Amino acid dipepetide frequency for Lactococcus phage p2 (Lactococcus lactis bacteriophage p2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.577AlaAla: 0.577 ± 0.199
0.115AlaCys: 0.115 ± 0.112
3.461AlaAsp: 3.461 ± 0.567
4.846AlaGlu: 4.846 ± 0.805
3.115AlaPhe: 3.115 ± 0.706
5.423AlaGly: 5.423 ± 1.17
1.038AlaHis: 1.038 ± 0.351
4.846AlaIle: 4.846 ± 1.256
5.538AlaLys: 5.538 ± 0.976
7.73AlaLeu: 7.73 ± 1.03
2.308AlaMet: 2.308 ± 0.683
4.5AlaAsn: 4.5 ± 0.87
0.692AlaPro: 0.692 ± 0.343
2.192AlaGln: 2.192 ± 0.492
1.731AlaArg: 1.731 ± 0.449
3.577AlaSer: 3.577 ± 0.858
2.769AlaThr: 2.769 ± 0.693
4.615AlaVal: 4.615 ± 0.946
1.961AlaTrp: 1.961 ± 0.896
1.385AlaTyr: 1.385 ± 0.389
0.0AlaXaa: 0.0 ± 0.0
Cys
0.231CysAla: 0.231 ± 0.174
0.0CysCys: 0.0 ± 0.0
0.346CysAsp: 0.346 ± 0.201
0.346CysGlu: 0.346 ± 0.212
0.231CysPhe: 0.231 ± 0.146
1.038CysGly: 1.038 ± 0.368
0.346CysHis: 0.346 ± 0.199
0.346CysIle: 0.346 ± 0.198
0.577CysLys: 0.577 ± 0.327
0.346CysLeu: 0.346 ± 0.188
0.0CysMet: 0.0 ± 0.0
0.346CysAsn: 0.346 ± 0.198
0.346CysPro: 0.346 ± 0.214
0.231CysGln: 0.231 ± 0.167
0.577CysArg: 0.577 ± 0.252
0.231CysSer: 0.231 ± 0.155
0.115CysThr: 0.115 ± 0.115
0.346CysVal: 0.346 ± 0.208
0.115CysTrp: 0.115 ± 0.116
0.462CysTyr: 0.462 ± 0.229
0.0CysXaa: 0.0 ± 0.0
Asp
2.077AspAla: 2.077 ± 0.48
0.115AspCys: 0.115 ± 0.134
3.692AspAsp: 3.692 ± 0.804
3.808AspGlu: 3.808 ± 0.808
3.692AspPhe: 3.692 ± 0.655
3.808AspGly: 3.808 ± 0.648
0.577AspHis: 0.577 ± 0.308
4.384AspIle: 4.384 ± 0.671
5.307AspLys: 5.307 ± 0.588
5.654AspLeu: 5.654 ± 0.918
1.154AspMet: 1.154 ± 0.326
3.577AspAsn: 3.577 ± 0.715
1.269AspPro: 1.269 ± 0.487
0.692AspGln: 0.692 ± 0.276
1.846AspArg: 1.846 ± 0.555
3.0AspSer: 3.0 ± 0.564
4.615AspThr: 4.615 ± 0.607
3.346AspVal: 3.346 ± 0.718
0.923AspTrp: 0.923 ± 0.344
2.538AspTyr: 2.538 ± 0.508
0.0AspXaa: 0.0 ± 0.0
Glu
3.808GluAla: 3.808 ± 0.58
0.808GluCys: 0.808 ± 0.37
3.115GluAsp: 3.115 ± 0.596
5.769GluGlu: 5.769 ± 1.103
3.923GluPhe: 3.923 ± 0.665
2.077GluGly: 2.077 ± 0.421
0.808GluHis: 0.808 ± 0.343
6.577GluIle: 6.577 ± 1.015
6.923GluLys: 6.923 ± 1.332
10.615GluLeu: 10.615 ± 1.811
2.538GluMet: 2.538 ± 0.428
4.961GluAsn: 4.961 ± 0.831
1.5GluPro: 1.5 ± 0.404
4.731GluGln: 4.731 ± 0.968
3.115GluArg: 3.115 ± 0.706
4.038GluSer: 4.038 ± 0.583
4.615GluThr: 4.615 ± 0.719
3.808GluVal: 3.808 ± 0.678
1.038GluTrp: 1.038 ± 0.351
3.231GluTyr: 3.231 ± 0.8
0.0GluXaa: 0.0 ± 0.0
Phe
3.461PheAla: 3.461 ± 0.827
0.346PheCys: 0.346 ± 0.204
3.461PheAsp: 3.461 ± 0.722
2.654PheGlu: 2.654 ± 0.553
2.423PhePhe: 2.423 ± 0.837
2.654PheGly: 2.654 ± 0.675
0.692PheHis: 0.692 ± 0.253
2.885PheIle: 2.885 ± 0.488
4.731PheLys: 4.731 ± 0.755
2.077PheLeu: 2.077 ± 0.48
1.038PheMet: 1.038 ± 0.302
3.115PheAsn: 3.115 ± 0.697
0.692PhePro: 0.692 ± 0.281
1.154PheGln: 1.154 ± 0.367
1.154PheArg: 1.154 ± 0.329
3.923PheSer: 3.923 ± 0.957
2.769PheThr: 2.769 ± 0.529
2.769PheVal: 2.769 ± 0.481
0.346PheTrp: 0.346 ± 0.189
1.5PheTyr: 1.5 ± 0.389
0.0PheXaa: 0.0 ± 0.0
Gly
4.038GlyAla: 4.038 ± 1.585
0.462GlyCys: 0.462 ± 0.22
2.769GlyAsp: 2.769 ± 0.698
4.384GlyGlu: 4.384 ± 0.756
2.192GlyPhe: 2.192 ± 0.539
4.038GlyGly: 4.038 ± 0.885
0.808GlyHis: 0.808 ± 0.281
4.154GlyIle: 4.154 ± 1.527
6.461GlyLys: 6.461 ± 0.649
5.423GlyLeu: 5.423 ± 1.139
1.154GlyMet: 1.154 ± 0.4
3.692GlyAsn: 3.692 ± 0.602
0.231GlyPro: 0.231 ± 0.154
2.308GlyGln: 2.308 ± 0.56
2.192GlyArg: 2.192 ± 0.363
6.0GlySer: 6.0 ± 1.258
3.346GlyThr: 3.346 ± 0.78
5.538GlyVal: 5.538 ± 1.665
1.385GlyTrp: 1.385 ± 0.361
3.231GlyTyr: 3.231 ± 0.648
0.0GlyXaa: 0.0 ± 0.0
His
0.923HisAla: 0.923 ± 0.368
0.462HisCys: 0.462 ± 0.28
0.462HisAsp: 0.462 ± 0.212
0.692HisGlu: 0.692 ± 0.276
0.577HisPhe: 0.577 ± 0.281
1.038HisGly: 1.038 ± 0.477
0.115HisHis: 0.115 ± 0.122
1.269HisIle: 1.269 ± 0.362
0.923HisLys: 0.923 ± 0.273
0.692HisLeu: 0.692 ± 0.287
0.0HisMet: 0.0 ± 0.0
1.038HisAsn: 1.038 ± 0.364
0.115HisPro: 0.115 ± 0.107
0.346HisGln: 0.346 ± 0.178
0.346HisArg: 0.346 ± 0.202
0.231HisSer: 0.231 ± 0.173
0.923HisThr: 0.923 ± 0.41
0.808HisVal: 0.808 ± 0.335
0.231HisTrp: 0.231 ± 0.223
0.577HisTyr: 0.577 ± 0.253
0.0HisXaa: 0.0 ± 0.0
Ile
4.5IleAla: 4.5 ± 0.584
0.115IleCys: 0.115 ± 0.116
5.654IleAsp: 5.654 ± 0.717
6.346IleGlu: 6.346 ± 1.137
2.885IlePhe: 2.885 ± 0.607
3.346IleGly: 3.346 ± 0.914
0.808IleHis: 0.808 ± 0.305
4.269IleIle: 4.269 ± 0.483
5.654IleLys: 5.654 ± 0.723
4.5IleLeu: 4.5 ± 0.915
1.846IleMet: 1.846 ± 0.511
4.846IleAsn: 4.846 ± 0.658
1.269IlePro: 1.269 ± 0.343
1.846IleGln: 1.846 ± 0.406
1.961IleArg: 1.961 ± 0.51
3.692IleSer: 3.692 ± 0.888
6.461IleThr: 6.461 ± 0.758
5.654IleVal: 5.654 ± 0.906
1.038IleTrp: 1.038 ± 0.53
1.961IleTyr: 1.961 ± 0.451
0.0IleXaa: 0.0 ± 0.0
Lys
6.461LysAla: 6.461 ± 0.937
0.577LysCys: 0.577 ± 0.312
4.154LysAsp: 4.154 ± 0.705
9.23LysGlu: 9.23 ± 1.485
2.538LysPhe: 2.538 ± 0.609
6.577LysGly: 6.577 ± 1.132
1.038LysHis: 1.038 ± 0.397
5.077LysIle: 5.077 ± 0.832
8.654LysLys: 8.654 ± 1.121
7.384LysLeu: 7.384 ± 0.837
3.346LysMet: 3.346 ± 0.512
5.654LysAsn: 5.654 ± 0.728
1.615LysPro: 1.615 ± 0.455
3.692LysGln: 3.692 ± 0.688
3.0LysArg: 3.0 ± 0.648
4.615LysSer: 4.615 ± 0.759
6.461LysThr: 6.461 ± 0.886
6.346LysVal: 6.346 ± 0.795
0.808LysTrp: 0.808 ± 0.249
3.923LysTyr: 3.923 ± 0.675
0.0LysXaa: 0.0 ± 0.0
Leu
5.538LeuAla: 5.538 ± 0.661
0.231LeuCys: 0.231 ± 0.182
4.615LeuAsp: 4.615 ± 0.744
5.423LeuGlu: 5.423 ± 1.012
3.115LeuPhe: 3.115 ± 0.658
4.731LeuGly: 4.731 ± 0.835
1.269LeuHis: 1.269 ± 0.386
7.154LeuIle: 7.154 ± 1.243
8.654LeuLys: 8.654 ± 1.073
6.577LeuLeu: 6.577 ± 1.139
1.5LeuMet: 1.5 ± 0.413
4.846LeuAsn: 4.846 ± 0.97
2.538LeuPro: 2.538 ± 0.547
3.346LeuGln: 3.346 ± 0.486
2.885LeuArg: 2.885 ± 0.569
5.192LeuSer: 5.192 ± 0.761
6.231LeuThr: 6.231 ± 0.801
6.115LeuVal: 6.115 ± 0.74
1.385LeuTrp: 1.385 ± 0.36
4.731LeuTyr: 4.731 ± 0.85
0.0LeuXaa: 0.0 ± 0.0
Met
2.654MetAla: 2.654 ± 0.53
0.0MetCys: 0.0 ± 0.0
1.154MetAsp: 1.154 ± 0.283
1.961MetGlu: 1.961 ± 0.552
0.577MetPhe: 0.577 ± 0.323
0.923MetGly: 0.923 ± 0.3
0.231MetHis: 0.231 ± 0.177
2.308MetIle: 2.308 ± 0.561
2.769MetLys: 2.769 ± 0.57
1.154MetLeu: 1.154 ± 0.393
0.346MetMet: 0.346 ± 0.202
1.846MetAsn: 1.846 ± 0.522
0.346MetPro: 0.346 ± 0.206
2.077MetGln: 2.077 ± 0.441
0.346MetArg: 0.346 ± 0.196
1.615MetSer: 1.615 ± 0.319
1.731MetThr: 1.731 ± 0.4
1.385MetVal: 1.385 ± 0.34
0.115MetTrp: 0.115 ± 0.108
1.385MetTyr: 1.385 ± 0.416
0.0MetXaa: 0.0 ± 0.0
Asn
4.731AsnAla: 4.731 ± 1.083
0.231AsnCys: 0.231 ± 0.164
3.692AsnAsp: 3.692 ± 0.872
5.654AsnGlu: 5.654 ± 0.961
2.308AsnPhe: 2.308 ± 0.614
6.461AsnGly: 6.461 ± 0.938
0.692AsnHis: 0.692 ± 0.255
4.154AsnIle: 4.154 ± 0.638
5.307AsnLys: 5.307 ± 1.284
4.731AsnLeu: 4.731 ± 0.664
1.731AsnMet: 1.731 ± 0.398
3.346AsnAsn: 3.346 ± 0.671
2.192AsnPro: 2.192 ± 0.496
1.961AsnGln: 1.961 ± 0.449
1.5AsnArg: 1.5 ± 0.301
4.384AsnSer: 4.384 ± 0.6
3.808AsnThr: 3.808 ± 0.718
3.346AsnVal: 3.346 ± 0.536
1.154AsnTrp: 1.154 ± 0.344
2.423AsnTyr: 2.423 ± 0.628
0.0AsnXaa: 0.0 ± 0.0
Pro
1.731ProAla: 1.731 ± 0.414
0.115ProCys: 0.115 ± 0.115
1.731ProAsp: 1.731 ± 0.451
1.154ProGlu: 1.154 ± 0.439
1.038ProPhe: 1.038 ± 0.279
0.231ProGly: 0.231 ± 0.174
0.231ProHis: 0.231 ± 0.158
1.731ProIle: 1.731 ± 0.453
2.308ProLys: 2.308 ± 0.568
1.615ProLeu: 1.615 ± 0.396
0.577ProMet: 0.577 ± 0.248
1.961ProAsn: 1.961 ± 0.847
0.462ProPro: 0.462 ± 0.291
0.231ProGln: 0.231 ± 0.162
0.462ProArg: 0.462 ± 0.225
0.923ProSer: 0.923 ± 0.367
1.961ProThr: 1.961 ± 0.395
1.615ProVal: 1.615 ± 0.45
0.0ProTrp: 0.0 ± 0.0
0.577ProTyr: 0.577 ± 0.258
0.0ProXaa: 0.0 ± 0.0
Gln
3.577GlnAla: 3.577 ± 0.713
0.231GlnCys: 0.231 ± 0.2
1.846GlnAsp: 1.846 ± 0.457
2.654GlnGlu: 2.654 ± 0.722
1.269GlnPhe: 1.269 ± 0.383
2.192GlnGly: 2.192 ± 0.498
0.115GlnHis: 0.115 ± 0.127
1.038GlnIle: 1.038 ± 0.238
3.346GlnLys: 3.346 ± 0.712
4.269GlnLeu: 4.269 ± 0.746
0.923GlnMet: 0.923 ± 0.235
2.192GlnAsn: 2.192 ± 0.42
1.038GlnPro: 1.038 ± 0.301
1.154GlnGln: 1.154 ± 0.405
1.5GlnArg: 1.5 ± 0.503
2.308GlnSer: 2.308 ± 0.471
2.654GlnThr: 2.654 ± 0.483
2.192GlnVal: 2.192 ± 0.479
0.692GlnTrp: 0.692 ± 0.22
1.154GlnTyr: 1.154 ± 0.345
0.0GlnXaa: 0.0 ± 0.0
Arg
2.538ArgAla: 2.538 ± 0.722
0.462ArgCys: 0.462 ± 0.226
1.615ArgAsp: 1.615 ± 0.381
2.192ArgGlu: 2.192 ± 0.442
0.923ArgPhe: 0.923 ± 0.305
1.731ArgGly: 1.731 ± 0.403
0.462ArgHis: 0.462 ± 0.23
1.961ArgIle: 1.961 ± 0.491
4.269ArgLys: 4.269 ± 0.848
3.692ArgLeu: 3.692 ± 0.615
0.577ArgMet: 0.577 ± 0.285
2.192ArgAsn: 2.192 ± 0.617
0.923ArgPro: 0.923 ± 0.348
1.5ArgGln: 1.5 ± 0.38
2.077ArgArg: 2.077 ± 0.542
1.385ArgSer: 1.385 ± 0.38
1.615ArgThr: 1.615 ± 0.353
1.961ArgVal: 1.961 ± 0.531
0.346ArgTrp: 0.346 ± 0.216
1.731ArgTyr: 1.731 ± 0.467
0.0ArgXaa: 0.0 ± 0.0
Ser
4.846SerAla: 4.846 ± 1.72
0.692SerCys: 0.692 ± 0.317
3.461SerAsp: 3.461 ± 0.592
4.731SerGlu: 4.731 ± 0.786
3.115SerPhe: 3.115 ± 0.726
4.961SerGly: 4.961 ± 1.461
0.692SerHis: 0.692 ± 0.255
4.269SerIle: 4.269 ± 0.706
4.846SerLys: 4.846 ± 0.697
5.884SerLeu: 5.884 ± 0.781
2.077SerMet: 2.077 ± 0.375
3.231SerAsn: 3.231 ± 0.504
1.154SerPro: 1.154 ± 0.382
1.961SerGln: 1.961 ± 0.468
2.654SerArg: 2.654 ± 0.458
4.731SerSer: 4.731 ± 1.117
2.769SerThr: 2.769 ± 0.681
4.154SerVal: 4.154 ± 0.822
0.808SerTrp: 0.808 ± 0.332
2.423SerTyr: 2.423 ± 0.571
0.0SerXaa: 0.0 ± 0.0
Thr
4.846ThrAla: 4.846 ± 0.635
0.231ThrCys: 0.231 ± 0.183
3.346ThrAsp: 3.346 ± 0.837
6.0ThrGlu: 6.0 ± 0.771
2.769ThrPhe: 2.769 ± 0.635
4.384ThrGly: 4.384 ± 0.894
0.231ThrHis: 0.231 ± 0.157
3.692ThrIle: 3.692 ± 0.676
5.077ThrLys: 5.077 ± 0.69
5.769ThrLeu: 5.769 ± 0.783
0.808ThrMet: 0.808 ± 0.32
4.731ThrAsn: 4.731 ± 0.774
1.846ThrPro: 1.846 ± 0.283
2.769ThrGln: 2.769 ± 0.403
1.615ThrArg: 1.615 ± 0.476
4.615ThrSer: 4.615 ± 0.731
4.5ThrThr: 4.5 ± 0.706
5.077ThrVal: 5.077 ± 0.956
1.269ThrTrp: 1.269 ± 0.511
2.654ThrTyr: 2.654 ± 0.58
0.0ThrXaa: 0.0 ± 0.0
Val
3.577ValAla: 3.577 ± 0.63
0.577ValCys: 0.577 ± 0.245
4.384ValAsp: 4.384 ± 0.764
5.423ValGlu: 5.423 ± 0.818
3.577ValPhe: 3.577 ± 0.784
4.038ValGly: 4.038 ± 0.703
0.346ValHis: 0.346 ± 0.17
4.5ValIle: 4.5 ± 0.549
5.769ValLys: 5.769 ± 0.741
3.577ValLeu: 3.577 ± 0.523
1.961ValMet: 1.961 ± 0.431
2.769ValAsn: 2.769 ± 0.496
1.5ValPro: 1.5 ± 0.485
2.308ValGln: 2.308 ± 0.574
3.231ValArg: 3.231 ± 0.78
5.307ValSer: 5.307 ± 1.346
5.538ValThr: 5.538 ± 0.954
3.346ValVal: 3.346 ± 0.855
0.462ValTrp: 0.462 ± 0.217
3.115ValTyr: 3.115 ± 0.503
0.0ValXaa: 0.0 ± 0.0
Trp
0.808TrpAla: 0.808 ± 0.26
0.115TrpCys: 0.115 ± 0.114
0.692TrpAsp: 0.692 ± 0.458
0.462TrpGlu: 0.462 ± 0.218
0.923TrpPhe: 0.923 ± 0.442
1.154TrpGly: 1.154 ± 0.435
0.231TrpHis: 0.231 ± 0.161
0.692TrpIle: 0.692 ± 0.327
1.269TrpLys: 1.269 ± 0.345
1.038TrpLeu: 1.038 ± 0.435
0.231TrpMet: 0.231 ± 0.168
1.5TrpAsn: 1.5 ± 0.659
0.0TrpPro: 0.0 ± 0.0
0.692TrpGln: 0.692 ± 0.2
0.462TrpArg: 0.462 ± 0.261
1.5TrpSer: 1.5 ± 0.304
0.577TrpThr: 0.577 ± 0.233
0.692TrpVal: 0.692 ± 0.319
0.231TrpTrp: 0.231 ± 0.157
1.154TrpTyr: 1.154 ± 0.354
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.5TyrAla: 1.5 ± 0.487
0.692TyrCys: 0.692 ± 0.365
2.423TyrAsp: 2.423 ± 0.821
4.269TyrGlu: 4.269 ± 0.9
2.654TyrPhe: 2.654 ± 0.541
3.0TyrGly: 3.0 ± 0.64
1.038TyrHis: 1.038 ± 0.348
3.346TyrIle: 3.346 ± 0.789
2.769TyrLys: 2.769 ± 0.571
3.346TyrLeu: 3.346 ± 0.777
0.692TyrMet: 0.692 ± 0.322
3.461TyrAsn: 3.461 ± 0.534
0.923TyrPro: 0.923 ± 0.351
1.154TyrGln: 1.154 ± 0.52
1.5TyrArg: 1.5 ± 0.458
2.308TyrSer: 2.308 ± 0.519
2.769TyrThr: 2.769 ± 0.555
2.192TyrVal: 2.192 ± 0.571
0.115TyrTrp: 0.115 ± 0.115
2.192TyrTyr: 2.192 ± 0.615
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 50 proteins (8668 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski