Amino acid dipepetide frequency for Tenuibacillus multivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.207AlaAla: 4.207 ± 0.082
0.498AlaCys: 0.498 ± 0.028
3.169AlaAsp: 3.169 ± 0.069
4.239AlaGlu: 4.239 ± 0.091
3.156AlaPhe: 3.156 ± 0.069
4.396AlaGly: 4.396 ± 0.075
1.202AlaHis: 1.202 ± 0.039
5.57AlaIle: 5.57 ± 0.095
4.041AlaLys: 4.041 ± 0.072
6.637AlaLeu: 6.637 ± 0.108
1.913AlaMet: 1.913 ± 0.048
2.734AlaAsn: 2.734 ± 0.06
1.835AlaPro: 1.835 ± 0.052
2.139AlaGln: 2.139 ± 0.059
2.351AlaArg: 2.351 ± 0.053
3.737AlaSer: 3.737 ± 0.075
3.273AlaThr: 3.273 ± 0.072
4.697AlaVal: 4.697 ± 0.074
0.558AlaTrp: 0.558 ± 0.029
2.252AlaTyr: 2.252 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.316CysAla: 0.316 ± 0.02
0.073CysCys: 0.073 ± 0.011
0.37CysAsp: 0.37 ± 0.027
0.418CysGlu: 0.418 ± 0.024
0.231CysPhe: 0.231 ± 0.019
0.586CysGly: 0.586 ± 0.028
0.2CysHis: 0.2 ± 0.016
0.386CysIle: 0.386 ± 0.022
0.277CysLys: 0.277 ± 0.021
0.483CysLeu: 0.483 ± 0.027
0.141CysMet: 0.141 ± 0.013
0.225CysAsn: 0.225 ± 0.014
0.31CysPro: 0.31 ± 0.02
0.258CysGln: 0.258 ± 0.021
0.232CysArg: 0.232 ± 0.018
0.376CysSer: 0.376 ± 0.02
0.292CysThr: 0.292 ± 0.018
0.348CysVal: 0.348 ± 0.02
0.058CysTrp: 0.058 ± 0.009
0.234CysTyr: 0.234 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.296AspAla: 3.296 ± 0.069
0.327AspCys: 0.327 ± 0.021
3.637AspAsp: 3.637 ± 0.076
5.83AspGlu: 5.83 ± 0.111
2.649AspPhe: 2.649 ± 0.062
3.629AspGly: 3.629 ± 0.079
1.526AspHis: 1.526 ± 0.038
4.7AspIle: 4.7 ± 0.08
2.851AspLys: 2.851 ± 0.057
5.766AspLeu: 5.766 ± 0.083
1.567AspMet: 1.567 ± 0.04
2.073AspAsn: 2.073 ± 0.053
2.228AspPro: 2.228 ± 0.057
3.333AspGln: 3.333 ± 0.073
2.554AspArg: 2.554 ± 0.059
2.837AspSer: 2.837 ± 0.061
2.625AspThr: 2.625 ± 0.067
4.56AspVal: 4.56 ± 0.081
0.702AspTrp: 0.702 ± 0.033
2.612AspTyr: 2.612 ± 0.052
0.0AspXaa: 0.0 ± 0.0
Glu
5.292GluAla: 5.292 ± 0.094
0.279GluCys: 0.279 ± 0.018
4.764GluAsp: 4.764 ± 0.089
7.598GluGlu: 7.598 ± 0.129
2.653GluPhe: 2.653 ± 0.054
4.54GluGly: 4.54 ± 0.079
1.837GluHis: 1.837 ± 0.043
5.458GluIle: 5.458 ± 0.087
5.988GluLys: 5.988 ± 0.09
7.113GluLeu: 7.113 ± 0.094
2.302GluMet: 2.302 ± 0.059
3.958GluAsn: 3.958 ± 0.072
2.309GluPro: 2.309 ± 0.059
4.077GluGln: 4.077 ± 0.092
3.665GluArg: 3.665 ± 0.068
3.982GluSer: 3.982 ± 0.079
3.946GluThr: 3.946 ± 0.07
5.346GluVal: 5.346 ± 0.095
0.95GluTrp: 0.95 ± 0.035
2.468GluTyr: 2.468 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
2.663PheAla: 2.663 ± 0.062
0.289PheCys: 0.289 ± 0.019
2.652PheAsp: 2.652 ± 0.058
3.079PheGlu: 3.079 ± 0.061
2.22PhePhe: 2.22 ± 0.059
3.17PheGly: 3.17 ± 0.079
0.937PheHis: 0.937 ± 0.041
4.073PheIle: 4.073 ± 0.096
2.54PheLys: 2.54 ± 0.061
4.275PheLeu: 4.275 ± 0.093
1.22PheMet: 1.22 ± 0.042
2.174PheAsn: 2.174 ± 0.049
1.585PhePro: 1.585 ± 0.047
1.604PheGln: 1.604 ± 0.043
1.573PheArg: 1.573 ± 0.044
3.051PheSer: 3.051 ± 0.073
2.418PheThr: 2.418 ± 0.058
3.185PheVal: 3.185 ± 0.073
0.479PheTrp: 0.479 ± 0.027
1.792PheTyr: 1.792 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
4.357GlyAla: 4.357 ± 0.085
0.51GlyCys: 0.51 ± 0.028
3.59GlyAsp: 3.59 ± 0.068
4.827GlyGlu: 4.827 ± 0.088
3.312GlyPhe: 3.312 ± 0.077
4.396GlyGly: 4.396 ± 0.104
1.515GlyHis: 1.515 ± 0.043
5.478GlyIle: 5.478 ± 0.094
4.198GlyLys: 4.198 ± 0.076
6.321GlyLeu: 6.321 ± 0.102
2.019GlyMet: 2.019 ± 0.042
2.477GlyAsn: 2.477 ± 0.064
1.763GlyPro: 1.763 ± 0.047
2.629GlyGln: 2.629 ± 0.075
2.523GlyArg: 2.523 ± 0.054
3.839GlySer: 3.839 ± 0.071
3.686GlyThr: 3.686 ± 0.089
4.963GlyVal: 4.963 ± 0.086
0.746GlyTrp: 0.746 ± 0.036
2.891GlyTyr: 2.891 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
1.386HisAla: 1.386 ± 0.044
0.164HisCys: 0.164 ± 0.014
1.414HisAsp: 1.414 ± 0.045
1.637HisGlu: 1.637 ± 0.044
1.079HisPhe: 1.079 ± 0.035
1.426HisGly: 1.426 ± 0.043
0.759HisHis: 0.759 ± 0.031
1.767HisIle: 1.767 ± 0.044
1.067HisLys: 1.067 ± 0.035
2.234HisLeu: 2.234 ± 0.058
0.561HisMet: 0.561 ± 0.025
0.896HisAsn: 0.896 ± 0.033
1.092HisPro: 1.092 ± 0.041
1.124HisGln: 1.124 ± 0.04
0.929HisArg: 0.929 ± 0.033
1.247HisSer: 1.247 ± 0.038
1.068HisThr: 1.068 ± 0.036
1.571HisVal: 1.571 ± 0.049
0.241HisTrp: 0.241 ± 0.015
0.958HisTyr: 0.958 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.571IleAla: 5.571 ± 0.096
0.497IleCys: 0.497 ± 0.026
5.087IleAsp: 5.087 ± 0.081
6.097IleGlu: 6.097 ± 0.085
3.551IlePhe: 3.551 ± 0.08
5.861IleGly: 5.861 ± 0.112
1.743IleHis: 1.743 ± 0.048
6.156IleIle: 6.156 ± 0.111
4.693IleLys: 4.693 ± 0.087
7.08IleLeu: 7.08 ± 0.118
1.92IleMet: 1.92 ± 0.046
3.794IleAsn: 3.794 ± 0.076
3.334IlePro: 3.334 ± 0.065
3.153IleGln: 3.153 ± 0.064
3.072IleArg: 3.072 ± 0.057
4.785IleSer: 4.785 ± 0.089
4.162IleThr: 4.162 ± 0.075
5.59IleVal: 5.59 ± 0.087
0.633IleTrp: 0.633 ± 0.028
2.754IleTyr: 2.754 ± 0.064
0.001IleXaa: 0.001 ± 0.001
Lys
3.839LysAla: 3.839 ± 0.083
0.247LysCys: 0.247 ± 0.019
3.958LysAsp: 3.958 ± 0.072
5.93LysGlu: 5.93 ± 0.102
1.812LysPhe: 1.812 ± 0.047
3.925LysGly: 3.925 ± 0.07
1.644LysHis: 1.644 ± 0.044
4.184LysIle: 4.184 ± 0.064
4.851LysLys: 4.851 ± 0.087
5.221LysLeu: 5.221 ± 0.092
1.952LysMet: 1.952 ± 0.049
3.044LysAsn: 3.044 ± 0.06
2.1LysPro: 2.1 ± 0.055
3.419LysGln: 3.419 ± 0.073
3.329LysArg: 3.329 ± 0.065
3.222LysSer: 3.222 ± 0.06
3.181LysThr: 3.181 ± 0.054
4.247LysVal: 4.247 ± 0.078
0.754LysTrp: 0.754 ± 0.028
1.99LysTyr: 1.99 ± 0.048
0.0LysXaa: 0.0 ± 0.0
Leu
6.342LeuAla: 6.342 ± 0.094
0.524LeuCys: 0.524 ± 0.027
5.555LeuAsp: 5.555 ± 0.101
6.839LeuGlu: 6.839 ± 0.104
4.682LeuPhe: 4.682 ± 0.111
6.194LeuGly: 6.194 ± 0.1
1.801LeuHis: 1.801 ± 0.052
7.789LeuIle: 7.789 ± 0.134
6.324LeuLys: 6.324 ± 0.099
9.372LeuLeu: 9.372 ± 0.144
2.629LeuMet: 2.629 ± 0.055
5.003LeuAsn: 5.003 ± 0.083
3.613LeuPro: 3.613 ± 0.072
3.39LeuGln: 3.39 ± 0.073
3.421LeuArg: 3.421 ± 0.07
6.529LeuSer: 6.529 ± 0.097
5.491LeuThr: 5.491 ± 0.079
6.077LeuVal: 6.077 ± 0.094
0.756LeuTrp: 0.756 ± 0.034
3.187LeuTyr: 3.187 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
1.983MetAla: 1.983 ± 0.046
0.142MetCys: 0.142 ± 0.011
1.712MetAsp: 1.712 ± 0.043
1.836MetGlu: 1.836 ± 0.045
1.185MetPhe: 1.185 ± 0.047
1.764MetGly: 1.764 ± 0.041
0.427MetHis: 0.427 ± 0.02
2.238MetIle: 2.238 ± 0.053
2.232MetLys: 2.232 ± 0.048
2.549MetLeu: 2.549 ± 0.055
0.978MetMet: 0.978 ± 0.036
1.696MetAsn: 1.696 ± 0.046
0.957MetPro: 0.957 ± 0.04
1.008MetGln: 1.008 ± 0.035
1.138MetArg: 1.138 ± 0.038
1.797MetSer: 1.797 ± 0.046
1.804MetThr: 1.804 ± 0.048
1.942MetVal: 1.942 ± 0.053
0.187MetTrp: 0.187 ± 0.016
0.786MetTyr: 0.786 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
2.475AsnAla: 2.475 ± 0.055
0.269AsnCys: 0.269 ± 0.017
2.832AsnAsp: 2.832 ± 0.067
4.17AsnGlu: 4.17 ± 0.078
1.719AsnPhe: 1.719 ± 0.044
3.266AsnGly: 3.266 ± 0.08
1.35AsnHis: 1.35 ± 0.041
3.605AsnIle: 3.605 ± 0.067
2.625AsnLys: 2.625 ± 0.059
3.915AsnLeu: 3.915 ± 0.068
1.356AsnMet: 1.356 ± 0.043
2.122AsnAsn: 2.122 ± 0.074
2.142AsnPro: 2.142 ± 0.055
2.876AsnGln: 2.876 ± 0.062
2.331AsnArg: 2.331 ± 0.057
2.16AsnSer: 2.16 ± 0.058
2.202AsnThr: 2.202 ± 0.052
3.199AsnVal: 3.199 ± 0.061
0.539AsnTrp: 0.539 ± 0.028
1.692AsnTyr: 1.692 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
1.756ProAla: 1.756 ± 0.049
0.179ProCys: 0.179 ± 0.015
2.244ProAsp: 2.244 ± 0.053
2.991ProGlu: 2.991 ± 0.056
1.879ProPhe: 1.879 ± 0.051
2.216ProGly: 2.216 ± 0.057
0.79ProHis: 0.79 ± 0.035
3.055ProIle: 3.055 ± 0.066
2.192ProLys: 2.192 ± 0.048
3.233ProLeu: 3.233 ± 0.054
0.816ProMet: 0.816 ± 0.03
1.99ProAsn: 1.99 ± 0.057
0.942ProPro: 0.942 ± 0.038
1.151ProGln: 1.151 ± 0.039
1.075ProArg: 1.075 ± 0.041
2.17ProSer: 2.17 ± 0.045
1.954ProThr: 1.954 ± 0.048
2.658ProVal: 2.658 ± 0.06
0.374ProTrp: 0.374 ± 0.024
1.526ProTyr: 1.526 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
3.079GlnAla: 3.079 ± 0.066
0.153GlnCys: 0.153 ± 0.016
2.435GlnAsp: 2.435 ± 0.057
3.373GlnGlu: 3.373 ± 0.066
1.864GlnPhe: 1.864 ± 0.048
2.397GlnGly: 2.397 ± 0.058
0.995GlnHis: 0.995 ± 0.035
3.079GlnIle: 3.079 ± 0.062
2.752GlnLys: 2.752 ± 0.063
4.734GlnLeu: 4.734 ± 0.098
1.31GlnMet: 1.31 ± 0.038
2.003GlnAsn: 2.003 ± 0.051
1.403GlnPro: 1.403 ± 0.046
2.171GlnGln: 2.171 ± 0.075
1.653GlnArg: 1.653 ± 0.043
2.723GlnSer: 2.723 ± 0.059
2.271GlnThr: 2.271 ± 0.055
2.81GlnVal: 2.81 ± 0.06
0.472GlnTrp: 0.472 ± 0.023
1.511GlnTyr: 1.511 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
2.282ArgAla: 2.282 ± 0.054
0.234ArgCys: 0.234 ± 0.018
2.419ArgAsp: 2.419 ± 0.056
3.205ArgGlu: 3.205 ± 0.061
1.853ArgPhe: 1.853 ± 0.046
2.394ArgGly: 2.394 ± 0.052
0.897ArgHis: 0.897 ± 0.034
3.102ArgIle: 3.102 ± 0.061
2.914ArgLys: 2.914 ± 0.07
4.094ArgLeu: 4.094 ± 0.076
1.243ArgMet: 1.243 ± 0.039
1.823ArgAsn: 1.823 ± 0.043
1.256ArgPro: 1.256 ± 0.043
1.855ArgGln: 1.855 ± 0.046
1.868ArgArg: 1.868 ± 0.049
2.171ArgSer: 2.171 ± 0.052
1.937ArgThr: 1.937 ± 0.045
2.773ArgVal: 2.773 ± 0.047
0.36ArgTrp: 0.36 ± 0.019
1.59ArgTyr: 1.59 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
3.267SerAla: 3.267 ± 0.073
0.308SerCys: 0.308 ± 0.018
3.219SerAsp: 3.219 ± 0.064
4.162SerGlu: 4.162 ± 0.084
3.07SerPhe: 3.07 ± 0.065
4.242SerGly: 4.242 ± 0.08
1.331SerHis: 1.331 ± 0.038
5.139SerIle: 5.139 ± 0.085
3.496SerLys: 3.496 ± 0.054
5.817SerLeu: 5.817 ± 0.088
1.799SerMet: 1.799 ± 0.052
2.701SerAsn: 2.701 ± 0.058
1.966SerPro: 1.966 ± 0.048
2.316SerGln: 2.316 ± 0.056
2.18SerArg: 2.18 ± 0.054
3.741SerSer: 3.741 ± 0.08
2.948SerThr: 2.948 ± 0.059
4.087SerVal: 4.087 ± 0.075
0.543SerTrp: 0.543 ± 0.027
2.268SerTyr: 2.268 ± 0.05
0.0SerXaa: 0.0 ± 0.0
Thr
3.356ThrAla: 3.356 ± 0.063
0.335ThrCys: 0.335 ± 0.019
2.968ThrAsp: 2.968 ± 0.063
3.612ThrGlu: 3.612 ± 0.072
2.618ThrPhe: 2.618 ± 0.064
3.809ThrGly: 3.809 ± 0.066
1.079ThrHis: 1.079 ± 0.035
4.55ThrIle: 4.55 ± 0.076
2.902ThrLys: 2.902 ± 0.064
5.144ThrLeu: 5.144 ± 0.072
1.321ThrMet: 1.321 ± 0.039
2.543ThrAsn: 2.543 ± 0.054
2.096ThrPro: 2.096 ± 0.055
1.654ThrGln: 1.654 ± 0.045
1.708ThrArg: 1.708 ± 0.045
3.212ThrSer: 3.212 ± 0.061
2.944ThrThr: 2.944 ± 0.059
4.022ThrVal: 4.022 ± 0.076
0.519ThrTrp: 0.519 ± 0.026
2.106ThrTyr: 2.106 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
4.582ValAla: 4.582 ± 0.079
0.483ValCys: 0.483 ± 0.021
4.312ValAsp: 4.312 ± 0.08
5.176ValGlu: 5.176 ± 0.084
3.011ValPhe: 3.011 ± 0.071
4.699ValGly: 4.699 ± 0.08
1.376ValHis: 1.376 ± 0.043
5.73ValIle: 5.73 ± 0.099
4.375ValLys: 4.375 ± 0.069
6.657ValLeu: 6.657 ± 0.081
2.054ValMet: 2.054 ± 0.054
3.444ValAsn: 3.444 ± 0.073
2.536ValPro: 2.536 ± 0.062
2.625ValGln: 2.625 ± 0.055
2.626ValArg: 2.626 ± 0.062
4.417ValSer: 4.417 ± 0.08
4.079ValThr: 4.079 ± 0.071
5.15ValVal: 5.15 ± 0.091
0.603ValTrp: 0.603 ± 0.027
2.37ValTyr: 2.37 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.528TrpAla: 0.528 ± 0.028
0.059TrpCys: 0.059 ± 0.009
0.57TrpAsp: 0.57 ± 0.027
0.666TrpGlu: 0.666 ± 0.028
0.587TrpPhe: 0.587 ± 0.027
0.6TrpGly: 0.6 ± 0.024
0.206TrpHis: 0.206 ± 0.019
0.851TrpIle: 0.851 ± 0.032
0.631TrpLys: 0.631 ± 0.028
1.161TrpLeu: 1.161 ± 0.041
0.354TrpMet: 0.354 ± 0.022
0.535TrpAsn: 0.535 ± 0.025
0.258TrpPro: 0.258 ± 0.019
0.366TrpGln: 0.366 ± 0.021
0.364TrpArg: 0.364 ± 0.023
0.576TrpSer: 0.576 ± 0.027
0.486TrpThr: 0.486 ± 0.025
0.696TrpVal: 0.696 ± 0.029
0.134TrpTrp: 0.134 ± 0.014
0.375TrpTyr: 0.375 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.028TyrAla: 2.028 ± 0.056
0.244TyrCys: 0.244 ± 0.017
2.392TyrAsp: 2.392 ± 0.057
2.844TyrGlu: 2.844 ± 0.062
1.85TyrPhe: 1.85 ± 0.05
2.532TyrGly: 2.532 ± 0.059
1.006TyrHis: 1.006 ± 0.04
2.623TyrIle: 2.623 ± 0.057
1.9TyrLys: 1.9 ± 0.049
3.715TyrLeu: 3.715 ± 0.071
0.906TyrMet: 0.906 ± 0.033
1.609TyrAsn: 1.609 ± 0.047
1.465TyrPro: 1.465 ± 0.046
2.041TyrGln: 2.041 ± 0.048
1.676TyrArg: 1.676 ± 0.045
2.028TyrSer: 2.028 ± 0.052
1.73TyrThr: 1.73 ± 0.047
2.384TyrVal: 2.384 ± 0.053
0.392TyrTrp: 0.392 ± 0.021
1.593TyrTyr: 1.593 ± 0.05
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.001XaaLys: 0.001 ± 0.001
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.004XaaXaa: 0.004 ± 0.004
Statistics based on 3018 proteins (845311 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski