Amino acid dipepetide frequency for Amphiplicatus metriothermophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	25.961AlaAla: 25.961 ± 0.331	1.319AlaCys: 1.319 ± 0.037	7.714AlaAsp: 7.714 ± 0.098	9.522AlaGlu: 9.522 ± 0.121	5.882AlaPhe: 5.882 ± 0.09	13.541AlaGly: 13.541 ± 0.158	2.529AlaHis: 2.529 ± 0.055	6.127AlaIle: 6.127 ± 0.091	4.018AlaLys: 4.018 ± 0.074	16.892AlaLeu: 16.892 ± 0.208	3.349AlaMet: 3.349 ± 0.061	2.668AlaAsn: 2.668 ± 0.06	8.877AlaPro: 8.877 ± 0.151	3.904AlaGln: 3.904 ± 0.067	14.412AlaArg: 14.412 ± 0.181	6.102AlaSer: 6.102 ± 0.078	5.216AlaThr: 5.216 ± 0.073	9.589AlaVal: 9.589 ± 0.114	1.744AlaTrp: 1.744 ± 0.048	3.039AlaTyr: 3.039 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	1.395CysAla: 1.395 ± 0.043	0.099CysCys: 0.099 ± 0.01	0.496CysAsp: 0.496 ± 0.024	0.486CysGlu: 0.486 ± 0.024	0.336CysPhe: 0.336 ± 0.021	0.896CysGly: 0.896 ± 0.03	0.161CysHis: 0.161 ± 0.012	0.276CysIle: 0.276 ± 0.019	0.169CysLys: 0.169 ± 0.013	0.722CysLeu: 0.722 ± 0.025	0.119CysMet: 0.119 ± 0.011	0.176CysAsn: 0.176 ± 0.014	0.447CysPro: 0.447 ± 0.025	0.173CysGln: 0.173 ± 0.014	0.644CysArg: 0.644 ± 0.026	0.338CysSer: 0.338 ± 0.017	0.305CysThr: 0.305 ± 0.021	0.629CysVal: 0.629 ± 0.032	0.112CysTrp: 0.112 ± 0.012	0.167CysTyr: 0.167 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	8.388AspAla: 8.388 ± 0.094	0.491AspCys: 0.491 ± 0.029	3.298AspAsp: 3.298 ± 0.065	4.0AspGlu: 4.0 ± 0.075	2.455AspPhe: 2.455 ± 0.051	5.671AspGly: 5.671 ± 0.095	1.046AspHis: 1.046 ± 0.033	2.801AspIle: 2.801 ± 0.057	1.408AspLys: 1.408 ± 0.037	5.636AspLeu: 5.636 ± 0.08	1.129AspMet: 1.129 ± 0.037	1.088AspAsn: 1.088 ± 0.036	3.796AspPro: 3.796 ± 0.066	1.308AspGln: 1.308 ± 0.038	4.49AspArg: 4.49 ± 0.067	2.012AspSer: 2.012 ± 0.045	1.702AspThr: 1.702 ± 0.046	3.966AspVal: 3.966 ± 0.066	0.978AspTrp: 0.978 ± 0.035	1.754AspTyr: 1.754 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	10.545GluAla: 10.545 ± 0.138	0.376GluCys: 0.376 ± 0.02	3.481GluAsp: 3.481 ± 0.072	4.812GluGlu: 4.812 ± 0.092	1.834GluPhe: 1.834 ± 0.053	5.223GluGly: 5.223 ± 0.083	0.987GluHis: 0.987 ± 0.033	4.038GluIle: 4.038 ± 0.072	3.049GluLys: 3.049 ± 0.057	4.816GluLeu: 4.816 ± 0.075	1.493GluMet: 1.493 ± 0.04	1.894GluAsn: 1.894 ± 0.053	3.185GluPro: 3.185 ± 0.066	1.693GluGln: 1.693 ± 0.042	6.182GluArg: 6.182 ± 0.1	2.776GluSer: 2.776 ± 0.052	4.485GluThr: 4.485 ± 0.069	3.272GluVal: 3.272 ± 0.069	0.775GluTrp: 0.775 ± 0.033	1.129GluTyr: 1.129 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	5.766PheAla: 5.766 ± 0.086	0.389PheCys: 0.389 ± 0.021	2.948PheAsp: 2.948 ± 0.06	2.639PheGlu: 2.639 ± 0.055	1.605PhePhe: 1.605 ± 0.05	3.562PheGly: 3.562 ± 0.064	0.742PheHis: 0.742 ± 0.029	1.777PheIle: 1.777 ± 0.046	0.845PheLys: 0.845 ± 0.032	3.745PheLeu: 3.745 ± 0.069	0.809PheMet: 0.809 ± 0.033	1.031PheAsn: 1.031 ± 0.036	1.611PhePro: 1.611 ± 0.045	0.836PheGln: 0.836 ± 0.032	2.616PheArg: 2.616 ± 0.057	2.213PheSer: 2.213 ± 0.051	1.563PheThr: 1.563 ± 0.046	2.91PheVal: 2.91 ± 0.056	0.572PheTrp: 0.572 ± 0.026	1.02PheTyr: 1.02 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	13.786GlyAla: 13.786 ± 0.201	0.792GlyCys: 0.792 ± 0.029	4.587GlyAsp: 4.587 ± 0.078	6.356GlyGlu: 6.356 ± 0.089	3.698GlyPhe: 3.698 ± 0.062	7.854GlyGly: 7.854 ± 0.111	1.495GlyHis: 1.495 ± 0.044	2.603GlyIle: 2.603 ± 0.053	2.596GlyLys: 2.596 ± 0.061	8.804GlyLeu: 8.804 ± 0.105	1.727GlyMet: 1.727 ± 0.05	1.409GlyAsn: 1.409 ± 0.038	4.158GlyPro: 4.158 ± 0.069	1.957GlyGln: 1.957 ± 0.052	7.134GlyArg: 7.134 ± 0.095	3.321GlySer: 3.321 ± 0.074	2.829GlyThr: 2.829 ± 0.061	7.407GlyVal: 7.407 ± 0.088	1.373GlyTrp: 1.373 ± 0.038	2.218GlyTyr: 2.218 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.253HisAla: 2.253 ± 0.05	0.192HisCys: 0.192 ± 0.013	0.98HisAsp: 0.98 ± 0.031	1.091HisGlu: 1.091 ± 0.04	0.768HisPhe: 0.768 ± 0.031	1.64HisGly: 1.64 ± 0.039	0.429HisHis: 0.429 ± 0.026	0.745HisIle: 0.745 ± 0.028	0.42HisLys: 0.42 ± 0.027	1.676HisLeu: 1.676 ± 0.042	0.383HisMet: 0.383 ± 0.02	0.383HisAsn: 0.383 ± 0.021	1.225HisPro: 1.225 ± 0.039	0.451HisGln: 0.451 ± 0.022	1.2HisArg: 1.2 ± 0.037	0.637HisSer: 0.637 ± 0.029	0.578HisThr: 0.578 ± 0.028	1.333HisVal: 1.333 ± 0.037	0.226HisTrp: 0.226 ± 0.016	0.531HisTyr: 0.531 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.284IleAla: 7.284 ± 0.084	0.434IleCys: 0.434 ± 0.023	3.465IleAsp: 3.465 ± 0.059	3.873IleGlu: 3.873 ± 0.067	1.639IlePhe: 1.639 ± 0.046	4.229IleGly: 4.229 ± 0.072	0.76IleHis: 0.76 ± 0.031	1.895IleIle: 1.895 ± 0.046	1.089IleLys: 1.089 ± 0.04	4.113IleLeu: 4.113 ± 0.072	0.762IleMet: 0.762 ± 0.033	1.088IleAsn: 1.088 ± 0.039	2.02IlePro: 2.02 ± 0.05	0.835IleGln: 0.835 ± 0.031	3.406IleArg: 3.406 ± 0.065	2.045IleSer: 2.045 ± 0.044	1.715IleThr: 1.715 ± 0.041	4.028IleVal: 4.028 ± 0.073	0.484IleTrp: 0.484 ± 0.025	1.057IleTyr: 1.057 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.48LysAla: 4.48 ± 0.081	0.137LysCys: 0.137 ± 0.013	1.671LysAsp: 1.671 ± 0.046	1.863LysGlu: 1.863 ± 0.044	0.867LysPhe: 0.867 ± 0.031	2.656LysGly: 2.656 ± 0.056	0.492LysHis: 0.492 ± 0.026	1.729LysIle: 1.729 ± 0.048	1.507LysLys: 1.507 ± 0.052	2.684LysLeu: 2.684 ± 0.06	0.603LysMet: 0.603 ± 0.026	0.863LysAsn: 0.863 ± 0.031	1.887LysPro: 1.887 ± 0.048	0.724LysGln: 0.724 ± 0.028	2.518LysArg: 2.518 ± 0.06	1.539LysSer: 1.539 ± 0.04	2.045LysThr: 2.045 ± 0.056	1.828LysVal: 1.828 ± 0.051	0.343LysTrp: 0.343 ± 0.017	0.664LysTyr: 0.664 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	16.194LeuAla: 16.194 ± 0.209	0.788LeuCys: 0.788 ± 0.03	6.341LeuAsp: 6.341 ± 0.089	5.853LeuGlu: 5.853 ± 0.075	3.919LeuPhe: 3.919 ± 0.077	7.717LeuGly: 7.717 ± 0.087	1.631LeuHis: 1.631 ± 0.047	4.655LeuIle: 4.655 ± 0.076	3.747LeuLys: 3.747 ± 0.074	8.419LeuLeu: 8.419 ± 0.113	1.904LeuMet: 1.904 ± 0.051	2.22LeuAsn: 2.22 ± 0.055	4.73LeuPro: 4.73 ± 0.071	2.198LeuGln: 2.198 ± 0.05	7.145LeuArg: 7.145 ± 0.105	5.611LeuSer: 5.611 ± 0.079	4.537LeuThr: 4.537 ± 0.074	6.849LeuVal: 6.849 ± 0.094	1.15LeuTrp: 1.15 ± 0.031	2.223LeuTyr: 2.223 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.775MetAla: 2.775 ± 0.063	0.123MetCys: 0.123 ± 0.012	0.878MetAsp: 0.878 ± 0.034	1.034MetGlu: 1.034 ± 0.032	0.614MetPhe: 0.614 ± 0.026	1.455MetGly: 1.455 ± 0.043	0.336MetHis: 0.336 ± 0.02	1.14MetIle: 1.14 ± 0.04	1.035MetLys: 1.035 ± 0.038	2.068MetLeu: 2.068 ± 0.048	0.498MetMet: 0.498 ± 0.025	0.62MetAsn: 0.62 ± 0.023	1.126MetPro: 1.126 ± 0.036	0.543MetGln: 0.543 ± 0.026	1.961MetArg: 1.961 ± 0.049	1.409MetSer: 1.409 ± 0.037	1.653MetThr: 1.653 ± 0.037	1.06MetVal: 1.06 ± 0.035	0.191MetTrp: 0.191 ± 0.013	0.263MetTyr: 0.263 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.13AsnAla: 3.13 ± 0.058	0.208AsnCys: 0.208 ± 0.016	1.246AsnAsp: 1.246 ± 0.04	1.287AsnGlu: 1.287 ± 0.038	0.867AsnPhe: 0.867 ± 0.034	2.058AsnGly: 2.058 ± 0.054	0.395AsnHis: 0.395 ± 0.023	1.171AsnIle: 1.171 ± 0.044	0.554AsnLys: 0.554 ± 0.024	2.197AsnLeu: 2.197 ± 0.055	0.449AsnMet: 0.449 ± 0.021	0.583AsnAsn: 0.583 ± 0.028	1.659AsnPro: 1.659 ± 0.043	0.577AsnGln: 0.577 ± 0.027	1.626AsnArg: 1.626 ± 0.042	0.882AsnSer: 0.882 ± 0.035	0.839AsnThr: 0.839 ± 0.033	1.767AsnVal: 1.767 ± 0.048	0.363AsnTrp: 0.363 ± 0.019	0.613AsnTyr: 0.613 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	8.217ProAla: 8.217 ± 0.119	0.389ProCys: 0.389 ± 0.023	3.864ProAsp: 3.864 ± 0.065	4.24ProGlu: 4.24 ± 0.081	2.115ProPhe: 2.115 ± 0.043	4.815ProGly: 4.815 ± 0.084	0.957ProHis: 0.957 ± 0.031	2.06ProIle: 2.06 ± 0.051	1.57ProLys: 1.57 ± 0.036	4.727ProLeu: 4.727 ± 0.076	1.024ProMet: 1.024 ± 0.037	1.165ProAsn: 1.165 ± 0.044	3.137ProPro: 3.137 ± 0.073	1.423ProGln: 1.423 ± 0.042	3.523ProArg: 3.523 ± 0.065	2.512ProSer: 2.512 ± 0.048	2.101ProThr: 2.101 ± 0.048	4.112ProVal: 4.112 ± 0.06	0.63ProTrp: 0.63 ± 0.025	1.269ProTyr: 1.269 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.649GlnAla: 3.649 ± 0.066	0.184GlnCys: 0.184 ± 0.014	1.118GlnAsp: 1.118 ± 0.04	1.389GlnGlu: 1.389 ± 0.04	0.874GlnPhe: 0.874 ± 0.028	1.962GlnGly: 1.962 ± 0.043	0.403GlnHis: 0.403 ± 0.021	1.458GlnIle: 1.458 ± 0.046	0.859GlnLys: 0.859 ± 0.029	2.091GlnLeu: 2.091 ± 0.049	0.626GlnMet: 0.626 ± 0.026	0.642GlnAsn: 0.642 ± 0.03	1.268GlnPro: 1.268 ± 0.036	0.66GlnGln: 0.66 ± 0.029	1.905GlnArg: 1.905 ± 0.048	1.241GlnSer: 1.241 ± 0.041	1.439GlnThr: 1.439 ± 0.04	1.378GlnVal: 1.378 ± 0.04	0.277GlnTrp: 0.277 ± 0.016	0.551GlnTyr: 0.551 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	12.761ArgAla: 12.761 ± 0.162	0.548ArgCys: 0.548 ± 0.022	4.213ArgAsp: 4.213 ± 0.073	5.37ArgGlu: 5.37 ± 0.076	3.412ArgPhe: 3.412 ± 0.069	5.471ArgGly: 5.471 ± 0.08	1.49ArgHis: 1.49 ± 0.039	4.149ArgIle: 4.149 ± 0.067	2.59ArgLys: 2.59 ± 0.055	9.743ArgLeu: 9.743 ± 0.143	1.827ArgMet: 1.827 ± 0.042	1.764ArgAsn: 1.764 ± 0.038	4.409ArgPro: 4.409 ± 0.076	2.104ArgGln: 2.104 ± 0.053	8.554ArgArg: 8.554 ± 0.128	3.108ArgSer: 3.108 ± 0.058	3.133ArgThr: 3.133 ± 0.06	4.972ArgVal: 4.972 ± 0.069	1.04ArgTrp: 1.04 ± 0.035	2.033ArgTyr: 2.033 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	6.002SerAla: 6.002 ± 0.082	0.339SerCys: 0.339 ± 0.02	2.437SerAsp: 2.437 ± 0.057	2.525SerGlu: 2.525 ± 0.053	2.053SerPhe: 2.053 ± 0.047	4.571SerGly: 4.571 ± 0.075	0.774SerHis: 0.774 ± 0.031	2.105SerIle: 2.105 ± 0.046	1.261SerLys: 1.261 ± 0.037	4.632SerLeu: 4.632 ± 0.081	1.022SerMet: 1.022 ± 0.036	1.046SerAsn: 1.046 ± 0.032	2.78SerPro: 2.78 ± 0.057	1.143SerGln: 1.143 ± 0.032	3.244SerArg: 3.244 ± 0.051	2.161SerSer: 2.161 ± 0.058	1.884SerThr: 1.884 ± 0.049	3.383SerVal: 3.383 ± 0.064	0.662SerTrp: 0.662 ± 0.028	1.135SerTyr: 1.135 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.664ThrAla: 5.664 ± 0.081	0.335ThrCys: 0.335 ± 0.021	2.406ThrAsp: 2.406 ± 0.055	2.277ThrGlu: 2.277 ± 0.049	1.68ThrPhe: 1.68 ± 0.053	4.33ThrGly: 4.33 ± 0.071	0.732ThrHis: 0.732 ± 0.032	2.255ThrIle: 2.255 ± 0.05	1.096ThrLys: 1.096 ± 0.033	4.776ThrLeu: 4.776 ± 0.066	0.802ThrMet: 0.802 ± 0.026	0.953ThrAsn: 0.953 ± 0.034	3.168ThrPro: 3.168 ± 0.066	1.025ThrGln: 1.025 ± 0.029	3.129ThrArg: 3.129 ± 0.058	1.801ThrSer: 1.801 ± 0.048	2.073ThrThr: 2.073 ± 0.055	3.321ThrVal: 3.321 ± 0.069	0.441ThrTrp: 0.441 ± 0.025	0.96ThrTyr: 0.96 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.487ValAla: 9.487 ± 0.12	0.659ValCys: 0.659 ± 0.025	4.124ValAsp: 4.124 ± 0.068	5.247ValGlu: 5.247 ± 0.085	3.062ValPhe: 3.062 ± 0.06	5.323ValGly: 5.323 ± 0.078	1.114ValHis: 1.114 ± 0.034	3.709ValIle: 3.709 ± 0.068	2.276ValLys: 2.276 ± 0.05	6.348ValLeu: 6.348 ± 0.086	1.571ValMet: 1.571 ± 0.043	1.957ValAsn: 1.957 ± 0.043	2.716ValPro: 2.716 ± 0.05	1.473ValGln: 1.473 ± 0.046	5.197ValArg: 5.197 ± 0.07	3.749ValSer: 3.749 ± 0.074	3.448ValThr: 3.448 ± 0.062	5.686ValVal: 5.686 ± 0.088	0.987ValTrp: 0.987 ± 0.036	1.801ValTyr: 1.801 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.426TrpAla: 1.426 ± 0.046	0.102TrpCys: 0.102 ± 0.011	0.552TrpAsp: 0.552 ± 0.021	0.601TrpGlu: 0.601 ± 0.026	0.535TrpPhe: 0.535 ± 0.029	0.882TrpGly: 0.882 ± 0.034	0.212TrpHis: 0.212 ± 0.015	0.672TrpIle: 0.672 ± 0.031	0.42TrpLys: 0.42 ± 0.02	1.503TrpLeu: 1.503 ± 0.041	0.276TrpMet: 0.276 ± 0.016	0.345TrpAsn: 0.345 ± 0.02	0.663TrpPro: 0.663 ± 0.029	0.283TrpGln: 0.283 ± 0.018	1.864TrpArg: 1.864 ± 0.054	0.742TrpSer: 0.742 ± 0.026	0.792TrpThr: 0.792 ± 0.029	0.616TrpVal: 0.616 ± 0.027	0.186TrpTrp: 0.186 ± 0.018	0.233TrpTyr: 0.233 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.244TyrAla: 3.244 ± 0.06	0.243TyrCys: 0.243 ± 0.018	1.6TyrAsp: 1.6 ± 0.047	1.584TyrGlu: 1.584 ± 0.039	0.981TyrPhe: 0.981 ± 0.033	2.248TyrGly: 2.248 ± 0.046	0.454TyrHis: 0.454 ± 0.023	0.855TyrIle: 0.855 ± 0.029	0.59TyrLys: 0.59 ± 0.027	2.239TyrLeu: 2.239 ± 0.05	0.404TyrMet: 0.404 ± 0.021	0.579TyrAsn: 0.579 ± 0.026	0.99TyrPro: 0.99 ± 0.036	0.665TyrGln: 0.665 ± 0.027	1.939TyrArg: 1.939 ± 0.046	0.96TyrSer: 0.96 ± 0.035	0.886TyrThr: 0.886 ± 0.033	1.828TyrVal: 1.828 ± 0.049	0.371TyrTrp: 0.371 ± 0.019	0.732TyrTyr: 0.732 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2934 proteins (946893 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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