Amino acid dipepetide frequency for White spot syndrome virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.512AlaAla: 7.512 ± 0.726
0.904AlaCys: 0.904 ± 0.123
2.668AlaAsp: 2.668 ± 0.183
3.795AlaGlu: 3.795 ± 0.219
2.221AlaPhe: 2.221 ± 0.176
2.924AlaGly: 2.924 ± 0.396
1.049AlaHis: 1.049 ± 0.111
4.074AlaIle: 4.074 ± 0.276
3.717AlaLys: 3.717 ± 0.199
5.391AlaLeu: 5.391 ± 0.331
1.552AlaMet: 1.552 ± 0.153
3.103AlaAsn: 3.103 ± 0.207
2.846AlaPro: 2.846 ± 0.276
1.563AlaGln: 1.563 ± 0.165
2.623AlaArg: 2.623 ± 0.207
5.838AlaSer: 5.838 ± 0.304
3.438AlaThr: 3.438 ± 0.187
4.208AlaVal: 4.208 ± 0.256
0.346AlaTrp: 0.346 ± 0.063
1.317AlaTyr: 1.317 ± 0.111
0.0AlaXaa: 0.0 ± 0.0
Cys
0.871CysAla: 0.871 ± 0.101
0.391CysCys: 0.391 ± 0.078
1.083CysAsp: 1.083 ± 0.117
0.859CysGlu: 0.859 ± 0.088
1.016CysPhe: 1.016 ± 0.109
1.083CysGly: 1.083 ± 0.125
0.279CysHis: 0.279 ± 0.055
1.016CysIle: 1.016 ± 0.142
1.261CysLys: 1.261 ± 0.144
1.529CysLeu: 1.529 ± 0.148
0.435CysMet: 0.435 ± 0.073
0.893CysAsn: 0.893 ± 0.095
0.871CysPro: 0.871 ± 0.114
0.402CysGln: 0.402 ± 0.067
0.915CysArg: 0.915 ± 0.099
1.697CysSer: 1.697 ± 0.153
1.172CysThr: 1.172 ± 0.127
1.373CysVal: 1.373 ± 0.144
0.19CysTrp: 0.19 ± 0.04
0.525CysTyr: 0.525 ± 0.087
0.0CysXaa: 0.0 ± 0.0
Asp
3.46AspAla: 3.46 ± 0.235
0.904AspCys: 0.904 ± 0.112
5.179AspAsp: 5.179 ± 0.423
5.38AspGlu: 5.38 ± 0.383
2.668AspPhe: 2.668 ± 0.193
3.572AspGly: 3.572 ± 0.48
0.837AspHis: 0.837 ± 0.101
4.152AspIle: 4.152 ± 0.218
3.851AspLys: 3.851 ± 0.236
3.951AspLeu: 3.951 ± 0.218
1.775AspMet: 1.775 ± 0.196
3.382AspAsn: 3.382 ± 0.254
2.087AspPro: 2.087 ± 0.182
1.44AspGln: 1.44 ± 0.13
2.311AspArg: 2.311 ± 0.15
4.163AspSer: 4.163 ± 0.236
3.795AspThr: 3.795 ± 0.201
4.063AspVal: 4.063 ± 0.253
0.569AspTrp: 0.569 ± 0.083
2.076AspTyr: 2.076 ± 0.133
0.0AspXaa: 0.0 ± 0.0
Glu
3.438GluAla: 3.438 ± 0.266
0.938GluCys: 0.938 ± 0.127
6.106GluAsp: 6.106 ± 0.491
12.055GluGlu: 12.055 ± 0.986
2.266GluPhe: 2.266 ± 0.182
4.152GluGly: 4.152 ± 0.236
1.139GluHis: 1.139 ± 0.129
3.628GluIle: 3.628 ± 0.219
6.128GluLys: 6.128 ± 0.342
3.951GluLeu: 3.951 ± 0.226
2.098GluMet: 2.098 ± 0.152
4.688GluAsn: 4.688 ± 0.238
1.607GluPro: 1.607 ± 0.175
2.4GluGln: 2.4 ± 0.232
4.364GluArg: 4.364 ± 0.357
3.918GluSer: 3.918 ± 0.245
4.219GluThr: 4.219 ± 0.229
2.958GluVal: 2.958 ± 0.208
0.681GluTrp: 0.681 ± 0.072
2.009GluTyr: 2.009 ± 0.137
0.0GluXaa: 0.0 ± 0.0
Phe
2.11PheAla: 2.11 ± 0.153
0.826PheCys: 0.826 ± 0.099
2.311PheAsp: 2.311 ± 0.159
2.433PheGlu: 2.433 ± 0.204
2.333PhePhe: 2.333 ± 0.198
2.277PheGly: 2.277 ± 0.127
0.893PheHis: 0.893 ± 0.091
2.679PheIle: 2.679 ± 0.199
2.735PheLys: 2.735 ± 0.141
4.063PheLeu: 4.063 ± 0.221
1.027PheMet: 1.027 ± 0.085
2.779PheAsn: 2.779 ± 0.167
1.998PhePro: 1.998 ± 0.175
1.038PheGln: 1.038 ± 0.132
1.976PheArg: 1.976 ± 0.183
4.509PheSer: 4.509 ± 0.211
2.043PheThr: 2.043 ± 0.145
2.936PheVal: 2.936 ± 0.198
0.413PheTrp: 0.413 ± 0.08
1.339PheTyr: 1.339 ± 0.181
0.0PheXaa: 0.0 ± 0.0
Gly
3.527GlyAla: 3.527 ± 0.54
0.904GlyCys: 0.904 ± 0.097
3.449GlyAsp: 3.449 ± 0.146
4.677GlyGlu: 4.677 ± 0.64
2.087GlyPhe: 2.087 ± 0.161
5.748GlyGly: 5.748 ± 0.431
0.826GlyHis: 0.826 ± 0.09
2.902GlyIle: 2.902 ± 0.227
3.963GlyLys: 3.963 ± 0.265
3.628GlyLeu: 3.628 ± 0.232
1.306GlyMet: 1.306 ± 0.136
2.991GlyAsn: 2.991 ± 0.139
2.59GlyPro: 2.59 ± 1.086
1.306GlyGln: 1.306 ± 0.158
3.393GlyArg: 3.393 ± 0.606
4.431GlySer: 4.431 ± 0.216
2.857GlyThr: 2.857 ± 0.224
4.163GlyVal: 4.163 ± 0.242
0.413GlyTrp: 0.413 ± 0.071
1.172GlyTyr: 1.172 ± 0.124
0.0GlyXaa: 0.0 ± 0.0
His
0.781HisAla: 0.781 ± 0.088
0.391HisCys: 0.391 ± 0.084
0.926HisAsp: 0.926 ± 0.111
1.049HisGlu: 1.049 ± 0.108
0.982HisPhe: 0.982 ± 0.11
0.748HisGly: 0.748 ± 0.083
0.547HisHis: 0.547 ± 0.122
1.284HisIle: 1.284 ± 0.131
1.15HisLys: 1.15 ± 0.102
1.898HisLeu: 1.898 ± 0.166
0.469HisMet: 0.469 ± 0.074
0.893HisAsn: 0.893 ± 0.108
0.893HisPro: 0.893 ± 0.093
0.714HisGln: 0.714 ± 0.109
0.915HisArg: 0.915 ± 0.102
1.529HisSer: 1.529 ± 0.122
1.105HisThr: 1.105 ± 0.127
1.261HisVal: 1.261 ± 0.109
0.123HisTrp: 0.123 ± 0.036
0.525HisTyr: 0.525 ± 0.076
0.0HisXaa: 0.0 ± 0.0
Ile
3.282IleAla: 3.282 ± 0.218
1.06IleCys: 1.06 ± 0.128
3.326IleAsp: 3.326 ± 0.17
3.717IleGlu: 3.717 ± 0.206
2.768IlePhe: 2.768 ± 0.201
2.813IleGly: 2.813 ± 0.305
1.105IleHis: 1.105 ± 0.122
3.683IleIle: 3.683 ± 0.241
4.42IleLys: 4.42 ± 0.248
5.034IleLeu: 5.034 ± 0.24
1.406IleMet: 1.406 ± 0.136
3.762IleAsn: 3.762 ± 0.23
2.657IlePro: 2.657 ± 0.161
1.685IleGln: 1.685 ± 0.128
2.958IleArg: 2.958 ± 0.172
5.045IleSer: 5.045 ± 0.216
3.65IleThr: 3.65 ± 0.196
4.331IleVal: 4.331 ± 0.258
0.446IleTrp: 0.446 ± 0.075
1.206IleTyr: 1.206 ± 0.1
0.0IleXaa: 0.0 ± 0.0
Lys
3.248LysAla: 3.248 ± 0.208
1.429LysCys: 1.429 ± 0.145
4.175LysAsp: 4.175 ± 0.23
5.224LysGlu: 5.224 ± 0.285
2.344LysPhe: 2.344 ± 0.133
3.583LysGly: 3.583 ± 0.299
1.764LysHis: 1.764 ± 0.14
4.443LysIle: 4.443 ± 0.271
7.735LysLys: 7.735 ± 0.513
5.112LysLeu: 5.112 ± 0.243
2.355LysMet: 2.355 ± 0.157
5.168LysAsn: 5.168 ± 0.31
2.009LysPro: 2.009 ± 0.155
2.333LysGln: 2.333 ± 0.172
5.246LysArg: 5.246 ± 0.342
5.19LysSer: 5.19 ± 0.271
4.722LysThr: 4.722 ± 0.235
3.382LysVal: 3.382 ± 0.218
0.67LysTrp: 0.67 ± 0.085
2.411LysTyr: 2.411 ± 0.172
0.0LysXaa: 0.0 ± 0.0
Leu
4.956LeuAla: 4.956 ± 0.257
1.752LeuCys: 1.752 ± 0.192
4.331LeuAsp: 4.331 ± 0.203
4.867LeuGlu: 4.867 ± 0.219
3.862LeuPhe: 3.862 ± 0.199
3.739LeuGly: 3.739 ± 0.25
1.518LeuHis: 1.518 ± 0.131
3.918LeuIle: 3.918 ± 0.266
5.414LeuLys: 5.414 ± 0.278
7.992LeuLeu: 7.992 ± 0.362
2.177LeuMet: 2.177 ± 0.177
4.23LeuAsn: 4.23 ± 0.224
3.862LeuPro: 3.862 ± 0.183
2.5LeuGln: 2.5 ± 0.163
3.795LeuArg: 3.795 ± 0.192
6.999LeuSer: 6.999 ± 0.349
4.03LeuThr: 4.03 ± 0.291
4.599LeuVal: 4.599 ± 0.197
0.491LeuTrp: 0.491 ± 0.078
2.757LeuTyr: 2.757 ± 0.165
0.0LeuXaa: 0.0 ± 0.0
Met
2.054MetAla: 2.054 ± 0.158
0.636MetCys: 0.636 ± 0.121
2.076MetAsp: 2.076 ± 0.133
1.965MetGlu: 1.965 ± 0.152
1.094MetPhe: 1.094 ± 0.108
1.563MetGly: 1.563 ± 0.141
0.413MetHis: 0.413 ± 0.072
1.038MetIle: 1.038 ± 0.091
1.831MetLys: 1.831 ± 0.156
1.875MetLeu: 1.875 ± 0.152
0.993MetMet: 0.993 ± 0.108
1.183MetAsn: 1.183 ± 0.119
0.848MetPro: 0.848 ± 0.098
0.714MetGln: 0.714 ± 0.086
1.306MetArg: 1.306 ± 0.12
2.344MetSer: 2.344 ± 0.166
1.63MetThr: 1.63 ± 0.114
1.652MetVal: 1.652 ± 0.144
0.257MetTrp: 0.257 ± 0.045
0.993MetTyr: 0.993 ± 0.108
0.0MetXaa: 0.0 ± 0.0
Asn
3.304AsnAla: 3.304 ± 0.235
1.06AsnCys: 1.06 ± 0.098
3.215AsnAsp: 3.215 ± 0.248
3.248AsnGlu: 3.248 ± 0.229
2.467AsnPhe: 2.467 ± 0.166
3.204AsnGly: 3.204 ± 0.235
0.926AsnHis: 0.926 ± 0.096
4.387AsnIle: 4.387 ± 0.291
5.592AsnLys: 5.592 ± 0.296
4.297AsnLeu: 4.297 ± 0.216
1.574AsnMet: 1.574 ± 0.134
6.173AsnAsn: 6.173 ± 0.369
2.255AsnPro: 2.255 ± 0.169
1.418AsnGln: 1.418 ± 0.145
2.824AsnArg: 2.824 ± 0.151
4.811AsnSer: 4.811 ± 0.35
4.219AsnThr: 4.219 ± 0.271
4.297AsnVal: 4.297 ± 0.22
0.614AsnTrp: 0.614 ± 0.08
1.641AsnTyr: 1.641 ± 0.138
0.0AsnXaa: 0.0 ± 0.0
Pro
2.712ProAla: 2.712 ± 0.272
0.614ProCys: 0.614 ± 0.078
1.685ProAsp: 1.685 ± 0.118
2.891ProGlu: 2.891 ± 0.223
2.043ProPhe: 2.043 ± 0.175
1.976ProGly: 1.976 ± 0.452
0.759ProHis: 0.759 ± 0.091
2.634ProIle: 2.634 ± 0.155
2.467ProLys: 2.467 ± 0.204
3.505ProLeu: 3.505 ± 0.239
0.848ProMet: 0.848 ± 0.096
1.775ProAsn: 1.775 ± 0.15
4.309ProPro: 4.309 ± 0.645
1.507ProGln: 1.507 ± 0.322
1.987ProArg: 1.987 ± 0.209
4.744ProSer: 4.744 ± 0.293
2.724ProThr: 2.724 ± 0.197
3.204ProVal: 3.204 ± 0.173
0.324ProTrp: 0.324 ± 0.068
1.083ProTyr: 1.083 ± 0.123
0.0ProXaa: 0.0 ± 0.0
Gln
1.507GlnAla: 1.507 ± 0.123
0.413GlnCys: 0.413 ± 0.063
1.261GlnAsp: 1.261 ± 0.103
2.266GlnGlu: 2.266 ± 0.181
1.228GlnPhe: 1.228 ± 0.107
1.652GlnGly: 1.652 ± 0.449
0.804GlnHis: 0.804 ± 0.105
1.362GlnIle: 1.362 ± 0.156
2.031GlnLys: 2.031 ± 0.146
2.299GlnLeu: 2.299 ± 0.208
0.848GlnMet: 0.848 ± 0.101
1.462GlnAsn: 1.462 ± 0.152
1.172GlnPro: 1.172 ± 0.144
3.561GlnGln: 3.561 ± 0.776
1.808GlnArg: 1.808 ± 0.282
1.819GlnSer: 1.819 ± 0.178
1.619GlnThr: 1.619 ± 0.14
1.652GlnVal: 1.652 ± 0.121
0.19GlnTrp: 0.19 ± 0.04
1.272GlnTyr: 1.272 ± 0.12
0.0GlnXaa: 0.0 ± 0.0
Arg
3.092ArgAla: 3.092 ± 0.241
0.915ArgCys: 0.915 ± 0.117
3.125ArgAsp: 3.125 ± 0.239
3.572ArgGlu: 3.572 ± 0.38
1.752ArgPhe: 1.752 ± 0.108
3.438ArgGly: 3.438 ± 0.63
1.161ArgHis: 1.161 ± 0.125
2.869ArgIle: 2.869 ± 0.194
4.13ArgLys: 4.13 ± 0.28
4.063ArgLeu: 4.063 ± 0.238
1.295ArgMet: 1.295 ± 0.105
3.215ArgAsn: 3.215 ± 0.224
2.098ArgPro: 2.098 ± 0.169
1.998ArgGln: 1.998 ± 0.167
3.661ArgArg: 3.661 ± 0.295
3.404ArgSer: 3.404 ± 0.194
2.69ArgThr: 2.69 ± 0.157
3.047ArgVal: 3.047 ± 0.179
0.301ArgTrp: 0.301 ± 0.063
1.451ArgTyr: 1.451 ± 0.138
0.0ArgXaa: 0.0 ± 0.0
Ser
5.469SerAla: 5.469 ± 0.391
1.429SerCys: 1.429 ± 0.136
5.302SerAsp: 5.302 ± 0.34
4.487SerGlu: 4.487 ± 0.239
3.795SerPhe: 3.795 ± 0.193
4.498SerGly: 4.498 ± 0.24
1.317SerHis: 1.317 ± 0.122
5.324SerIle: 5.324 ± 0.224
5.458SerLys: 5.458 ± 0.264
6.798SerLeu: 6.798 ± 0.304
2.244SerMet: 2.244 ± 0.174
5.358SerAsn: 5.358 ± 0.351
4.108SerPro: 4.108 ± 0.299
1.708SerGln: 1.708 ± 0.141
3.84SerArg: 3.84 ± 0.22
14.511SerSer: 14.511 ± 1.073
5.581SerThr: 5.581 ± 0.301
5.536SerVal: 5.536 ± 0.301
0.58SerTrp: 0.58 ± 0.078
2.098SerTyr: 2.098 ± 0.177
0.0SerXaa: 0.0 ± 0.0
Thr
4.085ThrAla: 4.085 ± 0.246
1.161ThrCys: 1.161 ± 0.121
3.427ThrAsp: 3.427 ± 0.225
3.527ThrGlu: 3.527 ± 0.165
2.735ThrPhe: 2.735 ± 0.199
3.773ThrGly: 3.773 ± 0.394
1.016ThrHis: 1.016 ± 0.103
3.382ThrIle: 3.382 ± 0.203
3.538ThrLys: 3.538 ± 0.155
4.487ThrLeu: 4.487 ± 0.228
1.429ThrMet: 1.429 ± 0.117
3.873ThrAsn: 3.873 ± 0.199
3.494ThrPro: 3.494 ± 0.278
1.317ThrGln: 1.317 ± 0.138
2.578ThrArg: 2.578 ± 0.131
6.128ThrSer: 6.128 ± 0.315
4.867ThrThr: 4.867 ± 0.407
3.471ThrVal: 3.471 ± 0.222
0.413ThrTrp: 0.413 ± 0.059
1.529ThrTyr: 1.529 ± 0.115
0.0ThrXaa: 0.0 ± 0.0
Val
3.639ValAla: 3.639 ± 0.209
1.362ValCys: 1.362 ± 0.132
3.717ValAsp: 3.717 ± 0.191
4.163ValGlu: 4.163 ± 0.223
3.215ValPhe: 3.215 ± 0.198
3.449ValGly: 3.449 ± 0.287
1.272ValHis: 1.272 ± 0.139
3.527ValIle: 3.527 ± 0.219
4.498ValLys: 4.498 ± 0.22
5.302ValLeu: 5.302 ± 0.322
1.652ValMet: 1.652 ± 0.139
3.65ValAsn: 3.65 ± 0.223
2.902ValPro: 2.902 ± 0.194
1.708ValGln: 1.708 ± 0.123
2.724ValArg: 2.724 ± 0.153
5.481ValSer: 5.481 ± 0.283
3.672ValThr: 3.672 ± 0.247
4.487ValVal: 4.487 ± 0.208
0.48ValTrp: 0.48 ± 0.084
2.177ValTyr: 2.177 ± 0.151
0.0ValXaa: 0.0 ± 0.0
Trp
0.491TrpAla: 0.491 ± 0.071
0.19TrpCys: 0.19 ± 0.049
0.346TrpAsp: 0.346 ± 0.067
0.48TrpGlu: 0.48 ± 0.079
0.335TrpPhe: 0.335 ± 0.058
0.469TrpGly: 0.469 ± 0.077
0.067TrpHis: 0.067 ± 0.023
0.446TrpIle: 0.446 ± 0.056
0.592TrpLys: 0.592 ± 0.087
0.67TrpLeu: 0.67 ± 0.092
0.279TrpMet: 0.279 ± 0.05
0.659TrpAsn: 0.659 ± 0.087
0.223TrpPro: 0.223 ± 0.056
0.179TrpGln: 0.179 ± 0.043
0.458TrpArg: 0.458 ± 0.075
0.491TrpSer: 0.491 ± 0.065
0.558TrpThr: 0.558 ± 0.08
0.491TrpVal: 0.491 ± 0.082
0.112TrpTrp: 0.112 ± 0.038
0.212TrpTyr: 0.212 ± 0.04
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.552TyrAla: 1.552 ± 0.127
0.58TyrCys: 0.58 ± 0.085
1.909TyrAsp: 1.909 ± 0.148
2.087TyrGlu: 2.087 ± 0.179
1.507TyrPhe: 1.507 ± 0.141
1.674TyrGly: 1.674 ± 0.155
0.491TyrHis: 0.491 ± 0.078
1.607TyrIle: 1.607 ± 0.129
2.043TyrLys: 2.043 ± 0.173
1.942TyrLeu: 1.942 ± 0.172
0.692TyrMet: 0.692 ± 0.088
2.288TyrAsn: 2.288 ± 0.144
0.96TyrPro: 0.96 ± 0.108
0.737TyrGln: 0.737 ± 0.083
1.596TyrArg: 1.596 ± 0.172
2.389TyrSer: 2.389 ± 0.175
1.641TyrThr: 1.641 ± 0.137
1.965TyrVal: 1.965 ± 0.159
0.134TyrTrp: 0.134 ± 0.042
1.194TyrTyr: 1.194 ± 0.104
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 164 proteins (89590 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski