Amino acid dipepetide frequency for Aquiflexum balticum DSM 16537

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.397AlaAla: 4.397 ± 0.071
0.539AlaCys: 0.539 ± 0.017
3.291AlaAsp: 3.291 ± 0.045
4.039AlaGlu: 4.039 ± 0.054
3.466AlaPhe: 3.466 ± 0.049
4.702AlaGly: 4.702 ± 0.058
1.127AlaHis: 1.127 ± 0.023
4.948AlaIle: 4.948 ± 0.056
4.112AlaLys: 4.112 ± 0.053
5.987AlaLeu: 5.987 ± 0.07
1.596AlaMet: 1.596 ± 0.04
2.948AlaAsn: 2.948 ± 0.046
2.055AlaPro: 2.055 ± 0.05
2.16AlaGln: 2.16 ± 0.037
2.141AlaArg: 2.141 ± 0.037
3.928AlaSer: 3.928 ± 0.057
3.05AlaThr: 3.05 ± 0.059
4.088AlaVal: 4.088 ± 0.053
0.759AlaTrp: 0.759 ± 0.023
2.377AlaTyr: 2.377 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.407CysAla: 0.407 ± 0.021
0.096CysCys: 0.096 ± 0.009
0.339CysAsp: 0.339 ± 0.013
0.447CysGlu: 0.447 ± 0.019
0.408CysPhe: 0.408 ± 0.019
0.583CysGly: 0.583 ± 0.019
0.208CysHis: 0.208 ± 0.012
0.485CysIle: 0.485 ± 0.016
0.375CysLys: 0.375 ± 0.015
0.619CysLeu: 0.619 ± 0.018
0.142CysMet: 0.142 ± 0.01
0.315CysAsn: 0.315 ± 0.014
0.355CysPro: 0.355 ± 0.023
0.294CysGln: 0.294 ± 0.016
0.248CysArg: 0.248 ± 0.013
0.525CysSer: 0.525 ± 0.02
0.35CysThr: 0.35 ± 0.014
0.339CysVal: 0.339 ± 0.015
0.073CysTrp: 0.073 ± 0.006
0.253CysTyr: 0.253 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
3.113AspAla: 3.113 ± 0.054
0.358AspCys: 0.358 ± 0.015
2.329AspAsp: 2.329 ± 0.051
3.595AspGlu: 3.595 ± 0.056
3.84AspPhe: 3.84 ± 0.048
3.955AspGly: 3.955 ± 0.071
1.012AspHis: 1.012 ± 0.027
4.213AspIle: 4.213 ± 0.06
3.646AspLys: 3.646 ± 0.059
5.852AspLeu: 5.852 ± 0.064
1.273AspMet: 1.273 ± 0.028
2.572AspAsn: 2.572 ± 0.045
2.481AspPro: 2.481 ± 0.045
2.071AspGln: 2.071 ± 0.042
2.266AspArg: 2.266 ± 0.037
3.113AspSer: 3.113 ± 0.047
2.126AspThr: 2.126 ± 0.042
2.884AspVal: 2.884 ± 0.043
0.925AspTrp: 0.925 ± 0.018
2.432AspTyr: 2.432 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
4.267GluAla: 4.267 ± 0.062
0.294GluCys: 0.294 ± 0.013
3.596GluAsp: 3.596 ± 0.051
5.395GluGlu: 5.395 ± 0.068
3.371GluPhe: 3.371 ± 0.039
4.463GluGly: 4.463 ± 0.057
1.039GluHis: 1.039 ± 0.025
5.987GluIle: 5.987 ± 0.068
6.299GluLys: 6.299 ± 0.062
6.468GluLeu: 6.468 ± 0.071
1.904GluMet: 1.904 ± 0.036
4.614GluAsn: 4.614 ± 0.058
1.9GluPro: 1.9 ± 0.036
2.068GluGln: 2.068 ± 0.038
2.762GluArg: 2.762 ± 0.044
3.89GluSer: 3.89 ± 0.054
3.25GluThr: 3.25 ± 0.041
4.368GluVal: 4.368 ± 0.065
0.842GluTrp: 0.842 ± 0.022
2.291GluTyr: 2.291 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
3.172PheAla: 3.172 ± 0.046
0.432PheCys: 0.432 ± 0.015
3.373PheAsp: 3.373 ± 0.045
3.964PheGlu: 3.964 ± 0.051
3.239PhePhe: 3.239 ± 0.055
4.195PheGly: 4.195 ± 0.049
1.036PheHis: 1.036 ± 0.024
3.689PheIle: 3.689 ± 0.053
3.231PheLys: 3.231 ± 0.045
5.499PheLeu: 5.499 ± 0.069
1.202PheMet: 1.202 ± 0.027
2.954PheAsn: 2.954 ± 0.051
2.175PhePro: 2.175 ± 0.038
2.0PheGln: 2.0 ± 0.042
2.282PheArg: 2.282 ± 0.04
4.306PheSer: 4.306 ± 0.053
2.914PheThr: 2.914 ± 0.047
3.191PheVal: 3.191 ± 0.042
0.764PheTrp: 0.764 ± 0.024
2.16PheTyr: 2.16 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
4.105GlyAla: 4.105 ± 0.063
0.56GlyCys: 0.56 ± 0.028
3.517GlyAsp: 3.517 ± 0.053
4.376GlyGlu: 4.376 ± 0.055
4.176GlyPhe: 4.176 ± 0.061
5.089GlyGly: 5.089 ± 0.099
1.207GlyHis: 1.207 ± 0.031
5.954GlyIle: 5.954 ± 0.063
5.406GlyLys: 5.406 ± 0.066
6.751GlyLeu: 6.751 ± 0.074
1.954GlyMet: 1.954 ± 0.035
4.028GlyAsn: 4.028 ± 0.073
1.943GlyPro: 1.943 ± 0.045
2.396GlyGln: 2.396 ± 0.034
2.775GlyArg: 2.775 ± 0.047
4.295GlySer: 4.295 ± 0.06
3.847GlyThr: 3.847 ± 0.061
4.32GlyVal: 4.32 ± 0.06
0.952GlyTrp: 0.952 ± 0.025
2.798GlyTyr: 2.798 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
1.077HisAla: 1.077 ± 0.028
0.184HisCys: 0.184 ± 0.011
0.862HisAsp: 0.862 ± 0.025
1.062HisGlu: 1.062 ± 0.024
1.227HisPhe: 1.227 ± 0.029
1.22HisGly: 1.22 ± 0.026
0.567HisHis: 0.567 ± 0.022
1.354HisIle: 1.354 ± 0.03
0.972HisLys: 0.972 ± 0.023
1.926HisLeu: 1.926 ± 0.04
0.382HisMet: 0.382 ± 0.014
0.729HisAsn: 0.729 ± 0.02
1.07HisPro: 1.07 ± 0.026
0.872HisGln: 0.872 ± 0.025
0.725HisArg: 0.725 ± 0.021
1.109HisSer: 1.109 ± 0.027
0.835HisThr: 0.835 ± 0.023
0.995HisVal: 0.995 ± 0.025
0.286HisTrp: 0.286 ± 0.016
0.783HisTyr: 0.783 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.029IleAla: 5.029 ± 0.059
0.611IleCys: 0.611 ± 0.019
4.212IleAsp: 4.212 ± 0.06
5.077IleGlu: 5.077 ± 0.054
3.936IlePhe: 3.936 ± 0.052
5.279IleGly: 5.279 ± 0.067
1.611IleHis: 1.611 ± 0.032
5.414IleIle: 5.414 ± 0.063
5.139IleLys: 5.139 ± 0.065
7.522IleLeu: 7.522 ± 0.081
1.448IleMet: 1.448 ± 0.03
4.197IleAsn: 4.197 ± 0.058
3.675IlePro: 3.675 ± 0.054
2.99IleGln: 2.99 ± 0.047
3.211IleArg: 3.211 ± 0.048
5.927IleSer: 5.927 ± 0.073
3.887IleThr: 3.887 ± 0.052
4.134IleVal: 4.134 ± 0.057
0.929IleTrp: 0.929 ± 0.024
2.673IleTyr: 2.673 ± 0.041
0.0IleXaa: 0.0 ± 0.0
Lys
4.392LysAla: 4.392 ± 0.056
0.311LysCys: 0.311 ± 0.013
4.06LysAsp: 4.06 ± 0.056
5.843LysGlu: 5.843 ± 0.067
2.896LysPhe: 2.896 ± 0.047
4.657LysGly: 4.657 ± 0.058
1.059LysHis: 1.059 ± 0.026
5.735LysIle: 5.735 ± 0.056
5.743LysLys: 5.743 ± 0.072
6.006LysLeu: 6.006 ± 0.073
1.97LysMet: 1.97 ± 0.033
4.325LysAsn: 4.325 ± 0.054
2.521LysPro: 2.521 ± 0.039
1.928LysGln: 1.928 ± 0.036
2.642LysArg: 2.642 ± 0.04
4.757LysSer: 4.757 ± 0.059
3.726LysThr: 3.726 ± 0.048
4.51LysVal: 4.51 ± 0.055
0.84LysTrp: 0.84 ± 0.021
2.536LysTyr: 2.536 ± 0.039
0.0LysXaa: 0.0 ± 0.0
Leu
6.219LeuAla: 6.219 ± 0.061
0.622LeuCys: 0.622 ± 0.024
5.476LeuAsp: 5.476 ± 0.071
7.027LeuGlu: 7.027 ± 0.069
5.204LeuPhe: 5.204 ± 0.063
6.625LeuGly: 6.625 ± 0.08
1.602LeuHis: 1.602 ± 0.035
7.459LeuIle: 7.459 ± 0.083
6.955LeuLys: 6.955 ± 0.076
9.145LeuLeu: 9.145 ± 0.099
2.456LeuMet: 2.456 ± 0.04
5.291LeuAsn: 5.291 ± 0.067
4.079LeuPro: 4.079 ± 0.053
3.116LeuGln: 3.116 ± 0.046
3.618LeuArg: 3.618 ± 0.045
6.869LeuSer: 6.869 ± 0.075
5.038LeuThr: 5.038 ± 0.064
5.888LeuVal: 5.888 ± 0.069
1.005LeuTrp: 1.005 ± 0.03
3.006LeuTyr: 3.006 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
1.895MetAla: 1.895 ± 0.03
0.111MetCys: 0.111 ± 0.009
1.522MetAsp: 1.522 ± 0.027
1.873MetGlu: 1.873 ± 0.03
0.873MetPhe: 0.873 ± 0.025
1.822MetGly: 1.822 ± 0.033
0.414MetHis: 0.414 ± 0.017
1.749MetIle: 1.749 ± 0.033
2.198MetLys: 2.198 ± 0.039
2.096MetLeu: 2.096 ± 0.039
0.726MetMet: 0.726 ± 0.021
1.261MetAsn: 1.261 ± 0.028
0.983MetPro: 0.983 ± 0.024
0.763MetGln: 0.763 ± 0.022
0.971MetArg: 0.971 ± 0.025
1.345MetSer: 1.345 ± 0.032
1.223MetThr: 1.223 ± 0.026
1.711MetVal: 1.711 ± 0.031
0.204MetTrp: 0.204 ± 0.011
0.623MetTyr: 0.623 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.205AsnAla: 3.205 ± 0.05
0.374AsnCys: 0.374 ± 0.018
2.584AsnAsp: 2.584 ± 0.049
3.304AsnGlu: 3.304 ± 0.042
3.085AsnPhe: 3.085 ± 0.046
3.877AsnGly: 3.877 ± 0.078
1.064AsnHis: 1.064 ± 0.023
4.096AsnIle: 4.096 ± 0.055
3.322AsnLys: 3.322 ± 0.049
5.581AsnLeu: 5.581 ± 0.072
1.265AsnMet: 1.265 ± 0.026
2.95AsnAsn: 2.95 ± 0.052
3.226AsnPro: 3.226 ± 0.044
2.389AsnGln: 2.389 ± 0.039
2.352AsnArg: 2.352 ± 0.04
3.623AsnSer: 3.623 ± 0.056
2.803AsnThr: 2.803 ± 0.073
2.897AsnVal: 2.897 ± 0.039
0.848AsnTrp: 0.848 ± 0.024
2.199AsnTyr: 2.199 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
2.316ProAla: 2.316 ± 0.044
0.213ProCys: 0.213 ± 0.011
2.637ProAsp: 2.637 ± 0.045
3.419ProGlu: 3.419 ± 0.05
2.248ProPhe: 2.248 ± 0.036
2.737ProGly: 2.737 ± 0.051
0.714ProHis: 0.714 ± 0.021
2.93ProIle: 2.93 ± 0.045
2.632ProLys: 2.632 ± 0.043
3.477ProLeu: 3.477 ± 0.045
0.894ProMet: 0.894 ± 0.024
2.337ProAsn: 2.337 ± 0.04
1.107ProPro: 1.107 ± 0.031
1.322ProGln: 1.322 ± 0.028
1.185ProArg: 1.185 ± 0.028
2.462ProSer: 2.462 ± 0.041
1.998ProThr: 1.998 ± 0.04
2.751ProVal: 2.751 ± 0.048
0.467ProTrp: 0.467 ± 0.019
1.537ProTyr: 1.537 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
2.125GlnAla: 2.125 ± 0.034
0.174GlnCys: 0.174 ± 0.016
1.762GlnAsp: 1.762 ± 0.042
2.539GlnGlu: 2.539 ± 0.043
1.748GlnPhe: 1.748 ± 0.03
2.122GlnGly: 2.122 ± 0.043
0.566GlnHis: 0.566 ± 0.02
2.769GlnIle: 2.769 ± 0.042
2.782GlnLys: 2.782 ± 0.045
3.415GlnLeu: 3.415 ± 0.052
0.936GlnMet: 0.936 ± 0.024
2.118GlnAsn: 2.118 ± 0.038
1.195GlnPro: 1.195 ± 0.03
1.316GlnGln: 1.316 ± 0.031
1.441GlnArg: 1.441 ± 0.03
2.238GlnSer: 2.238 ± 0.042
1.78GlnThr: 1.78 ± 0.033
2.383GlnVal: 2.383 ± 0.041
0.444GlnTrp: 0.444 ± 0.016
1.274GlnTyr: 1.274 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
2.216ArgAla: 2.216 ± 0.04
0.199ArgCys: 0.199 ± 0.01
2.074ArgAsp: 2.074 ± 0.041
2.759ArgGlu: 2.759 ± 0.041
2.288ArgPhe: 2.288 ± 0.038
2.263ArgGly: 2.263 ± 0.04
0.675ArgHis: 0.675 ± 0.021
3.422ArgIle: 3.422 ± 0.047
2.978ArgLys: 2.978 ± 0.043
3.763ArgLeu: 3.763 ± 0.054
1.093ArgMet: 1.093 ± 0.025
2.379ArgAsn: 2.379 ± 0.043
1.437ArgPro: 1.437 ± 0.029
1.386ArgGln: 1.386 ± 0.03
1.537ArgArg: 1.537 ± 0.034
2.28ArgSer: 2.28 ± 0.036
1.941ArgThr: 1.941 ± 0.038
2.342ArgVal: 2.342 ± 0.035
0.501ArgTrp: 0.501 ± 0.018
1.596ArgTyr: 1.596 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
3.705SerAla: 3.705 ± 0.053
0.593SerCys: 0.593 ± 0.019
3.516SerAsp: 3.516 ± 0.048
4.174SerGlu: 4.174 ± 0.06
4.035SerPhe: 4.035 ± 0.049
5.268SerGly: 5.268 ± 0.067
1.21SerHis: 1.21 ± 0.028
5.035SerIle: 5.035 ± 0.06
4.539SerLys: 4.539 ± 0.055
6.632SerLeu: 6.632 ± 0.077
1.477SerMet: 1.477 ± 0.029
3.606SerAsn: 3.606 ± 0.054
2.691SerPro: 2.691 ± 0.052
2.39SerGln: 2.39 ± 0.046
2.542SerArg: 2.542 ± 0.038
4.22SerSer: 4.22 ± 0.059
3.15SerThr: 3.15 ± 0.042
3.794SerVal: 3.794 ± 0.065
0.865SerTrp: 0.865 ± 0.023
2.39SerTyr: 2.39 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
3.295ThrAla: 3.295 ± 0.056
0.34ThrCys: 0.34 ± 0.015
2.845ThrAsp: 2.845 ± 0.052
3.122ThrGlu: 3.122 ± 0.043
2.875ThrPhe: 2.875 ± 0.036
4.159ThrGly: 4.159 ± 0.06
0.934ThrHis: 0.934 ± 0.026
3.784ThrIle: 3.784 ± 0.059
3.06ThrLys: 3.06 ± 0.052
4.875ThrLeu: 4.875 ± 0.053
0.985ThrMet: 0.985 ± 0.022
2.473ThrAsn: 2.473 ± 0.044
2.165ThrPro: 2.165 ± 0.041
1.669ThrGln: 1.669 ± 0.037
1.642ThrArg: 1.642 ± 0.031
3.182ThrSer: 3.182 ± 0.05
2.588ThrThr: 2.588 ± 0.068
3.461ThrVal: 3.461 ± 0.076
0.725ThrTrp: 0.725 ± 0.024
2.066ThrTyr: 2.066 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
3.803ValAla: 3.803 ± 0.059
0.463ValCys: 0.463 ± 0.016
3.333ValAsp: 3.333 ± 0.053
3.954ValGlu: 3.954 ± 0.055
3.694ValPhe: 3.694 ± 0.055
3.981ValGly: 3.981 ± 0.055
1.085ValHis: 1.085 ± 0.028
4.546ValIle: 4.546 ± 0.058
4.002ValLys: 4.002 ± 0.051
5.875ValLeu: 5.875 ± 0.057
1.499ValMet: 1.499 ± 0.029
3.334ValAsn: 3.334 ± 0.055
2.404ValPro: 2.404 ± 0.042
1.871ValGln: 1.871 ± 0.036
2.447ValArg: 2.447 ± 0.043
4.376ValSer: 4.376 ± 0.059
3.146ValThr: 3.146 ± 0.065
3.773ValVal: 3.773 ± 0.058
0.712ValTrp: 0.712 ± 0.022
2.235ValTyr: 2.235 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
0.756TrpAla: 0.756 ± 0.026
0.081TrpCys: 0.081 ± 0.007
0.751TrpAsp: 0.751 ± 0.024
0.916TrpGlu: 0.916 ± 0.024
0.634TrpPhe: 0.634 ± 0.02
0.88TrpGly: 0.88 ± 0.026
0.258TrpHis: 0.258 ± 0.014
0.976TrpIle: 0.976 ± 0.028
0.908TrpLys: 0.908 ± 0.023
1.192TrpLeu: 1.192 ± 0.03
0.407TrpMet: 0.407 ± 0.017
0.741TrpAsn: 0.741 ± 0.023
0.353TrpPro: 0.353 ± 0.017
0.456TrpGln: 0.456 ± 0.019
0.537TrpArg: 0.537 ± 0.018
0.794TrpSer: 0.794 ± 0.022
0.702TrpThr: 0.702 ± 0.024
0.843TrpVal: 0.843 ± 0.024
0.211TrpTrp: 0.211 ± 0.012
0.482TrpTyr: 0.482 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.216TyrAla: 2.216 ± 0.034
0.306TyrCys: 0.306 ± 0.013
1.977TyrAsp: 1.977 ± 0.036
2.182TyrGlu: 2.182 ± 0.04
2.536TyrPhe: 2.536 ± 0.037
2.569TyrGly: 2.569 ± 0.04
0.849TyrHis: 0.849 ± 0.019
2.354TyrIle: 2.354 ± 0.038
2.16TyrLys: 2.16 ± 0.039
4.021TyrLeu: 4.021 ± 0.049
0.756TyrMet: 0.756 ± 0.023
1.87TyrAsn: 1.87 ± 0.036
1.567TyrPro: 1.567 ± 0.031
1.671TyrGln: 1.671 ± 0.032
1.807TyrArg: 1.807 ± 0.035
2.594TyrSer: 2.594 ± 0.038
1.89TyrThr: 1.89 ± 0.044
1.859TyrVal: 1.859 ± 0.035
0.527TyrTrp: 0.527 ± 0.02
1.546TyrTyr: 1.546 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4889 proteins (1724006 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski