Amino acid dipepetide frequency for Caulobacter sp. B11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.636AlaAla: 20.636 ± 0.293
1.262AlaCys: 1.262 ± 0.059
7.547AlaAsp: 7.547 ± 0.137
7.353AlaGlu: 7.353 ± 0.129
4.789AlaPhe: 4.789 ± 0.105
11.838AlaGly: 11.838 ± 0.164
2.186AlaHis: 2.186 ± 0.067
5.798AlaIle: 5.798 ± 0.116
4.451AlaLys: 4.451 ± 0.103
14.712AlaLeu: 14.712 ± 0.227
3.533AlaMet: 3.533 ± 0.086
2.76AlaAsn: 2.76 ± 0.094
7.226AlaPro: 7.226 ± 0.135
4.656AlaGln: 4.656 ± 0.106
10.394AlaArg: 10.394 ± 0.163
6.882AlaSer: 6.882 ± 0.125
6.121AlaThr: 6.121 ± 0.121
10.219AlaVal: 10.219 ± 0.163
2.087AlaTrp: 2.087 ± 0.072
2.866AlaTyr: 2.866 ± 0.074
0.0AlaXaa: 0.0 ± 0.0
Cys
1.053CysAla: 1.053 ± 0.047
0.106CysCys: 0.106 ± 0.017
0.525CysAsp: 0.525 ± 0.033
0.401CysGlu: 0.401 ± 0.028
0.317CysPhe: 0.317 ± 0.022
0.855CysGly: 0.855 ± 0.047
0.16CysHis: 0.16 ± 0.017
0.281CysIle: 0.281 ± 0.025
0.23CysLys: 0.23 ± 0.02
0.743CysLeu: 0.743 ± 0.038
0.129CysMet: 0.129 ± 0.014
0.175CysAsn: 0.175 ± 0.019
0.469CysPro: 0.469 ± 0.035
0.234CysGln: 0.234 ± 0.02
0.532CysArg: 0.532 ± 0.035
0.382CysSer: 0.382 ± 0.027
0.317CysThr: 0.317 ± 0.026
0.642CysVal: 0.642 ± 0.035
0.118CysTrp: 0.118 ± 0.017
0.171CysTyr: 0.171 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
7.319AspAla: 7.319 ± 0.121
0.411AspCys: 0.411 ± 0.031
3.48AspAsp: 3.48 ± 0.116
3.282AspGlu: 3.282 ± 0.099
2.273AspPhe: 2.273 ± 0.079
5.519AspGly: 5.519 ± 0.123
1.332AspHis: 1.332 ± 0.059
2.6AspIle: 2.6 ± 0.075
1.823AspLys: 1.823 ± 0.061
6.984AspLeu: 6.984 ± 0.13
1.211AspMet: 1.211 ± 0.049
1.298AspAsn: 1.298 ± 0.055
3.904AspPro: 3.904 ± 0.091
2.089AspGln: 2.089 ± 0.065
4.59AspArg: 4.59 ± 0.106
2.296AspSer: 2.296 ± 0.064
2.379AspThr: 2.379 ± 0.085
4.122AspVal: 4.122 ± 0.094
1.028AspTrp: 1.028 ± 0.046
1.553AspTyr: 1.553 ± 0.057
0.0AspXaa: 0.0 ± 0.0
Glu
8.47GluAla: 8.47 ± 0.14
0.262GluCys: 0.262 ± 0.023
2.636GluAsp: 2.636 ± 0.075
2.227GluGlu: 2.227 ± 0.074
1.465GluPhe: 1.465 ± 0.044
4.569GluGly: 4.569 ± 0.108
1.057GluHis: 1.057 ± 0.05
2.963GluIle: 2.963 ± 0.084
1.743GluLys: 1.743 ± 0.065
4.555GluLeu: 4.555 ± 0.097
1.157GluMet: 1.157 ± 0.052
1.157GluAsn: 1.157 ± 0.045
2.699GluPro: 2.699 ± 0.078
1.872GluGln: 1.872 ± 0.07
4.696GluArg: 4.696 ± 0.103
2.178GluSer: 2.178 ± 0.067
3.398GluThr: 3.398 ± 0.087
3.693GluVal: 3.693 ± 0.078
0.561GluTrp: 0.561 ± 0.036
0.872GluTyr: 0.872 ± 0.044
0.0GluXaa: 0.0 ± 0.0
Phe
4.55PheAla: 4.55 ± 0.102
0.369PheCys: 0.369 ± 0.025
2.71PheAsp: 2.71 ± 0.074
2.246PheGlu: 2.246 ± 0.071
1.167PhePhe: 1.167 ± 0.05
3.52PheGly: 3.52 ± 0.106
0.716PheHis: 0.716 ± 0.044
1.463PheIle: 1.463 ± 0.058
1.211PheLys: 1.211 ± 0.052
2.997PheLeu: 2.997 ± 0.077
0.773PheMet: 0.773 ± 0.04
1.072PheAsn: 1.072 ± 0.049
1.448PhePro: 1.448 ± 0.056
1.11PheGln: 1.11 ± 0.043
2.034PheArg: 2.034 ± 0.065
2.123PheSer: 2.123 ± 0.06
2.136PheThr: 2.136 ± 0.067
2.682PheVal: 2.682 ± 0.077
0.544PheTrp: 0.544 ± 0.036
0.764PheTyr: 0.764 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
11.146GlyAla: 11.146 ± 0.175
0.793GlyCys: 0.793 ± 0.039
5.04GlyAsp: 5.04 ± 0.131
4.831GlyGlu: 4.831 ± 0.109
3.727GlyPhe: 3.727 ± 0.095
10.063GlyGly: 10.063 ± 1.406
1.754GlyHis: 1.754 ± 0.073
2.78GlyIle: 2.78 ± 0.075
3.316GlyLys: 3.316 ± 0.088
10.175GlyLeu: 10.175 ± 0.152
2.092GlyMet: 2.092 ± 0.058
1.642GlyAsn: 1.642 ± 0.094
4.422GlyPro: 4.422 ± 0.113
3.345GlyGln: 3.345 ± 0.088
6.509GlyArg: 6.509 ± 0.133
4.24GlySer: 4.24 ± 0.098
3.024GlyThr: 3.024 ± 0.076
7.988GlyVal: 7.988 ± 0.139
1.463GlyTrp: 1.463 ± 0.056
2.184GlyTyr: 2.184 ± 0.082
0.0GlyXaa: 0.0 ± 0.0
His
2.159HisAla: 2.159 ± 0.078
0.184HisCys: 0.184 ± 0.02
1.066HisAsp: 1.066 ± 0.046
0.998HisGlu: 0.998 ± 0.039
0.631HisPhe: 0.631 ± 0.041
1.921HisGly: 1.921 ± 0.064
0.479HisHis: 0.479 ± 0.04
0.665HisIle: 0.665 ± 0.032
0.42HisLys: 0.42 ± 0.028
1.84HisLeu: 1.84 ± 0.069
0.416HisMet: 0.416 ± 0.028
0.401HisAsn: 0.401 ± 0.025
1.317HisPro: 1.317 ± 0.058
0.614HisGln: 0.614 ± 0.037
1.384HisArg: 1.384 ± 0.056
0.675HisSer: 0.675 ± 0.032
0.671HisThr: 0.671 ± 0.037
1.389HisVal: 1.389 ± 0.048
0.293HisTrp: 0.293 ± 0.025
0.538HisTyr: 0.538 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.564IleAla: 6.564 ± 0.133
0.435IleCys: 0.435 ± 0.028
3.455IleAsp: 3.455 ± 0.087
3.183IleGlu: 3.183 ± 0.085
1.465IlePhe: 1.465 ± 0.066
4.067IleGly: 4.067 ± 0.107
0.758IleHis: 0.758 ± 0.04
1.916IleIle: 1.916 ± 0.065
1.393IleLys: 1.393 ± 0.055
4.103IleLeu: 4.103 ± 0.108
0.819IleMet: 0.819 ± 0.037
1.237IleAsn: 1.237 ± 0.056
1.826IlePro: 1.826 ± 0.06
1.279IleGln: 1.279 ± 0.051
2.763IleArg: 2.763 ± 0.083
2.448IleSer: 2.448 ± 0.069
2.366IleThr: 2.366 ± 0.065
3.522IleVal: 3.522 ± 0.091
0.585IleTrp: 0.585 ± 0.031
0.91IleTyr: 0.91 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
5.103LysAla: 5.103 ± 0.108
0.129LysCys: 0.129 ± 0.016
1.688LysAsp: 1.688 ± 0.065
1.131LysGlu: 1.131 ± 0.058
0.935LysPhe: 0.935 ± 0.039
2.874LysGly: 2.874 ± 0.072
0.488LysHis: 0.488 ± 0.03
1.68LysIle: 1.68 ± 0.066
1.11LysLys: 1.11 ± 0.06
3.005LysLeu: 3.005 ± 0.091
0.659LysMet: 0.659 ± 0.036
0.656LysAsn: 0.656 ± 0.038
2.174LysPro: 2.174 ± 0.066
0.793LysGln: 0.793 ± 0.042
2.178LysArg: 2.178 ± 0.077
1.75LysSer: 1.75 ± 0.065
2.206LysThr: 2.206 ± 0.068
2.486LysVal: 2.486 ± 0.074
0.298LysTrp: 0.298 ± 0.024
0.559LysTyr: 0.559 ± 0.032
0.0LysXaa: 0.0 ± 0.0
Leu
14.976LeuAla: 14.976 ± 0.22
0.838LeuCys: 0.838 ± 0.041
6.621LeuAsp: 6.621 ± 0.133
5.344LeuGlu: 5.344 ± 0.111
3.468LeuPhe: 3.468 ± 0.093
8.533LeuGly: 8.533 ± 0.154
1.703LeuHis: 1.703 ± 0.048
5.08LeuIle: 5.08 ± 0.121
3.906LeuLys: 3.906 ± 0.097
9.206LeuLeu: 9.206 ± 0.166
2.322LeuMet: 2.322 ± 0.071
2.733LeuAsn: 2.733 ± 0.078
5.023LeuPro: 5.023 ± 0.099
2.636LeuGln: 2.636 ± 0.08
6.751LeuArg: 6.751 ± 0.112
6.275LeuSer: 6.275 ± 0.121
6.234LeuThr: 6.234 ± 0.116
7.516LeuVal: 7.516 ± 0.135
1.245LeuTrp: 1.245 ± 0.055
1.914LeuTyr: 1.914 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
3.413MetAla: 3.413 ± 0.083
0.125MetCys: 0.125 ± 0.015
1.18MetAsp: 1.18 ± 0.044
0.851MetGlu: 0.851 ± 0.039
0.593MetPhe: 0.593 ± 0.036
1.754MetGly: 1.754 ± 0.061
0.306MetHis: 0.306 ± 0.026
1.323MetIle: 1.323 ± 0.05
0.85MetLys: 0.85 ± 0.036
2.284MetLeu: 2.284 ± 0.072
0.608MetMet: 0.608 ± 0.04
0.72MetAsn: 0.72 ± 0.033
1.169MetPro: 1.169 ± 0.049
0.659MetGln: 0.659 ± 0.036
1.566MetArg: 1.566 ± 0.05
1.648MetSer: 1.648 ± 0.052
1.855MetThr: 1.855 ± 0.064
1.68MetVal: 1.68 ± 0.051
0.182MetTrp: 0.182 ± 0.021
0.232MetTyr: 0.232 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.067AsnAla: 3.067 ± 0.079
0.2AsnCys: 0.2 ± 0.02
1.338AsnAsp: 1.338 ± 0.081
0.929AsnGlu: 0.929 ± 0.046
0.777AsnPhe: 0.777 ± 0.042
2.163AsnGly: 2.163 ± 0.074
0.418AsnHis: 0.418 ± 0.03
1.127AsnIle: 1.127 ± 0.055
0.513AsnLys: 0.513 ± 0.034
2.609AsnLeu: 2.609 ± 0.086
0.477AsnMet: 0.477 ± 0.032
0.614AsnAsn: 0.614 ± 0.041
1.64AsnPro: 1.64 ± 0.062
0.709AsnGln: 0.709 ± 0.042
1.56AsnArg: 1.56 ± 0.053
1.114AsnSer: 1.114 ± 0.057
1.119AsnThr: 1.119 ± 0.058
1.693AsnVal: 1.693 ± 0.065
0.357AsnTrp: 0.357 ± 0.025
0.587AsnTyr: 0.587 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
7.399ProAla: 7.399 ± 0.136
0.376ProCys: 0.376 ± 0.029
3.833ProAsp: 3.833 ± 0.096
3.252ProGlu: 3.252 ± 0.08
2.026ProPhe: 2.026 ± 0.071
4.989ProGly: 4.989 ± 0.111
0.922ProHis: 0.922 ± 0.047
2.334ProIle: 2.334 ± 0.069
1.574ProLys: 1.574 ± 0.054
4.949ProLeu: 4.949 ± 0.103
1.349ProMet: 1.349 ± 0.055
1.201ProAsn: 1.201 ± 0.053
3.286ProPro: 3.286 ± 0.125
1.631ProGln: 1.631 ± 0.047
3.487ProArg: 3.487 ± 0.098
2.898ProSer: 2.898 ± 0.078
2.832ProThr: 2.832 ± 0.072
4.145ProVal: 4.145 ± 0.096
0.831ProTrp: 0.831 ± 0.04
1.157ProTyr: 1.157 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
5.131GlnAla: 5.131 ± 0.108
0.19GlnCys: 0.19 ± 0.018
1.691GlnAsp: 1.691 ± 0.053
1.277GlnGlu: 1.277 ± 0.048
1.045GlnPhe: 1.045 ± 0.043
2.756GlnGly: 2.756 ± 0.08
0.585GlnHis: 0.585 ± 0.035
1.688GlnIle: 1.688 ± 0.061
0.929GlnLys: 0.929 ± 0.048
2.83GlnLeu: 2.83 ± 0.089
0.781GlnMet: 0.781 ± 0.036
0.623GlnAsn: 0.623 ± 0.037
1.691GlnPro: 1.691 ± 0.058
0.981GlnGln: 0.981 ± 0.045
2.435GlnArg: 2.435 ± 0.073
1.642GlnSer: 1.642 ± 0.064
1.845GlnThr: 1.845 ± 0.061
2.541GlnVal: 2.541 ± 0.075
0.393GlnTrp: 0.393 ± 0.026
0.574GlnTyr: 0.574 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
8.967ArgAla: 8.967 ± 0.156
0.488ArgCys: 0.488 ± 0.031
4.388ArgAsp: 4.388 ± 0.108
3.687ArgGlu: 3.687 ± 0.093
2.894ArgPhe: 2.894 ± 0.075
5.232ArgGly: 5.232 ± 0.114
1.526ArgHis: 1.526 ± 0.058
3.379ArgIle: 3.379 ± 0.08
2.149ArgLys: 2.149 ± 0.071
8.607ArgLeu: 8.607 ± 0.157
1.887ArgMet: 1.887 ± 0.059
1.422ArgAsn: 1.422 ± 0.055
4.434ArgPro: 4.434 ± 0.106
2.609ArgGln: 2.609 ± 0.063
6.264ArgArg: 6.264 ± 0.132
3.396ArgSer: 3.396 ± 0.074
3.436ArgThr: 3.436 ± 0.077
5.078ArgVal: 5.078 ± 0.107
1.157ArgTrp: 1.157 ± 0.052
1.695ArgTyr: 1.695 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
6.526SerAla: 6.526 ± 0.105
0.34SerCys: 0.34 ± 0.023
2.913SerAsp: 2.913 ± 0.075
2.29SerGlu: 2.29 ± 0.068
1.973SerPhe: 1.973 ± 0.06
5.337SerGly: 5.337 ± 0.098
0.903SerHis: 0.903 ± 0.043
2.305SerIle: 2.305 ± 0.068
1.492SerLys: 1.492 ± 0.052
5.652SerLeu: 5.652 ± 0.096
1.224SerMet: 1.224 ± 0.051
1.323SerAsn: 1.323 ± 0.061
3.238SerPro: 3.238 ± 0.081
1.652SerGln: 1.652 ± 0.057
3.639SerArg: 3.639 ± 0.076
2.649SerSer: 2.649 ± 0.079
2.687SerThr: 2.687 ± 0.073
3.609SerVal: 3.609 ± 0.093
0.735SerTrp: 0.735 ± 0.04
1.095SerTyr: 1.095 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
6.671ThrAla: 6.671 ± 0.128
0.39ThrCys: 0.39 ± 0.031
2.773ThrAsp: 2.773 ± 0.066
2.231ThrGlu: 2.231 ± 0.071
1.929ThrPhe: 1.929 ± 0.069
5.166ThrGly: 5.166 ± 0.104
0.91ThrHis: 0.91 ± 0.04
2.423ThrIle: 2.423 ± 0.073
1.365ThrLys: 1.365 ± 0.061
5.698ThrLeu: 5.698 ± 0.111
0.992ThrMet: 0.992 ± 0.046
1.194ThrAsn: 1.194 ± 0.058
3.793ThrPro: 3.793 ± 0.082
1.465ThrGln: 1.465 ± 0.048
3.383ThrArg: 3.383 ± 0.094
2.505ThrSer: 2.505 ± 0.074
2.754ThrThr: 2.754 ± 0.087
4.223ThrVal: 4.223 ± 0.081
0.692ThrTrp: 0.692 ± 0.038
1.283ThrTyr: 1.283 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
10.139ValAla: 10.139 ± 0.152
0.625ValCys: 0.625 ± 0.037
4.396ValAsp: 4.396 ± 0.104
5.017ValGlu: 5.017 ± 0.101
2.706ValPhe: 2.706 ± 0.076
6.222ValGly: 6.222 ± 0.104
1.281ValHis: 1.281 ± 0.047
3.89ValIle: 3.89 ± 0.095
2.381ValLys: 2.381 ± 0.074
7.629ValLeu: 7.629 ± 0.145
1.779ValMet: 1.779 ± 0.064
1.773ValAsn: 1.773 ± 0.067
2.936ValPro: 2.936 ± 0.079
2.214ValGln: 2.214 ± 0.064
5.266ValArg: 5.266 ± 0.1
4.352ValSer: 4.352 ± 0.102
4.529ValThr: 4.529 ± 0.096
6.095ValVal: 6.095 ± 0.124
1.079ValTrp: 1.079 ± 0.049
1.501ValTyr: 1.501 ± 0.053
0.0ValXaa: 0.0 ± 0.0
Trp
1.473TrpAla: 1.473 ± 0.058
0.12TrpCys: 0.12 ± 0.017
0.669TrpAsp: 0.669 ± 0.035
0.547TrpGlu: 0.547 ± 0.034
0.58TrpPhe: 0.58 ± 0.038
1.002TrpGly: 1.002 ± 0.045
0.181TrpHis: 0.181 ± 0.021
0.673TrpIle: 0.673 ± 0.037
0.483TrpLys: 0.483 ± 0.033
1.655TrpLeu: 1.655 ± 0.069
0.397TrpMet: 0.397 ± 0.026
0.437TrpAsn: 0.437 ± 0.028
0.747TrpPro: 0.747 ± 0.039
0.361TrpGln: 0.361 ± 0.03
1.524TrpArg: 1.524 ± 0.06
1.022TrpSer: 1.022 ± 0.05
1.047TrpThr: 1.047 ± 0.046
0.813TrpVal: 0.813 ± 0.044
0.306TrpTrp: 0.306 ± 0.024
0.251TrpTyr: 0.251 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.552TyrAla: 2.552 ± 0.072
0.198TyrCys: 0.198 ± 0.02
1.541TyrAsp: 1.541 ± 0.059
1.152TyrGlu: 1.152 ± 0.057
0.872TyrPhe: 0.872 ± 0.037
2.157TyrGly: 2.157 ± 0.096
0.397TyrHis: 0.397 ± 0.024
0.728TyrIle: 0.728 ± 0.042
0.564TyrLys: 0.564 ± 0.035
2.091TyrLeu: 2.091 ± 0.07
0.39TyrMet: 0.39 ± 0.027
0.576TyrAsn: 0.576 ± 0.036
1.026TyrPro: 1.026 ± 0.049
0.722TyrGln: 0.722 ± 0.038
1.743TyrArg: 1.743 ± 0.059
1.108TyrSer: 1.108 ± 0.047
0.88TyrThr: 0.88 ± 0.045
1.676TyrVal: 1.676 ± 0.062
0.333TyrTrp: 0.333 ± 0.029
0.532TyrTyr: 0.532 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1996 proteins (526181 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski