Amino acid dipepetide frequency for Planctomycetes bacterium Pla163

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.726AlaAla: 17.726 ± 0.187	1.228AlaCys: 1.228 ± 0.03	7.413AlaAsp: 7.413 ± 0.077	7.562AlaGlu: 7.562 ± 0.079	4.321AlaPhe: 4.321 ± 0.053	10.752AlaGly: 10.752 ± 0.104	2.27AlaHis: 2.27 ± 0.046	4.609AlaIle: 4.609 ± 0.063	2.474AlaLys: 2.474 ± 0.054	15.349AlaLeu: 15.349 ± 0.128	1.954AlaMet: 1.954 ± 0.036	2.564AlaAsn: 2.564 ± 0.048	7.176AlaPro: 7.176 ± 0.085	3.268AlaGln: 3.268 ± 0.048	11.616AlaArg: 11.616 ± 0.134	7.472AlaSer: 7.472 ± 0.078	7.011AlaThr: 7.011 ± 0.08	9.347AlaVal: 9.347 ± 0.095	1.928AlaTrp: 1.928 ± 0.039	2.018AlaTyr: 2.018 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.138CysAla: 1.138 ± 0.03	0.099CysCys: 0.099 ± 0.009	0.601CysAsp: 0.601 ± 0.024	0.566CysGlu: 0.566 ± 0.02	0.325CysPhe: 0.325 ± 0.015	0.979CysGly: 0.979 ± 0.023	0.307CysHis: 0.307 ± 0.033	0.291CysIle: 0.291 ± 0.014	0.126CysLys: 0.126 ± 0.01	0.815CysLeu: 0.815 ± 0.024	0.119CysMet: 0.119 ± 0.009	0.168CysAsn: 0.168 ± 0.012	0.446CysPro: 0.446 ± 0.019	0.193CysGln: 0.193 ± 0.011	0.604CysArg: 0.604 ± 0.02	0.481CysSer: 0.481 ± 0.021	0.493CysThr: 0.493 ± 0.02	0.795CysVal: 0.795 ± 0.026	0.111CysTrp: 0.111 ± 0.009	0.177CysTyr: 0.177 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.974AspAla: 8.974 ± 0.095	0.409AspCys: 0.409 ± 0.024	4.501AspAsp: 4.501 ± 0.067	5.022AspGlu: 5.022 ± 0.068	2.061AspPhe: 2.061 ± 0.046	7.987AspGly: 7.987 ± 0.126	1.379AspHis: 1.379 ± 0.029	1.467AspIle: 1.467 ± 0.036	0.746AspLys: 0.746 ± 0.026	7.577AspLeu: 7.577 ± 0.084	0.935AspMet: 0.935 ± 0.026	0.799AspAsn: 0.799 ± 0.023	4.875AspPro: 4.875 ± 0.063	1.549AspGln: 1.549 ± 0.034	5.092AspArg: 5.092 ± 0.078	2.727AspSer: 2.727 ± 0.048	2.692AspThr: 2.692 ± 0.042	5.611AspVal: 5.611 ± 0.069	1.05AspTrp: 1.05 ± 0.03	1.074AspTyr: 1.074 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	7.529GluAla: 7.529 ± 0.105	0.417GluCys: 0.417 ± 0.019	3.338GluAsp: 3.338 ± 0.054	3.625GluGlu: 3.625 ± 0.069	2.07GluPhe: 2.07 ± 0.037	4.9GluGly: 4.9 ± 0.068	1.657GluHis: 1.657 ± 0.039	2.554GluIle: 2.554 ± 0.045	1.308GluLys: 1.308 ± 0.037	8.712GluLeu: 8.712 ± 0.089	1.011GluMet: 1.011 ± 0.027	1.26GluAsn: 1.26 ± 0.03	3.892GluPro: 3.892 ± 0.052	2.072GluGln: 2.072 ± 0.045	8.727GluArg: 8.727 ± 0.114	3.549GluSer: 3.549 ± 0.052	2.895GluThr: 2.895 ± 0.045	5.087GluVal: 5.087 ± 0.062	0.93GluTrp: 0.93 ± 0.029	1.113GluTyr: 1.113 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.605PheAla: 4.605 ± 0.065	0.352PheCys: 0.352 ± 0.017	3.343PheAsp: 3.343 ± 0.058	3.158PheGlu: 3.158 ± 0.058	1.086PhePhe: 1.086 ± 0.033	3.798PheGly: 3.798 ± 0.055	0.668PheHis: 0.668 ± 0.02	0.703PheIle: 0.703 ± 0.024	0.557PheLys: 0.557 ± 0.024	2.985PheLeu: 2.985 ± 0.054	0.556PheMet: 0.556 ± 0.021	0.638PheAsn: 0.638 ± 0.023	1.344PhePro: 1.344 ± 0.031	0.896PheGln: 0.896 ± 0.027	1.906PheArg: 1.906 ± 0.038	1.598PheSer: 1.598 ± 0.037	1.904PheThr: 1.904 ± 0.037	3.222PheVal: 3.222 ± 0.044	0.434PheTrp: 0.434 ± 0.017	0.615PheTyr: 0.615 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	11.818GlyAla: 11.818 ± 0.128	0.88GlyCys: 0.88 ± 0.026	6.129GlyAsp: 6.129 ± 0.106	5.504GlyGlu: 5.504 ± 0.067	3.268GlyPhe: 3.268 ± 0.05	8.878GlyGly: 8.878 ± 0.132	1.827GlyHis: 1.827 ± 0.037	3.176GlyIle: 3.176 ± 0.049	1.674GlyLys: 1.674 ± 0.039	9.447GlyLeu: 9.447 ± 0.088	1.572GlyMet: 1.572 ± 0.037	1.789GlyAsn: 1.789 ± 0.046	4.756GlyPro: 4.756 ± 0.058	2.251GlyGln: 2.251 ± 0.042	7.744GlyArg: 7.744 ± 0.086	5.979GlySer: 5.979 ± 0.073	5.644GlyThr: 5.644 ± 0.068	6.832GlyVal: 6.832 ± 0.077	1.55GlyTrp: 1.55 ± 0.034	1.846GlyTyr: 1.846 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.418HisAla: 2.418 ± 0.048	0.2HisCys: 0.2 ± 0.011	1.253HisAsp: 1.253 ± 0.028	1.248HisGlu: 1.248 ± 0.03	0.75HisPhe: 0.75 ± 0.024	2.049HisGly: 2.049 ± 0.052	0.543HisHis: 0.543 ± 0.022	0.515HisIle: 0.515 ± 0.018	0.295HisLys: 0.295 ± 0.014	2.397HisLeu: 2.397 ± 0.044	0.359HisMet: 0.359 ± 0.015	0.293HisAsn: 0.293 ± 0.016	1.391HisPro: 1.391 ± 0.033	0.49HisGln: 0.49 ± 0.021	1.576HisArg: 1.576 ± 0.034	0.847HisSer: 0.847 ± 0.026	1.021HisThr: 1.021 ± 0.029	1.838HisVal: 1.838 ± 0.038	0.355HisTrp: 0.355 ± 0.018	0.439HisTyr: 0.439 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	4.941IleAla: 4.941 ± 0.061	0.317IleCys: 0.317 ± 0.015	3.218IleAsp: 3.218 ± 0.048	3.429IleGlu: 3.429 ± 0.052	0.896IlePhe: 0.896 ± 0.03	3.704IleGly: 3.704 ± 0.059	0.69IleHis: 0.69 ± 0.022	0.658IleIle: 0.658 ± 0.024	0.578IleLys: 0.578 ± 0.024	2.773IleLeu: 2.773 ± 0.043	0.348IleMet: 0.348 ± 0.017	0.623IleAsn: 0.623 ± 0.024	1.439IlePro: 1.439 ± 0.032	0.897IleGln: 0.897 ± 0.027	1.815IleArg: 1.815 ± 0.039	1.54IleSer: 1.54 ± 0.031	1.64IleThr: 1.64 ± 0.039	3.149IleVal: 3.149 ± 0.049	0.379IleTrp: 0.379 ± 0.018	0.642IleTyr: 0.642 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	1.918LysAla: 1.918 ± 0.056	0.123LysCys: 0.123 ± 0.008	1.111LysAsp: 1.111 ± 0.027	1.044LysGlu: 1.044 ± 0.033	0.468LysPhe: 0.468 ± 0.019	1.679LysGly: 1.679 ± 0.041	0.397LysHis: 0.397 ± 0.017	0.791LysIle: 0.791 ± 0.025	0.881LysLys: 0.881 ± 0.05	1.855LysLeu: 1.855 ± 0.037	0.332LysMet: 0.332 ± 0.015	0.487LysAsn: 0.487 ± 0.02	0.98LysPro: 0.98 ± 0.03	0.527LysGln: 0.527 ± 0.023	1.688LysArg: 1.688 ± 0.039	1.13LysSer: 1.13 ± 0.034	0.89LysThr: 0.89 ± 0.032	1.437LysVal: 1.437 ± 0.04	0.238LysTrp: 0.238 ± 0.014	0.338LysTyr: 0.338 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	15.854LeuAla: 15.854 ± 0.123	1.083LeuCys: 1.083 ± 0.028	8.122LeuAsp: 8.122 ± 0.095	8.825LeuGlu: 8.825 ± 0.089	3.753LeuPhe: 3.753 ± 0.056	9.78LeuGly: 9.78 ± 0.093	1.907LeuHis: 1.907 ± 0.035	2.98LeuIle: 2.98 ± 0.049	1.686LeuLys: 1.686 ± 0.043	10.448LeuLeu: 10.448 ± 0.114	1.56LeuMet: 1.56 ± 0.034	1.476LeuAsn: 1.476 ± 0.037	5.645LeuPro: 5.645 ± 0.069	2.054LeuGln: 2.054 ± 0.042	8.231LeuArg: 8.231 ± 0.093	5.146LeuSer: 5.146 ± 0.067	4.909LeuThr: 4.909 ± 0.064	10.73LeuVal: 10.73 ± 0.101	1.474LeuTrp: 1.474 ± 0.035	1.715LeuTyr: 1.715 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	1.785MetAla: 1.785 ± 0.039	0.13MetCys: 0.13 ± 0.01	0.922MetAsp: 0.922 ± 0.028	0.857MetGlu: 0.857 ± 0.023	0.469MetPhe: 0.469 ± 0.018	1.415MetGly: 1.415 ± 0.035	0.321MetHis: 0.321 ± 0.013	0.585MetIle: 0.585 ± 0.022	0.476MetLys: 0.476 ± 0.017	1.583MetLeu: 1.583 ± 0.038	0.232MetMet: 0.232 ± 0.014	0.499MetAsn: 0.499 ± 0.018	0.912MetPro: 0.912 ± 0.024	0.522MetGln: 0.522 ± 0.017	1.395MetArg: 1.395 ± 0.034	1.124MetSer: 1.124 ± 0.026	1.082MetThr: 1.082 ± 0.031	1.175MetVal: 1.175 ± 0.027	0.186MetTrp: 0.186 ± 0.012	0.265MetTyr: 0.265 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.324AsnAla: 2.324 ± 0.044	0.186AsnCys: 0.186 ± 0.011	1.32AsnAsp: 1.32 ± 0.033	1.124AsnGlu: 1.124 ± 0.028	0.641AsnPhe: 0.641 ± 0.022	2.237AsnGly: 2.237 ± 0.059	0.386AsnHis: 0.386 ± 0.017	0.552AsnIle: 0.552 ± 0.022	0.34AsnLys: 0.34 ± 0.017	1.957AsnLeu: 1.957 ± 0.037	0.325AsnMet: 0.325 ± 0.015	0.413AsnAsn: 0.413 ± 0.021	1.222AsnPro: 1.222 ± 0.033	0.514AsnGln: 0.514 ± 0.023	1.299AsnArg: 1.299 ± 0.033	1.031AsnSer: 1.031 ± 0.033	1.012AsnThr: 1.012 ± 0.031	1.594AsnVal: 1.594 ± 0.036	0.331AsnTrp: 0.331 ± 0.017	0.404AsnTyr: 0.404 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	6.444ProAla: 6.444 ± 0.075	0.37ProCys: 0.37 ± 0.017	4.017ProAsp: 4.017 ± 0.056	3.611ProGlu: 3.611 ± 0.05	2.09ProPhe: 2.09 ± 0.037	5.066ProGly: 5.066 ± 0.072	1.091ProHis: 1.091 ± 0.033	2.093ProIle: 2.093 ± 0.032	1.126ProLys: 1.126 ± 0.031	5.458ProLeu: 5.458 ± 0.069	0.85ProMet: 0.85 ± 0.023	1.381ProAsn: 1.381 ± 0.033	2.864ProPro: 2.864 ± 0.055	1.393ProGln: 1.393 ± 0.031	4.076ProArg: 4.076 ± 0.062	3.611ProSer: 3.611 ± 0.047	3.456ProThr: 3.456 ± 0.053	4.224ProVal: 4.224 ± 0.052	0.837ProTrp: 0.837 ± 0.026	0.963ProTyr: 0.963 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	2.685GlnAla: 2.685 ± 0.044	0.176GlnCys: 0.176 ± 0.012	1.34GlnAsp: 1.34 ± 0.036	1.282GlnGlu: 1.282 ± 0.035	0.821GlnPhe: 0.821 ± 0.026	1.961GlnGly: 1.961 ± 0.039	0.542GlnHis: 0.542 ± 0.021	1.139GlnIle: 1.139 ± 0.024	0.514GlnLys: 0.514 ± 0.023	3.016GlnLeu: 3.016 ± 0.048	0.516GlnMet: 0.516 ± 0.019	0.565GlnAsn: 0.565 ± 0.022	1.364GlnPro: 1.364 ± 0.033	0.774GlnGln: 0.774 ± 0.034	2.537GlnArg: 2.537 ± 0.046	1.417GlnSer: 1.417 ± 0.028	1.067GlnThr: 1.067 ± 0.027	2.245GlnVal: 2.245 ± 0.042	0.357GlnTrp: 0.357 ± 0.015	0.453GlnTyr: 0.453 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	11.251ArgAla: 11.251 ± 0.141	0.701ArgCys: 0.701 ± 0.022	4.766ArgAsp: 4.766 ± 0.07	5.313ArgGlu: 5.313 ± 0.072	3.308ArgPhe: 3.308 ± 0.056	6.489ArgGly: 6.489 ± 0.079	1.613ArgHis: 1.613 ± 0.037	3.454ArgIle: 3.454 ± 0.054	1.227ArgLys: 1.227 ± 0.035	9.03ArgLeu: 9.03 ± 0.101	1.712ArgMet: 1.712 ± 0.031	1.36ArgAsn: 1.36 ± 0.033	4.48ArgPro: 4.48 ± 0.066	1.819ArgGln: 1.819 ± 0.038	7.735ArgArg: 7.735 ± 0.11	5.079ArgSer: 5.079 ± 0.071	4.894ArgThr: 4.894 ± 0.065	6.751ArgVal: 6.751 ± 0.079	1.3ArgTrp: 1.3 ± 0.033	1.645ArgTyr: 1.645 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.594SerAla: 6.594 ± 0.076	0.554SerCys: 0.554 ± 0.026	3.668SerAsp: 3.668 ± 0.052	3.173SerGlu: 3.173 ± 0.053	2.014SerPhe: 2.014 ± 0.038	6.199SerGly: 6.199 ± 0.078	1.013SerHis: 1.013 ± 0.027	2.377SerIle: 2.377 ± 0.045	1.225SerLys: 1.225 ± 0.034	5.129SerLeu: 5.129 ± 0.066	1.068SerMet: 1.068 ± 0.027	1.483SerAsn: 1.483 ± 0.037	2.784SerPro: 2.784 ± 0.047	1.296SerGln: 1.296 ± 0.029	3.761SerArg: 3.761 ± 0.064	3.7SerSer: 3.7 ± 0.066	3.444SerThr: 3.444 ± 0.056	4.15SerVal: 4.15 ± 0.068	0.845SerTrp: 0.845 ± 0.03	1.044SerTyr: 1.044 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.232ThrAla: 6.232 ± 0.083	0.505ThrCys: 0.505 ± 0.018	3.357ThrAsp: 3.357 ± 0.052	2.993ThrGlu: 2.993 ± 0.049	2.104ThrPhe: 2.104 ± 0.043	5.222ThrGly: 5.222 ± 0.066	0.993ThrHis: 0.993 ± 0.029	2.089ThrIle: 2.089 ± 0.04	1.055ThrLys: 1.055 ± 0.036	5.648ThrLeu: 5.648 ± 0.066	0.749ThrMet: 0.749 ± 0.023	1.246ThrAsn: 1.246 ± 0.033	3.248ThrPro: 3.248 ± 0.053	1.22ThrGln: 1.22 ± 0.027	3.787ThrArg: 3.787 ± 0.052	3.283ThrSer: 3.283 ± 0.051	3.299ThrThr: 3.299 ± 0.053	4.197ThrVal: 4.197 ± 0.058	0.965ThrTrp: 0.965 ± 0.027	1.072ThrTyr: 1.072 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	10.523ValAla: 10.523 ± 0.095	0.748ValCys: 0.748 ± 0.024	6.036ValAsp: 6.036 ± 0.071	6.307ValGlu: 6.307 ± 0.078	2.589ValPhe: 2.589 ± 0.047	6.931ValGly: 6.931 ± 0.07	1.95ValHis: 1.95 ± 0.04	2.351ValIle: 2.351 ± 0.045	1.342ValLys: 1.342 ± 0.033	9.495ValLeu: 9.495 ± 0.093	1.119ValMet: 1.119 ± 0.035	1.385ValAsn: 1.385 ± 0.035	4.637ValPro: 4.637 ± 0.056	2.131ValGln: 2.131 ± 0.041	7.204ValArg: 7.204 ± 0.09	3.711ValSer: 3.711 ± 0.057	4.092ValThr: 4.092 ± 0.067	7.995ValVal: 7.995 ± 0.093	1.041ValTrp: 1.041 ± 0.027	1.337ValTyr: 1.337 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.26TrpAla: 1.26 ± 0.035	0.197TrpCys: 0.197 ± 0.012	0.752TrpAsp: 0.752 ± 0.025	0.775TrpGlu: 0.775 ± 0.025	0.604TrpPhe: 0.604 ± 0.022	0.897TrpGly: 0.897 ± 0.027	0.321TrpHis: 0.321 ± 0.015	0.882TrpIle: 0.882 ± 0.029	0.4TrpLys: 0.4 ± 0.019	1.72TrpLeu: 1.72 ± 0.038	0.337TrpMet: 0.337 ± 0.016	0.469TrpAsn: 0.469 ± 0.02	0.712TrpPro: 0.712 ± 0.025	0.407TrpGln: 0.407 ± 0.017	1.484TrpArg: 1.484 ± 0.036	1.141TrpSer: 1.141 ± 0.032	0.917TrpThr: 0.917 ± 0.029	1.006TrpVal: 1.006 ± 0.025	0.279TrpTrp: 0.279 ± 0.013	0.326TrpTyr: 0.326 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.04TyrAla: 2.04 ± 0.043	0.16TyrCys: 0.16 ± 0.012	1.32TyrAsp: 1.32 ± 0.039	1.229TyrGlu: 1.229 ± 0.031	0.728TyrPhe: 0.728 ± 0.027	1.643TyrGly: 1.643 ± 0.032	0.401TyrHis: 0.401 ± 0.018	0.412TyrIle: 0.412 ± 0.017	0.284TyrLys: 0.284 ± 0.016	1.981TyrLeu: 1.981 ± 0.043	0.278TyrMet: 0.278 ± 0.014	0.314TyrAsn: 0.314 ± 0.015	0.853TyrPro: 0.853 ± 0.027	0.498TyrGln: 0.498 ± 0.018	1.649TyrArg: 1.649 ± 0.038	0.955TyrSer: 0.955 ± 0.028	0.903TyrThr: 0.903 ± 0.03	1.539TyrVal: 1.539 ± 0.038	0.297TyrTrp: 0.297 ± 0.015	0.424TyrTyr: 0.424 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3741 proteins (1465947 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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