Amino acid dipepetide frequency for Candidatus Phytoplasma oryzae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.434AlaAla: 1.434 ± 0.123
0.304AlaCys: 0.304 ± 0.05
1.164AlaAsp: 1.164 ± 0.109
1.627AlaGlu: 1.627 ± 0.109
1.923AlaPhe: 1.923 ± 0.126
1.636AlaGly: 1.636 ± 0.152
0.641AlaHis: 0.641 ± 0.075
3.339AlaIle: 3.339 ± 0.175
2.994AlaLys: 2.994 ± 0.187
3.441AlaLeu: 3.441 ± 0.171
0.649AlaMet: 0.649 ± 0.072
1.83AlaAsn: 1.83 ± 0.126
0.573AlaPro: 0.573 ± 0.06
1.315AlaGln: 1.315 ± 0.099
1.105AlaArg: 1.105 ± 0.111
2.058AlaSer: 2.058 ± 0.139
1.425AlaThr: 1.425 ± 0.134
1.375AlaVal: 1.375 ± 0.107
0.186AlaTrp: 0.186 ± 0.043
1.13AlaTyr: 1.13 ± 0.096
0.0AlaXaa: 0.0 ± 0.0
Cys
0.219CysAla: 0.219 ± 0.041
0.152CysCys: 0.152 ± 0.038
0.346CysAsp: 0.346 ± 0.053
0.464CysGlu: 0.464 ± 0.068
0.843CysPhe: 0.843 ± 0.092
0.363CysGly: 0.363 ± 0.058
0.152CysHis: 0.152 ± 0.04
0.767CysIle: 0.767 ± 0.087
0.624CysLys: 0.624 ± 0.085
1.206CysLeu: 1.206 ± 0.097
0.076CysMet: 0.076 ± 0.027
0.624CysAsn: 0.624 ± 0.075
0.278CysPro: 0.278 ± 0.048
0.245CysGln: 0.245 ± 0.044
0.211CysArg: 0.211 ± 0.049
0.683CysSer: 0.683 ± 0.088
0.202CysThr: 0.202 ± 0.049
0.287CysVal: 0.287 ± 0.049
0.034CysTrp: 0.034 ± 0.018
0.396CysTyr: 0.396 ± 0.057
0.0CysXaa: 0.0 ± 0.0
Asp
1.189AspAla: 1.189 ± 0.105
0.304AspCys: 0.304 ± 0.042
1.771AspAsp: 1.771 ± 0.143
2.386AspGlu: 2.386 ± 0.151
3.753AspPhe: 3.753 ± 0.209
1.56AspGly: 1.56 ± 0.153
0.59AspHis: 0.59 ± 0.059
6.063AspIle: 6.063 ± 0.237
4.318AspLys: 4.318 ± 0.196
5.329AspLeu: 5.329 ± 0.222
0.632AspMet: 0.632 ± 0.07
3.441AspAsn: 3.441 ± 0.189
1.096AspPro: 1.096 ± 0.097
1.585AspGln: 1.585 ± 0.144
0.776AspArg: 0.776 ± 0.079
2.462AspSer: 2.462 ± 0.152
1.4AspThr: 1.4 ± 0.113
1.788AspVal: 1.788 ± 0.144
0.202AspTrp: 0.202 ± 0.039
1.982AspTyr: 1.982 ± 0.138
0.0AspXaa: 0.0 ± 0.0
Glu
2.176GluAla: 2.176 ± 0.143
0.312GluCys: 0.312 ± 0.059
2.665GluAsp: 2.665 ± 0.131
5.785GluGlu: 5.785 ± 0.259
2.623GluPhe: 2.623 ± 0.169
2.159GluGly: 2.159 ± 0.157
0.734GluHis: 0.734 ± 0.071
8.576GluIle: 8.576 ± 0.334
10.726GluLys: 10.726 ± 0.358
5.405GluLeu: 5.405 ± 0.272
1.358GluMet: 1.358 ± 0.099
5.414GluAsn: 5.414 ± 0.267
1.054GluPro: 1.054 ± 0.106
2.665GluGln: 2.665 ± 0.173
1.501GluArg: 1.501 ± 0.124
2.741GluSer: 2.741 ± 0.146
2.496GluThr: 2.496 ± 0.151
2.606GluVal: 2.606 ± 0.147
0.261GluTrp: 0.261 ± 0.047
2.209GluTyr: 2.209 ± 0.155
0.0GluXaa: 0.0 ± 0.0
Phe
1.509PheAla: 1.509 ± 0.102
0.818PheCys: 0.818 ± 0.087
2.808PheAsp: 2.808 ± 0.136
2.833PheGlu: 2.833 ± 0.173
7.471PhePhe: 7.471 ± 0.426
1.923PheGly: 1.923 ± 0.134
1.231PheHis: 1.231 ± 0.11
7.64PheIle: 7.64 ± 0.34
6.721PheLys: 6.721 ± 0.256
11.106PheLeu: 11.106 ± 0.46
1.189PheMet: 1.189 ± 0.091
5.178PheAsn: 5.178 ± 0.223
1.602PhePro: 1.602 ± 0.125
2.69PheGln: 2.69 ± 0.166
1.467PheArg: 1.467 ± 0.12
4.933PheSer: 4.933 ± 0.204
1.67PheThr: 1.67 ± 0.141
2.783PheVal: 2.783 ± 0.147
0.464PheTrp: 0.464 ± 0.063
3.761PheTyr: 3.761 ± 0.204
0.0PheXaa: 0.0 ± 0.0
Gly
1.627GlyAla: 1.627 ± 0.123
0.472GlyCys: 0.472 ± 0.069
1.72GlyAsp: 1.72 ± 0.113
1.931GlyGlu: 1.931 ± 0.146
2.816GlyPhe: 2.816 ± 0.151
2.15GlyGly: 2.15 ± 0.168
0.978GlyHis: 0.978 ± 0.085
5.169GlyIle: 5.169 ± 0.245
4.098GlyLys: 4.098 ± 0.241
3.575GlyLeu: 3.575 ± 0.203
0.751GlyMet: 0.751 ± 0.082
2.252GlyAsn: 2.252 ± 0.147
1.012GlyPro: 1.012 ± 0.083
1.459GlyGln: 1.459 ± 0.121
1.299GlyArg: 1.299 ± 0.132
2.336GlySer: 2.336 ± 0.146
1.864GlyThr: 1.864 ± 0.143
2.235GlyVal: 2.235 ± 0.149
0.219GlyTrp: 0.219 ± 0.046
1.695GlyTyr: 1.695 ± 0.128
0.0GlyXaa: 0.0 ± 0.0
His
0.498HisAla: 0.498 ± 0.07
0.118HisCys: 0.118 ± 0.035
0.59HisAsp: 0.59 ± 0.078
0.784HisGlu: 0.784 ± 0.07
1.231HisPhe: 1.231 ± 0.096
0.818HisGly: 0.818 ± 0.096
0.388HisHis: 0.388 ± 0.062
1.518HisIle: 1.518 ± 0.107
1.661HisLys: 1.661 ± 0.1
1.855HisLeu: 1.855 ± 0.123
0.152HisMet: 0.152 ± 0.03
1.206HisAsn: 1.206 ± 0.102
0.616HisPro: 0.616 ± 0.078
0.59HisGln: 0.59 ± 0.088
0.607HisArg: 0.607 ± 0.081
0.961HisSer: 0.961 ± 0.091
0.658HisThr: 0.658 ± 0.078
0.675HisVal: 0.675 ± 0.074
0.059HisTrp: 0.059 ± 0.021
0.776HisTyr: 0.776 ± 0.08
0.0HisXaa: 0.0 ± 0.0
Ile
4.039IleAla: 4.039 ± 0.22
1.105IleCys: 1.105 ± 0.098
5.523IleAsp: 5.523 ± 0.203
7.497IleGlu: 7.497 ± 0.276
8.981IlePhe: 8.981 ± 0.357
4.967IleGly: 4.967 ± 0.232
1.729IleHis: 1.729 ± 0.135
14.664IleIle: 14.664 ± 0.465
14.9IleLys: 14.9 ± 0.448
14.023IleLeu: 14.023 ± 0.382
1.703IleMet: 1.703 ± 0.118
9.757IleAsn: 9.757 ± 0.284
3.28IlePro: 3.28 ± 0.181
4.436IleGln: 4.436 ± 0.211
3.263IleArg: 3.263 ± 0.172
8.551IleSer: 8.551 ± 0.315
4.646IleThr: 4.646 ± 0.206
4.866IleVal: 4.866 ± 0.185
0.489IleTrp: 0.489 ± 0.074
4.604IleTyr: 4.604 ± 0.191
0.0IleXaa: 0.0 ± 0.0
Lys
2.985LysAla: 2.985 ± 0.171
0.658LysCys: 0.658 ± 0.085
5.135LysAsp: 5.135 ± 0.225
10.709LysGlu: 10.709 ± 0.313
5.152LysPhe: 5.152 ± 0.234
4.284LysGly: 4.284 ± 0.211
1.315LysHis: 1.315 ± 0.108
19.075LysIle: 19.075 ± 0.462
24.041LysLys: 24.041 ± 0.631
8.331LysLeu: 8.331 ± 0.265
2.698LysMet: 2.698 ± 0.174
13.425LysAsn: 13.425 ± 0.338
2.336LysPro: 2.336 ± 0.142
4.393LysGln: 4.393 ± 0.207
3.457LysArg: 3.457 ± 0.205
5.498LysSer: 5.498 ± 0.227
5.734LysThr: 5.734 ± 0.257
4.689LysVal: 4.689 ± 0.21
0.708LysTrp: 0.708 ± 0.076
5.388LysTyr: 5.388 ± 0.231
0.0LysXaa: 0.0 ± 0.0
Leu
3.474LeuAla: 3.474 ± 0.17
0.869LeuCys: 0.869 ± 0.073
4.697LeuAsp: 4.697 ± 0.235
7.471LeuGlu: 7.471 ± 0.267
7.075LeuPhe: 7.075 ± 0.315
4.739LeuGly: 4.739 ± 0.203
1.358LeuHis: 1.358 ± 0.11
10.92LeuIle: 10.92 ± 0.347
14.394LeuLys: 14.394 ± 0.436
9.942LeuLeu: 9.942 ± 0.342
1.712LeuMet: 1.712 ± 0.125
8.542LeuAsn: 8.542 ± 0.303
2.631LeuPro: 2.631 ± 0.149
3.002LeuGln: 3.002 ± 0.201
2.715LeuArg: 2.715 ± 0.168
7.429LeuSer: 7.429 ± 0.262
4.242LeuThr: 4.242 ± 0.192
4.579LeuVal: 4.579 ± 0.225
0.557LeuTrp: 0.557 ± 0.065
3.508LeuTyr: 3.508 ± 0.168
0.0LeuXaa: 0.0 ± 0.0
Met
0.683MetAla: 0.683 ± 0.083
0.076MetCys: 0.076 ± 0.026
0.725MetAsp: 0.725 ± 0.074
0.852MetGlu: 0.852 ± 0.079
1.096MetPhe: 1.096 ± 0.097
0.776MetGly: 0.776 ± 0.076
0.287MetHis: 0.287 ± 0.047
2.395MetIle: 2.395 ± 0.144
2.133MetLys: 2.133 ± 0.13
1.56MetLeu: 1.56 ± 0.132
0.363MetMet: 0.363 ± 0.049
1.636MetAsn: 1.636 ± 0.111
0.481MetPro: 0.481 ± 0.068
0.531MetGln: 0.531 ± 0.06
0.396MetArg: 0.396 ± 0.058
0.961MetSer: 0.961 ± 0.089
0.7MetThr: 0.7 ± 0.079
0.708MetVal: 0.708 ± 0.068
0.084MetTrp: 0.084 ± 0.026
0.523MetTyr: 0.523 ± 0.069
0.0MetXaa: 0.0 ± 0.0
Asn
1.855AsnAla: 1.855 ± 0.142
0.624AsnCys: 0.624 ± 0.07
3.348AsnAsp: 3.348 ± 0.185
4.25AsnGlu: 4.25 ± 0.196
6.873AsnPhe: 6.873 ± 0.277
2.252AsnGly: 2.252 ± 0.162
1.375AsnHis: 1.375 ± 0.107
11.443AsnIle: 11.443 ± 0.44
10.903AsnLys: 10.903 ± 0.297
8.778AsnLeu: 8.778 ± 0.267
1.155AsnMet: 1.155 ± 0.104
8.036AsnAsn: 8.036 ± 0.365
1.864AsnPro: 1.864 ± 0.14
3.584AsnGln: 3.584 ± 0.194
1.577AsnArg: 1.577 ± 0.116
4.596AsnSer: 4.596 ± 0.195
2.538AsnThr: 2.538 ± 0.13
2.901AsnVal: 2.901 ± 0.178
0.32AsnTrp: 0.32 ± 0.055
4.039AsnTyr: 4.039 ± 0.188
0.0AsnXaa: 0.0 ± 0.0
Pro
0.573ProAla: 0.573 ± 0.083
0.236ProCys: 0.236 ± 0.052
0.911ProAsp: 0.911 ± 0.095
1.552ProGlu: 1.552 ± 0.109
2.142ProPhe: 2.142 ± 0.158
1.079ProGly: 1.079 ± 0.096
0.582ProHis: 0.582 ± 0.081
2.496ProIle: 2.496 ± 0.153
2.564ProLys: 2.564 ± 0.137
2.344ProLeu: 2.344 ± 0.134
0.228ProMet: 0.228 ± 0.05
1.602ProAsn: 1.602 ± 0.106
0.498ProPro: 0.498 ± 0.072
0.995ProGln: 0.995 ± 0.103
0.531ProArg: 0.531 ± 0.057
1.729ProSer: 1.729 ± 0.139
1.197ProThr: 1.197 ± 0.107
1.096ProVal: 1.096 ± 0.092
0.16ProTrp: 0.16 ± 0.036
1.164ProTyr: 1.164 ± 0.082
0.0ProXaa: 0.0 ± 0.0
Gln
1.105GlnAla: 1.105 ± 0.106
0.202GlnCys: 0.202 ± 0.043
1.425GlnAsp: 1.425 ± 0.119
3.044GlnGlu: 3.044 ± 0.174
1.375GlnPhe: 1.375 ± 0.114
1.206GlnGly: 1.206 ± 0.091
0.455GlnHis: 0.455 ± 0.073
5.051GlnIle: 5.051 ± 0.183
7.328GlnLys: 7.328 ± 0.342
2.8GlnLeu: 2.8 ± 0.173
0.7GlnMet: 0.7 ± 0.081
4.073GlnAsn: 4.073 ± 0.182
0.675GlnPro: 0.675 ± 0.082
1.484GlnGln: 1.484 ± 0.127
0.944GlnArg: 0.944 ± 0.092
1.476GlnSer: 1.476 ± 0.105
1.83GlnThr: 1.83 ± 0.14
1.189GlnVal: 1.189 ± 0.111
0.219GlnTrp: 0.219 ± 0.05
1.375GlnTyr: 1.375 ± 0.088
0.0GlnXaa: 0.0 ± 0.0
Arg
0.691ArgAla: 0.691 ± 0.081
0.211ArgCys: 0.211 ± 0.041
1.079ArgAsp: 1.079 ± 0.115
1.509ArgGlu: 1.509 ± 0.122
1.307ArgPhe: 1.307 ± 0.101
1.13ArgGly: 1.13 ± 0.125
0.54ArgHis: 0.54 ± 0.075
3.516ArgIle: 3.516 ± 0.151
3.289ArgLys: 3.289 ± 0.172
2.403ArgLeu: 2.403 ± 0.175
0.691ArgMet: 0.691 ± 0.09
2.074ArgAsn: 2.074 ± 0.157
0.708ArgPro: 0.708 ± 0.078
1.13ArgGln: 1.13 ± 0.092
1.096ArgArg: 1.096 ± 0.111
1.434ArgSer: 1.434 ± 0.107
1.088ArgThr: 1.088 ± 0.099
1.012ArgVal: 1.012 ± 0.096
0.135ArgTrp: 0.135 ± 0.039
1.189ArgTyr: 1.189 ± 0.112
0.0ArgXaa: 0.0 ± 0.0
Ser
1.712SerAla: 1.712 ± 0.123
0.557SerCys: 0.557 ± 0.071
2.555SerAsp: 2.555 ± 0.151
3.651SerGlu: 3.651 ± 0.147
5.279SerPhe: 5.279 ± 0.222
2.8SerGly: 2.8 ± 0.167
0.995SerHis: 0.995 ± 0.091
6.948SerIle: 6.948 ± 0.26
6.282SerLys: 6.282 ± 0.236
7.294SerLeu: 7.294 ± 0.259
0.877SerMet: 0.877 ± 0.094
4.056SerAsn: 4.056 ± 0.167
1.299SerPro: 1.299 ± 0.117
2.538SerGln: 2.538 ± 0.154
1.746SerArg: 1.746 ± 0.123
4.461SerSer: 4.461 ± 0.24
2.049SerThr: 2.049 ± 0.144
2.572SerVal: 2.572 ± 0.149
0.304SerTrp: 0.304 ± 0.056
2.597SerTyr: 2.597 ± 0.127
0.0SerXaa: 0.0 ± 0.0
Thr
1.299ThrAla: 1.299 ± 0.126
0.287ThrCys: 0.287 ± 0.053
1.661ThrAsp: 1.661 ± 0.121
2.42ThrGlu: 2.42 ± 0.18
2.614ThrPhe: 2.614 ± 0.183
2.066ThrGly: 2.066 ± 0.169
0.691ThrHis: 0.691 ± 0.083
4.107ThrIle: 4.107 ± 0.205
4.832ThrLys: 4.832 ± 0.2
3.862ThrLeu: 3.862 ± 0.196
0.649ThrMet: 0.649 ± 0.074
2.783ThrAsn: 2.783 ± 0.165
1.315ThrPro: 1.315 ± 0.108
1.391ThrGln: 1.391 ± 0.098
1.138ThrArg: 1.138 ± 0.1
2.395ThrSer: 2.395 ± 0.137
1.83ThrThr: 1.83 ± 0.136
1.459ThrVal: 1.459 ± 0.115
0.177ThrTrp: 0.177 ± 0.039
1.459ThrTyr: 1.459 ± 0.106
0.0ThrXaa: 0.0 ± 0.0
Val
1.577ValAla: 1.577 ± 0.103
0.388ValCys: 0.388 ± 0.057
2.15ValAsp: 2.15 ± 0.124
2.209ValGlu: 2.209 ± 0.155
3.086ValPhe: 3.086 ± 0.167
1.855ValGly: 1.855 ± 0.146
0.708ValHis: 0.708 ± 0.071
4.756ValIle: 4.756 ± 0.208
3.677ValLys: 3.677 ± 0.189
4.84ValLeu: 4.84 ± 0.202
0.666ValMet: 0.666 ± 0.074
2.757ValAsn: 2.757 ± 0.145
1.164ValPro: 1.164 ± 0.111
1.273ValGln: 1.273 ± 0.093
1.088ValArg: 1.088 ± 0.107
2.935ValSer: 2.935 ± 0.169
1.45ValThr: 1.45 ± 0.111
2.032ValVal: 2.032 ± 0.157
0.177ValTrp: 0.177 ± 0.039
1.72ValTyr: 1.72 ± 0.126
0.0ValXaa: 0.0 ± 0.0
Trp
0.076TrpAla: 0.076 ± 0.025
0.059TrpCys: 0.059 ± 0.021
0.219TrpAsp: 0.219 ± 0.045
0.245TrpGlu: 0.245 ± 0.046
0.514TrpPhe: 0.514 ± 0.073
0.245TrpGly: 0.245 ± 0.045
0.101TrpHis: 0.101 ± 0.029
0.649TrpIle: 0.649 ± 0.072
0.472TrpLys: 0.472 ± 0.06
0.565TrpLeu: 0.565 ± 0.072
0.101TrpMet: 0.101 ± 0.025
0.261TrpAsn: 0.261 ± 0.046
0.169TrpPro: 0.169 ± 0.044
0.219TrpGln: 0.219 ± 0.042
0.211TrpArg: 0.211 ± 0.049
0.253TrpSer: 0.253 ± 0.041
0.177TrpThr: 0.177 ± 0.036
0.16TrpVal: 0.16 ± 0.038
0.034TrpTrp: 0.034 ± 0.018
0.236TrpTyr: 0.236 ± 0.046
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.425TyrAla: 1.425 ± 0.1
0.422TyrCys: 0.422 ± 0.058
2.133TyrAsp: 2.133 ± 0.136
2.243TyrGlu: 2.243 ± 0.155
3.643TyrPhe: 3.643 ± 0.188
1.653TyrGly: 1.653 ± 0.125
0.911TyrHis: 0.911 ± 0.084
3.93TyrIle: 3.93 ± 0.172
4.065TyrLys: 4.065 ± 0.175
5.194TyrLeu: 5.194 ± 0.213
0.607TyrMet: 0.607 ± 0.07
3.365TyrAsn: 3.365 ± 0.176
1.029TyrPro: 1.029 ± 0.104
2.429TyrGln: 2.429 ± 0.182
1.105TyrArg: 1.105 ± 0.086
2.682TyrSer: 2.682 ± 0.132
1.24TyrThr: 1.24 ± 0.101
1.501TyrVal: 1.501 ± 0.102
0.177TyrTrp: 0.177 ± 0.039
2.1TyrTyr: 2.1 ± 0.132
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 392 proteins (118588 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski