Amino acid dipepetide frequency for Streptomyces toyocaensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.99AlaAla: 20.99 ± 0.188	1.095AlaCys: 1.095 ± 0.024	8.337AlaAsp: 8.337 ± 0.064	8.928AlaGlu: 8.928 ± 0.102	3.361AlaPhe: 3.361 ± 0.044	13.745AlaGly: 13.745 ± 0.103	3.016AlaHis: 3.016 ± 0.038	2.995AlaIle: 2.995 ± 0.043	2.552AlaLys: 2.552 ± 0.045	14.666AlaLeu: 14.666 ± 0.123	2.402AlaMet: 2.402 ± 0.039	1.722AlaAsn: 1.722 ± 0.031	7.3AlaPro: 7.3 ± 0.085	3.499AlaGln: 3.499 ± 0.047	11.06AlaArg: 11.06 ± 0.095	5.734AlaSer: 5.734 ± 0.062	6.751AlaThr: 6.751 ± 0.056	12.731AlaVal: 12.731 ± 0.105	1.854AlaTrp: 1.854 ± 0.032	2.687AlaTyr: 2.687 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.132CysAla: 1.132 ± 0.026	0.095CysCys: 0.095 ± 0.008	0.485CysAsp: 0.485 ± 0.014	0.404CysGlu: 0.404 ± 0.013	0.213CysPhe: 0.213 ± 0.01	0.971CysGly: 0.971 ± 0.025	0.201CysHis: 0.201 ± 0.012	0.14CysIle: 0.14 ± 0.008	0.093CysLys: 0.093 ± 0.006	0.762CysLeu: 0.762 ± 0.02	0.119CysMet: 0.119 ± 0.008	0.132CysAsn: 0.132 ± 0.009	0.507CysPro: 0.507 ± 0.017	0.151CysGln: 0.151 ± 0.008	0.619CysArg: 0.619 ± 0.018	0.429CysSer: 0.429 ± 0.015	0.521CysThr: 0.521 ± 0.018	0.681CysVal: 0.681 ± 0.017	0.131CysTrp: 0.131 ± 0.008	0.149CysTyr: 0.149 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.875AspAla: 7.875 ± 0.073	0.443AspCys: 0.443 ± 0.016	3.78AspAsp: 3.78 ± 0.039	4.032AspGlu: 4.032 ± 0.052	1.614AspPhe: 1.614 ± 0.029	6.697AspGly: 6.697 ± 0.066	1.442AspHis: 1.442 ± 0.028	1.8AspIle: 1.8 ± 0.028	1.134AspLys: 1.134 ± 0.025	6.34AspLeu: 6.34 ± 0.068	0.86AspMet: 0.86 ± 0.021	0.92AspAsn: 0.92 ± 0.026	4.547AspPro: 4.547 ± 0.053	1.418AspGln: 1.418 ± 0.029	5.202AspArg: 5.202 ± 0.051	2.419AspSer: 2.419 ± 0.036	3.337AspThr: 3.337 ± 0.042	4.975AspVal: 4.975 ± 0.049	1.035AspTrp: 1.035 ± 0.022	1.057AspTyr: 1.057 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	7.632GluAla: 7.632 ± 0.082	0.377GluCys: 0.377 ± 0.015	3.068GluAsp: 3.068 ± 0.047	3.945GluGlu: 3.945 ± 0.06	1.434GluPhe: 1.434 ± 0.029	4.605GluGly: 4.605 ± 0.049	1.584GluHis: 1.584 ± 0.028	2.201GluIle: 2.201 ± 0.037	1.474GluLys: 1.474 ± 0.03	6.792GluLeu: 6.792 ± 0.063	0.886GluMet: 0.886 ± 0.025	1.069GluAsn: 1.069 ± 0.021	3.588GluPro: 3.588 ± 0.053	2.226GluGln: 2.226 ± 0.035	5.971GluArg: 5.971 ± 0.058	2.515GluSer: 2.515 ± 0.036	2.958GluThr: 2.958 ± 0.037	4.614GluVal: 4.614 ± 0.055	0.767GluTrp: 0.767 ± 0.02	1.118GluTyr: 1.118 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.577PheAla: 3.577 ± 0.041	0.256PheCys: 0.256 ± 0.012	1.91PheAsp: 1.91 ± 0.036	1.413PheGlu: 1.413 ± 0.029	0.836PhePhe: 0.836 ± 0.022	2.897PheGly: 2.897 ± 0.041	0.606PheHis: 0.606 ± 0.02	0.609PheIle: 0.609 ± 0.02	0.467PheLys: 0.467 ± 0.017	2.571PheLeu: 2.571 ± 0.04	0.396PheMet: 0.396 ± 0.014	0.504PheAsn: 0.504 ± 0.016	1.336PhePro: 1.336 ± 0.025	0.617PheGln: 0.617 ± 0.016	1.894PheArg: 1.894 ± 0.032	1.372PheSer: 1.372 ± 0.025	1.972PheThr: 1.972 ± 0.032	2.259PheVal: 2.259 ± 0.034	0.407PheTrp: 0.407 ± 0.013	0.526PheTyr: 0.526 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	11.208GlyAla: 11.208 ± 0.093	0.834GlyCys: 0.834 ± 0.019	5.58GlyAsp: 5.58 ± 0.065	5.471GlyGlu: 5.471 ± 0.054	2.843GlyPhe: 2.843 ± 0.042	9.086GlyGly: 9.086 ± 0.088	2.449GlyHis: 2.449 ± 0.035	3.288GlyIle: 3.288 ± 0.042	2.272GlyLys: 2.272 ± 0.038	9.444GlyLeu: 9.444 ± 0.08	2.007GlyMet: 2.007 ± 0.037	1.677GlyAsn: 1.677 ± 0.034	5.524GlyPro: 5.524 ± 0.067	2.503GlyGln: 2.503 ± 0.038	8.419GlyArg: 8.419 ± 0.082	5.251GlySer: 5.251 ± 0.057	6.705GlyThr: 6.705 ± 0.063	7.684GlyVal: 7.684 ± 0.069	1.676GlyTrp: 1.676 ± 0.033	2.224GlyTyr: 2.224 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.777HisAla: 2.777 ± 0.042	0.219HisCys: 0.219 ± 0.012	1.395HisAsp: 1.395 ± 0.026	1.259HisGlu: 1.259 ± 0.023	0.631HisPhe: 0.631 ± 0.017	2.54HisGly: 2.54 ± 0.037	0.73HisHis: 0.73 ± 0.023	0.617HisIle: 0.617 ± 0.017	0.333HisLys: 0.333 ± 0.011	2.496HisLeu: 2.496 ± 0.035	0.352HisMet: 0.352 ± 0.011	0.344HisAsn: 0.344 ± 0.013	1.886HisPro: 1.886 ± 0.033	0.627HisGln: 0.627 ± 0.018	2.289HisArg: 2.289 ± 0.031	0.968HisSer: 0.968 ± 0.026	1.398HisThr: 1.398 ± 0.03	1.773HisVal: 1.773 ± 0.033	0.382HisTrp: 0.382 ± 0.014	0.456HisTyr: 0.456 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.385IleAla: 4.385 ± 0.051	0.256IleCys: 0.256 ± 0.013	2.103IleAsp: 2.103 ± 0.032	1.887IleGlu: 1.887 ± 0.033	0.626IlePhe: 0.626 ± 0.02	3.355IleGly: 3.355 ± 0.048	0.571IleHis: 0.571 ± 0.016	0.767IleIle: 0.767 ± 0.021	0.65IleLys: 0.65 ± 0.02	2.2IleLeu: 2.2 ± 0.036	0.44IleMet: 0.44 ± 0.015	0.619IleAsn: 0.619 ± 0.02	1.614IlePro: 1.614 ± 0.026	0.641IleGln: 0.641 ± 0.017	2.13IleArg: 2.13 ± 0.032	1.461IleSer: 1.461 ± 0.027	2.05IleThr: 2.05 ± 0.037	2.589IleVal: 2.589 ± 0.043	0.335IleTrp: 0.335 ± 0.015	0.448IleTyr: 0.448 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.72LysAla: 2.72 ± 0.046	0.103LysCys: 0.103 ± 0.008	1.307LysAsp: 1.307 ± 0.031	1.224LysGlu: 1.224 ± 0.028	0.397LysPhe: 0.397 ± 0.017	1.787LysGly: 1.787 ± 0.039	0.379LysHis: 0.379 ± 0.013	0.787LysIle: 0.787 ± 0.022	0.82LysLys: 0.82 ± 0.026	1.857LysLeu: 1.857 ± 0.032	0.347LysMet: 0.347 ± 0.012	0.476LysAsn: 0.476 ± 0.016	1.219LysPro: 1.219 ± 0.026	0.647LysGln: 0.647 ± 0.018	1.452LysArg: 1.452 ± 0.028	1.001LysSer: 1.001 ± 0.026	1.143LysThr: 1.143 ± 0.026	1.781LysVal: 1.781 ± 0.034	0.255LysTrp: 0.255 ± 0.01	0.427LysTyr: 0.427 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	14.977LeuAla: 14.977 ± 0.123	0.879LeuCys: 0.879 ± 0.023	6.755LeuAsp: 6.755 ± 0.057	4.888LeuGlu: 4.888 ± 0.048	2.542LeuPhe: 2.542 ± 0.042	9.23LeuGly: 9.23 ± 0.08	2.318LeuHis: 2.318 ± 0.035	3.032LeuIle: 3.032 ± 0.046	1.926LeuLys: 1.926 ± 0.034	11.419LeuLeu: 11.419 ± 0.112	1.632LeuMet: 1.632 ± 0.029	1.607LeuAsn: 1.607 ± 0.027	6.628LeuPro: 6.628 ± 0.068	2.15LeuGln: 2.15 ± 0.034	9.111LeuArg: 9.111 ± 0.071	5.166LeuSer: 5.166 ± 0.052	7.049LeuThr: 7.049 ± 0.059	8.939LeuVal: 8.939 ± 0.089	1.301LeuTrp: 1.301 ± 0.027	1.801LeuTyr: 1.801 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.223MetAla: 2.223 ± 0.036	0.135MetCys: 0.135 ± 0.009	0.879MetAsp: 0.879 ± 0.02	0.781MetGlu: 0.781 ± 0.018	0.451MetPhe: 0.451 ± 0.017	1.285MetGly: 1.285 ± 0.029	0.358MetHis: 0.358 ± 0.015	0.645MetIle: 0.645 ± 0.019	0.404MetLys: 0.404 ± 0.014	1.644MetLeu: 1.644 ± 0.032	0.297MetMet: 0.297 ± 0.013	0.415MetAsn: 0.415 ± 0.013	1.08MetPro: 1.08 ± 0.025	0.44MetGln: 0.44 ± 0.015	1.461MetArg: 1.461 ± 0.032	1.299MetSer: 1.299 ± 0.026	1.591MetThr: 1.591 ± 0.03	1.279MetVal: 1.279 ± 0.026	0.205MetTrp: 0.205 ± 0.009	0.318MetTyr: 0.318 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.098AsnAla: 2.098 ± 0.034	0.162AsnCys: 0.162 ± 0.008	0.926AsnAsp: 0.926 ± 0.021	0.797AsnGlu: 0.797 ± 0.021	0.446AsnPhe: 0.446 ± 0.015	1.767AsnGly: 1.767 ± 0.035	0.392AsnHis: 0.392 ± 0.015	0.584AsnIle: 0.584 ± 0.02	0.383AsnLys: 0.383 ± 0.014	1.516AsnLeu: 1.516 ± 0.027	0.281AsnMet: 0.281 ± 0.014	0.393AsnAsn: 0.393 ± 0.015	1.272AsnPro: 1.272 ± 0.029	0.46AsnGln: 0.46 ± 0.017	1.242AsnArg: 1.242 ± 0.025	0.805AsnSer: 0.805 ± 0.024	1.024AsnThr: 1.024 ± 0.029	1.337AsnVal: 1.337 ± 0.028	0.277AsnTrp: 0.277 ± 0.011	0.373AsnTyr: 0.373 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	8.969ProAla: 8.969 ± 0.084	0.353ProCys: 0.353 ± 0.011	4.647ProAsp: 4.647 ± 0.058	4.513ProGlu: 4.513 ± 0.061	1.499ProPhe: 1.499 ± 0.028	7.183ProGly: 7.183 ± 0.086	1.435ProHis: 1.435 ± 0.029	1.1ProIle: 1.1 ± 0.025	1.068ProLys: 1.068 ± 0.027	5.451ProLeu: 5.451 ± 0.057	0.974ProMet: 0.974 ± 0.021	0.802ProAsn: 0.802 ± 0.021	3.765ProPro: 3.765 ± 0.07	1.607ProGln: 1.607 ± 0.04	4.284ProArg: 4.284 ± 0.055	3.192ProSer: 3.192 ± 0.044	2.986ProThr: 2.986 ± 0.046	5.807ProVal: 5.807 ± 0.06	0.873ProTrp: 0.873 ± 0.022	1.421ProTyr: 1.421 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.521GlnAla: 3.521 ± 0.051	0.154GlnCys: 0.154 ± 0.009	1.366GlnAsp: 1.366 ± 0.026	1.461GlnGlu: 1.461 ± 0.027	0.618GlnPhe: 0.618 ± 0.017	2.171GlnGly: 2.171 ± 0.035	0.621GlnHis: 0.621 ± 0.018	0.956GlnIle: 0.956 ± 0.023	0.604GlnLys: 0.604 ± 0.018	2.796GlnLeu: 2.796 ± 0.035	0.478GlnMet: 0.478 ± 0.016	0.47GlnAsn: 0.47 ± 0.018	1.573GlnPro: 1.573 ± 0.032	1.143GlnGln: 1.143 ± 0.028	2.294GlnArg: 2.294 ± 0.037	1.161GlnSer: 1.161 ± 0.024	1.238GlnThr: 1.238 ± 0.022	2.278GlnVal: 2.278 ± 0.031	0.451GlnTrp: 0.451 ± 0.016	0.583GlnTyr: 0.583 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	10.714ArgAla: 10.714 ± 0.093	0.617ArgCys: 0.617 ± 0.018	4.643ArgAsp: 4.643 ± 0.054	5.168ArgGlu: 5.168 ± 0.057	2.394ArgPhe: 2.394 ± 0.032	6.24ArgGly: 6.24 ± 0.058	2.303ArgHis: 2.303 ± 0.032	3.142ArgIle: 3.142 ± 0.04	1.58ArgLys: 1.58 ± 0.034	9.392ArgLeu: 9.392 ± 0.094	1.834ArgMet: 1.834 ± 0.032	1.331ArgAsn: 1.331 ± 0.025	5.409ArgPro: 5.409 ± 0.06	2.282ArgGln: 2.282 ± 0.035	8.536ArgArg: 8.536 ± 0.078	4.169ArgSer: 4.169 ± 0.047	5.716ArgThr: 5.716 ± 0.064	6.311ArgVal: 6.311 ± 0.059	1.387ArgTrp: 1.387 ± 0.026	1.791ArgTyr: 1.791 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	6.455SerAla: 6.455 ± 0.059	0.398SerCys: 0.398 ± 0.015	2.583SerAsp: 2.583 ± 0.035	2.405SerGlu: 2.405 ± 0.032	1.443SerPhe: 1.443 ± 0.029	5.884SerGly: 5.884 ± 0.062	0.993SerHis: 0.993 ± 0.026	1.224SerIle: 1.224 ± 0.024	0.947SerLys: 0.947 ± 0.022	4.715SerLeu: 4.715 ± 0.046	0.987SerMet: 0.987 ± 0.023	0.773SerAsn: 0.773 ± 0.021	3.134SerPro: 3.134 ± 0.043	1.13SerGln: 1.13 ± 0.025	3.775SerArg: 3.775 ± 0.045	2.588SerSer: 2.588 ± 0.048	2.892SerThr: 2.892 ± 0.045	4.295SerVal: 4.295 ± 0.053	0.822SerTrp: 0.822 ± 0.021	1.138SerTyr: 1.138 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	9.028ThrAla: 9.028 ± 0.076	0.428ThrCys: 0.428 ± 0.013	3.722ThrAsp: 3.722 ± 0.045	3.352ThrGlu: 3.352 ± 0.042	1.556ThrPhe: 1.556 ± 0.032	6.924ThrGly: 6.924 ± 0.06	1.231ThrHis: 1.231 ± 0.023	1.531ThrIle: 1.531 ± 0.033	1.055ThrLys: 1.055 ± 0.027	5.705ThrLeu: 5.705 ± 0.055	0.931ThrMet: 0.931 ± 0.022	0.918ThrAsn: 0.918 ± 0.023	4.132ThrPro: 4.132 ± 0.057	1.241ThrGln: 1.241 ± 0.027	4.117ThrArg: 4.117 ± 0.049	3.024ThrSer: 3.024 ± 0.038	3.794ThrThr: 3.794 ± 0.056	6.379ThrVal: 6.379 ± 0.066	0.887ThrTrp: 0.887 ± 0.022	1.351ThrTyr: 1.351 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	10.772ValAla: 10.772 ± 0.096	0.788ValCys: 0.788 ± 0.02	5.071ValAsp: 5.071 ± 0.057	4.862ValGlu: 4.862 ± 0.054	2.422ValPhe: 2.422 ± 0.038	6.5ValGly: 6.5 ± 0.061	2.099ValHis: 2.099 ± 0.032	2.732ValIle: 2.732 ± 0.039	1.64ValLys: 1.64 ± 0.036	9.858ValLeu: 9.858 ± 0.092	1.418ValMet: 1.418 ± 0.03	1.58ValAsn: 1.58 ± 0.033	5.654ValPro: 5.654 ± 0.055	1.994ValGln: 1.994 ± 0.034	7.89ValArg: 7.89 ± 0.068	4.237ValSer: 4.237 ± 0.05	6.005ValThr: 6.005 ± 0.063	8.409ValVal: 8.409 ± 0.081	1.179ValTrp: 1.179 ± 0.025	1.586ValTyr: 1.586 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.64TrpAla: 1.64 ± 0.028	0.165TrpCys: 0.165 ± 0.009	0.812TrpAsp: 0.812 ± 0.022	0.776TrpGlu: 0.776 ± 0.021	0.502TrpPhe: 0.502 ± 0.018	1.01TrpGly: 1.01 ± 0.022	0.359TrpHis: 0.359 ± 0.016	0.524TrpIle: 0.524 ± 0.017	0.356TrpLys: 0.356 ± 0.012	1.75TrpLeu: 1.75 ± 0.031	0.283TrpMet: 0.283 ± 0.012	0.397TrpAsn: 0.397 ± 0.012	0.76TrpPro: 0.76 ± 0.022	0.609TrpGln: 0.609 ± 0.018	1.36TrpArg: 1.36 ± 0.029	0.898TrpSer: 0.898 ± 0.023	1.034TrpThr: 1.034 ± 0.021	0.959TrpVal: 0.959 ± 0.022	0.325TrpTrp: 0.325 ± 0.015	0.358TrpTyr: 0.358 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.733TyrAla: 2.733 ± 0.036	0.178TyrCys: 0.178 ± 0.009	1.555TyrAsp: 1.555 ± 0.032	1.26TyrGlu: 1.26 ± 0.026	0.598TyrPhe: 0.598 ± 0.016	2.269TyrGly: 2.269 ± 0.04	0.384TyrHis: 0.384 ± 0.015	0.451TyrIle: 0.451 ± 0.016	0.37TyrLys: 0.37 ± 0.016	1.978TyrLeu: 1.978 ± 0.03	0.27TyrMet: 0.27 ± 0.012	0.382TyrAsn: 0.382 ± 0.017	0.999TyrPro: 0.999 ± 0.023	0.552TyrGln: 0.552 ± 0.019	1.853TyrArg: 1.853 ± 0.037	0.894TyrSer: 0.894 ± 0.023	1.14TyrThr: 1.14 ± 0.026	1.616TyrVal: 1.616 ± 0.028	0.328TyrTrp: 0.328 ± 0.013	0.414TyrTyr: 0.414 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6315 proteins (2084183 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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