Amino acid dipepetide frequency for Stygiolobus rod-shaped virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.501AlaAla: 0.501 ± 0.218
0.0AlaCys: 0.0 ± 0.0
1.752AlaAsp: 1.752 ± 0.494
2.003AlaGlu: 2.003 ± 0.43
2.629AlaPhe: 2.629 ± 0.663
3.129AlaGly: 3.129 ± 0.657
0.376AlaHis: 0.376 ± 0.206
6.759AlaIle: 6.759 ± 0.958
3.505AlaLys: 3.505 ± 0.862
6.008AlaLeu: 6.008 ± 0.961
1.001AlaMet: 1.001 ± 0.393
3.38AlaAsn: 3.38 ± 0.69
1.127AlaPro: 1.127 ± 0.337
2.253AlaGln: 2.253 ± 0.691
1.878AlaArg: 1.878 ± 0.422
2.378AlaSer: 2.378 ± 0.402
2.003AlaThr: 2.003 ± 0.418
2.879AlaVal: 2.879 ± 0.431
0.876AlaTrp: 0.876 ± 0.295
3.004AlaTyr: 3.004 ± 0.629
0.0AlaXaa: 0.0 ± 0.0
Cys
0.125CysAla: 0.125 ± 0.124
0.25CysCys: 0.25 ± 0.163
0.25CysAsp: 0.25 ± 0.189
1.502CysGlu: 1.502 ± 0.469
0.25CysPhe: 0.25 ± 0.189
0.25CysGly: 0.25 ± 0.159
0.0CysHis: 0.0 ± 0.0
0.876CysIle: 0.876 ± 0.448
1.252CysLys: 1.252 ± 0.541
0.25CysLeu: 0.25 ± 0.163
0.25CysMet: 0.25 ± 0.159
0.751CysAsn: 0.751 ± 0.362
0.25CysPro: 0.25 ± 0.247
0.501CysGln: 0.501 ± 0.218
0.25CysArg: 0.25 ± 0.198
0.751CysSer: 0.751 ± 0.403
0.125CysThr: 0.125 ± 0.114
0.626CysVal: 0.626 ± 0.324
0.125CysTrp: 0.125 ± 0.144
0.501CysTyr: 0.501 ± 0.296
0.0CysXaa: 0.0 ± 0.0
Asp
2.879AspAla: 2.879 ± 0.534
0.751AspCys: 0.751 ± 0.304
2.629AspAsp: 2.629 ± 0.765
3.505AspGlu: 3.505 ± 0.681
2.378AspPhe: 2.378 ± 0.543
1.502AspGly: 1.502 ± 0.422
0.501AspHis: 0.501 ± 0.257
4.757AspIle: 4.757 ± 0.948
2.503AspLys: 2.503 ± 0.584
5.758AspLeu: 5.758 ± 0.967
0.376AspMet: 0.376 ± 0.199
2.503AspAsn: 2.503 ± 0.514
1.127AspPro: 1.127 ± 0.319
1.127AspGln: 1.127 ± 0.4
1.502AspArg: 1.502 ± 0.482
2.378AspSer: 2.378 ± 0.587
1.377AspThr: 1.377 ± 0.386
2.754AspVal: 2.754 ± 0.658
0.376AspTrp: 0.376 ± 0.202
1.752AspTyr: 1.752 ± 0.621
0.0AspXaa: 0.0 ± 0.0
Glu
2.003GluAla: 2.003 ± 0.571
0.626GluCys: 0.626 ± 0.31
1.752GluAsp: 1.752 ± 0.577
6.759GluGlu: 6.759 ± 1.861
2.378GluPhe: 2.378 ± 0.612
1.502GluGly: 1.502 ± 0.507
1.127GluHis: 1.127 ± 0.446
8.136GluIle: 8.136 ± 1.147
9.138GluLys: 9.138 ± 1.62
6.509GluLeu: 6.509 ± 0.927
1.001GluMet: 1.001 ± 0.418
4.131GluAsn: 4.131 ± 0.501
1.252GluPro: 1.252 ± 0.331
3.129GluGln: 3.129 ± 0.711
2.378GluArg: 2.378 ± 0.533
2.503GluSer: 2.503 ± 0.51
3.88GluThr: 3.88 ± 0.871
3.254GluVal: 3.254 ± 0.686
0.501GluTrp: 0.501 ± 0.256
4.131GluTyr: 4.131 ± 0.693
0.0GluXaa: 0.0 ± 0.0
Phe
3.38PheAla: 3.38 ± 0.951
1.127PheCys: 1.127 ± 0.498
2.629PheAsp: 2.629 ± 0.542
3.129PheGlu: 3.129 ± 0.66
3.004PhePhe: 3.004 ± 0.732
2.754PheGly: 2.754 ± 0.612
0.626PheHis: 0.626 ± 0.273
5.007PheIle: 5.007 ± 0.768
4.006PheLys: 4.006 ± 0.584
5.257PheLeu: 5.257 ± 0.86
1.001PheMet: 1.001 ± 0.403
3.88PheAsn: 3.88 ± 0.725
2.003PhePro: 2.003 ± 0.358
2.879PheGln: 2.879 ± 0.532
1.127PheArg: 1.127 ± 0.382
4.506PheSer: 4.506 ± 0.96
3.004PheThr: 3.004 ± 0.581
2.503PheVal: 2.503 ± 0.589
0.376PheTrp: 0.376 ± 0.268
2.879PheTyr: 2.879 ± 0.541
0.0PheXaa: 0.0 ± 0.0
Gly
1.627GlyAla: 1.627 ± 0.445
0.501GlyCys: 0.501 ± 0.2
1.001GlyAsp: 1.001 ± 0.285
2.503GlyGlu: 2.503 ± 0.509
2.503GlyPhe: 2.503 ± 0.588
2.378GlyGly: 2.378 ± 0.756
0.25GlyHis: 0.25 ± 0.185
4.256GlyIle: 4.256 ± 0.71
2.503GlyLys: 2.503 ± 0.598
3.63GlyLeu: 3.63 ± 0.641
0.626GlyMet: 0.626 ± 0.227
2.879GlyAsn: 2.879 ± 0.669
1.252GlyPro: 1.252 ± 0.334
1.878GlyGln: 1.878 ± 0.49
0.751GlyArg: 0.751 ± 0.32
2.754GlySer: 2.754 ± 1.059
1.878GlyThr: 1.878 ± 0.44
3.755GlyVal: 3.755 ± 0.652
0.25GlyTrp: 0.25 ± 0.163
3.254GlyTyr: 3.254 ± 0.591
0.0GlyXaa: 0.0 ± 0.0
His
0.25HisAla: 0.25 ± 0.149
0.0HisCys: 0.0 ± 0.0
0.626HisAsp: 0.626 ± 0.286
1.377HisGlu: 1.377 ± 0.511
1.252HisPhe: 1.252 ± 0.49
0.876HisGly: 0.876 ± 0.273
0.25HisHis: 0.25 ± 0.168
1.627HisIle: 1.627 ± 0.475
0.25HisLys: 0.25 ± 0.18
0.876HisLeu: 0.876 ± 0.374
0.376HisMet: 0.376 ± 0.277
0.751HisAsn: 0.751 ± 0.262
0.376HisPro: 0.376 ± 0.255
0.751HisGln: 0.751 ± 0.285
0.751HisArg: 0.751 ± 0.334
0.876HisSer: 0.876 ± 0.389
0.376HisThr: 0.376 ± 0.189
0.25HisVal: 0.25 ± 0.193
0.0HisTrp: 0.0 ± 0.0
0.376HisTyr: 0.376 ± 0.257
0.0HisXaa: 0.0 ± 0.0
Ile
5.257IleAla: 5.257 ± 0.853
0.751IleCys: 0.751 ± 0.322
5.508IleAsp: 5.508 ± 0.873
7.635IleGlu: 7.635 ± 0.91
5.883IlePhe: 5.883 ± 1.058
3.38IleGly: 3.38 ± 0.678
2.754IleHis: 2.754 ± 0.572
9.889IleIle: 9.889 ± 1.361
6.259IleLys: 6.259 ± 0.905
9.388IleLeu: 9.388 ± 1.323
1.502IleMet: 1.502 ± 0.405
6.634IleAsn: 6.634 ± 0.988
4.631IlePro: 4.631 ± 0.517
3.63IleGln: 3.63 ± 0.787
3.38IleArg: 3.38 ± 0.786
8.512IleSer: 8.512 ± 1.14
5.508IleThr: 5.508 ± 0.747
5.007IleVal: 5.007 ± 0.736
1.001IleTrp: 1.001 ± 0.338
6.759IleTyr: 6.759 ± 0.963
0.0IleXaa: 0.0 ± 0.0
Lys
3.505LysAla: 3.505 ± 0.583
0.751LysCys: 0.751 ± 0.334
3.38LysAsp: 3.38 ± 0.81
5.132LysGlu: 5.132 ± 1.214
3.004LysPhe: 3.004 ± 0.613
1.752LysGly: 1.752 ± 0.413
0.376LysHis: 0.376 ± 0.27
9.513LysIle: 9.513 ± 1.229
6.259LysLys: 6.259 ± 1.347
7.51LysLeu: 7.51 ± 1.245
1.752LysMet: 1.752 ± 0.599
5.007LysAsn: 5.007 ± 0.995
1.502LysPro: 1.502 ± 0.476
3.004LysGln: 3.004 ± 0.707
2.629LysArg: 2.629 ± 0.673
3.254LysSer: 3.254 ± 0.757
3.129LysThr: 3.129 ± 0.6
4.631LysVal: 4.631 ± 0.623
0.376LysTrp: 0.376 ± 0.191
5.132LysTyr: 5.132 ± 0.772
0.0LysXaa: 0.0 ± 0.0
Leu
5.132LeuAla: 5.132 ± 1.093
0.626LeuCys: 0.626 ± 0.259
4.631LeuAsp: 4.631 ± 1.045
7.761LeuGlu: 7.761 ± 1.409
4.381LeuPhe: 4.381 ± 1.022
4.631LeuGly: 4.631 ± 1.045
1.377LeuHis: 1.377 ± 0.33
8.136LeuIle: 8.136 ± 1.265
6.884LeuLys: 6.884 ± 1.374
9.388LeuLeu: 9.388 ± 1.376
1.878LeuMet: 1.878 ± 0.454
8.387LeuAsn: 8.387 ± 1.309
4.381LeuPro: 4.381 ± 0.83
6.509LeuGln: 6.509 ± 0.946
3.88LeuArg: 3.88 ± 0.68
7.51LeuSer: 7.51 ± 1.113
5.132LeuThr: 5.132 ± 0.952
5.007LeuVal: 5.007 ± 0.949
0.501LeuTrp: 0.501 ± 0.236
6.133LeuTyr: 6.133 ± 1.179
0.0LeuXaa: 0.0 ± 0.0
Met
1.502MetAla: 1.502 ± 0.463
0.0MetCys: 0.0 ± 0.0
0.376MetAsp: 0.376 ± 0.212
1.001MetGlu: 1.001 ± 0.359
1.001MetPhe: 1.001 ± 0.336
0.376MetGly: 0.376 ± 0.201
0.0MetHis: 0.0 ± 0.0
1.627MetIle: 1.627 ± 0.385
2.128MetLys: 2.128 ± 0.491
1.502MetLeu: 1.502 ± 0.443
0.501MetMet: 0.501 ± 0.223
0.626MetAsn: 0.626 ± 0.251
0.876MetPro: 0.876 ± 0.409
0.626MetGln: 0.626 ± 0.3
0.751MetArg: 0.751 ± 0.302
1.878MetSer: 1.878 ± 0.51
1.252MetThr: 1.252 ± 0.374
0.876MetVal: 0.876 ± 0.361
0.376MetTrp: 0.376 ± 0.211
0.751MetTyr: 0.751 ± 0.322
0.0MetXaa: 0.0 ± 0.0
Asn
3.63AsnAla: 3.63 ± 1.113
1.252AsnCys: 1.252 ± 0.424
2.003AsnAsp: 2.003 ± 0.465
3.63AsnGlu: 3.63 ± 0.656
5.758AsnPhe: 5.758 ± 0.721
3.38AsnGly: 3.38 ± 0.974
0.0AsnHis: 0.0 ± 0.0
8.387AsnIle: 8.387 ± 1.302
3.254AsnLys: 3.254 ± 0.783
10.89AsnLeu: 10.89 ± 2.055
0.751AsnMet: 0.751 ± 0.305
6.133AsnAsn: 6.133 ± 1.15
2.629AsnPro: 2.629 ± 0.505
2.629AsnGln: 2.629 ± 0.823
1.752AsnArg: 1.752 ± 0.54
5.633AsnSer: 5.633 ± 0.637
3.38AsnThr: 3.38 ± 0.657
4.131AsnVal: 4.131 ± 0.632
0.376AsnTrp: 0.376 ± 0.223
4.381AsnTyr: 4.381 ± 0.638
0.0AsnXaa: 0.0 ± 0.0
Pro
1.377ProAla: 1.377 ± 0.316
0.25ProCys: 0.25 ± 0.179
1.627ProAsp: 1.627 ± 0.411
1.752ProGlu: 1.752 ± 0.487
1.878ProPhe: 1.878 ± 0.478
1.627ProGly: 1.627 ± 0.469
0.376ProHis: 0.376 ± 0.221
2.754ProIle: 2.754 ± 0.542
2.503ProLys: 2.503 ± 0.578
2.503ProLeu: 2.503 ± 0.449
0.376ProMet: 0.376 ± 0.27
3.254ProAsn: 3.254 ± 0.878
1.627ProPro: 1.627 ± 0.408
1.127ProGln: 1.127 ± 0.454
1.001ProArg: 1.001 ± 0.304
3.63ProSer: 3.63 ± 0.662
2.503ProThr: 2.503 ± 0.707
3.129ProVal: 3.129 ± 0.567
0.25ProTrp: 0.25 ± 0.178
1.752ProTyr: 1.752 ± 0.61
0.0ProXaa: 0.0 ± 0.0
Gln
1.878GlnAla: 1.878 ± 0.41
0.376GlnCys: 0.376 ± 0.278
2.253GlnAsp: 2.253 ± 0.583
2.253GlnGlu: 2.253 ± 0.593
2.503GlnPhe: 2.503 ± 0.667
1.502GlnGly: 1.502 ± 0.408
0.501GlnHis: 0.501 ± 0.214
4.882GlnIle: 4.882 ± 0.914
3.505GlnLys: 3.505 ± 0.496
7.01GlnLeu: 7.01 ± 1.243
1.377GlnMet: 1.377 ± 0.426
4.256GlnAsn: 4.256 ± 0.768
1.252GlnPro: 1.252 ± 0.377
3.004GlnGln: 3.004 ± 0.714
0.751GlnArg: 0.751 ± 0.236
2.754GlnSer: 2.754 ± 0.688
1.627GlnThr: 1.627 ± 0.416
1.878GlnVal: 1.878 ± 0.516
0.25GlnTrp: 0.25 ± 0.173
3.63GlnTyr: 3.63 ± 0.77
0.0GlnXaa: 0.0 ± 0.0
Arg
1.252ArgAla: 1.252 ± 0.406
0.626ArgCys: 0.626 ± 0.269
1.001ArgAsp: 1.001 ± 0.448
2.503ArgGlu: 2.503 ± 0.588
1.752ArgPhe: 1.752 ± 0.557
0.876ArgGly: 0.876 ± 0.312
0.501ArgHis: 0.501 ± 0.271
3.254ArgIle: 3.254 ± 0.804
3.254ArgLys: 3.254 ± 0.527
3.254ArgLeu: 3.254 ± 0.723
0.751ArgMet: 0.751 ± 0.264
3.88ArgAsn: 3.88 ± 0.814
0.376ArgPro: 0.376 ± 0.152
2.003ArgGln: 2.003 ± 0.484
1.377ArgArg: 1.377 ± 0.535
2.253ArgSer: 2.253 ± 0.568
0.876ArgThr: 0.876 ± 0.405
1.252ArgVal: 1.252 ± 0.409
0.25ArgTrp: 0.25 ± 0.185
2.629ArgTyr: 2.629 ± 0.673
0.0ArgXaa: 0.0 ± 0.0
Ser
2.378SerAla: 2.378 ± 0.761
0.125SerCys: 0.125 ± 0.124
3.004SerAsp: 3.004 ± 0.665
3.63SerGlu: 3.63 ± 0.747
4.757SerPhe: 4.757 ± 1.013
4.131SerGly: 4.131 ± 1.093
1.252SerHis: 1.252 ± 0.431
5.007SerIle: 5.007 ± 0.661
3.755SerLys: 3.755 ± 0.67
6.008SerLeu: 6.008 ± 1.114
1.878SerMet: 1.878 ± 0.45
4.506SerAsn: 4.506 ± 0.925
2.754SerPro: 2.754 ± 0.629
5.257SerGln: 5.257 ± 1.124
3.63SerArg: 3.63 ± 0.932
4.506SerSer: 4.506 ± 1.025
4.006SerThr: 4.006 ± 0.569
4.006SerVal: 4.006 ± 0.845
0.501SerTrp: 0.501 ± 0.263
3.254SerTyr: 3.254 ± 0.613
0.0SerXaa: 0.0 ± 0.0
Thr
2.879ThrAla: 2.879 ± 0.683
0.25ThrCys: 0.25 ± 0.247
2.003ThrAsp: 2.003 ± 0.623
3.004ThrGlu: 3.004 ± 0.62
2.503ThrPhe: 2.503 ± 0.481
2.378ThrGly: 2.378 ± 0.611
0.25ThrHis: 0.25 ± 0.182
6.509ThrIle: 6.509 ± 0.894
3.004ThrLys: 3.004 ± 0.611
4.131ThrLeu: 4.131 ± 1.001
1.127ThrMet: 1.127 ± 0.338
4.131ThrAsn: 4.131 ± 0.611
3.004ThrPro: 3.004 ± 0.731
1.752ThrGln: 1.752 ± 0.408
1.502ThrArg: 1.502 ± 0.475
3.38ThrSer: 3.38 ± 0.583
2.629ThrThr: 2.629 ± 0.498
2.503ThrVal: 2.503 ± 0.454
0.626ThrTrp: 0.626 ± 0.259
1.878ThrTyr: 1.878 ± 0.41
0.0ThrXaa: 0.0 ± 0.0
Val
3.254ValAla: 3.254 ± 0.623
0.25ValCys: 0.25 ± 0.162
3.63ValAsp: 3.63 ± 0.595
3.505ValGlu: 3.505 ± 0.687
3.88ValPhe: 3.88 ± 0.722
1.878ValGly: 1.878 ± 0.496
0.876ValHis: 0.876 ± 0.342
4.006ValIle: 4.006 ± 0.836
3.505ValLys: 3.505 ± 0.482
5.257ValLeu: 5.257 ± 0.81
0.376ValMet: 0.376 ± 0.205
4.006ValAsn: 4.006 ± 0.547
2.754ValPro: 2.754 ± 0.722
2.128ValGln: 2.128 ± 0.459
2.128ValArg: 2.128 ± 0.538
4.882ValSer: 4.882 ± 1.009
3.129ValThr: 3.129 ± 0.664
2.879ValVal: 2.879 ± 0.541
0.25ValTrp: 0.25 ± 0.155
3.129ValTyr: 3.129 ± 0.802
0.0ValXaa: 0.0 ± 0.0
Trp
0.501TrpAla: 0.501 ± 0.243
0.125TrpCys: 0.125 ± 0.122
0.125TrpAsp: 0.125 ± 0.122
0.751TrpGlu: 0.751 ± 0.315
0.125TrpPhe: 0.125 ± 0.091
0.0TrpGly: 0.0 ± 0.0
0.125TrpHis: 0.125 ± 0.119
0.626TrpIle: 0.626 ± 0.292
0.751TrpLys: 0.751 ± 0.254
0.876TrpLeu: 0.876 ± 0.359
0.25TrpMet: 0.25 ± 0.153
0.876TrpAsn: 0.876 ± 0.274
0.125TrpPro: 0.125 ± 0.144
0.376TrpGln: 0.376 ± 0.182
0.376TrpArg: 0.376 ± 0.268
0.501TrpSer: 0.501 ± 0.282
0.626TrpThr: 0.626 ± 0.328
0.501TrpVal: 0.501 ± 0.205
0.0TrpTrp: 0.0 ± 0.0
0.376TrpTyr: 0.376 ± 0.189
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.131TyrAla: 4.131 ± 0.713
0.501TyrCys: 0.501 ± 0.28
2.253TyrAsp: 2.253 ± 0.563
2.754TyrGlu: 2.754 ± 0.698
3.254TyrPhe: 3.254 ± 0.698
2.128TyrGly: 2.128 ± 0.49
0.751TyrHis: 0.751 ± 0.383
7.26TyrIle: 7.26 ± 0.987
3.38TyrLys: 3.38 ± 0.67
6.259TyrLeu: 6.259 ± 0.843
0.751TyrMet: 0.751 ± 0.288
4.006TyrAsn: 4.006 ± 0.803
2.128TyrPro: 2.128 ± 0.558
2.879TyrGln: 2.879 ± 0.602
2.128TyrArg: 2.128 ± 0.554
3.505TyrSer: 3.505 ± 0.689
3.004TyrThr: 3.004 ± 0.661
3.88TyrVal: 3.88 ± 0.711
0.751TyrTrp: 0.751 ± 0.347
4.131TyrTyr: 4.131 ± 0.585
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 37 proteins (7990 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski