Amino acid dipepetide frequency for Sphingopyxis indica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.333AlaAla: 21.333 ± 0.244	1.004AlaCys: 1.004 ± 0.031	8.274AlaAsp: 8.274 ± 0.085	8.08AlaGlu: 8.08 ± 0.103	4.376AlaPhe: 4.376 ± 0.062	12.294AlaGly: 12.294 ± 0.13	2.43AlaHis: 2.43 ± 0.05	6.924AlaIle: 6.924 ± 0.078	4.378AlaLys: 4.378 ± 0.074	14.29AlaLeu: 14.29 ± 0.16	4.085AlaMet: 4.085 ± 0.06	3.178AlaAsn: 3.178 ± 0.065	7.043AlaPro: 7.043 ± 0.085	4.157AlaGln: 4.157 ± 0.063	10.148AlaArg: 10.148 ± 0.142	6.897AlaSer: 6.897 ± 0.091	6.618AlaThr: 6.618 ± 0.093	8.63AlaVal: 8.63 ± 0.097	1.84AlaTrp: 1.84 ± 0.041	2.645AlaTyr: 2.645 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.943CysAla: 0.943 ± 0.029	0.098CysCys: 0.098 ± 0.01	0.54CysAsp: 0.54 ± 0.021	0.39CysGlu: 0.39 ± 0.018	0.28CysPhe: 0.28 ± 0.016	0.788CysGly: 0.788 ± 0.024	0.202CysHis: 0.202 ± 0.018	0.335CysIle: 0.335 ± 0.018	0.151CysLys: 0.151 ± 0.011	0.681CysLeu: 0.681 ± 0.023	0.126CysMet: 0.126 ± 0.012	0.202CysAsn: 0.202 ± 0.013	0.42CysPro: 0.42 ± 0.019	0.212CysGln: 0.212 ± 0.013	0.575CysArg: 0.575 ± 0.023	0.395CysSer: 0.395 ± 0.017	0.352CysThr: 0.352 ± 0.017	0.483CysVal: 0.483 ± 0.022	0.112CysTrp: 0.112 ± 0.009	0.18CysTyr: 0.18 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.795AspAla: 8.795 ± 0.078	0.447AspCys: 0.447 ± 0.019	3.733AspAsp: 3.733 ± 0.061	3.644AspGlu: 3.644 ± 0.062	2.334AspPhe: 2.334 ± 0.053	5.934AspGly: 5.934 ± 0.098	1.314AspHis: 1.314 ± 0.033	3.082AspIle: 3.082 ± 0.055	1.768AspLys: 1.768 ± 0.039	5.746AspLeu: 5.746 ± 0.078	1.452AspMet: 1.452 ± 0.038	1.413AspAsn: 1.413 ± 0.037	3.99AspPro: 3.99 ± 0.061	1.689AspGln: 1.689 ± 0.036	5.119AspArg: 5.119 ± 0.073	2.457AspSer: 2.457 ± 0.05	2.585AspThr: 2.585 ± 0.053	4.009AspVal: 4.009 ± 0.058	1.214AspTrp: 1.214 ± 0.03	1.79AspTyr: 1.79 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	8.382GluAla: 8.382 ± 0.121	0.324GluCys: 0.324 ± 0.018	2.737GluAsp: 2.737 ± 0.058	3.023GluGlu: 3.023 ± 0.054	1.47GluPhe: 1.47 ± 0.036	4.765GluGly: 4.765 ± 0.061	1.012GluHis: 1.012 ± 0.03	2.963GluIle: 2.963 ± 0.051	1.901GluLys: 1.901 ± 0.042	5.114GluLeu: 5.114 ± 0.069	1.413GluMet: 1.413 ± 0.04	1.299GluAsn: 1.299 ± 0.035	2.689GluPro: 2.689 ± 0.049	1.858GluGln: 1.858 ± 0.041	5.076GluArg: 5.076 ± 0.07	2.345GluSer: 2.345 ± 0.047	3.126GluThr: 3.126 ± 0.051	3.582GluVal: 3.582 ± 0.058	0.806GluTrp: 0.806 ± 0.025	1.023GluTyr: 1.023 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	5.138PheAla: 5.138 ± 0.072	0.294PheCys: 0.294 ± 0.017	2.819PheAsp: 2.819 ± 0.046	2.065PheGlu: 2.065 ± 0.04	1.29PhePhe: 1.29 ± 0.036	3.668PheGly: 3.668 ± 0.06	0.69PheHis: 0.69 ± 0.022	1.393PheIle: 1.393 ± 0.038	0.801PheLys: 0.801 ± 0.027	3.113PheLeu: 3.113 ± 0.057	0.701PheMet: 0.701 ± 0.025	0.943PheAsn: 0.943 ± 0.035	1.567PhePro: 1.567 ± 0.036	0.884PheGln: 0.884 ± 0.027	2.293PheArg: 2.293 ± 0.045	1.889PheSer: 1.889 ± 0.042	1.915PheThr: 1.915 ± 0.043	2.579PheVal: 2.579 ± 0.05	0.52PheTrp: 0.52 ± 0.021	0.877PheTyr: 0.877 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.703GlyAla: 10.703 ± 0.116	0.779GlyCys: 0.779 ± 0.028	5.506GlyAsp: 5.506 ± 0.092	5.309GlyGlu: 5.309 ± 0.069	3.665GlyPhe: 3.665 ± 0.064	8.561GlyGly: 8.561 ± 0.176	1.832GlyHis: 1.832 ± 0.037	4.443GlyIle: 4.443 ± 0.065	3.251GlyLys: 3.251 ± 0.055	8.504GlyLeu: 8.504 ± 0.103	2.165GlyMet: 2.165 ± 0.044	2.232GlyAsn: 2.232 ± 0.064	3.689GlyPro: 3.689 ± 0.056	2.889GlyGln: 2.889 ± 0.055	6.72GlyArg: 6.72 ± 0.09	4.865GlySer: 4.865 ± 0.107	4.813GlyThr: 4.813 ± 0.109	6.162GlyVal: 6.162 ± 0.081	1.758GlyTrp: 1.758 ± 0.044	2.312GlyTyr: 2.312 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.311HisAla: 2.311 ± 0.041	0.228HisCys: 0.228 ± 0.014	1.248HisAsp: 1.248 ± 0.032	0.95HisGlu: 0.95 ± 0.027	0.831HisPhe: 0.831 ± 0.028	1.952HisGly: 1.952 ± 0.039	0.551HisHis: 0.551 ± 0.022	1.008HisIle: 1.008 ± 0.036	0.44HisLys: 0.44 ± 0.02	1.855HisLeu: 1.855 ± 0.041	0.471HisMet: 0.471 ± 0.022	0.459HisAsn: 0.459 ± 0.019	1.287HisPro: 1.287 ± 0.038	0.48HisGln: 0.48 ± 0.019	1.542HisArg: 1.542 ± 0.035	0.931HisSer: 0.931 ± 0.032	0.585HisThr: 0.585 ± 0.021	1.441HisVal: 1.441 ± 0.033	0.382HisTrp: 0.382 ± 0.018	0.584HisTyr: 0.584 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.944IleAla: 7.944 ± 0.099	0.39IleCys: 0.39 ± 0.019	4.094IleAsp: 4.094 ± 0.054	3.485IleGlu: 3.485 ± 0.05	1.685IlePhe: 1.685 ± 0.038	4.972IleGly: 4.972 ± 0.066	0.859IleHis: 0.859 ± 0.026	1.913IleIle: 1.913 ± 0.044	1.126IleLys: 1.126 ± 0.029	4.084IleLeu: 4.084 ± 0.067	0.809IleMet: 0.809 ± 0.028	1.167IleAsn: 1.167 ± 0.041	2.207IlePro: 2.207 ± 0.046	1.054IleGln: 1.054 ± 0.028	3.257IleArg: 3.257 ± 0.054	2.378IleSer: 2.378 ± 0.051	2.272IleThr: 2.272 ± 0.05	4.185IleVal: 4.185 ± 0.067	0.634IleTrp: 0.634 ± 0.024	1.017IleTyr: 1.017 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.196LysAla: 4.196 ± 0.069	0.138LysCys: 0.138 ± 0.012	1.668LysAsp: 1.668 ± 0.041	1.339LysGlu: 1.339 ± 0.037	0.796LysPhe: 0.796 ± 0.032	2.641LysGly: 2.641 ± 0.05	0.511LysHis: 0.511 ± 0.02	1.392LysIle: 1.392 ± 0.035	1.085LysLys: 1.085 ± 0.037	3.063LysLeu: 3.063 ± 0.054	0.682LysMet: 0.682 ± 0.027	0.673LysAsn: 0.673 ± 0.025	1.887LysPro: 1.887 ± 0.042	0.83LysGln: 0.83 ± 0.024	2.316LysArg: 2.316 ± 0.055	1.551LysSer: 1.551 ± 0.038	1.617LysThr: 1.617 ± 0.038	1.987LysVal: 1.987 ± 0.044	0.412LysTrp: 0.412 ± 0.019	0.609LysTyr: 0.609 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.696LeuAla: 14.696 ± 0.165	0.733LeuCys: 0.733 ± 0.023	6.33LeuAsp: 6.33 ± 0.079	4.391LeuGlu: 4.391 ± 0.068	3.818LeuPhe: 3.818 ± 0.062	8.284LeuGly: 8.284 ± 0.094	1.832LeuHis: 1.832 ± 0.04	4.702LeuIle: 4.702 ± 0.078	2.814LeuLys: 2.814 ± 0.05	9.443LeuLeu: 9.443 ± 0.117	2.048LeuMet: 2.048 ± 0.045	2.244LeuAsn: 2.244 ± 0.048	5.642LeuPro: 5.642 ± 0.078	2.373LeuGln: 2.373 ± 0.05	6.716LeuArg: 6.716 ± 0.087	5.734LeuSer: 5.734 ± 0.074	5.516LeuThr: 5.516 ± 0.084	7.11LeuVal: 7.11 ± 0.093	1.374LeuTrp: 1.374 ± 0.038	2.024LeuTyr: 2.024 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.268MetAla: 3.268 ± 0.065	0.144MetCys: 0.144 ± 0.01	1.046MetAsp: 1.046 ± 0.026	1.064MetGlu: 1.064 ± 0.03	0.648MetPhe: 0.648 ± 0.025	1.78MetGly: 1.78 ± 0.045	0.405MetHis: 0.405 ± 0.017	1.287MetIle: 1.287 ± 0.034	0.9MetLys: 0.9 ± 0.03	2.576MetLeu: 2.576 ± 0.05	0.621MetMet: 0.621 ± 0.024	0.622MetAsn: 0.622 ± 0.023	1.406MetPro: 1.406 ± 0.036	0.707MetGln: 0.707 ± 0.027	1.797MetArg: 1.797 ± 0.035	1.379MetSer: 1.379 ± 0.037	1.841MetThr: 1.841 ± 0.037	1.487MetVal: 1.487 ± 0.036	0.223MetTrp: 0.223 ± 0.015	0.235MetTyr: 0.235 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.054AsnAla: 3.054 ± 0.063	0.235AsnCys: 0.235 ± 0.015	1.426AsnAsp: 1.426 ± 0.037	1.143AsnGlu: 1.143 ± 0.032	0.965AsnPhe: 0.965 ± 0.034	2.302AsnGly: 2.302 ± 0.059	0.473AsnHis: 0.473 ± 0.019	1.327AsnIle: 1.327 ± 0.033	0.593AsnLys: 0.593 ± 0.024	2.299AsnLeu: 2.299 ± 0.047	0.542AsnMet: 0.542 ± 0.021	0.641AsnAsn: 0.641 ± 0.026	1.727AsnPro: 1.727 ± 0.042	0.725AsnGln: 0.725 ± 0.024	1.862AsnArg: 1.862 ± 0.034	1.232AsnSer: 1.232 ± 0.038	0.93AsnThr: 0.93 ± 0.033	1.697AsnVal: 1.697 ± 0.042	0.438AsnTrp: 0.438 ± 0.021	0.761AsnTyr: 0.761 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	7.834ProAla: 7.834 ± 0.098	0.342ProCys: 0.342 ± 0.019	3.94ProAsp: 3.94 ± 0.055	3.452ProGlu: 3.452 ± 0.059	1.917ProPhe: 1.917 ± 0.037	4.995ProGly: 4.995 ± 0.072	1.011ProHis: 1.011 ± 0.031	2.327ProIle: 2.327 ± 0.047	1.569ProLys: 1.569 ± 0.042	5.112ProLeu: 5.112 ± 0.072	1.158ProMet: 1.158 ± 0.029	1.204ProAsn: 1.204 ± 0.031	3.256ProPro: 3.256 ± 0.119	1.617ProGln: 1.617 ± 0.04	3.204ProArg: 3.204 ± 0.054	2.632ProSer: 2.632 ± 0.046	2.533ProThr: 2.533 ± 0.058	4.434ProVal: 4.434 ± 0.076	0.743ProTrp: 0.743 ± 0.024	1.145ProTyr: 1.145 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.933GlnAla: 3.933 ± 0.064	0.222GlnCys: 0.222 ± 0.014	1.354GlnAsp: 1.354 ± 0.032	1.189GlnGlu: 1.189 ± 0.034	1.038GlnPhe: 1.038 ± 0.028	2.323GlnGly: 2.323 ± 0.048	0.526GlnHis: 0.526 ± 0.022	1.694GlnIle: 1.694 ± 0.04	0.875GlnLys: 0.875 ± 0.032	3.043GlnLeu: 3.043 ± 0.057	0.771GlnMet: 0.771 ± 0.026	0.749GlnAsn: 0.749 ± 0.026	1.741GlnPro: 1.741 ± 0.033	1.133GlnGln: 1.133 ± 0.038	2.422GlnArg: 2.422 ± 0.048	1.662GlnSer: 1.662 ± 0.041	1.45GlnThr: 1.45 ± 0.036	1.961GlnVal: 1.961 ± 0.042	0.446GlnTrp: 0.446 ± 0.018	0.629GlnTyr: 0.629 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	9.219ArgAla: 9.219 ± 0.12	0.513ArgCys: 0.513 ± 0.023	4.494ArgAsp: 4.494 ± 0.074	4.162ArgGlu: 4.162 ± 0.072	3.188ArgPhe: 3.188 ± 0.052	5.314ArgGly: 5.314 ± 0.082	1.813ArgHis: 1.813 ± 0.041	4.314ArgIle: 4.314 ± 0.069	2.11ArgLys: 2.11 ± 0.045	8.309ArgLeu: 8.309 ± 0.101	1.861ArgMet: 1.861 ± 0.042	1.756ArgAsn: 1.756 ± 0.04	3.819ArgPro: 3.819 ± 0.061	2.401ArgGln: 2.401 ± 0.05	6.082ArgArg: 6.082 ± 0.103	3.693ArgSer: 3.693 ± 0.058	3.502ArgThr: 3.502 ± 0.056	4.791ArgVal: 4.791 ± 0.057	1.327ArgTrp: 1.327 ± 0.037	1.901ArgTyr: 1.901 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.341SerAla: 6.341 ± 0.084	0.387SerCys: 0.387 ± 0.017	3.347SerAsp: 3.347 ± 0.058	2.706SerGlu: 2.706 ± 0.05	2.133SerPhe: 2.133 ± 0.046	5.477SerGly: 5.477 ± 0.102	0.941SerHis: 0.941 ± 0.028	2.574SerIle: 2.574 ± 0.051	1.353SerLys: 1.353 ± 0.04	5.02SerLeu: 5.02 ± 0.059	1.096SerMet: 1.096 ± 0.033	1.355SerAsn: 1.355 ± 0.04	2.869SerPro: 2.869 ± 0.056	1.426SerGln: 1.426 ± 0.041	3.368SerArg: 3.368 ± 0.051	2.551SerSer: 2.551 ± 0.06	2.315SerThr: 2.315 ± 0.055	3.596SerVal: 3.596 ± 0.062	0.818SerTrp: 0.818 ± 0.029	1.349SerTyr: 1.349 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.314ThrAla: 6.314 ± 0.11	0.36ThrCys: 0.36 ± 0.019	2.951ThrAsp: 2.951 ± 0.062	2.349ThrGlu: 2.349 ± 0.041	1.547ThrPhe: 1.547 ± 0.038	5.261ThrGly: 5.261 ± 0.095	0.931ThrHis: 0.931 ± 0.025	2.949ThrIle: 2.949 ± 0.062	1.24ThrLys: 1.24 ± 0.039	5.708ThrLeu: 5.708 ± 0.089	1.146ThrMet: 1.146 ± 0.031	1.271ThrAsn: 1.271 ± 0.036	3.449ThrPro: 3.449 ± 0.064	1.321ThrGln: 1.321 ± 0.037	3.4ThrArg: 3.4 ± 0.051	2.574ThrSer: 2.574 ± 0.058	2.522ThrThr: 2.522 ± 0.061	3.788ThrVal: 3.788 ± 0.069	0.536ThrTrp: 0.536 ± 0.021	1.09ThrTyr: 1.09 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.986ValAla: 9.986 ± 0.097	0.475ValCys: 0.475 ± 0.021	4.501ValAsp: 4.501 ± 0.062	4.411ValGlu: 4.411 ± 0.064	2.013ValPhe: 2.013 ± 0.039	5.61ValGly: 5.61 ± 0.072	1.331ValHis: 1.331 ± 0.031	3.367ValIle: 3.367 ± 0.058	1.959ValLys: 1.959 ± 0.04	5.881ValLeu: 5.881 ± 0.07	1.496ValMet: 1.496 ± 0.034	1.856ValAsn: 1.856 ± 0.05	3.906ValPro: 3.906 ± 0.05	1.996ValGln: 1.996 ± 0.044	5.211ValArg: 5.211 ± 0.068	3.709ValSer: 3.709 ± 0.066	4.356ValThr: 4.356 ± 0.07	4.904ValVal: 4.904 ± 0.067	0.875ValTrp: 0.875 ± 0.029	1.387ValTyr: 1.387 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.478TrpAla: 1.478 ± 0.039	0.133TrpCys: 0.133 ± 0.01	0.835TrpAsp: 0.835 ± 0.029	0.6TrpGlu: 0.6 ± 0.023	0.582TrpPhe: 0.582 ± 0.023	1.012TrpGly: 1.012 ± 0.03	0.37TrpHis: 0.37 ± 0.017	0.697TrpIle: 0.697 ± 0.026	0.487TrpLys: 0.487 ± 0.02	1.902TrpLeu: 1.902 ± 0.047	0.384TrpMet: 0.384 ± 0.019	0.46TrpAsn: 0.46 ± 0.021	0.757TrpPro: 0.757 ± 0.028	0.688TrpGln: 0.688 ± 0.025	1.413TrpArg: 1.413 ± 0.038	0.94TrpSer: 0.94 ± 0.029	0.901TrpThr: 0.901 ± 0.028	0.874TrpVal: 0.874 ± 0.03	0.276TrpTrp: 0.276 ± 0.016	0.327TrpTyr: 0.327 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.756TyrAla: 2.756 ± 0.049	0.22TyrCys: 0.22 ± 0.013	1.671TyrAsp: 1.671 ± 0.058	1.157TyrGlu: 1.157 ± 0.033	0.862TyrPhe: 0.862 ± 0.027	2.225TyrGly: 2.225 ± 0.048	0.5TyrHis: 0.5 ± 0.02	0.844TyrIle: 0.844 ± 0.027	0.591TyrLys: 0.591 ± 0.02	2.082TyrLeu: 2.082 ± 0.041	0.408TyrMet: 0.408 ± 0.018	0.649TyrAsn: 0.649 ± 0.026	1.075TyrPro: 1.075 ± 0.029	0.721TyrGln: 0.721 ± 0.029	2.051TyrArg: 2.051 ± 0.045	1.206TyrSer: 1.206 ± 0.04	0.958TyrThr: 0.958 ± 0.035	1.529TyrVal: 1.529 ± 0.04	0.381TyrTrp: 0.381 ± 0.021	0.68TyrTyr: 0.68 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3865 proteins (1231734 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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