Amino acid dipepetide frequency for Bacillus phage phi105 (Bacteriophage phi-105)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.749AlaAla: 7.749 ± 1.354
0.937AlaCys: 0.937 ± 0.245
4.343AlaAsp: 4.343 ± 0.775
5.279AlaGlu: 5.279 ± 0.896
3.236AlaPhe: 3.236 ± 0.589
4.768AlaGly: 4.768 ± 0.78
0.851AlaHis: 0.851 ± 0.313
4.002AlaIle: 4.002 ± 0.56
5.62AlaLys: 5.62 ± 0.681
8.004AlaLeu: 8.004 ± 1.469
2.129AlaMet: 2.129 ± 0.481
3.917AlaAsn: 3.917 ± 0.783
2.129AlaPro: 2.129 ± 0.408
3.406AlaGln: 3.406 ± 0.576
3.406AlaArg: 3.406 ± 0.614
3.832AlaSer: 3.832 ± 0.763
4.598AlaThr: 4.598 ± 0.522
4.768AlaVal: 4.768 ± 0.516
0.681AlaTrp: 0.681 ± 0.324
2.469AlaTyr: 2.469 ± 0.478
0.0AlaXaa: 0.0 ± 0.0
Cys
0.426CysAla: 0.426 ± 0.179
0.085CysCys: 0.085 ± 0.076
0.255CysAsp: 0.255 ± 0.146
0.851CysGlu: 0.851 ± 0.256
0.255CysPhe: 0.255 ± 0.133
0.341CysGly: 0.341 ± 0.185
0.17CysHis: 0.17 ± 0.131
0.511CysIle: 0.511 ± 0.236
0.341CysLys: 0.341 ± 0.171
0.511CysLeu: 0.511 ± 0.204
0.085CysMet: 0.085 ± 0.11
0.511CysAsn: 0.511 ± 0.205
0.511CysPro: 0.511 ± 0.203
0.255CysGln: 0.255 ± 0.15
0.426CysArg: 0.426 ± 0.179
0.596CysSer: 0.596 ± 0.231
0.341CysThr: 0.341 ± 0.195
0.426CysVal: 0.426 ± 0.174
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.065AspAla: 3.065 ± 0.593
0.426AspCys: 0.426 ± 0.185
3.917AspAsp: 3.917 ± 0.618
4.257AspGlu: 4.257 ± 0.632
2.384AspPhe: 2.384 ± 0.455
5.535AspGly: 5.535 ± 0.85
1.362AspHis: 1.362 ± 0.357
4.428AspIle: 4.428 ± 0.577
4.598AspLys: 4.598 ± 0.542
5.279AspLeu: 5.279 ± 0.644
1.703AspMet: 1.703 ± 0.334
1.788AspAsn: 1.788 ± 0.412
1.873AspPro: 1.873 ± 0.537
2.98AspGln: 2.98 ± 0.503
2.299AspArg: 2.299 ± 0.398
4.002AspSer: 4.002 ± 0.461
3.406AspThr: 3.406 ± 0.442
3.151AspVal: 3.151 ± 0.51
0.596AspTrp: 0.596 ± 0.23
2.81AspTyr: 2.81 ± 0.337
0.0AspXaa: 0.0 ± 0.0
Glu
5.62GluAla: 5.62 ± 0.897
0.0GluCys: 0.0 ± 0.0
3.661GluAsp: 3.661 ± 0.588
7.493GluGlu: 7.493 ± 1.097
2.64GluPhe: 2.64 ± 0.48
5.364GluGly: 5.364 ± 0.738
1.703GluHis: 1.703 ± 0.463
5.364GluIle: 5.364 ± 0.717
7.153GluLys: 7.153 ± 0.915
7.408GluLeu: 7.408 ± 0.728
1.873GluMet: 1.873 ± 0.357
3.661GluAsn: 3.661 ± 0.642
2.469GluPro: 2.469 ± 0.616
3.832GluGln: 3.832 ± 0.523
5.45GluArg: 5.45 ± 0.616
5.364GluSer: 5.364 ± 0.678
4.087GluThr: 4.087 ± 0.631
3.236GluVal: 3.236 ± 0.512
1.277GluTrp: 1.277 ± 0.297
2.895GluTyr: 2.895 ± 0.467
0.0GluXaa: 0.0 ± 0.0
Phe
2.129PheAla: 2.129 ± 0.294
0.0PheCys: 0.0 ± 0.0
1.788PheAsp: 1.788 ± 0.348
4.428PheGlu: 4.428 ± 0.545
1.533PhePhe: 1.533 ± 0.349
2.214PheGly: 2.214 ± 0.422
0.426PheHis: 0.426 ± 0.187
2.469PheIle: 2.469 ± 0.423
3.576PheLys: 3.576 ± 0.365
3.151PheLeu: 3.151 ± 0.538
1.107PheMet: 1.107 ± 0.306
1.958PheAsn: 1.958 ± 0.48
1.362PhePro: 1.362 ± 0.354
0.851PheGln: 0.851 ± 0.315
1.788PheArg: 1.788 ± 0.403
2.554PheSer: 2.554 ± 0.466
3.832PheThr: 3.832 ± 0.63
1.703PheVal: 1.703 ± 0.394
0.341PheTrp: 0.341 ± 0.161
1.618PheTyr: 1.618 ± 0.361
0.0PheXaa: 0.0 ± 0.0
Gly
4.939GlyAla: 4.939 ± 0.807
0.681GlyCys: 0.681 ± 0.228
3.747GlyAsp: 3.747 ± 0.687
4.854GlyGlu: 4.854 ± 0.978
2.554GlyPhe: 2.554 ± 0.449
5.875GlyGly: 5.875 ± 1.023
0.851GlyHis: 0.851 ± 0.267
5.96GlyIle: 5.96 ± 0.606
5.875GlyLys: 5.875 ± 0.73
4.598GlyLeu: 4.598 ± 0.58
1.958GlyMet: 1.958 ± 0.418
4.087GlyAsn: 4.087 ± 0.579
1.703GlyPro: 1.703 ± 0.699
2.64GlyGln: 2.64 ± 0.441
2.299GlyArg: 2.299 ± 0.517
4.513GlySer: 4.513 ± 0.813
3.321GlyThr: 3.321 ± 0.696
3.576GlyVal: 3.576 ± 0.775
0.766GlyTrp: 0.766 ± 0.223
3.151GlyTyr: 3.151 ± 0.5
0.0GlyXaa: 0.0 ± 0.0
His
1.277HisAla: 1.277 ± 0.414
0.341HisCys: 0.341 ± 0.144
1.107HisAsp: 1.107 ± 0.239
1.448HisGlu: 1.448 ± 0.337
0.681HisPhe: 0.681 ± 0.25
1.022HisGly: 1.022 ± 0.237
0.596HisHis: 0.596 ± 0.22
2.129HisIle: 2.129 ± 0.554
1.277HisLys: 1.277 ± 0.274
1.277HisLeu: 1.277 ± 0.351
0.511HisMet: 0.511 ± 0.197
0.596HisAsn: 0.596 ± 0.239
1.362HisPro: 1.362 ± 0.343
0.596HisGln: 0.596 ± 0.227
0.681HisArg: 0.681 ± 0.242
0.851HisSer: 0.851 ± 0.254
0.341HisThr: 0.341 ± 0.186
1.277HisVal: 1.277 ± 0.386
0.341HisTrp: 0.341 ± 0.138
0.766HisTyr: 0.766 ± 0.261
0.0HisXaa: 0.0 ± 0.0
Ile
4.854IleAla: 4.854 ± 0.542
0.511IleCys: 0.511 ± 0.214
4.513IleAsp: 4.513 ± 0.51
5.62IleGlu: 5.62 ± 0.658
1.448IlePhe: 1.448 ± 0.334
3.576IleGly: 3.576 ± 0.612
1.703IleHis: 1.703 ± 0.408
3.576IleIle: 3.576 ± 0.604
5.45IleLys: 5.45 ± 0.833
5.024IleLeu: 5.024 ± 0.758
1.192IleMet: 1.192 ± 0.367
4.002IleAsn: 4.002 ± 0.644
2.64IlePro: 2.64 ± 0.501
1.703IleGln: 1.703 ± 0.37
2.554IleArg: 2.554 ± 0.559
3.661IleSer: 3.661 ± 0.552
4.939IleThr: 4.939 ± 0.959
2.81IleVal: 2.81 ± 0.404
0.511IleTrp: 0.511 ± 0.256
2.044IleTyr: 2.044 ± 0.394
0.0IleXaa: 0.0 ± 0.0
Lys
8.6LysAla: 8.6 ± 0.844
0.341LysCys: 0.341 ± 0.181
5.79LysAsp: 5.79 ± 0.668
7.153LysGlu: 7.153 ± 0.742
2.299LysPhe: 2.299 ± 0.382
5.705LysGly: 5.705 ± 1.226
1.533LysHis: 1.533 ± 0.306
5.024LysIle: 5.024 ± 0.767
9.963LysLys: 9.963 ± 0.93
5.535LysLeu: 5.535 ± 0.821
3.236LysMet: 3.236 ± 0.572
4.768LysAsn: 4.768 ± 0.607
2.81LysPro: 2.81 ± 0.491
4.087LysGln: 4.087 ± 0.692
3.576LysArg: 3.576 ± 0.629
4.428LysSer: 4.428 ± 0.69
5.79LysThr: 5.79 ± 0.728
4.598LysVal: 4.598 ± 0.597
1.192LysTrp: 1.192 ± 0.331
3.321LysTyr: 3.321 ± 0.634
0.0LysXaa: 0.0 ± 0.0
Leu
5.535LeuAla: 5.535 ± 0.765
0.681LeuCys: 0.681 ± 0.263
5.705LeuAsp: 5.705 ± 0.689
5.194LeuGlu: 5.194 ± 0.612
3.576LeuPhe: 3.576 ± 0.541
3.747LeuGly: 3.747 ± 0.673
1.618LeuHis: 1.618 ± 0.454
4.343LeuIle: 4.343 ± 0.484
8.6LeuLys: 8.6 ± 0.813
5.45LeuLeu: 5.45 ± 0.575
2.64LeuMet: 2.64 ± 0.526
4.598LeuAsn: 4.598 ± 0.597
2.469LeuPro: 2.469 ± 0.499
2.895LeuGln: 2.895 ± 0.622
3.661LeuArg: 3.661 ± 0.427
5.194LeuSer: 5.194 ± 0.715
5.024LeuThr: 5.024 ± 0.555
4.172LeuVal: 4.172 ± 0.572
0.426LeuTrp: 0.426 ± 0.165
3.151LeuTyr: 3.151 ± 0.517
0.0LeuXaa: 0.0 ± 0.0
Met
2.469MetAla: 2.469 ± 0.491
0.0MetCys: 0.0 ± 0.0
1.107MetAsp: 1.107 ± 0.266
2.299MetGlu: 2.299 ± 0.494
1.533MetPhe: 1.533 ± 0.386
1.533MetGly: 1.533 ± 0.393
0.341MetHis: 0.341 ± 0.171
1.362MetIle: 1.362 ± 0.409
2.554MetLys: 2.554 ± 0.481
2.129MetLeu: 2.129 ± 0.42
0.681MetMet: 0.681 ± 0.26
0.937MetAsn: 0.937 ± 0.289
1.192MetPro: 1.192 ± 0.269
0.937MetGln: 0.937 ± 0.258
0.851MetArg: 0.851 ± 0.245
1.703MetSer: 1.703 ± 0.49
2.384MetThr: 2.384 ± 0.322
1.192MetVal: 1.192 ± 0.331
0.426MetTrp: 0.426 ± 0.219
0.766MetTyr: 0.766 ± 0.29
0.0MetXaa: 0.0 ± 0.0
Asn
4.172AsnAla: 4.172 ± 0.655
0.511AsnCys: 0.511 ± 0.205
2.725AsnAsp: 2.725 ± 0.471
3.065AsnGlu: 3.065 ± 0.532
2.214AsnPhe: 2.214 ± 0.507
5.194AsnGly: 5.194 ± 0.912
0.937AsnHis: 0.937 ± 0.231
3.236AsnIle: 3.236 ± 0.499
3.832AsnLys: 3.832 ± 0.634
3.661AsnLeu: 3.661 ± 0.522
0.937AsnMet: 0.937 ± 0.334
1.788AsnAsn: 1.788 ± 0.392
2.554AsnPro: 2.554 ± 0.474
1.703AsnGln: 1.703 ± 0.403
1.958AsnArg: 1.958 ± 0.433
3.576AsnSer: 3.576 ± 0.483
2.214AsnThr: 2.214 ± 0.461
2.81AsnVal: 2.81 ± 0.692
0.681AsnTrp: 0.681 ± 0.299
2.044AsnTyr: 2.044 ± 0.405
0.0AsnXaa: 0.0 ± 0.0
Pro
2.554ProAla: 2.554 ± 0.527
0.341ProCys: 0.341 ± 0.207
2.299ProAsp: 2.299 ± 0.541
3.661ProGlu: 3.661 ± 0.71
1.788ProPhe: 1.788 ± 0.421
2.469ProGly: 2.469 ± 0.559
0.681ProHis: 0.681 ± 0.256
1.873ProIle: 1.873 ± 0.459
2.81ProLys: 2.81 ± 0.629
2.214ProLeu: 2.214 ± 0.498
0.681ProMet: 0.681 ± 0.242
1.533ProAsn: 1.533 ± 0.353
0.937ProPro: 0.937 ± 0.281
1.958ProGln: 1.958 ± 0.549
1.277ProArg: 1.277 ± 0.344
2.384ProSer: 2.384 ± 0.475
2.044ProThr: 2.044 ± 0.409
2.214ProVal: 2.214 ± 0.447
0.426ProTrp: 0.426 ± 0.193
1.448ProTyr: 1.448 ± 0.358
0.0ProXaa: 0.0 ± 0.0
Gln
4.002GlnAla: 4.002 ± 0.838
0.426GlnCys: 0.426 ± 0.175
2.129GlnAsp: 2.129 ± 0.413
4.002GlnGlu: 4.002 ± 0.612
1.362GlnPhe: 1.362 ± 0.324
2.299GlnGly: 2.299 ± 0.791
1.022GlnHis: 1.022 ± 0.272
2.129GlnIle: 2.129 ± 0.451
4.172GlnLys: 4.172 ± 0.717
3.491GlnLeu: 3.491 ± 0.73
1.703GlnMet: 1.703 ± 0.435
1.788GlnAsn: 1.788 ± 0.53
1.703GlnPro: 1.703 ± 0.417
2.214GlnGln: 2.214 ± 0.635
1.788GlnArg: 1.788 ± 0.409
1.788GlnSer: 1.788 ± 0.415
1.958GlnThr: 1.958 ± 0.412
1.533GlnVal: 1.533 ± 0.304
0.426GlnTrp: 0.426 ± 0.236
1.362GlnTyr: 1.362 ± 0.297
0.0GlnXaa: 0.0 ± 0.0
Arg
2.895ArgAla: 2.895 ± 0.462
0.341ArgCys: 0.341 ± 0.176
2.129ArgAsp: 2.129 ± 0.448
3.491ArgGlu: 3.491 ± 0.585
1.703ArgPhe: 1.703 ± 0.41
2.044ArgGly: 2.044 ± 0.462
1.107ArgHis: 1.107 ± 0.304
2.299ArgIle: 2.299 ± 0.413
4.939ArgLys: 4.939 ± 0.796
3.491ArgLeu: 3.491 ± 0.476
0.937ArgMet: 0.937 ± 0.273
2.214ArgAsn: 2.214 ± 0.509
1.277ArgPro: 1.277 ± 0.37
2.98ArgGln: 2.98 ± 0.544
2.299ArgArg: 2.299 ± 0.5
3.065ArgSer: 3.065 ± 0.474
1.958ArgThr: 1.958 ± 0.434
2.384ArgVal: 2.384 ± 0.422
0.766ArgTrp: 0.766 ± 0.216
2.044ArgTyr: 2.044 ± 0.459
0.0ArgXaa: 0.0 ± 0.0
Ser
4.939SerAla: 4.939 ± 0.835
0.085SerCys: 0.085 ± 0.084
3.661SerAsp: 3.661 ± 0.443
4.002SerGlu: 4.002 ± 0.601
2.895SerPhe: 2.895 ± 0.517
4.598SerGly: 4.598 ± 0.675
1.022SerHis: 1.022 ± 0.255
4.002SerIle: 4.002 ± 0.53
5.364SerLys: 5.364 ± 0.64
5.45SerLeu: 5.45 ± 0.672
1.958SerMet: 1.958 ± 0.404
3.321SerAsn: 3.321 ± 0.524
2.64SerPro: 2.64 ± 0.398
2.129SerGln: 2.129 ± 0.387
2.469SerArg: 2.469 ± 0.509
4.002SerSer: 4.002 ± 0.647
3.236SerThr: 3.236 ± 0.5
3.917SerVal: 3.917 ± 0.637
0.511SerTrp: 0.511 ± 0.24
2.129SerTyr: 2.129 ± 0.4
0.0SerXaa: 0.0 ± 0.0
Thr
5.109ThrAla: 5.109 ± 0.758
0.426ThrCys: 0.426 ± 0.18
4.087ThrAsp: 4.087 ± 0.62
5.194ThrGlu: 5.194 ± 0.725
2.554ThrPhe: 2.554 ± 0.523
5.279ThrGly: 5.279 ± 0.757
0.681ThrHis: 0.681 ± 0.248
3.236ThrIle: 3.236 ± 0.602
4.428ThrLys: 4.428 ± 0.532
3.747ThrLeu: 3.747 ± 0.595
0.426ThrMet: 0.426 ± 0.175
2.81ThrAsn: 2.81 ± 0.639
2.554ThrPro: 2.554 ± 0.368
1.958ThrGln: 1.958 ± 0.501
1.788ThrArg: 1.788 ± 0.39
3.832ThrSer: 3.832 ± 0.839
2.129ThrThr: 2.129 ± 0.478
4.428ThrVal: 4.428 ± 0.655
0.681ThrTrp: 0.681 ± 0.247
2.129ThrTyr: 2.129 ± 0.406
0.0ThrXaa: 0.0 ± 0.0
Val
2.725ValAla: 2.725 ± 0.487
0.255ValCys: 0.255 ± 0.169
3.661ValAsp: 3.661 ± 0.623
4.683ValGlu: 4.683 ± 0.533
1.873ValPhe: 1.873 ± 0.369
2.895ValGly: 2.895 ± 0.56
0.937ValHis: 0.937 ± 0.243
3.236ValIle: 3.236 ± 0.617
4.854ValLys: 4.854 ± 0.609
4.683ValLeu: 4.683 ± 0.666
1.533ValMet: 1.533 ± 0.419
2.299ValAsn: 2.299 ± 0.436
2.384ValPro: 2.384 ± 0.551
1.873ValGln: 1.873 ± 0.366
3.236ValArg: 3.236 ± 0.563
3.151ValSer: 3.151 ± 0.416
3.236ValThr: 3.236 ± 0.582
3.576ValVal: 3.576 ± 0.682
0.341ValTrp: 0.341 ± 0.16
2.64ValTyr: 2.64 ± 0.407
0.0ValXaa: 0.0 ± 0.0
Trp
1.022TrpAla: 1.022 ± 0.242
0.085TrpCys: 0.085 ± 0.072
0.681TrpAsp: 0.681 ± 0.221
0.596TrpGlu: 0.596 ± 0.203
0.511TrpPhe: 0.511 ± 0.217
1.022TrpGly: 1.022 ± 0.334
0.426TrpHis: 0.426 ± 0.222
0.426TrpIle: 0.426 ± 0.155
0.681TrpLys: 0.681 ± 0.275
0.511TrpLeu: 0.511 ± 0.209
0.255TrpMet: 0.255 ± 0.233
1.022TrpAsn: 1.022 ± 0.342
0.085TrpPro: 0.085 ± 0.084
0.341TrpGln: 0.341 ± 0.188
0.937TrpArg: 0.937 ± 0.295
1.022TrpSer: 1.022 ± 0.29
0.341TrpThr: 0.341 ± 0.152
0.426TrpVal: 0.426 ± 0.209
0.0TrpTrp: 0.0 ± 0.0
0.255TrpTyr: 0.255 ± 0.124
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.044TyrAla: 2.044 ± 0.589
0.426TyrCys: 0.426 ± 0.21
2.554TyrAsp: 2.554 ± 0.461
2.98TyrGlu: 2.98 ± 0.616
1.788TyrPhe: 1.788 ± 0.438
2.469TyrGly: 2.469 ± 0.467
0.511TyrHis: 0.511 ± 0.187
2.725TyrIle: 2.725 ± 0.431
3.661TyrLys: 3.661 ± 0.6
3.065TyrLeu: 3.065 ± 0.568
0.851TyrMet: 0.851 ± 0.299
2.214TyrAsn: 2.214 ± 0.474
0.937TyrPro: 0.937 ± 0.323
1.958TyrGln: 1.958 ± 0.369
1.618TyrArg: 1.618 ± 0.467
2.81TyrSer: 2.81 ± 0.513
2.299TyrThr: 2.299 ± 0.454
1.873TyrVal: 1.873 ± 0.436
0.255TyrTrp: 0.255 ± 0.162
1.533TyrTyr: 1.533 ± 0.561
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 51 proteins (11745 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski