Amino acid dipepetide frequency for candidate division MSBL1 archaeon SCGC-AAA259M10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.026AlaAla: 4.026 ± 0.189
0.707AlaCys: 0.707 ± 0.058
3.328AlaAsp: 3.328 ± 0.128
5.759AlaGlu: 5.759 ± 0.187
2.501AlaPhe: 2.501 ± 0.121
4.718AlaGly: 4.718 ± 0.194
1.081AlaHis: 1.081 ± 0.086
4.085AlaIle: 4.085 ± 0.166
3.811AlaLys: 3.811 ± 0.144
5.685AlaLeu: 5.685 ± 0.181
1.42AlaMet: 1.42 ± 0.088
1.589AlaAsn: 1.589 ± 0.086
1.928AlaPro: 1.928 ± 0.098
1.345AlaGln: 1.345 ± 0.077
3.438AlaArg: 3.438 ± 0.142
3.722AlaSer: 3.722 ± 0.132
2.7AlaThr: 2.7 ± 0.138
4.539AlaVal: 4.539 ± 0.151
0.568AlaTrp: 0.568 ± 0.054
1.624AlaTyr: 1.624 ± 0.082
0.0AlaXaa: 0.0 ± 0.0
Cys
0.409CysAla: 0.409 ± 0.051
0.115CysCys: 0.115 ± 0.029
0.593CysAsp: 0.593 ± 0.056
0.991CysGlu: 0.991 ± 0.078
0.364CysPhe: 0.364 ± 0.04
1.3CysGly: 1.3 ± 0.102
0.254CysHis: 0.254 ± 0.038
0.488CysIle: 0.488 ± 0.051
0.543CysLys: 0.543 ± 0.055
0.787CysLeu: 0.787 ± 0.057
0.229CysMet: 0.229 ± 0.034
0.259CysAsn: 0.259 ± 0.035
0.827CysPro: 0.827 ± 0.07
0.289CysGln: 0.289 ± 0.041
0.573CysArg: 0.573 ± 0.063
0.673CysSer: 0.673 ± 0.059
0.428CysThr: 0.428 ± 0.053
0.518CysVal: 0.518 ± 0.051
0.075CysTrp: 0.075 ± 0.02
0.314CysTyr: 0.314 ± 0.044
0.0CysXaa: 0.0 ± 0.0
Asp
3.094AspAla: 3.094 ± 0.144
0.563AspCys: 0.563 ± 0.054
2.426AspAsp: 2.426 ± 0.134
5.56AspGlu: 5.56 ± 0.154
2.66AspPhe: 2.66 ± 0.121
3.722AspGly: 3.722 ± 0.145
0.962AspHis: 0.962 ± 0.083
4.504AspIle: 4.504 ± 0.146
3.657AspLys: 3.657 ± 0.169
6.766AspLeu: 6.766 ± 0.197
1.34AspMet: 1.34 ± 0.092
1.749AspAsn: 1.749 ± 0.107
2.915AspPro: 2.915 ± 0.136
1.141AspGln: 1.141 ± 0.071
3.786AspArg: 3.786 ± 0.16
3.373AspSer: 3.373 ± 0.125
2.481AspThr: 2.481 ± 0.133
4.18AspVal: 4.18 ± 0.156
0.867AspTrp: 0.867 ± 0.065
2.127AspTyr: 2.127 ± 0.114
0.0AspXaa: 0.0 ± 0.0
Glu
5.54GluAla: 5.54 ± 0.197
0.742GluCys: 0.742 ± 0.072
6.138GluAsp: 6.138 ± 0.216
12.321GluGlu: 12.321 ± 0.372
3.353GluPhe: 3.353 ± 0.136
6.756GluGly: 6.756 ± 0.181
1.38GluHis: 1.38 ± 0.071
8.455GluIle: 8.455 ± 0.254
10.896GluLys: 10.896 ± 0.315
8.544GluLeu: 8.544 ± 0.243
2.157GluMet: 2.157 ± 0.099
4.937GluAsn: 4.937 ± 0.162
2.855GluPro: 2.855 ± 0.117
1.619GluGln: 1.619 ± 0.113
5.939GluArg: 5.939 ± 0.222
4.853GluSer: 4.853 ± 0.175
4.878GluThr: 4.878 ± 0.165
6.875GluVal: 6.875 ± 0.199
0.977GluTrp: 0.977 ± 0.076
2.506GluTyr: 2.506 ± 0.118
0.0GluXaa: 0.0 ± 0.0
Phe
2.302PheAla: 2.302 ± 0.113
0.364PheCys: 0.364 ± 0.043
2.705PheAsp: 2.705 ± 0.122
3.791PheGlu: 3.791 ± 0.142
1.863PhePhe: 1.863 ± 0.125
3.408PheGly: 3.408 ± 0.135
0.727PheHis: 0.727 ± 0.055
2.277PheIle: 2.277 ± 0.126
2.277PheLys: 2.277 ± 0.115
4.474PheLeu: 4.474 ± 0.194
0.897PheMet: 0.897 ± 0.065
1.131PheAsn: 1.131 ± 0.08
1.729PhePro: 1.729 ± 0.096
0.972PheGln: 0.972 ± 0.067
2.038PheArg: 2.038 ± 0.091
3.383PheSer: 3.383 ± 0.157
1.719PheThr: 1.719 ± 0.112
2.431PheVal: 2.431 ± 0.11
0.513PheTrp: 0.513 ± 0.059
1.355PheTyr: 1.355 ± 0.089
0.0PheXaa: 0.0 ± 0.0
Gly
4.434GlyAla: 4.434 ± 0.181
0.673GlyCys: 0.673 ± 0.053
3.772GlyAsp: 3.772 ± 0.139
7.369GlyGlu: 7.369 ± 0.215
3.104GlyPhe: 3.104 ± 0.137
5.864GlyGly: 5.864 ± 0.198
1.226GlyHis: 1.226 ± 0.081
5.361GlyIle: 5.361 ± 0.173
5.744GlyLys: 5.744 ± 0.199
7.04GlyLeu: 7.04 ± 0.213
2.048GlyMet: 2.048 ± 0.109
2.471GlyAsn: 2.471 ± 0.107
2.501GlyPro: 2.501 ± 0.131
1.5GlyGln: 1.5 ± 0.088
4.125GlyArg: 4.125 ± 0.147
4.549GlySer: 4.549 ± 0.14
3.767GlyThr: 3.767 ± 0.142
5.57GlyVal: 5.57 ± 0.21
0.902GlyTrp: 0.902 ± 0.067
2.566GlyTyr: 2.566 ± 0.117
0.0GlyXaa: 0.0 ± 0.0
His
0.977HisAla: 0.977 ± 0.068
0.334HisCys: 0.334 ± 0.039
0.872HisAsp: 0.872 ± 0.068
1.36HisGlu: 1.36 ± 0.092
0.792HisPhe: 0.792 ± 0.065
1.27HisGly: 1.27 ± 0.081
0.309HisHis: 0.309 ± 0.041
1.036HisIle: 1.036 ± 0.067
0.797HisLys: 0.797 ± 0.06
1.719HisLeu: 1.719 ± 0.093
0.384HisMet: 0.384 ± 0.047
0.598HisAsn: 0.598 ± 0.059
1.191HisPro: 1.191 ± 0.088
0.458HisGln: 0.458 ± 0.046
0.991HisArg: 0.991 ± 0.061
1.196HisSer: 1.196 ± 0.094
0.762HisThr: 0.762 ± 0.066
1.081HisVal: 1.081 ± 0.076
0.229HisTrp: 0.229 ± 0.034
0.573HisTyr: 0.573 ± 0.054
0.0HisXaa: 0.0 ± 0.0
Ile
4.484IleAla: 4.484 ± 0.143
0.762IleCys: 0.762 ± 0.069
4.474IleAsp: 4.474 ± 0.145
7.045IleGlu: 7.045 ± 0.214
2.845IlePhe: 2.845 ± 0.125
5.48IleGly: 5.48 ± 0.181
1.216IleHis: 1.216 ± 0.075
4.718IleIle: 4.718 ± 0.183
4.25IleLys: 4.25 ± 0.135
6.432IleLeu: 6.432 ± 0.206
1.3IleMet: 1.3 ± 0.079
2.516IleAsn: 2.516 ± 0.098
3.159IlePro: 3.159 ± 0.131
1.699IleGln: 1.699 ± 0.11
3.886IleArg: 3.886 ± 0.14
4.937IleSer: 4.937 ± 0.175
3.318IleThr: 3.318 ± 0.135
4.888IleVal: 4.888 ± 0.173
0.583IleTrp: 0.583 ± 0.06
2.132IleTyr: 2.132 ± 0.096
0.0IleXaa: 0.0 ± 0.0
Lys
4.574LysAla: 4.574 ± 0.157
0.727LysCys: 0.727 ± 0.074
4.155LysAsp: 4.155 ± 0.142
7.872LysGlu: 7.872 ± 0.281
2.372LysPhe: 2.372 ± 0.112
4.818LysGly: 4.818 ± 0.173
1.181LysHis: 1.181 ± 0.08
6.457LysIle: 6.457 ± 0.21
7.314LysLys: 7.314 ± 0.281
6.372LysLeu: 6.372 ± 0.197
1.779LysMet: 1.779 ± 0.103
3.687LysAsn: 3.687 ± 0.143
2.476LysPro: 2.476 ± 0.12
1.48LysGln: 1.48 ± 0.099
4.479LysArg: 4.479 ± 0.154
4.344LysSer: 4.344 ± 0.179
3.622LysThr: 3.622 ± 0.143
4.987LysVal: 4.987 ± 0.165
0.717LysTrp: 0.717 ± 0.059
2.197LysTyr: 2.197 ± 0.106
0.0LysXaa: 0.0 ± 0.0
Leu
5.884LeuAla: 5.884 ± 0.214
0.807LeuCys: 0.807 ± 0.066
5.939LeuAsp: 5.939 ± 0.184
9.586LeuGlu: 9.586 ± 0.298
3.512LeuPhe: 3.512 ± 0.152
6.836LeuGly: 6.836 ± 0.226
1.46LeuHis: 1.46 ± 0.08
5.759LeuIle: 5.759 ± 0.206
6.846LeuLys: 6.846 ± 0.227
7.957LeuLeu: 7.957 ± 0.259
1.943LeuMet: 1.943 ± 0.103
3.642LeuAsn: 3.642 ± 0.125
3.747LeuPro: 3.747 ± 0.124
2.267LeuGln: 2.267 ± 0.098
5.555LeuArg: 5.555 ± 0.187
6.497LeuSer: 6.497 ± 0.2
4.863LeuThr: 4.863 ± 0.176
5.944LeuVal: 5.944 ± 0.192
0.991LeuTrp: 0.991 ± 0.07
2.511LeuTyr: 2.511 ± 0.104
0.0LeuXaa: 0.0 ± 0.0
Met
1.211MetAla: 1.211 ± 0.075
0.174MetCys: 0.174 ± 0.028
1.345MetAsp: 1.345 ± 0.087
2.257MetGlu: 2.257 ± 0.106
0.717MetPhe: 0.717 ± 0.061
1.609MetGly: 1.609 ± 0.071
0.289MetHis: 0.289 ± 0.035
1.624MetIle: 1.624 ± 0.1
1.963MetLys: 1.963 ± 0.098
1.744MetLeu: 1.744 ± 0.088
0.523MetMet: 0.523 ± 0.059
0.986MetAsn: 0.986 ± 0.079
0.932MetPro: 0.932 ± 0.068
0.478MetGln: 0.478 ± 0.048
1.136MetArg: 1.136 ± 0.059
1.53MetSer: 1.53 ± 0.087
1.27MetThr: 1.27 ± 0.075
1.564MetVal: 1.564 ± 0.092
0.184MetTrp: 0.184 ± 0.036
0.438MetTyr: 0.438 ± 0.041
0.0MetXaa: 0.0 ± 0.0
Asn
2.028AsnAla: 2.028 ± 0.112
0.583AsnCys: 0.583 ± 0.063
1.53AsnAsp: 1.53 ± 0.092
2.785AsnGlu: 2.785 ± 0.117
1.814AsnPhe: 1.814 ± 0.109
2.675AsnGly: 2.675 ± 0.122
0.688AsnHis: 0.688 ± 0.063
2.83AsnIle: 2.83 ± 0.131
2.237AsnLys: 2.237 ± 0.119
4.394AsnLeu: 4.394 ± 0.158
0.767AsnMet: 0.767 ± 0.066
1.241AsnAsn: 1.241 ± 0.092
2.357AsnPro: 2.357 ± 0.107
0.887AsnGln: 0.887 ± 0.059
2.272AsnArg: 2.272 ± 0.107
2.302AsnSer: 2.302 ± 0.131
1.639AsnThr: 1.639 ± 0.088
2.561AsnVal: 2.561 ± 0.113
0.528AsnTrp: 0.528 ± 0.054
1.35AsnTyr: 1.35 ± 0.083
0.0AsnXaa: 0.0 ± 0.0
Pro
2.078ProAla: 2.078 ± 0.094
0.369ProCys: 0.369 ± 0.042
2.76ProAsp: 2.76 ± 0.125
4.678ProGlu: 4.678 ± 0.151
1.669ProPhe: 1.669 ± 0.101
2.949ProGly: 2.949 ± 0.126
0.817ProHis: 0.817 ± 0.063
2.641ProIle: 2.641 ± 0.104
2.496ProLys: 2.496 ± 0.107
3.298ProLeu: 3.298 ± 0.147
0.707ProMet: 0.707 ± 0.064
1.445ProAsn: 1.445 ± 0.079
1.868ProPro: 1.868 ± 0.103
1.066ProGln: 1.066 ± 0.077
1.858ProArg: 1.858 ± 0.109
2.954ProSer: 2.954 ± 0.121
1.973ProThr: 1.973 ± 0.1
2.939ProVal: 2.939 ± 0.134
0.463ProTrp: 0.463 ± 0.043
1.47ProTyr: 1.47 ± 0.075
0.0ProXaa: 0.0 ± 0.0
Gln
1.216GlnAla: 1.216 ± 0.084
0.214GlnCys: 0.214 ± 0.033
1.265GlnAsp: 1.265 ± 0.076
2.172GlnGlu: 2.172 ± 0.099
0.807GlnPhe: 0.807 ± 0.062
1.385GlnGly: 1.385 ± 0.083
0.414GlnHis: 0.414 ± 0.039
1.764GlnIle: 1.764 ± 0.089
2.127GlnLys: 2.127 ± 0.114
1.818GlnLeu: 1.818 ± 0.095
0.588GlnMet: 0.588 ± 0.053
0.981GlnAsn: 0.981 ± 0.076
0.707GlnPro: 0.707 ± 0.053
0.518GlnGln: 0.518 ± 0.047
1.32GlnArg: 1.32 ± 0.078
1.211GlnSer: 1.211 ± 0.071
1.161GlnThr: 1.161 ± 0.073
1.544GlnVal: 1.544 ± 0.09
0.199GlnTrp: 0.199 ± 0.035
0.648GlnTyr: 0.648 ± 0.051
0.0GlnXaa: 0.0 ± 0.0
Arg
3.378ArgAla: 3.378 ± 0.143
0.508ArgCys: 0.508 ± 0.048
3.293ArgAsp: 3.293 ± 0.137
6.616ArgGlu: 6.616 ± 0.195
2.247ArgPhe: 2.247 ± 0.117
4.25ArgGly: 4.25 ± 0.166
0.737ArgHis: 0.737 ± 0.072
3.896ArgIle: 3.896 ± 0.133
5.63ArgLys: 5.63 ± 0.192
4.614ArgLeu: 4.614 ± 0.185
1.36ArgMet: 1.36 ± 0.075
2.541ArgAsn: 2.541 ± 0.125
1.918ArgPro: 1.918 ± 0.099
1.096ArgGln: 1.096 ± 0.082
3.458ArgArg: 3.458 ± 0.153
3.214ArgSer: 3.214 ± 0.119
2.83ArgThr: 2.83 ± 0.129
3.732ArgVal: 3.732 ± 0.155
0.653ArgTrp: 0.653 ± 0.062
1.584ArgTyr: 1.584 ± 0.095
0.0ArgXaa: 0.0 ± 0.0
Ser
3.657SerAla: 3.657 ± 0.136
0.643SerCys: 0.643 ± 0.059
3.612SerAsp: 3.612 ± 0.15
6.696SerGlu: 6.696 ± 0.224
2.974SerPhe: 2.974 ± 0.129
5.176SerGly: 5.176 ± 0.16
1.131SerHis: 1.131 ± 0.075
4.165SerIle: 4.165 ± 0.149
4.633SerLys: 4.633 ± 0.18
5.919SerLeu: 5.919 ± 0.171
1.335SerMet: 1.335 ± 0.087
2.232SerAsn: 2.232 ± 0.098
2.735SerPro: 2.735 ± 0.108
1.5SerGln: 1.5 ± 0.087
3.453SerArg: 3.453 ± 0.122
4.185SerSer: 4.185 ± 0.18
2.9SerThr: 2.9 ± 0.115
4.19SerVal: 4.19 ± 0.156
0.707SerTrp: 0.707 ± 0.062
1.973SerTyr: 1.973 ± 0.109
0.0SerXaa: 0.0 ± 0.0
Thr
3.134ThrAla: 3.134 ± 0.134
0.503ThrCys: 0.503 ± 0.054
2.964ThrAsp: 2.964 ± 0.124
4.225ThrGlu: 4.225 ± 0.125
1.853ThrPhe: 1.853 ± 0.093
4.195ThrGly: 4.195 ± 0.15
0.907ThrHis: 0.907 ± 0.074
3.139ThrIle: 3.139 ± 0.125
2.775ThrLys: 2.775 ± 0.11
4.399ThrLeu: 4.399 ± 0.154
0.922ThrMet: 0.922 ± 0.076
1.49ThrAsn: 1.49 ± 0.098
2.362ThrPro: 2.362 ± 0.116
1.046ThrGln: 1.046 ± 0.067
2.461ThrArg: 2.461 ± 0.132
3.144ThrSer: 3.144 ± 0.131
2.606ThrThr: 2.606 ± 0.172
4.016ThrVal: 4.016 ± 0.14
0.488ThrTrp: 0.488 ± 0.059
1.604ThrTyr: 1.604 ± 0.091
0.0ThrXaa: 0.0 ± 0.0
Val
3.926ValAla: 3.926 ± 0.164
0.767ValCys: 0.767 ± 0.061
4.27ValAsp: 4.27 ± 0.177
6.965ValGlu: 6.965 ± 0.182
2.994ValPhe: 2.994 ± 0.142
5.012ValGly: 5.012 ± 0.177
1.33ValHis: 1.33 ± 0.075
4.32ValIle: 4.32 ± 0.146
4.952ValLys: 4.952 ± 0.146
6.417ValLeu: 6.417 ± 0.197
1.45ValMet: 1.45 ± 0.079
2.466ValAsn: 2.466 ± 0.124
2.631ValPro: 2.631 ± 0.13
1.674ValGln: 1.674 ± 0.097
3.707ValArg: 3.707 ± 0.138
4.907ValSer: 4.907 ± 0.191
3.547ValThr: 3.547 ± 0.139
4.838ValVal: 4.838 ± 0.192
0.698ValTrp: 0.698 ± 0.058
1.908ValTyr: 1.908 ± 0.098
0.0ValXaa: 0.0 ± 0.0
Trp
0.712TrpAla: 0.712 ± 0.066
0.11TrpCys: 0.11 ± 0.023
0.593TrpAsp: 0.593 ± 0.059
0.972TrpGlu: 0.972 ± 0.07
0.478TrpPhe: 0.478 ± 0.059
0.782TrpGly: 0.782 ± 0.064
0.164TrpHis: 0.164 ± 0.03
0.807TrpIle: 0.807 ± 0.061
0.986TrpLys: 0.986 ± 0.07
1.021TrpLeu: 1.021 ± 0.079
0.239TrpMet: 0.239 ± 0.034
0.448TrpAsn: 0.448 ± 0.046
0.254TrpPro: 0.254 ± 0.037
0.244TrpGln: 0.244 ± 0.035
0.892TrpArg: 0.892 ± 0.07
0.702TrpSer: 0.702 ± 0.058
0.573TrpThr: 0.573 ± 0.074
0.658TrpVal: 0.658 ± 0.07
0.12TrpTrp: 0.12 ± 0.024
0.224TrpTyr: 0.224 ± 0.034
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.515TyrAla: 1.515 ± 0.092
0.364TyrCys: 0.364 ± 0.037
1.838TyrAsp: 1.838 ± 0.12
2.7TyrGlu: 2.7 ± 0.1
1.435TyrPhe: 1.435 ± 0.086
2.377TyrGly: 2.377 ± 0.12
0.658TyrHis: 0.658 ± 0.063
1.804TyrIle: 1.804 ± 0.098
1.674TyrLys: 1.674 ± 0.095
3.144TyrLeu: 3.144 ± 0.144
0.583TyrMet: 0.583 ± 0.054
1.056TyrAsn: 1.056 ± 0.078
1.41TyrPro: 1.41 ± 0.081
0.782TyrGln: 0.782 ± 0.066
2.187TyrArg: 2.187 ± 0.106
2.142TyrSer: 2.142 ± 0.102
1.196TyrThr: 1.196 ± 0.08
1.724TyrVal: 1.724 ± 0.089
0.518TyrTrp: 0.518 ± 0.05
1.181TyrTyr: 1.181 ± 0.087
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 893 proteins (200716 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski