Amino acid dipepetide frequency for Thermoplasmatales archaeon A-plasma

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.493AlaAla: 5.493 ± 0.125	0.476AlaCys: 0.476 ± 0.033	3.33AlaAsp: 3.33 ± 0.081	3.953AlaGlu: 3.953 ± 0.101	3.526AlaPhe: 3.526 ± 0.102	6.003AlaGly: 6.003 ± 0.118	1.035AlaHis: 1.035 ± 0.039	5.794AlaIle: 5.794 ± 0.121	2.964AlaLys: 2.964 ± 0.076	6.641AlaLeu: 6.641 ± 0.143	2.643AlaMet: 2.643 ± 0.074	2.149AlaAsn: 2.149 ± 0.068	2.062AlaPro: 2.062 ± 0.059	1.63AlaGln: 1.63 ± 0.051	3.971AlaArg: 3.971 ± 0.088	5.455AlaSer: 5.455 ± 0.1	3.396AlaThr: 3.396 ± 0.086	6.102AlaVal: 6.102 ± 0.131	0.616AlaTrp: 0.616 ± 0.028	2.493AlaTyr: 2.493 ± 0.066	0.002AlaXaa: 0.002 ± 0.002
Cys	0.351CysAla: 0.351 ± 0.023	0.066CysCys: 0.066 ± 0.01	0.395CysAsp: 0.395 ± 0.026	0.32CysGlu: 0.32 ± 0.025	0.238CysPhe: 0.238 ± 0.023	0.749CysGly: 0.749 ± 0.041	0.194CysHis: 0.194 ± 0.019	0.43CysIle: 0.43 ± 0.029	0.247CysLys: 0.247 ± 0.022	0.485CysLeu: 0.485 ± 0.028	0.174CysMet: 0.174 ± 0.018	0.284CysAsn: 0.284 ± 0.025	0.436CysPro: 0.436 ± 0.039	0.18CysGln: 0.18 ± 0.018	0.495CysArg: 0.495 ± 0.033	0.572CysSer: 0.572 ± 0.027	0.362CysThr: 0.362 ± 0.028	0.349CysVal: 0.349 ± 0.025	0.051CysTrp: 0.051 ± 0.009	0.204CysTyr: 0.204 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.439AspAla: 3.439 ± 0.09	0.349AspCys: 0.349 ± 0.027	2.62AspAsp: 2.62 ± 0.072	3.311AspGlu: 3.311 ± 0.094	2.67AspPhe: 2.67 ± 0.073	3.609AspGly: 3.609 ± 0.101	1.106AspHis: 1.106 ± 0.049	4.223AspIle: 4.223 ± 0.099	1.855AspLys: 1.855 ± 0.061	5.743AspLeu: 5.743 ± 0.122	1.586AspMet: 1.586 ± 0.058	1.787AspAsn: 1.787 ± 0.061	2.62AspPro: 2.62 ± 0.076	1.474AspGln: 1.474 ± 0.053	3.294AspArg: 3.294 ± 0.073	3.755AspSer: 3.755 ± 0.09	2.394AspThr: 2.394 ± 0.066	3.732AspVal: 3.732 ± 0.079	0.476AspTrp: 0.476 ± 0.031	2.226AspTyr: 2.226 ± 0.065	0.0AspXaa: 0.0 ± 0.0
Glu	4.296GluAla: 4.296 ± 0.087	0.306GluCys: 0.306 ± 0.026	3.083GluAsp: 3.083 ± 0.088	4.089GluGlu: 4.089 ± 0.102	2.874GluPhe: 2.874 ± 0.078	3.435GluGly: 3.435 ± 0.09	0.961GluHis: 0.961 ± 0.042	5.898GluIle: 5.898 ± 0.125	4.902GluLys: 4.902 ± 0.118	4.885GluLeu: 4.885 ± 0.103	1.986GluMet: 1.986 ± 0.066	3.196GluAsn: 3.196 ± 0.062	1.85GluPro: 1.85 ± 0.067	1.281GluGln: 1.281 ± 0.046	3.241GluArg: 3.241 ± 0.075	4.244GluSer: 4.244 ± 0.094	3.241GluThr: 3.241 ± 0.088	3.779GluVal: 3.779 ± 0.092	0.565GluTrp: 0.565 ± 0.03	2.37GluTyr: 2.37 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	3.202PheAla: 3.202 ± 0.088	0.325PheCys: 0.325 ± 0.024	2.02PheAsp: 2.02 ± 0.059	1.86PheGlu: 1.86 ± 0.055	2.266PhePhe: 2.266 ± 0.077	3.299PheGly: 3.299 ± 0.082	1.019PheHis: 1.019 ± 0.046	3.56PheIle: 3.56 ± 0.099	1.656PheLys: 1.656 ± 0.057	4.994PheLeu: 4.994 ± 0.102	1.361PheMet: 1.361 ± 0.042	2.013PheAsn: 2.013 ± 0.072	2.11PhePro: 2.11 ± 0.059	1.407PheGln: 1.407 ± 0.049	2.854PheArg: 2.854 ± 0.08	4.484PheSer: 4.484 ± 0.092	2.663PheThr: 2.663 ± 0.069	3.034PheVal: 3.034 ± 0.085	0.42PheTrp: 0.42 ± 0.027	1.872PheTyr: 1.872 ± 0.061	0.003PheXaa: 0.003 ± 0.003
Gly	4.562GlyAla: 4.562 ± 0.097	0.465GlyCys: 0.465 ± 0.032	3.459GlyAsp: 3.459 ± 0.087	3.919GlyGlu: 3.919 ± 0.095	3.772GlyPhe: 3.772 ± 0.083	5.057GlyGly: 5.057 ± 0.109	1.4GlyHis: 1.4 ± 0.052	7.62GlyIle: 7.62 ± 0.125	5.334GlyLys: 5.334 ± 0.093	6.258GlyLeu: 6.258 ± 0.116	2.595GlyMet: 2.595 ± 0.073	3.689GlyAsn: 3.689 ± 0.102	2.226GlyPro: 2.226 ± 0.062	1.853GlyGln: 1.853 ± 0.057	3.97GlyArg: 3.97 ± 0.1	6.144GlySer: 6.144 ± 0.124	4.645GlyThr: 4.645 ± 0.101	4.838GlyVal: 4.838 ± 0.095	0.781GlyTrp: 0.781 ± 0.037	3.277GlyTyr: 3.277 ± 0.088	0.0GlyXaa: 0.0 ± 0.0
His	1.072HisAla: 1.072 ± 0.044	0.165HisCys: 0.165 ± 0.018	0.982HisAsp: 0.982 ± 0.039	0.992HisGlu: 0.992 ± 0.041	0.824HisPhe: 0.824 ± 0.035	1.598HisGly: 1.598 ± 0.049	0.386HisHis: 0.386 ± 0.029	1.356HisIle: 1.356 ± 0.043	0.633HisLys: 0.633 ± 0.04	1.605HisLeu: 1.605 ± 0.05	0.626HisMet: 0.626 ± 0.027	0.761HisAsn: 0.761 ± 0.033	0.997HisPro: 0.997 ± 0.038	0.408HisGln: 0.408 ± 0.028	1.104HisArg: 1.104 ± 0.04	1.334HisSer: 1.334 ± 0.049	0.966HisThr: 0.966 ± 0.038	1.251HisVal: 1.251 ± 0.054	0.175HisTrp: 0.175 ± 0.017	0.713HisTyr: 0.713 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.041IleAla: 6.041 ± 0.114	0.531IleCys: 0.531 ± 0.032	4.053IleAsp: 4.053 ± 0.093	4.196IleGlu: 4.196 ± 0.083	3.89IlePhe: 3.89 ± 0.102	5.554IleGly: 5.554 ± 0.119	1.375IleHis: 1.375 ± 0.047	6.388IleIle: 6.388 ± 0.129	3.701IleLys: 3.701 ± 0.096	7.735IleLeu: 7.735 ± 0.135	2.467IleMet: 2.467 ± 0.058	3.153IleAsn: 3.153 ± 0.07	3.907IlePro: 3.907 ± 0.08	1.914IleGln: 1.914 ± 0.062	4.654IleArg: 4.654 ± 0.105	7.519IleSer: 7.519 ± 0.139	4.492IleThr: 4.492 ± 0.084	5.511IleVal: 5.511 ± 0.107	0.624IleTrp: 0.624 ± 0.034	2.886IleTyr: 2.886 ± 0.074	0.0IleXaa: 0.0 ± 0.0
Lys	3.4LysAla: 3.4 ± 0.073	0.453LysCys: 0.453 ± 0.03	2.961LysAsp: 2.961 ± 0.079	3.863LysGlu: 3.863 ± 0.112	2.273LysPhe: 2.273 ± 0.063	3.42LysGly: 3.42 ± 0.077	0.939LysHis: 0.939 ± 0.037	4.599LysIle: 4.599 ± 0.105	3.65LysLys: 3.65 ± 0.1	4.627LysLeu: 4.627 ± 0.101	1.632LysMet: 1.632 ± 0.054	2.539LysAsn: 2.539 ± 0.073	1.974LysPro: 1.974 ± 0.061	1.244LysGln: 1.244 ± 0.047	2.818LysArg: 2.818 ± 0.07	3.687LysSer: 3.687 ± 0.084	2.677LysThr: 2.677 ± 0.067	3.384LysVal: 3.384 ± 0.081	0.482LysTrp: 0.482 ± 0.028	2.314LysTyr: 2.314 ± 0.066	0.0LysXaa: 0.0 ± 0.0
Leu	6.668LeuAla: 6.668 ± 0.128	0.497LeuCys: 0.497 ± 0.028	4.754LeuAsp: 4.754 ± 0.1	5.476LeuGlu: 5.476 ± 0.118	3.903LeuPhe: 3.903 ± 0.111	6.878LeuGly: 6.878 ± 0.126	1.591LeuHis: 1.591 ± 0.059	6.389LeuIle: 6.389 ± 0.126	5.576LeuLys: 5.576 ± 0.104	7.887LeuLeu: 7.887 ± 0.159	2.801LeuMet: 2.801 ± 0.064	3.898LeuAsn: 3.898 ± 0.084	3.878LeuPro: 3.878 ± 0.077	2.443LeuGln: 2.443 ± 0.056	4.996LeuArg: 4.996 ± 0.098	8.079LeuSer: 8.079 ± 0.126	4.528LeuThr: 4.528 ± 0.095	6.241LeuVal: 6.241 ± 0.114	0.847LeuTrp: 0.847 ± 0.043	3.18LeuTyr: 3.18 ± 0.073	0.002LeuXaa: 0.002 ± 0.002
Met	2.626MetAla: 2.626 ± 0.07	0.172MetCys: 0.172 ± 0.016	2.095MetAsp: 2.095 ± 0.068	2.403MetGlu: 2.403 ± 0.066	1.111MetPhe: 1.111 ± 0.045	2.522MetGly: 2.522 ± 0.076	0.541MetHis: 0.541 ± 0.029	2.304MetIle: 2.304 ± 0.07	2.277MetLys: 2.277 ± 0.064	2.488MetLeu: 2.488 ± 0.065	0.858MetMet: 0.858 ± 0.041	1.497MetAsn: 1.497 ± 0.044	1.3MetPro: 1.3 ± 0.05	0.827MetGln: 0.827 ± 0.039	1.559MetArg: 1.559 ± 0.053	2.125MetSer: 2.125 ± 0.063	1.542MetThr: 1.542 ± 0.051	2.246MetVal: 2.246 ± 0.065	0.223MetTrp: 0.223 ± 0.021	0.824MetTyr: 0.824 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	2.855AsnAla: 2.855 ± 0.082	0.316AsnCys: 0.316 ± 0.022	1.945AsnAsp: 1.945 ± 0.058	2.091AsnGlu: 2.091 ± 0.071	2.037AsnPhe: 2.037 ± 0.067	3.563AsnGly: 3.563 ± 0.1	0.721AsnHis: 0.721 ± 0.04	3.412AsnIle: 3.412 ± 0.086	1.411AsnLys: 1.411 ± 0.057	4.123AsnLeu: 4.123 ± 0.103	1.229AsnMet: 1.229 ± 0.045	1.513AsnAsn: 1.513 ± 0.072	2.341AsnPro: 2.341 ± 0.063	1.177AsnGln: 1.177 ± 0.047	2.403AsnArg: 2.403 ± 0.059	3.515AsnSer: 3.515 ± 0.099	2.146AsnThr: 2.146 ± 0.069	3.015AsnVal: 3.015 ± 0.079	0.413AsnTrp: 0.413 ± 0.027	1.783AsnTyr: 1.783 ± 0.077	0.0AsnXaa: 0.0 ± 0.0
Pro	2.991ProAla: 2.991 ± 0.087	0.233ProCys: 0.233 ± 0.021	2.91ProAsp: 2.91 ± 0.08	3.541ProGlu: 3.541 ± 0.084	1.889ProPhe: 1.889 ± 0.064	3.486ProGly: 3.486 ± 0.083	0.72ProHis: 0.72 ± 0.036	2.323ProIle: 2.323 ± 0.061	1.506ProLys: 1.506 ± 0.052	3.553ProLeu: 3.553 ± 0.073	1.186ProMet: 1.186 ± 0.049	1.251ProAsn: 1.251 ± 0.053	1.47ProPro: 1.47 ± 0.051	1.053ProGln: 1.053 ± 0.044	1.717ProArg: 1.717 ± 0.057	3.063ProSer: 3.063 ± 0.074	1.863ProThr: 1.863 ± 0.059	3.74ProVal: 3.74 ± 0.087	0.453ProTrp: 0.453 ± 0.029	1.644ProTyr: 1.644 ± 0.053	0.0ProXaa: 0.0 ± 0.0
Gln	1.679GlnAla: 1.679 ± 0.05	0.175GlnCys: 0.175 ± 0.02	1.39GlnAsp: 1.39 ± 0.05	1.887GlnGlu: 1.887 ± 0.065	1.07GlnPhe: 1.07 ± 0.048	1.899GlnGly: 1.899 ± 0.056	0.424GlnHis: 0.424 ± 0.029	2.057GlnIle: 2.057 ± 0.059	1.758GlnLys: 1.758 ± 0.057	1.95GlnLeu: 1.95 ± 0.059	0.905GlnMet: 0.905 ± 0.037	1.223GlnAsn: 1.223 ± 0.047	0.841GlnPro: 0.841 ± 0.035	0.745GlnGln: 0.745 ± 0.041	1.337GlnArg: 1.337 ± 0.054	1.659GlnSer: 1.659 ± 0.061	1.126GlnThr: 1.126 ± 0.04	1.679GlnVal: 1.679 ± 0.057	0.31GlnTrp: 0.31 ± 0.023	1.101GlnTyr: 1.101 ± 0.056	0.0GlnXaa: 0.0 ± 0.0
Arg	3.025ArgAla: 3.025 ± 0.074	0.374ArgCys: 0.374 ± 0.03	3.396ArgAsp: 3.396 ± 0.09	4.382ArgGlu: 4.382 ± 0.105	2.273ArgPhe: 2.273 ± 0.069	3.483ArgGly: 3.483 ± 0.082	0.96ArgHis: 0.96 ± 0.038	5.372ArgIle: 5.372 ± 0.106	4.657ArgLys: 4.657 ± 0.091	4.23ArgLeu: 4.23 ± 0.094	1.795ArgMet: 1.795 ± 0.054	3.063ArgAsn: 3.063 ± 0.076	1.688ArgPro: 1.688 ± 0.061	1.32ArgGln: 1.32 ± 0.046	3.08ArgArg: 3.08 ± 0.084	3.939ArgSer: 3.939 ± 0.092	2.695ArgThr: 2.695 ± 0.066	3.287ArgVal: 3.287 ± 0.084	0.49ArgTrp: 0.49 ± 0.031	2.171ArgTyr: 2.171 ± 0.068	0.0ArgXaa: 0.0 ± 0.0
Ser	5.661SerAla: 5.661 ± 0.115	0.483SerCys: 0.483 ± 0.034	4.022SerAsp: 4.022 ± 0.094	4.41SerGlu: 4.41 ± 0.098	3.612SerPhe: 3.612 ± 0.083	7.608SerGly: 7.608 ± 0.157	1.428SerHis: 1.428 ± 0.045	6.066SerIle: 6.066 ± 0.102	3.294SerLys: 3.294 ± 0.08	7.56SerLeu: 7.56 ± 0.119	2.692SerMet: 2.692 ± 0.075	2.871SerAsn: 2.871 ± 0.091	3.053SerPro: 3.053 ± 0.074	2.205SerGln: 2.205 ± 0.069	5.016SerArg: 5.016 ± 0.099	6.704SerSer: 6.704 ± 0.177	4.131SerThr: 4.131 ± 0.115	5.767SerVal: 5.767 ± 0.121	0.711SerTrp: 0.711 ± 0.029	3.161SerTyr: 3.161 ± 0.089	0.002SerXaa: 0.002 ± 0.002
Thr	4.012ThrAla: 4.012 ± 0.082	0.332ThrCys: 0.332 ± 0.025	2.721ThrAsp: 2.721 ± 0.075	2.974ThrGlu: 2.974 ± 0.072	2.428ThrPhe: 2.428 ± 0.083	5.329ThrGly: 5.329 ± 0.107	0.912ThrHis: 0.912 ± 0.033	3.837ThrIle: 3.837 ± 0.082	1.885ThrLys: 1.885 ± 0.058	4.613ThrLeu: 4.613 ± 0.094	1.559ThrMet: 1.559 ± 0.054	1.79ThrAsn: 1.79 ± 0.076	2.38ThrPro: 2.38 ± 0.063	1.191ThrGln: 1.191 ± 0.046	2.571ThrArg: 2.571 ± 0.078	3.82ThrSer: 3.82 ± 0.094	2.612ThrThr: 2.612 ± 0.087	4.545ThrVal: 4.545 ± 0.108	0.522ThrTrp: 0.522 ± 0.03	2.018ThrTyr: 2.018 ± 0.074	0.0ThrXaa: 0.0 ± 0.0
Val	5.242ValAla: 5.242 ± 0.111	0.492ValCys: 0.492 ± 0.036	3.638ValAsp: 3.638 ± 0.095	4.143ValGlu: 4.143 ± 0.079	3.304ValPhe: 3.304 ± 0.09	4.448ValGly: 4.448 ± 0.095	1.232ValHis: 1.232 ± 0.044	5.501ValIle: 5.501 ± 0.099	3.709ValLys: 3.709 ± 0.091	6.352ValLeu: 6.352 ± 0.117	2.169ValMet: 2.169 ± 0.063	3.131ValAsn: 3.131 ± 0.099	3.444ValPro: 3.444 ± 0.081	1.683ValGln: 1.683 ± 0.058	3.779ValArg: 3.779 ± 0.095	6.224ValSer: 6.224 ± 0.108	4.097ValThr: 4.097 ± 0.1	5.156ValVal: 5.156 ± 0.098	0.59ValTrp: 0.59 ± 0.032	2.586ValTyr: 2.586 ± 0.081	0.0ValXaa: 0.0 ± 0.0
Trp	0.613TrpAla: 0.613 ± 0.032	0.058TrpCys: 0.058 ± 0.01	0.454TrpAsp: 0.454 ± 0.029	0.584TrpGlu: 0.584 ± 0.03	0.446TrpPhe: 0.446 ± 0.029	0.619TrpGly: 0.619 ± 0.036	0.216TrpHis: 0.216 ± 0.02	0.824TrpIle: 0.824 ± 0.036	0.737TrpLys: 0.737 ± 0.035	0.829TrpLeu: 0.829 ± 0.038	0.271TrpMet: 0.271 ± 0.022	0.589TrpAsn: 0.589 ± 0.037	0.315TrpPro: 0.315 ± 0.024	0.284TrpGln: 0.284 ± 0.025	0.465TrpArg: 0.465 ± 0.028	0.555TrpSer: 0.555 ± 0.03	0.388TrpThr: 0.388 ± 0.029	0.543TrpVal: 0.543 ± 0.032	0.119TrpTrp: 0.119 ± 0.016	0.386TrpTyr: 0.386 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.505TyrAla: 2.505 ± 0.067	0.313TyrCys: 0.313 ± 0.019	2.04TyrAsp: 2.04 ± 0.065	2.09TyrGlu: 2.09 ± 0.058	2.013TyrPhe: 2.013 ± 0.06	3.304TyrGly: 3.304 ± 0.064	0.788TyrHis: 0.788 ± 0.035	2.639TyrIle: 2.639 ± 0.076	1.181TyrLys: 1.181 ± 0.048	3.956TyrLeu: 3.956 ± 0.088	1.002TyrMet: 1.002 ± 0.041	1.615TyrAsn: 1.615 ± 0.08	1.7TyrPro: 1.7 ± 0.058	0.897TyrGln: 0.897 ± 0.042	2.357TyrArg: 2.357 ± 0.076	3.578TyrSer: 3.578 ± 0.112	2.086TyrThr: 2.086 ± 0.079	2.724TyrVal: 2.724 ± 0.067	0.422TyrTrp: 0.422 ± 0.029	1.683TyrTyr: 1.683 ± 0.071	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.002XaaGlu: 0.002 ± 0.002	0.002XaaPhe: 0.002 ± 0.002	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.002XaaLys: 0.002 ± 0.002	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.002	0.002XaaSer: 0.002 ± 0.002	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2276 proteins (587698 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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