2.22AsnVal: 2.22 ± 0.043	0.646AsnTrp: 0.646 ± 0.021	1.138AsnTyr: 1.138 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	4.282ProAla: 4.282 ± 0.066	0.388ProCys: 0.388 ± 0.016	3.382ProAsp: 3.382 ± 0.049	3.605ProGlu: 3.605 ± 0.055	2.079ProPhe: 2.079 ± 0.036	3.57ProGly: 3.57 ± 0.048	0.975ProHis: 0.975 ± 0.028	3.25ProIle: 3.25 ± 0.049	1.942ProLys: 1.942 ± 0.036	5.14ProLeu: 5.14 ± 0.063	0.913ProMet: 0.913 ± 0.024	2.208ProAsn: 2.208 ± 0.036	2.73ProPro: 2.73 ± 0.065	2.379ProGln: 2.379 ± 0.04	2.029ProArg: 2.029 ± 0.037	3.508ProSer: 3.508 ± 0.056	3.462ProThr: 3.462 ± 0.051	3.876ProVal: 3.876 ± 0.062	0.632ProTrp: 0.632 ± 0.024	1.433ProTyr: 1.433 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	5.444GlnAla: 5.444 ± 0.075	0.384GlnCys: 0.384 ± 0.018	2.128GlnAsp: 2.128 ± 0.043	3.28GlnGlu: 3.28 ± 0.054	2.02GlnPhe: 2.02 ± 0.037	3.219GlnGly: 3.219 ± 0.042	1.018GlnHis: 1.018 ± 0.03	3.312GlnIle: 3.312 ± 0.052	2.126GlnLys: 2.126 ± 0.038	5.893GlnLeu: 5.893 ± 0.079	1.093GlnMet: 1.093 ± 0.025	1.649GlnAsn: 1.649 ± 0.034	3.069GlnPro: 3.069 ± 0.047	3.737GlnGln: 3.737 ± 0.075	3.465GlnArg: 3.465 ± 0.056	3.233GlnSer: 3.233 ± 0.054	3.439GlnThr: 3.439 ± 0.05	4.034GlnVal: 4.034 ± 0.048	0.74GlnTrp: 0.74 ± 0.027	1.22GlnTyr: 1.22 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	4.101ArgAla: 4.101 ± 0.055	0.588ArgCys: 0.588 ± 0.021	2.836ArgAsp: 2.836 ± 0.044	3.317ArgGlu: 3.317 ± 0.053	2.523ArgPhe: 2.523 ± 0.043	3.325ArgGly: 3.325 ± 0.051	1.14ArgHis: 1.14 ± 0.027	3.478ArgIle: 3.478 ± 0.05	2.154ArgLys: 2.154 ± 0.043	6.808ArgLeu: 6.808 ± 0.07	1.261ArgMet: 1.261 ± 0.033	2.084ArgAsn: 2.084 ± 0.03	2.45ArgPro: 2.45 ± 0.044	3.584ArgGln: 3.584 ± 0.066	3.595ArgArg: 3.595 ± 0.059	4.02ArgSer: 4.02 ± 0.055	2.951ArgThr: 2.951 ± 0.043	3.926ArgVal: 3.926 ± 0.056	0.975ArgTrp: 0.975 ± 0.027	2.045ArgTyr: 2.045 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.023SerAla: 5.023 ± 0.065	0.574SerCys: 0.574 ± 0.019	3.263SerAsp: 3.263 ± 0.053	3.392SerGlu: 3.392 ± 0.05	2.491SerPhe: 2.491 ± 0.05	4.7SerGly: 4.7 ± 0.08	1.331SerHis: 1.331 ± 0.027	3.427SerIle: 3.427 ± 0.05	2.113SerLys: 2.113 ± 0.042	7.534SerLeu: 7.534 ± 0.091	1.253SerMet: 1.253 ± 0.028	2.519SerAsn: 2.519 ± 0.044	3.924SerPro: 3.924 ± 0.065	3.451SerGln: 3.451 ± 0.057	3.435SerArg: 3.435 ± 0.051	4.847SerSer: 4.847 ± 0.082	3.855SerThr: 3.855 ± 0.067	4.274SerVal: 4.274 ± 0.062	0.856SerTrp: 0.856 ± 0.025	1.708SerTyr: 1.708 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.417ThrAla: 5.417 ± 0.06	0.543ThrCys: 0.543 ± 0.018	2.751ThrAsp: 2.751 ± 0.049	3.079ThrGlu: 3.079 ± 0.053	2.262ThrPhe: 2.262 ± 0.045	4.518ThrGly: 4.518 ± 0.069	1.101ThrHis: 1.101 ± 0.026	3.605ThrIle: 3.605 ± 0.046	1.881ThrLys: 1.881 ± 0.033	6.874ThrLeu: 6.874 ± 0.076	0.915ThrMet: 0.915 ± 0.026	2.113ThrAsn: 2.113 ± 0.044	3.717ThrPro: 3.717 ± 0.065	2.985ThrGln: 2.985 ± 0.041	2.899ThrArg: 2.899 ± 0.04	3.628ThrSer: 3.628 ± 0.053	3.52ThrThr: 3.52 ± 0.073	4.553ThrVal: 4.553 ± 0.064	0.795ThrTrp: 0.795 ± 0.023	1.716ThrTyr: 1.716 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	6.263ValAla: 6.263 ± 0.068	0.771ValCys: 0.771 ± 0.024	3.533ValAsp: 3.533 ± 0.054	4.457ValGlu: 4.457 ± 0.058	2.673ValPhe: 2.673 ± 0.041	4.938ValGly: 4.938 ± 0.058	1.228ValHis: 1.228 ± 0.029	4.214ValIle: 4.214 ± 0.055	2.74ValLys: 2.74 ± 0.043	7.4ValLeu: 7.4 ± 0.07	1.545ValMet: 1.545 ± 0.033	2.75ValAsn: 2.75 ± 0.048	3.466ValPro: 3.466 ± 0.052	3.311ValGln: 3.311 ± 0.05	3.819ValArg: 3.819 ± 0.049	4.496ValSer: 4.496 ± 0.061	4.034ValThr: 4.034 ± 0.058	5.304ValVal: 5.304 ± 0.071	0.959ValTrp: 0.959 ± 0.026	1.836ValTyr: 1.836 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.064TrpAla: 1.064 ± 0.03	0.148TrpCys: 0.148 ± 0.011	0.609TrpAsp: 0.609 ± 0.022	0.849TrpGlu: 0.849 ± 0.022	0.626TrpPhe: 0.626 ± 0.023	0.947TrpGly: 0.947 ± 0.026	0.353TrpHis: 0.353 ± 0.016	0.872TrpIle: 0.872 ± 0.026	0.593TrpLys: 0.593 ± 0.018	2.08TrpLeu: 2.08 ± 0.048	0.384TrpMet: 0.384 ± 0.018	0.603TrpAsn: 0.603 ± 0.017	0.149TrpPro: 0.149 ± 0.011	1.144TrpGln: 1.144 ± 0.033	0.907TrpArg: 0.907 ± 0.026	0.841TrpSer: 0.841 ± 0.023	0.67TrpThr: 0.67 ± 0.02	1.066TrpVal: 1.066 ± 0.026	0.256TrpTrp: 0.256 ± 0.015	0.406TrpTyr: 0.406 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.244TyrAla: 2.244 ± 0.036	0.373TyrCys: 0.373 ± 0.016	1.443TyrAsp: 1.443 ± 0.035	1.637TyrGlu: 1.637 ± 0.036	1.243TyrPhe: 1.243 ± 0.03	2.028TyrGly: 2.028 ± 0.038	0.637TyrHis: 0.637 ± 0.021	1.377TyrIle: 1.377 ± 0.033	0.884TyrLys: 0.884 ± 0.024	3.369TyrLeu: 3.369 ± 0.048	0.399TyrMet: 0.399 ± 0.017	0.957TyrAsn: 0.957 ± 0.024	1.637TyrPro: 1.637 ± 0.038	1.773TyrGln: 1.773 ± 0.035	2.14TyrArg: 2.14 ± 0.039	1.744TyrSer: 1.744 ± 0.034	1.474TyrThr: 1.474 ± 0.031	1.687TyrVal: 1.687 ± 0.037	0.52TyrTrp: 0.52 ± 0.019	0.942TyrTyr: 0.942 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4673 proteins (1516644 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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