Amino acid dipepetide frequency for Lutimaribacter saemankumensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.501AlaAla: 16.501 ± 0.186	1.111AlaCys: 1.111 ± 0.033	7.223AlaAsp: 7.223 ± 0.084	8.051AlaGlu: 8.051 ± 0.105	4.283AlaPhe: 4.283 ± 0.065	10.865AlaGly: 10.865 ± 0.124	2.575AlaHis: 2.575 ± 0.056	5.908AlaIle: 5.908 ± 0.08	3.532AlaLys: 3.532 ± 0.061	13.815AlaLeu: 13.815 ± 0.133	3.953AlaMet: 3.953 ± 0.061	2.594AlaAsn: 2.594 ± 0.052	5.921AlaPro: 5.921 ± 0.088	4.64AlaGln: 4.64 ± 0.077	9.434AlaArg: 9.434 ± 0.117	5.141AlaSer: 5.141 ± 0.067	5.699AlaThr: 5.699 ± 0.072	8.44AlaVal: 8.44 ± 0.104	1.517AlaTrp: 1.517 ± 0.048	2.6AlaTyr: 2.6 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.104CysAla: 1.104 ± 0.032	0.093CysCys: 0.093 ± 0.009	0.616CysAsp: 0.616 ± 0.022	0.438CysGlu: 0.438 ± 0.017	0.358CysPhe: 0.358 ± 0.018	0.982CysGly: 0.982 ± 0.029	0.265CysHis: 0.265 ± 0.016	0.441CysIle: 0.441 ± 0.023	0.216CysLys: 0.216 ± 0.015	0.803CysLeu: 0.803 ± 0.026	0.191CysMet: 0.191 ± 0.013	0.229CysAsn: 0.229 ± 0.012	0.549CysPro: 0.549 ± 0.022	0.221CysGln: 0.221 ± 0.016	0.557CysArg: 0.557 ± 0.024	0.455CysSer: 0.455 ± 0.021	0.425CysThr: 0.425 ± 0.021	0.646CysVal: 0.646 ± 0.024	0.107CysTrp: 0.107 ± 0.009	0.191CysTyr: 0.191 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.777AspAla: 7.777 ± 0.082	0.542AspCys: 0.542 ± 0.018	3.79AspAsp: 3.79 ± 0.097	3.762AspGlu: 3.762 ± 0.065	2.337AspPhe: 2.337 ± 0.04	5.74AspGly: 5.74 ± 0.102	1.41AspHis: 1.41 ± 0.039	3.246AspIle: 3.246 ± 0.046	1.742AspLys: 1.742 ± 0.046	6.285AspLeu: 6.285 ± 0.077	1.902AspMet: 1.902 ± 0.042	1.269AspAsn: 1.269 ± 0.037	3.778AspPro: 3.778 ± 0.053	1.858AspGln: 1.858 ± 0.04	4.687AspArg: 4.687 ± 0.072	2.195AspSer: 2.195 ± 0.046	3.165AspThr: 3.165 ± 0.08	4.318AspVal: 4.318 ± 0.071	1.245AspTrp: 1.245 ± 0.032	1.598AspTyr: 1.598 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.603GluAla: 7.603 ± 0.099	0.391GluCys: 0.391 ± 0.017	3.402GluAsp: 3.402 ± 0.061	3.51GluGlu: 3.51 ± 0.069	1.839GluPhe: 1.839 ± 0.044	4.75GluGly: 4.75 ± 0.076	1.08GluHis: 1.08 ± 0.032	3.676GluIle: 3.676 ± 0.065	2.428GluLys: 2.428 ± 0.061	5.078GluLeu: 5.078 ± 0.074	2.026GluMet: 2.026 ± 0.044	1.825GluAsn: 1.825 ± 0.046	2.486GluPro: 2.486 ± 0.051	1.946GluGln: 1.946 ± 0.039	4.22GluArg: 4.22 ± 0.068	2.081GluSer: 2.081 ± 0.041	3.653GluThr: 3.653 ± 0.058	4.213GluVal: 4.213 ± 0.071	0.789GluTrp: 0.789 ± 0.026	1.11GluTyr: 1.11 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.539PheAla: 4.539 ± 0.074	0.438PheCys: 0.438 ± 0.022	2.924PheAsp: 2.924 ± 0.051	2.165PheGlu: 2.165 ± 0.045	1.495PhePhe: 1.495 ± 0.044	3.717PheGly: 3.717 ± 0.063	0.803PheHis: 0.803 ± 0.027	1.619PheIle: 1.619 ± 0.044	0.937PheLys: 0.937 ± 0.031	3.448PheLeu: 3.448 ± 0.061	0.872PheMet: 0.872 ± 0.029	1.054PheAsn: 1.054 ± 0.028	1.562PhePro: 1.562 ± 0.037	1.002PheGln: 1.002 ± 0.03	2.202PheArg: 2.202 ± 0.042	2.098PheSer: 2.098 ± 0.044	2.092PheThr: 2.092 ± 0.045	2.765PheVal: 2.765 ± 0.052	0.632PheTrp: 0.632 ± 0.024	0.906PheTyr: 0.906 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.315GlyAla: 10.315 ± 0.117	0.862GlyCys: 0.862 ± 0.028	5.105GlyAsp: 5.105 ± 0.114	4.554GlyGlu: 4.554 ± 0.068	3.692GlyPhe: 3.692 ± 0.057	7.791GlyGly: 7.791 ± 0.107	2.146GlyHis: 2.146 ± 0.045	4.62GlyIle: 4.62 ± 0.066	3.153GlyLys: 3.153 ± 0.063	9.247GlyLeu: 9.247 ± 0.097	2.863GlyMet: 2.863 ± 0.047	2.166GlyAsn: 2.166 ± 0.054	3.867GlyPro: 3.867 ± 0.06	3.313GlyGln: 3.313 ± 0.072	5.944GlyArg: 5.944 ± 0.077	3.984GlySer: 3.984 ± 0.06	4.615GlyThr: 4.615 ± 0.074	6.594GlyVal: 6.594 ± 0.083	1.613GlyTrp: 1.613 ± 0.038	2.36GlyTyr: 2.36 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.397HisAla: 2.397 ± 0.045	0.228HisCys: 0.228 ± 0.015	1.423HisAsp: 1.423 ± 0.036	1.206HisGlu: 1.206 ± 0.034	0.836HisPhe: 0.836 ± 0.028	2.079HisGly: 2.079 ± 0.041	0.565HisHis: 0.565 ± 0.024	0.983HisIle: 0.983 ± 0.032	0.572HisLys: 0.572 ± 0.023	2.064HisLeu: 2.064 ± 0.047	0.578HisMet: 0.578 ± 0.024	0.455HisAsn: 0.455 ± 0.019	1.437HisPro: 1.437 ± 0.045	0.564HisGln: 0.564 ± 0.024	1.376HisArg: 1.376 ± 0.04	0.908HisSer: 0.908 ± 0.029	0.852HisThr: 0.852 ± 0.028	1.631HisVal: 1.631 ± 0.04	0.363HisTrp: 0.363 ± 0.017	0.561HisTyr: 0.561 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.076IleAla: 7.076 ± 0.084	0.6IleCys: 0.6 ± 0.024	3.629IleAsp: 3.629 ± 0.065	3.549IleGlu: 3.549 ± 0.06	1.778IlePhe: 1.778 ± 0.04	4.842IleGly: 4.842 ± 0.077	0.952IleHis: 0.952 ± 0.029	2.134IleIle: 2.134 ± 0.045	1.337IleLys: 1.337 ± 0.04	4.796IleLeu: 4.796 ± 0.077	1.112IleMet: 1.112 ± 0.032	1.313IleAsn: 1.313 ± 0.035	2.436IlePro: 2.436 ± 0.051	1.147IleGln: 1.147 ± 0.03	3.367IleArg: 3.367 ± 0.059	2.838IleSer: 2.838 ± 0.046	2.847IleThr: 2.847 ± 0.056	3.975IleVal: 3.975 ± 0.066	0.759IleTrp: 0.759 ± 0.028	1.131IleTyr: 1.131 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.788LysAla: 3.788 ± 0.065	0.201LysCys: 0.201 ± 0.013	1.732LysAsp: 1.732 ± 0.048	1.584LysGlu: 1.584 ± 0.051	0.948LysPhe: 0.948 ± 0.028	2.817LysGly: 2.817 ± 0.057	0.603LysHis: 0.603 ± 0.023	1.589LysIle: 1.589 ± 0.039	1.288LysLys: 1.288 ± 0.046	2.974LysLeu: 2.974 ± 0.052	0.897LysMet: 0.897 ± 0.029	0.739LysAsn: 0.739 ± 0.028	1.881LysPro: 1.881 ± 0.047	0.901LysGln: 0.901 ± 0.031	2.299LysArg: 2.299 ± 0.056	1.793LysSer: 1.793 ± 0.041	1.899LysThr: 1.899 ± 0.04	2.196LysVal: 2.196 ± 0.048	0.42LysTrp: 0.42 ± 0.021	0.688LysTyr: 0.688 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	12.765LeuAla: 12.765 ± 0.137	0.947LeuCys: 0.947 ± 0.033	6.076LeuAsp: 6.076 ± 0.069	5.333LeuGlu: 5.333 ± 0.069	3.563LeuPhe: 3.563 ± 0.074	8.58LeuGly: 8.58 ± 0.11	1.945LeuHis: 1.945 ± 0.048	5.081LeuIle: 5.081 ± 0.075	3.127LeuLys: 3.127 ± 0.047	8.734LeuLeu: 8.734 ± 0.11	2.682LeuMet: 2.682 ± 0.048	2.623LeuAsn: 2.623 ± 0.048	5.552LeuPro: 5.552 ± 0.085	2.85LeuGln: 2.85 ± 0.053	7.129LeuArg: 7.129 ± 0.101	6.379LeuSer: 6.379 ± 0.084	5.597LeuThr: 5.597 ± 0.071	6.834LeuVal: 6.834 ± 0.081	1.329LeuTrp: 1.329 ± 0.038	1.986LeuTyr: 1.986 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.724MetAla: 3.724 ± 0.054	0.2MetCys: 0.2 ± 0.013	1.538MetAsp: 1.538 ± 0.038	1.432MetGlu: 1.432 ± 0.035	0.849MetPhe: 0.849 ± 0.032	2.435MetGly: 2.435 ± 0.046	0.53MetHis: 0.53 ± 0.022	1.621MetIle: 1.621 ± 0.037	1.125MetLys: 1.125 ± 0.033	2.785MetLeu: 2.785 ± 0.056	0.846MetMet: 0.846 ± 0.028	0.812MetAsn: 0.812 ± 0.027	1.601MetPro: 1.601 ± 0.041	1.043MetGln: 1.043 ± 0.028	2.105MetArg: 2.105 ± 0.045	1.685MetSer: 1.685 ± 0.038	2.183MetThr: 2.183 ± 0.044	1.956MetVal: 1.956 ± 0.039	0.271MetTrp: 0.271 ± 0.016	0.351MetTyr: 0.351 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.107AsnAla: 3.107 ± 0.056	0.251AsnCys: 0.251 ± 0.015	1.406AsnAsp: 1.406 ± 0.051	1.215AsnGlu: 1.215 ± 0.036	0.985AsnPhe: 0.985 ± 0.031	2.429AsnGly: 2.429 ± 0.046	0.505AsnHis: 0.505 ± 0.022	1.398AsnIle: 1.398 ± 0.04	0.658AsnLys: 0.658 ± 0.025	2.337AsnLeu: 2.337 ± 0.045	0.661AsnMet: 0.661 ± 0.025	0.624AsnAsn: 0.624 ± 0.023	1.876AsnPro: 1.876 ± 0.039	0.653AsnGln: 0.653 ± 0.026	1.736AsnArg: 1.736 ± 0.034	1.089AsnSer: 1.089 ± 0.031	1.305AsnThr: 1.305 ± 0.041	1.843AsnVal: 1.843 ± 0.046	0.415AsnTrp: 0.415 ± 0.02	0.624AsnTyr: 0.624 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.9ProAla: 5.9 ± 0.078	0.366ProCys: 0.366 ± 0.018	4.233ProAsp: 4.233 ± 0.067	4.009ProGlu: 4.009 ± 0.072	2.004ProPhe: 2.004 ± 0.04	4.859ProGly: 4.859 ± 0.069	1.118ProHis: 1.118 ± 0.031	2.213ProIle: 2.213 ± 0.05	1.659ProLys: 1.659 ± 0.049	4.59ProLeu: 4.59 ± 0.076	1.392ProMet: 1.392 ± 0.039	1.312ProAsn: 1.312 ± 0.031	2.251ProPro: 2.251 ± 0.055	1.761ProGln: 1.761 ± 0.04	3.023ProArg: 3.023 ± 0.059	2.329ProSer: 2.329 ± 0.046	2.248ProThr: 2.248 ± 0.039	4.493ProVal: 4.493 ± 0.068	0.72ProTrp: 0.72 ± 0.024	1.178ProTyr: 1.178 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.315GlnAla: 4.315 ± 0.061	0.201GlnCys: 0.201 ± 0.013	1.733GlnAsp: 1.733 ± 0.043	1.59GlnGlu: 1.59 ± 0.038	1.078GlnPhe: 1.078 ± 0.03	2.773GlnGly: 2.773 ± 0.055	0.556GlnHis: 0.556 ± 0.022	1.891GlnIle: 1.891 ± 0.046	1.101GlnLys: 1.101 ± 0.036	2.743GlnLeu: 2.743 ± 0.055	1.117GlnMet: 1.117 ± 0.031	0.888GlnAsn: 0.888 ± 0.028	1.694GlnPro: 1.694 ± 0.043	1.051GlnGln: 1.051 ± 0.036	2.128GlnArg: 2.128 ± 0.053	1.71GlnSer: 1.71 ± 0.044	1.764GlnThr: 1.764 ± 0.042	2.393GlnVal: 2.393 ± 0.046	0.402GlnTrp: 0.402 ± 0.019	0.602GlnTyr: 0.602 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.643ArgAla: 8.643 ± 0.101	0.495ArgCys: 0.495 ± 0.021	4.77ArgAsp: 4.77 ± 0.065	3.79ArgGlu: 3.79 ± 0.058	2.784ArgPhe: 2.784 ± 0.057	4.915ArgGly: 4.915 ± 0.07	1.559ArgHis: 1.559 ± 0.038	4.099ArgIle: 4.099 ± 0.063	2.398ArgLys: 2.398 ± 0.052	7.383ArgLeu: 7.383 ± 0.097	2.18ArgMet: 2.18 ± 0.04	1.824ArgAsn: 1.824 ± 0.036	3.406ArgPro: 3.406 ± 0.061	2.324ArgGln: 2.324 ± 0.045	5.167ArgArg: 5.167 ± 0.081	2.958ArgSer: 2.958 ± 0.05	2.935ArgThr: 2.935 ± 0.054	4.905ArgVal: 4.905 ± 0.067	1.031ArgTrp: 1.031 ± 0.032	1.502ArgTyr: 1.502 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.367SerAla: 5.367 ± 0.07	0.437SerCys: 0.437 ± 0.02	3.132SerAsp: 3.132 ± 0.059	2.676SerGlu: 2.676 ± 0.049	2.093SerPhe: 2.093 ± 0.047	5.128SerGly: 5.128 ± 0.08	1.067SerHis: 1.067 ± 0.03	2.381SerIle: 2.381 ± 0.054	1.362SerLys: 1.362 ± 0.035	4.82SerLeu: 4.82 ± 0.073	1.288SerMet: 1.288 ± 0.035	1.249SerAsn: 1.249 ± 0.034	2.464SerPro: 2.464 ± 0.047	1.44SerGln: 1.44 ± 0.036	3.11SerArg: 3.11 ± 0.049	2.274SerSer: 2.274 ± 0.053	2.308SerThr: 2.308 ± 0.043	3.667SerVal: 3.667 ± 0.065	0.646SerTrp: 0.646 ± 0.023	1.215SerTyr: 1.215 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	5.972ThrAla: 5.972 ± 0.077	0.486ThrCys: 0.486 ± 0.021	3.2ThrAsp: 3.2 ± 0.055	2.901ThrGlu: 2.901 ± 0.051	1.866ThrPhe: 1.866 ± 0.041	5.478ThrGly: 5.478 ± 0.075	1.173ThrHis: 1.173 ± 0.03	2.702ThrIle: 2.702 ± 0.052	1.443ThrLys: 1.443 ± 0.035	5.638ThrLeu: 5.638 ± 0.075	1.266ThrMet: 1.266 ± 0.036	1.206ThrAsn: 1.206 ± 0.037	3.379ThrPro: 3.379 ± 0.056	1.55ThrGln: 1.55 ± 0.037	3.57ThrArg: 3.57 ± 0.059	2.315ThrSer: 2.315 ± 0.046	2.585ThrThr: 2.585 ± 0.05	4.101ThrVal: 4.101 ± 0.067	0.687ThrTrp: 0.687 ± 0.023	1.243ThrTyr: 1.243 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.881ValAla: 8.881 ± 0.099	0.661ValCys: 0.661 ± 0.025	4.234ValAsp: 4.234 ± 0.053	4.386ValGlu: 4.386 ± 0.07	2.969ValPhe: 2.969 ± 0.047	5.414ValGly: 5.414 ± 0.072	1.345ValHis: 1.345 ± 0.035	4.341ValIle: 4.341 ± 0.072	2.115ValLys: 2.115 ± 0.045	7.556ValLeu: 7.556 ± 0.086	2.301ValMet: 2.301 ± 0.045	1.954ValAsn: 1.954 ± 0.044	3.719ValPro: 3.719 ± 0.062	2.187ValGln: 2.187 ± 0.045	4.308ValArg: 4.308 ± 0.058	3.968ValSer: 3.968 ± 0.062	4.707ValThr: 4.707 ± 0.069	5.652ValVal: 5.652 ± 0.084	1.023ValTrp: 1.023 ± 0.027	1.428ValTyr: 1.428 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.495TrpAla: 1.495 ± 0.042	0.127TrpCys: 0.127 ± 0.011	0.844TrpAsp: 0.844 ± 0.028	0.673TrpGlu: 0.673 ± 0.024	0.578TrpPhe: 0.578 ± 0.023	1.088TrpGly: 1.088 ± 0.034	0.361TrpHis: 0.361 ± 0.018	0.735TrpIle: 0.735 ± 0.026	0.464TrpLys: 0.464 ± 0.021	1.718TrpLeu: 1.718 ± 0.041	0.461TrpMet: 0.461 ± 0.019	0.425TrpAsn: 0.425 ± 0.021	0.758TrpPro: 0.758 ± 0.026	0.617TrpGln: 0.617 ± 0.024	1.167TrpArg: 1.167 ± 0.034	0.771TrpSer: 0.771 ± 0.027	0.775TrpThr: 0.775 ± 0.031	0.995TrpVal: 0.995 ± 0.032	0.243TrpTrp: 0.243 ± 0.015	0.299TrpTyr: 0.299 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.535TyrAla: 2.535 ± 0.05	0.25TyrCys: 0.25 ± 0.014	1.636TyrAsp: 1.636 ± 0.039	1.28TyrGlu: 1.28 ± 0.039	0.934TyrPhe: 0.934 ± 0.031	2.123TyrGly: 2.123 ± 0.04	0.519TyrHis: 0.519 ± 0.022	0.94TyrIle: 0.94 ± 0.03	0.582TyrLys: 0.582 ± 0.025	2.3TyrLeu: 2.3 ± 0.044	0.501TyrMet: 0.501 ± 0.022	0.554TyrAsn: 0.554 ± 0.023	1.043TyrPro: 1.043 ± 0.031	0.664TyrGln: 0.664 ± 0.023	1.543TyrArg: 1.543 ± 0.034	1.15TyrSer: 1.15 ± 0.03	1.103TyrThr: 1.103 ± 0.029	1.534TyrVal: 1.534 ± 0.035	0.382TyrTrp: 0.382 ± 0.022	0.565TyrTyr: 0.565 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3753 proteins (1133726 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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