Amino acid dipepetide frequency for Salmonella phage 38

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.994AlaAla: 4.994 ± 0.382
0.672AlaCys: 0.672 ± 0.125
4.255AlaAsp: 4.255 ± 0.377
4.412AlaGlu: 4.412 ± 0.33
2.531AlaPhe: 2.531 ± 0.215
4.21AlaGly: 4.21 ± 0.36
1.389AlaHis: 1.389 ± 0.179
4.345AlaIle: 4.345 ± 0.307
3.852AlaLys: 3.852 ± 0.29
5.084AlaLeu: 5.084 ± 0.334
1.926AlaMet: 1.926 ± 0.196
3.359AlaAsn: 3.359 ± 0.28
2.329AlaPro: 2.329 ± 0.25
2.598AlaGln: 2.598 ± 0.25
3.516AlaArg: 3.516 ± 0.318
4.188AlaSer: 4.188 ± 0.314
4.39AlaThr: 4.39 ± 0.246
4.636AlaVal: 4.636 ± 0.274
0.918AlaTrp: 0.918 ± 0.156
2.396AlaTyr: 2.396 ± 0.269
0.0AlaXaa: 0.0 ± 0.0
Cys
0.739CysAla: 0.739 ± 0.111
0.112CysCys: 0.112 ± 0.049
0.739CysAsp: 0.739 ± 0.148
0.851CysGlu: 0.851 ± 0.139
0.426CysPhe: 0.426 ± 0.09
0.649CysGly: 0.649 ± 0.116
0.426CysHis: 0.426 ± 0.098
0.829CysIle: 0.829 ± 0.124
0.694CysLys: 0.694 ± 0.119
0.694CysLeu: 0.694 ± 0.122
0.403CysMet: 0.403 ± 0.085
0.672CysAsn: 0.672 ± 0.112
0.538CysPro: 0.538 ± 0.098
0.269CysGln: 0.269 ± 0.08
0.538CysArg: 0.538 ± 0.123
0.829CysSer: 0.829 ± 0.151
0.739CysThr: 0.739 ± 0.126
1.03CysVal: 1.03 ± 0.165
0.269CysTrp: 0.269 ± 0.076
0.426CysTyr: 0.426 ± 0.103
0.0CysXaa: 0.0 ± 0.0
Asp
4.412AspAla: 4.412 ± 0.329
0.739AspCys: 0.739 ± 0.139
3.718AspAsp: 3.718 ± 0.277
4.098AspGlu: 4.098 ± 0.3
3.068AspPhe: 3.068 ± 0.269
4.994AspGly: 4.994 ± 0.342
1.008AspHis: 1.008 ± 0.139
4.502AspIle: 4.502 ± 0.316
3.606AspLys: 3.606 ± 0.244
5.935AspLeu: 5.935 ± 0.376
2.105AspMet: 2.105 ± 0.224
3.135AspAsn: 3.135 ± 0.29
2.576AspPro: 2.576 ± 0.243
1.881AspGln: 1.881 ± 0.204
2.217AspArg: 2.217 ± 0.23
3.695AspSer: 3.695 ± 0.255
3.651AspThr: 3.651 ± 0.294
4.3AspVal: 4.3 ± 0.326
1.12AspTrp: 1.12 ± 0.164
3.135AspTyr: 3.135 ± 0.294
0.0AspXaa: 0.0 ± 0.0
Glu
4.031GluAla: 4.031 ± 0.371
0.649GluCys: 0.649 ± 0.128
4.457GluAsp: 4.457 ± 0.331
4.546GluGlu: 4.546 ± 0.413
3.091GluPhe: 3.091 ± 0.278
3.897GluGly: 3.897 ± 0.274
1.209GluHis: 1.209 ± 0.171
4.076GluIle: 4.076 ± 0.309
3.404GluLys: 3.404 ± 0.308
6.271GluLeu: 6.271 ± 0.361
2.128GluMet: 2.128 ± 0.208
3.225GluAsn: 3.225 ± 0.234
1.724GluPro: 1.724 ± 0.2
2.62GluGln: 2.62 ± 0.251
3.494GluArg: 3.494 ± 0.296
4.076GluSer: 4.076 ± 0.324
3.471GluThr: 3.471 ± 0.286
4.726GluVal: 4.726 ± 0.392
1.008GluTrp: 1.008 ± 0.157
3.091GluTyr: 3.091 ± 0.264
0.0GluXaa: 0.0 ± 0.0
Phe
2.284PheAla: 2.284 ± 0.227
0.403PheCys: 0.403 ± 0.107
2.665PheAsp: 2.665 ± 0.239
3.023PheGlu: 3.023 ± 0.289
1.501PhePhe: 1.501 ± 0.181
3.382PheGly: 3.382 ± 0.281
1.12PheHis: 1.12 ± 0.163
2.441PheIle: 2.441 ± 0.222
2.777PheLys: 2.777 ± 0.266
2.755PheLeu: 2.755 ± 0.228
1.142PheMet: 1.142 ± 0.153
2.643PheAsn: 2.643 ± 0.204
1.501PhePro: 1.501 ± 0.213
1.545PheGln: 1.545 ± 0.17
2.15PheArg: 2.15 ± 0.241
2.688PheSer: 2.688 ± 0.211
2.665PheThr: 2.665 ± 0.228
2.911PheVal: 2.911 ± 0.246
0.649PheTrp: 0.649 ± 0.132
1.501PheTyr: 1.501 ± 0.193
0.0PheXaa: 0.0 ± 0.0
Gly
3.74GlyAla: 3.74 ± 0.342
0.941GlyCys: 0.941 ± 0.141
3.964GlyAsp: 3.964 ± 0.315
4.345GlyGlu: 4.345 ± 0.301
2.844GlyPhe: 2.844 ± 0.261
4.882GlyGly: 4.882 ± 0.454
1.232GlyHis: 1.232 ± 0.169
4.614GlyIle: 4.614 ± 0.316
5.218GlyLys: 5.218 ± 0.345
4.927GlyLeu: 4.927 ± 0.313
2.128GlyMet: 2.128 ± 0.2
3.359GlyAsn: 3.359 ± 0.241
1.187GlyPro: 1.187 ± 0.165
2.329GlyGln: 2.329 ± 0.236
2.822GlyArg: 2.822 ± 0.286
4.658GlySer: 4.658 ± 0.39
3.83GlyThr: 3.83 ± 0.314
4.636GlyVal: 4.636 ± 0.316
1.277GlyTrp: 1.277 ± 0.168
2.844GlyTyr: 2.844 ± 0.249
0.0GlyXaa: 0.0 ± 0.0
His
1.008HisAla: 1.008 ± 0.173
0.291HisCys: 0.291 ± 0.083
1.523HisAsp: 1.523 ± 0.189
0.784HisGlu: 0.784 ± 0.13
0.941HisPhe: 0.941 ± 0.142
1.03HisGly: 1.03 ± 0.172
0.403HisHis: 0.403 ± 0.09
1.411HisIle: 1.411 ± 0.172
1.142HisLys: 1.142 ± 0.161
1.792HisLeu: 1.792 ± 0.215
0.717HisMet: 0.717 ± 0.131
0.672HisAsn: 0.672 ± 0.137
1.008HisPro: 1.008 ± 0.162
0.56HisGln: 0.56 ± 0.12
1.053HisArg: 1.053 ± 0.147
1.187HisSer: 1.187 ± 0.17
1.209HisThr: 1.209 ± 0.165
1.232HisVal: 1.232 ± 0.184
0.269HisTrp: 0.269 ± 0.074
0.851HisTyr: 0.851 ± 0.145
0.0HisXaa: 0.0 ± 0.0
Ile
4.121IleAla: 4.121 ± 0.274
0.806IleCys: 0.806 ± 0.127
4.905IleAsp: 4.905 ± 0.347
4.681IleGlu: 4.681 ± 0.316
1.814IlePhe: 1.814 ± 0.172
3.986IleGly: 3.986 ± 0.313
1.568IleHis: 1.568 ± 0.206
3.807IleIle: 3.807 ± 0.301
3.785IleLys: 3.785 ± 0.272
4.3IleLeu: 4.3 ± 0.339
1.635IleMet: 1.635 ± 0.165
3.382IleAsn: 3.382 ± 0.32
3.068IlePro: 3.068 ± 0.232
2.844IleGln: 2.844 ± 0.247
3.18IleArg: 3.18 ± 0.28
3.807IleSer: 3.807 ± 0.322
4.188IleThr: 4.188 ± 0.332
4.21IleVal: 4.21 ± 0.301
0.761IleTrp: 0.761 ± 0.149
2.016IleTyr: 2.016 ± 0.212
0.0IleXaa: 0.0 ± 0.0
Lys
4.233LysAla: 4.233 ± 0.313
0.627LysCys: 0.627 ± 0.12
3.74LysAsp: 3.74 ± 0.29
4.21LysGlu: 4.21 ± 0.305
2.822LysPhe: 2.822 ± 0.246
4.098LysGly: 4.098 ± 0.262
1.142LysHis: 1.142 ± 0.152
4.031LysIle: 4.031 ± 0.26
4.076LysLys: 4.076 ± 0.372
5.061LysLeu: 5.061 ± 0.324
2.352LysMet: 2.352 ± 0.219
2.598LysAsn: 2.598 ± 0.241
2.934LysPro: 2.934 ± 0.26
2.934LysGln: 2.934 ± 0.243
3.068LysArg: 3.068 ± 0.265
3.942LysSer: 3.942 ± 0.317
4.255LysThr: 4.255 ± 0.282
4.524LysVal: 4.524 ± 0.303
1.008LysTrp: 1.008 ± 0.164
2.15LysTyr: 2.15 ± 0.201
0.0LysXaa: 0.0 ± 0.0
Leu
6.293LeuAla: 6.293 ± 0.383
1.03LeuCys: 1.03 ± 0.15
4.86LeuAsp: 4.86 ± 0.325
5.353LeuGlu: 5.353 ± 0.4
3.404LeuPhe: 3.404 ± 0.277
5.263LeuGly: 5.263 ± 0.281
1.344LeuHis: 1.344 ± 0.192
3.651LeuIle: 3.651 ± 0.311
6.338LeuLys: 6.338 ± 0.435
6.002LeuLeu: 6.002 ± 0.342
2.038LeuMet: 2.038 ± 0.188
4.3LeuAsn: 4.3 ± 0.287
3.404LeuPro: 3.404 ± 0.247
2.911LeuGln: 2.911 ± 0.288
4.098LeuArg: 4.098 ± 0.283
5.42LeuSer: 5.42 ± 0.395
5.151LeuThr: 5.151 ± 0.367
5.599LeuVal: 5.599 ± 0.401
0.896LeuTrp: 0.896 ± 0.139
3.158LeuTyr: 3.158 ± 0.283
0.0LeuXaa: 0.0 ± 0.0
Met
2.576MetAla: 2.576 ± 0.233
0.314MetCys: 0.314 ± 0.084
1.814MetAsp: 1.814 ± 0.193
1.568MetGlu: 1.568 ± 0.19
1.545MetPhe: 1.545 ± 0.22
1.478MetGly: 1.478 ± 0.169
0.515MetHis: 0.515 ± 0.11
1.881MetIle: 1.881 ± 0.2
2.284MetLys: 2.284 ± 0.2
2.62MetLeu: 2.62 ± 0.229
1.209MetMet: 1.209 ± 0.176
1.568MetAsn: 1.568 ± 0.19
1.209MetPro: 1.209 ± 0.171
0.963MetGln: 0.963 ± 0.135
1.836MetArg: 1.836 ± 0.209
2.419MetSer: 2.419 ± 0.21
2.038MetThr: 2.038 ± 0.216
1.747MetVal: 1.747 ± 0.195
0.314MetTrp: 0.314 ± 0.09
1.097MetTyr: 1.097 ± 0.17
0.0MetXaa: 0.0 ± 0.0
Asn
3.807AsnAla: 3.807 ± 0.282
0.649AsnCys: 0.649 ± 0.106
2.822AsnAsp: 2.822 ± 0.213
2.665AsnGlu: 2.665 ± 0.263
1.993AsnPhe: 1.993 ± 0.221
3.986AsnGly: 3.986 ± 0.344
1.075AsnHis: 1.075 ± 0.189
3.359AsnIle: 3.359 ± 0.295
3.135AsnLys: 3.135 ± 0.255
3.83AsnLeu: 3.83 ± 0.357
1.792AsnMet: 1.792 ± 0.188
3.001AsnAsn: 3.001 ± 0.355
2.508AsnPro: 2.508 ± 0.224
2.15AsnGln: 2.15 ± 0.218
2.531AsnArg: 2.531 ± 0.235
2.956AsnSer: 2.956 ± 0.279
3.023AsnThr: 3.023 ± 0.317
3.763AsnVal: 3.763 ± 0.3
0.851AsnTrp: 0.851 ± 0.139
1.724AsnTyr: 1.724 ± 0.183
0.0AsnXaa: 0.0 ± 0.0
Pro
2.352ProAla: 2.352 ± 0.239
0.493ProCys: 0.493 ± 0.107
2.844ProAsp: 2.844 ± 0.286
3.337ProGlu: 3.337 ± 0.25
1.635ProPhe: 1.635 ± 0.194
2.352ProGly: 2.352 ± 0.221
0.582ProHis: 0.582 ± 0.115
2.24ProIle: 2.24 ± 0.213
2.307ProLys: 2.307 ± 0.217
3.471ProLeu: 3.471 ± 0.281
0.918ProMet: 0.918 ± 0.122
1.948ProAsn: 1.948 ± 0.199
1.12ProPro: 1.12 ± 0.169
1.299ProGln: 1.299 ± 0.17
1.657ProArg: 1.657 ± 0.178
2.598ProSer: 2.598 ± 0.255
2.464ProThr: 2.464 ± 0.246
2.867ProVal: 2.867 ± 0.227
0.605ProTrp: 0.605 ± 0.112
1.411ProTyr: 1.411 ± 0.193
0.0ProXaa: 0.0 ± 0.0
Gln
2.777GlnAla: 2.777 ± 0.231
0.403GlnCys: 0.403 ± 0.099
2.128GlnAsp: 2.128 ± 0.251
2.531GlnGlu: 2.531 ± 0.237
1.881GlnPhe: 1.881 ± 0.23
2.307GlnGly: 2.307 ± 0.219
0.963GlnHis: 0.963 ± 0.158
2.576GlnIle: 2.576 ± 0.194
2.128GlnLys: 2.128 ± 0.2
3.001GlnLeu: 3.001 ± 0.255
1.142GlnMet: 1.142 ± 0.144
1.635GlnAsn: 1.635 ± 0.187
1.12GlnPro: 1.12 ± 0.153
1.971GlnGln: 1.971 ± 0.217
2.329GlnArg: 2.329 ± 0.229
2.329GlnSer: 2.329 ± 0.228
2.195GlnThr: 2.195 ± 0.214
2.464GlnVal: 2.464 ± 0.226
0.56GlnTrp: 0.56 ± 0.124
1.433GlnTyr: 1.433 ± 0.185
0.0GlnXaa: 0.0 ± 0.0
Arg
3.091ArgAla: 3.091 ± 0.254
0.851ArgCys: 0.851 ± 0.148
2.979ArgAsp: 2.979 ± 0.263
3.091ArgGlu: 3.091 ± 0.261
2.128ArgPhe: 2.128 ± 0.217
2.598ArgGly: 2.598 ± 0.249
0.963ArgHis: 0.963 ± 0.163
3.359ArgIle: 3.359 ± 0.26
3.18ArgLys: 3.18 ± 0.28
4.838ArgLeu: 4.838 ± 0.401
1.59ArgMet: 1.59 ± 0.187
2.464ArgAsn: 2.464 ± 0.274
1.702ArgPro: 1.702 ± 0.208
2.038ArgGln: 2.038 ± 0.21
3.247ArgArg: 3.247 ± 0.287
3.046ArgSer: 3.046 ± 0.263
2.396ArgThr: 2.396 ± 0.252
3.068ArgVal: 3.068 ± 0.265
0.918ArgTrp: 0.918 ± 0.151
2.195ArgTyr: 2.195 ± 0.203
0.0ArgXaa: 0.0 ± 0.0
Ser
3.695SerAla: 3.695 ± 0.308
0.649SerCys: 0.649 ± 0.134
3.897SerAsp: 3.897 ± 0.265
3.763SerGlu: 3.763 ± 0.273
2.576SerPhe: 2.576 ± 0.219
4.77SerGly: 4.77 ± 0.407
0.873SerHis: 0.873 ± 0.163
4.322SerIle: 4.322 ± 0.33
3.964SerLys: 3.964 ± 0.301
5.554SerLeu: 5.554 ± 0.362
2.284SerMet: 2.284 ± 0.265
3.695SerAsn: 3.695 ± 0.265
2.464SerPro: 2.464 ± 0.225
2.352SerGln: 2.352 ± 0.218
3.113SerArg: 3.113 ± 0.275
4.636SerSer: 4.636 ± 0.391
3.83SerThr: 3.83 ± 0.327
4.86SerVal: 4.86 ± 0.337
0.829SerTrp: 0.829 ± 0.142
2.419SerTyr: 2.419 ± 0.206
0.0SerXaa: 0.0 ± 0.0
Thr
4.031ThrAla: 4.031 ± 0.26
0.493ThrCys: 0.493 ± 0.124
3.471ThrAsp: 3.471 ± 0.253
3.919ThrGlu: 3.919 ± 0.345
2.553ThrPhe: 2.553 ± 0.238
4.322ThrGly: 4.322 ± 0.37
0.985ThrHis: 0.985 ± 0.154
4.278ThrIle: 4.278 ± 0.362
3.852ThrLys: 3.852 ± 0.273
4.636ThrLeu: 4.636 ± 0.297
1.545ThrMet: 1.545 ± 0.234
2.911ThrAsn: 2.911 ± 0.241
3.561ThrPro: 3.561 ± 0.321
2.172ThrGln: 2.172 ± 0.237
3.046ThrArg: 3.046 ± 0.252
4.076ThrSer: 4.076 ± 0.395
3.897ThrThr: 3.897 ± 0.421
4.345ThrVal: 4.345 ± 0.355
0.806ThrTrp: 0.806 ± 0.133
2.016ThrTyr: 2.016 ± 0.232
0.0ThrXaa: 0.0 ± 0.0
Val
4.21ValAla: 4.21 ± 0.291
0.672ValCys: 0.672 ± 0.148
5.129ValAsp: 5.129 ± 0.317
4.614ValGlu: 4.614 ± 0.342
2.643ValPhe: 2.643 ± 0.275
4.39ValGly: 4.39 ± 0.352
1.165ValHis: 1.165 ± 0.147
4.39ValIle: 4.39 ± 0.294
5.173ValLys: 5.173 ± 0.332
5.375ValLeu: 5.375 ± 0.354
2.172ValMet: 2.172 ± 0.224
3.74ValAsn: 3.74 ± 0.286
2.508ValPro: 2.508 ± 0.26
2.576ValGln: 2.576 ± 0.251
2.867ValArg: 2.867 ± 0.242
4.815ValSer: 4.815 ± 0.325
4.726ValThr: 4.726 ± 0.371
6.159ValVal: 6.159 ± 0.473
1.165ValTrp: 1.165 ± 0.17
2.911ValTyr: 2.911 ± 0.271
0.0ValXaa: 0.0 ± 0.0
Trp
1.008TrpAla: 1.008 ± 0.158
0.493TrpCys: 0.493 ± 0.125
1.075TrpAsp: 1.075 ± 0.191
1.165TrpGlu: 1.165 ± 0.164
0.694TrpPhe: 0.694 ± 0.116
0.784TrpGly: 0.784 ± 0.128
0.202TrpHis: 0.202 ± 0.078
0.717TrpIle: 0.717 ± 0.115
0.717TrpLys: 0.717 ± 0.134
1.59TrpLeu: 1.59 ± 0.159
0.605TrpMet: 0.605 ± 0.124
0.694TrpAsn: 0.694 ± 0.127
0.47TrpPro: 0.47 ± 0.129
0.403TrpGln: 0.403 ± 0.083
0.963TrpArg: 0.963 ± 0.166
0.761TrpSer: 0.761 ± 0.129
0.649TrpThr: 0.649 ± 0.127
1.321TrpVal: 1.321 ± 0.17
0.246TrpTrp: 0.246 ± 0.074
0.403TrpTyr: 0.403 ± 0.094
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.598TyrAla: 2.598 ± 0.258
0.582TyrCys: 0.582 ± 0.097
2.911TyrAsp: 2.911 ± 0.22
2.24TyrGlu: 2.24 ± 0.213
1.657TyrPhe: 1.657 ± 0.177
2.396TyrGly: 2.396 ± 0.233
0.918TyrHis: 0.918 ± 0.173
2.038TyrIle: 2.038 ± 0.204
2.172TyrLys: 2.172 ± 0.204
2.777TyrLeu: 2.777 ± 0.256
1.142TyrMet: 1.142 ± 0.159
2.62TyrAsn: 2.62 ± 0.254
1.568TyrPro: 1.568 ± 0.19
1.456TyrGln: 1.456 ± 0.166
2.016TyrArg: 2.016 ± 0.208
2.419TyrSer: 2.419 ± 0.237
2.15TyrThr: 2.15 ± 0.266
3.001TyrVal: 3.001 ± 0.257
0.515TyrTrp: 0.515 ± 0.114
1.523TyrTyr: 1.523 ± 0.205
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 265 proteins (44652 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski