Amino acid dipepetide frequency for Rhodophyticola porphyridii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.244AlaAla: 17.244 ± 0.227	1.108AlaCys: 1.108 ± 0.032	7.434AlaAsp: 7.434 ± 0.089	8.914AlaGlu: 8.914 ± 0.114	4.416AlaPhe: 4.416 ± 0.068	11.033AlaGly: 11.033 ± 0.123	2.476AlaHis: 2.476 ± 0.051	5.976AlaIle: 5.976 ± 0.08	2.954AlaLys: 2.954 ± 0.068	13.962AlaLeu: 13.962 ± 0.172	3.825AlaMet: 3.825 ± 0.061	2.611AlaAsn: 2.611 ± 0.047	6.09AlaPro: 6.09 ± 0.091	4.064AlaGln: 4.064 ± 0.068	9.905AlaArg: 9.905 ± 0.115	5.389AlaSer: 5.389 ± 0.064	6.006AlaThr: 6.006 ± 0.077	8.354AlaVal: 8.354 ± 0.091	1.519AlaTrp: 1.519 ± 0.039	2.609AlaTyr: 2.609 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.098CysAla: 1.098 ± 0.031	0.118CysCys: 0.118 ± 0.01	0.609CysAsp: 0.609 ± 0.022	0.41CysGlu: 0.41 ± 0.02	0.353CysPhe: 0.353 ± 0.018	0.983CysGly: 0.983 ± 0.033	0.277CysHis: 0.277 ± 0.016	0.427CysIle: 0.427 ± 0.021	0.171CysLys: 0.171 ± 0.014	0.858CysLeu: 0.858 ± 0.028	0.168CysMet: 0.168 ± 0.011	0.201CysAsn: 0.201 ± 0.012	0.542CysPro: 0.542 ± 0.022	0.215CysGln: 0.215 ± 0.015	0.551CysArg: 0.551 ± 0.023	0.443CysSer: 0.443 ± 0.019	0.44CysThr: 0.44 ± 0.019	0.572CysVal: 0.572 ± 0.023	0.109CysTrp: 0.109 ± 0.009	0.189CysTyr: 0.189 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.382AspAla: 7.382 ± 0.084	0.493AspCys: 0.493 ± 0.021	3.377AspAsp: 3.377 ± 0.074	3.379AspGlu: 3.379 ± 0.06	2.22AspPhe: 2.22 ± 0.043	5.995AspGly: 5.995 ± 0.085	1.46AspHis: 1.46 ± 0.038	3.21AspIle: 3.21 ± 0.051	1.285AspLys: 1.285 ± 0.037	6.919AspLeu: 6.919 ± 0.089	1.745AspMet: 1.745 ± 0.038	1.098AspAsn: 1.098 ± 0.035	3.962AspPro: 3.962 ± 0.054	1.884AspGln: 1.884 ± 0.043	4.941AspArg: 4.941 ± 0.064	2.045AspSer: 2.045 ± 0.047	3.15AspThr: 3.15 ± 0.062	4.147AspVal: 4.147 ± 0.06	1.231AspTrp: 1.231 ± 0.04	1.434AspTyr: 1.434 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	8.444GluAla: 8.444 ± 0.108	0.335GluCys: 0.335 ± 0.017	3.413GluAsp: 3.413 ± 0.064	3.699GluGlu: 3.699 ± 0.065	1.796GluPhe: 1.796 ± 0.037	4.714GluGly: 4.714 ± 0.074	1.077GluHis: 1.077 ± 0.032	3.929GluIle: 3.929 ± 0.063	1.758GluLys: 1.758 ± 0.052	5.059GluLeu: 5.059 ± 0.068	2.014GluMet: 2.014 ± 0.047	1.667GluAsn: 1.667 ± 0.039	2.758GluPro: 2.758 ± 0.096	1.796GluGln: 1.796 ± 0.044	4.367GluArg: 4.367 ± 0.062	2.04GluSer: 2.04 ± 0.047	4.185GluThr: 4.185 ± 0.061	4.317GluVal: 4.317 ± 0.078	0.685GluTrp: 0.685 ± 0.022	1.026GluTyr: 1.026 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.529PheAla: 4.529 ± 0.071	0.411PheCys: 0.411 ± 0.017	2.885PheAsp: 2.885 ± 0.047	2.228PheGlu: 2.228 ± 0.049	1.41PhePhe: 1.41 ± 0.042	3.807PheGly: 3.807 ± 0.063	0.771PheHis: 0.771 ± 0.031	1.657PheIle: 1.657 ± 0.043	0.666PheLys: 0.666 ± 0.027	3.575PheLeu: 3.575 ± 0.058	0.854PheMet: 0.854 ± 0.03	1.049PheAsn: 1.049 ± 0.03	1.598PhePro: 1.598 ± 0.036	1.076PheGln: 1.076 ± 0.031	2.328PheArg: 2.328 ± 0.048	2.113PheSer: 2.113 ± 0.051	2.087PheThr: 2.087 ± 0.045	2.631PheVal: 2.631 ± 0.055	0.599PheTrp: 0.599 ± 0.022	0.94PheTyr: 0.94 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.276GlyAla: 10.276 ± 0.108	0.89GlyCys: 0.89 ± 0.029	4.98GlyAsp: 4.98 ± 0.087	4.747GlyGlu: 4.747 ± 0.069	3.955GlyPhe: 3.955 ± 0.069	7.583GlyGly: 7.583 ± 0.117	1.988GlyHis: 1.988 ± 0.046	4.469GlyIle: 4.469 ± 0.06	2.622GlyLys: 2.622 ± 0.062	9.639GlyLeu: 9.639 ± 0.103	2.631GlyMet: 2.631 ± 0.051	2.065GlyAsn: 2.065 ± 0.052	4.191GlyPro: 4.191 ± 0.062	3.229GlyGln: 3.229 ± 0.063	6.272GlyArg: 6.272 ± 0.091	4.177GlySer: 4.177 ± 0.069	4.85GlyThr: 4.85 ± 0.068	6.536GlyVal: 6.536 ± 0.081	1.554GlyTrp: 1.554 ± 0.036	2.299GlyTyr: 2.299 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.408HisAla: 2.408 ± 0.049	0.229HisCys: 0.229 ± 0.015	1.317HisAsp: 1.317 ± 0.037	1.1HisGlu: 1.1 ± 0.029	0.776HisPhe: 0.776 ± 0.026	2.042HisGly: 2.042 ± 0.045	0.585HisHis: 0.585 ± 0.025	1.029HisIle: 1.029 ± 0.028	0.443HisLys: 0.443 ± 0.02	2.26HisLeu: 2.26 ± 0.046	0.575HisMet: 0.575 ± 0.027	0.448HisAsn: 0.448 ± 0.021	1.47HisPro: 1.47 ± 0.035	0.618HisGln: 0.618 ± 0.024	1.496HisArg: 1.496 ± 0.043	0.894HisSer: 0.894 ± 0.028	0.825HisThr: 0.825 ± 0.029	1.568HisVal: 1.568 ± 0.037	0.35HisTrp: 0.35 ± 0.02	0.565HisTyr: 0.565 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.095IleAla: 7.095 ± 0.082	0.672IleCys: 0.672 ± 0.023	3.538IleAsp: 3.538 ± 0.06	3.335IleGlu: 3.335 ± 0.057	1.758IlePhe: 1.758 ± 0.043	5.049IleGly: 5.049 ± 0.076	0.971IleHis: 0.971 ± 0.029	2.199IleIle: 2.199 ± 0.052	1.095IleLys: 1.095 ± 0.033	5.014IleLeu: 5.014 ± 0.074	1.131IleMet: 1.131 ± 0.034	1.312IleAsn: 1.312 ± 0.037	2.455IlePro: 2.455 ± 0.046	1.07IleGln: 1.07 ± 0.034	3.559IleArg: 3.559 ± 0.055	3.04IleSer: 3.04 ± 0.051	2.969IleThr: 2.969 ± 0.053	3.817IleVal: 3.817 ± 0.061	0.834IleTrp: 0.834 ± 0.026	1.234IleTyr: 1.234 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.136LysAla: 3.136 ± 0.071	0.153LysCys: 0.153 ± 0.012	1.356LysAsp: 1.356 ± 0.045	1.162LysGlu: 1.162 ± 0.042	0.667LysPhe: 0.667 ± 0.023	2.17LysGly: 2.17 ± 0.051	0.543LysHis: 0.543 ± 0.024	1.39LysIle: 1.39 ± 0.044	0.934LysLys: 0.934 ± 0.041	2.454LysLeu: 2.454 ± 0.056	0.711LysMet: 0.711 ± 0.026	0.608LysAsn: 0.608 ± 0.026	1.519LysPro: 1.519 ± 0.046	0.72LysGln: 0.72 ± 0.028	1.947LysArg: 1.947 ± 0.047	1.545LysSer: 1.545 ± 0.048	1.684LysThr: 1.684 ± 0.044	1.756LysVal: 1.756 ± 0.053	0.292LysTrp: 0.292 ± 0.015	0.486LysTyr: 0.486 ± 0.023	0.001LysXaa: 0.001 ± 0.001
Leu	13.426LeuAla: 13.426 ± 0.151	0.944LeuCys: 0.944 ± 0.032	6.244LeuAsp: 6.244 ± 0.076	5.446LeuGlu: 5.446 ± 0.081	3.615LeuPhe: 3.615 ± 0.057	8.679LeuGly: 8.679 ± 0.093	2.014LeuHis: 2.014 ± 0.049	5.438LeuIle: 5.438 ± 0.079	2.75LeuLys: 2.75 ± 0.056	8.961LeuLeu: 8.961 ± 0.123	2.653LeuMet: 2.653 ± 0.057	2.679LeuAsn: 2.679 ± 0.051	5.747LeuPro: 5.747 ± 0.081	2.685LeuGln: 2.685 ± 0.048	7.317LeuArg: 7.317 ± 0.094	6.742LeuSer: 6.742 ± 0.089	5.878LeuThr: 5.878 ± 0.084	6.848LeuVal: 6.848 ± 0.08	1.272LeuTrp: 1.272 ± 0.037	2.026LeuTyr: 2.026 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.775MetAla: 3.775 ± 0.061	0.17MetCys: 0.17 ± 0.012	1.43MetAsp: 1.43 ± 0.039	1.457MetGlu: 1.457 ± 0.034	0.767MetPhe: 0.767 ± 0.03	2.23MetGly: 2.23 ± 0.048	0.473MetHis: 0.473 ± 0.022	1.596MetIle: 1.596 ± 0.039	0.882MetLys: 0.882 ± 0.031	2.671MetLeu: 2.671 ± 0.053	0.746MetMet: 0.746 ± 0.029	0.805MetAsn: 0.805 ± 0.027	1.642MetPro: 1.642 ± 0.036	0.976MetGln: 0.976 ± 0.029	1.998MetArg: 1.998 ± 0.042	1.71MetSer: 1.71 ± 0.034	2.147MetThr: 2.147 ± 0.043	1.873MetVal: 1.873 ± 0.041	0.216MetTrp: 0.216 ± 0.015	0.355MetTyr: 0.355 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.099AsnAla: 3.099 ± 0.064	0.221AsnCys: 0.221 ± 0.015	1.419AsnAsp: 1.419 ± 0.044	1.086AsnGlu: 1.086 ± 0.034	0.921AsnPhe: 0.921 ± 0.032	2.293AsnGly: 2.293 ± 0.051	0.48AsnHis: 0.48 ± 0.023	1.32AsnIle: 1.32 ± 0.037	0.467AsnLys: 0.467 ± 0.022	2.38AsnLeu: 2.38 ± 0.048	0.644AsnMet: 0.644 ± 0.027	0.59AsnAsn: 0.59 ± 0.025	1.84AsnPro: 1.84 ± 0.049	0.667AsnGln: 0.667 ± 0.024	1.783AsnArg: 1.783 ± 0.046	1.094AsnSer: 1.094 ± 0.034	1.28AsnThr: 1.28 ± 0.035	1.68AsnVal: 1.68 ± 0.044	0.403AsnTrp: 0.403 ± 0.02	0.587AsnTyr: 0.587 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.068ProAla: 6.068 ± 0.09	0.396ProCys: 0.396 ± 0.02	4.316ProAsp: 4.316 ± 0.067	4.367ProGlu: 4.367 ± 0.092	2.039ProPhe: 2.039 ± 0.042	5.113ProGly: 5.113 ± 0.067	1.104ProHis: 1.104 ± 0.03	2.347ProIle: 2.347 ± 0.046	1.379ProLys: 1.379 ± 0.036	4.695ProLeu: 4.695 ± 0.069	1.357ProMet: 1.357 ± 0.036	1.308ProAsn: 1.308 ± 0.037	2.605ProPro: 2.605 ± 0.063	1.566ProGln: 1.566 ± 0.04	3.178ProArg: 3.178 ± 0.063	2.498ProSer: 2.498 ± 0.047	2.391ProThr: 2.391 ± 0.047	4.567ProVal: 4.567 ± 0.065	0.716ProTrp: 0.716 ± 0.023	1.191ProTyr: 1.191 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.893GlnAla: 3.893 ± 0.059	0.19GlnCys: 0.19 ± 0.012	1.681GlnAsp: 1.681 ± 0.035	1.447GlnGlu: 1.447 ± 0.034	1.037GlnPhe: 1.037 ± 0.03	2.506GlnGly: 2.506 ± 0.049	0.566GlnHis: 0.566 ± 0.022	2.032GlnIle: 2.032 ± 0.049	0.848GlnLys: 0.848 ± 0.03	2.595GlnLeu: 2.595 ± 0.052	1.089GlnMet: 1.089 ± 0.031	0.838GlnAsn: 0.838 ± 0.029	1.628GlnPro: 1.628 ± 0.038	0.949GlnGln: 0.949 ± 0.032	2.136GlnArg: 2.136 ± 0.046	1.704GlnSer: 1.704 ± 0.037	1.819GlnThr: 1.819 ± 0.042	2.274GlnVal: 2.274 ± 0.046	0.357GlnTrp: 0.357 ± 0.014	0.551GlnTyr: 0.551 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.965ArgAla: 8.965 ± 0.097	0.538ArgCys: 0.538 ± 0.023	4.516ArgAsp: 4.516 ± 0.066	3.942ArgGlu: 3.942 ± 0.051	2.892ArgPhe: 2.892 ± 0.055	5.139ArgGly: 5.139 ± 0.073	1.712ArgHis: 1.712 ± 0.041	4.096ArgIle: 4.096 ± 0.067	2.067ArgLys: 2.067 ± 0.052	7.87ArgLeu: 7.87 ± 0.099	2.162ArgMet: 2.162 ± 0.046	1.787ArgAsn: 1.787 ± 0.046	3.755ArgPro: 3.755 ± 0.072	2.393ArgGln: 2.393 ± 0.048	5.375ArgArg: 5.375 ± 0.089	3.344ArgSer: 3.344 ± 0.058	3.11ArgThr: 3.11 ± 0.054	5.081ArgVal: 5.081 ± 0.073	0.957ArgTrp: 0.957 ± 0.032	1.674ArgTyr: 1.674 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.656SerAla: 5.656 ± 0.068	0.423SerCys: 0.423 ± 0.021	3.205SerAsp: 3.205 ± 0.063	2.782SerGlu: 2.782 ± 0.047	2.293SerPhe: 2.293 ± 0.048	5.325SerGly: 5.325 ± 0.078	1.123SerHis: 1.123 ± 0.031	2.422SerIle: 2.422 ± 0.049	1.209SerLys: 1.209 ± 0.038	4.98SerLeu: 4.98 ± 0.075	1.31SerMet: 1.31 ± 0.03	1.233SerAsn: 1.233 ± 0.035	2.488SerPro: 2.488 ± 0.051	1.431SerGln: 1.431 ± 0.03	3.282SerArg: 3.282 ± 0.063	2.386SerSer: 2.386 ± 0.055	2.404SerThr: 2.404 ± 0.046	3.712SerVal: 3.712 ± 0.059	0.691SerTrp: 0.691 ± 0.025	1.299SerTyr: 1.299 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	6.444ThrAla: 6.444 ± 0.076	0.471ThrCys: 0.471 ± 0.022	3.306ThrAsp: 3.306 ± 0.052	3.004ThrGlu: 3.004 ± 0.05	1.881ThrPhe: 1.881 ± 0.038	5.824ThrGly: 5.824 ± 0.097	1.189ThrHis: 1.189 ± 0.033	2.653ThrIle: 2.653 ± 0.056	1.155ThrLys: 1.155 ± 0.037	6.08ThrLeu: 6.08 ± 0.072	1.259ThrMet: 1.259 ± 0.031	1.161ThrAsn: 1.161 ± 0.035	3.515ThrPro: 3.515 ± 0.054	1.472ThrGln: 1.472 ± 0.039	3.923ThrArg: 3.923 ± 0.06	2.54ThrSer: 2.54 ± 0.045	2.683ThrThr: 2.683 ± 0.054	4.206ThrVal: 4.206 ± 0.063	0.73ThrTrp: 0.73 ± 0.026	1.199ThrTyr: 1.199 ± 0.036	0.001ThrXaa: 0.001 ± 0.001
Val	8.992ValAla: 8.992 ± 0.105	0.617ValCys: 0.617 ± 0.028	3.994ValAsp: 3.994 ± 0.055	4.639ValGlu: 4.639 ± 0.072	2.967ValPhe: 2.967 ± 0.054	5.299ValGly: 5.299 ± 0.071	1.295ValHis: 1.295 ± 0.036	4.304ValIle: 4.304 ± 0.065	1.725ValLys: 1.725 ± 0.049	7.481ValLeu: 7.481 ± 0.09	2.195ValMet: 2.195 ± 0.043	1.812ValAsn: 1.812 ± 0.049	3.58ValPro: 3.58 ± 0.058	2.048ValGln: 2.048 ± 0.043	4.188ValArg: 4.188 ± 0.069	4.052ValSer: 4.052 ± 0.059	4.795ValThr: 4.795 ± 0.07	5.393ValVal: 5.393 ± 0.079	0.946ValTrp: 0.946 ± 0.03	1.442ValTyr: 1.442 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.455TrpAla: 1.455 ± 0.041	0.132TrpCys: 0.132 ± 0.01	0.784TrpAsp: 0.784 ± 0.026	0.698TrpGlu: 0.698 ± 0.025	0.572TrpPhe: 0.572 ± 0.026	0.998TrpGly: 0.998 ± 0.032	0.355TrpHis: 0.355 ± 0.015	0.702TrpIle: 0.702 ± 0.025	0.356TrpLys: 0.356 ± 0.017	1.644TrpLeu: 1.644 ± 0.035	0.395TrpMet: 0.395 ± 0.021	0.42TrpAsn: 0.42 ± 0.021	0.752TrpPro: 0.752 ± 0.024	0.607TrpGln: 0.607 ± 0.025	1.17TrpArg: 1.17 ± 0.031	0.787TrpSer: 0.787 ± 0.028	0.843TrpThr: 0.843 ± 0.029	0.924TrpVal: 0.924 ± 0.03	0.253TrpTrp: 0.253 ± 0.014	0.267TrpTyr: 0.267 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.504TyrAla: 2.504 ± 0.05	0.222TyrCys: 0.222 ± 0.012	1.551TyrAsp: 1.551 ± 0.037	1.237TyrGlu: 1.237 ± 0.039	0.882TyrPhe: 0.882 ± 0.027	2.169TyrGly: 2.169 ± 0.036	0.54TyrHis: 0.54 ± 0.024	0.95TyrIle: 0.95 ± 0.028	0.467TyrLys: 0.467 ± 0.023	2.268TyrLeu: 2.268 ± 0.038	0.456TyrMet: 0.456 ± 0.019	0.565TyrAsn: 0.565 ± 0.02	1.068TyrPro: 1.068 ± 0.03	0.673TyrGln: 0.673 ± 0.026	1.659TyrArg: 1.659 ± 0.04	1.11TyrSer: 1.11 ± 0.028	1.146TyrThr: 1.146 ± 0.034	1.508TyrVal: 1.508 ± 0.032	0.398TyrTrp: 0.398 ± 0.021	0.544TyrTyr: 0.544 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3660 proteins (1138918 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---