Amino acid dipepetide frequency for Flavobacteriaceae bacterium YIM 102668

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.84AlaAla: 3.84 ± 0.085	0.521AlaCys: 0.521 ± 0.03	3.292AlaAsp: 3.292 ± 0.069	4.078AlaGlu: 4.078 ± 0.072	3.152AlaPhe: 3.152 ± 0.058	3.753AlaGly: 3.753 ± 0.074	0.925AlaHis: 0.925 ± 0.035	5.115AlaIle: 5.115 ± 0.087	5.004AlaLys: 5.004 ± 0.089	5.522AlaLeu: 5.522 ± 0.09	1.432AlaMet: 1.432 ± 0.047	3.647AlaAsn: 3.647 ± 0.063	1.651AlaPro: 1.651 ± 0.043	2.531AlaGln: 2.531 ± 0.061	1.895AlaArg: 1.895 ± 0.053	3.487AlaSer: 3.487 ± 0.066	3.321AlaThr: 3.321 ± 0.073	3.685AlaVal: 3.685 ± 0.084	0.555AlaTrp: 0.555 ± 0.027	2.353AlaTyr: 2.353 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.388CysAla: 0.388 ± 0.021	0.096CysCys: 0.096 ± 0.01	0.387CysAsp: 0.387 ± 0.023	0.425CysGlu: 0.425 ± 0.021	0.395CysPhe: 0.395 ± 0.023	0.555CysGly: 0.555 ± 0.028	0.135CysHis: 0.135 ± 0.018	0.578CysIle: 0.578 ± 0.026	0.432CysLys: 0.432 ± 0.024	0.573CysLeu: 0.573 ± 0.028	0.129CysMet: 0.129 ± 0.011	0.39CysAsn: 0.39 ± 0.023	0.269CysPro: 0.269 ± 0.024	0.195CysGln: 0.195 ± 0.016	0.173CysArg: 0.173 ± 0.016	0.437CysSer: 0.437 ± 0.023	0.387CysThr: 0.387 ± 0.023	0.409CysVal: 0.409 ± 0.022	0.051CysTrp: 0.051 ± 0.008	0.269CysTyr: 0.269 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.391AspAla: 3.391 ± 0.082	0.376AspCys: 0.376 ± 0.021	2.772AspAsp: 2.772 ± 0.062	4.324AspGlu: 4.324 ± 0.082	3.852AspPhe: 3.852 ± 0.072	3.387AspGly: 3.387 ± 0.068	0.882AspHis: 0.882 ± 0.029	4.403AspIle: 4.403 ± 0.084	4.372AspLys: 4.372 ± 0.068	5.699AspLeu: 5.699 ± 0.095	1.085AspMet: 1.085 ± 0.035	3.197AspAsn: 3.197 ± 0.067	1.597AspPro: 1.597 ± 0.05	2.039AspGln: 2.039 ± 0.051	1.91AspArg: 1.91 ± 0.04	3.026AspSer: 3.026 ± 0.068	2.388AspThr: 2.388 ± 0.059	3.513AspVal: 3.513 ± 0.069	0.679AspTrp: 0.679 ± 0.029	3.065AspTyr: 3.065 ± 0.065	0.0AspXaa: 0.0 ± 0.0
Glu	4.147GluAla: 4.147 ± 0.085	0.353GluCys: 0.353 ± 0.021	3.739GluAsp: 3.739 ± 0.067	5.39GluGlu: 5.39 ± 0.117	3.453GluPhe: 3.453 ± 0.069	3.6GluGly: 3.6 ± 0.072	1.06GluHis: 1.06 ± 0.034	6.59GluIle: 6.59 ± 0.097	6.097GluLys: 6.097 ± 0.09	6.446GluLeu: 6.446 ± 0.113	1.646GluMet: 1.646 ± 0.044	5.263GluAsn: 5.263 ± 0.082	1.503GluPro: 1.503 ± 0.048	2.51GluGln: 2.51 ± 0.057	2.338GluArg: 2.338 ± 0.054	3.321GluSer: 3.321 ± 0.067	3.55GluThr: 3.55 ± 0.069	4.747GluVal: 4.747 ± 0.074	0.673GluTrp: 0.673 ± 0.03	2.787GluTyr: 2.787 ± 0.062	0.0GluXaa: 0.0 ± 0.0
Phe	3.073PheAla: 3.073 ± 0.058	0.405PheCys: 0.405 ± 0.021	3.557PheAsp: 3.557 ± 0.076	3.632PheGlu: 3.632 ± 0.076	2.777PhePhe: 2.777 ± 0.075	3.694PheGly: 3.694 ± 0.069	0.835PheHis: 0.835 ± 0.028	4.579PheIle: 4.579 ± 0.079	4.039PheLys: 4.039 ± 0.065	4.658PheLeu: 4.658 ± 0.086	1.118PheMet: 1.118 ± 0.034	3.622PheAsn: 3.622 ± 0.065	1.766PhePro: 1.766 ± 0.05	1.67PheGln: 1.67 ± 0.044	1.616PheArg: 1.616 ± 0.044	3.854PheSer: 3.854 ± 0.073	3.143PheThr: 3.143 ± 0.061	3.253PheVal: 3.253 ± 0.071	0.563PheTrp: 0.563 ± 0.029	2.411PheTyr: 2.411 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	3.723GlyAla: 3.723 ± 0.079	0.472GlyCys: 0.472 ± 0.027	3.122GlyAsp: 3.122 ± 0.071	3.524GlyGlu: 3.524 ± 0.066	3.501GlyPhe: 3.501 ± 0.067	4.138GlyGly: 4.138 ± 0.111	0.998GlyHis: 0.998 ± 0.039	5.375GlyIle: 5.375 ± 0.103	4.94GlyLys: 4.94 ± 0.084	5.515GlyLeu: 5.515 ± 0.094	1.483GlyMet: 1.483 ± 0.047	3.73GlyAsn: 3.73 ± 0.083	1.191GlyPro: 1.191 ± 0.038	2.028GlyGln: 2.028 ± 0.055	1.964GlyArg: 1.964 ± 0.05	3.636GlySer: 3.636 ± 0.085	3.59GlyThr: 3.59 ± 0.077	4.26GlyVal: 4.26 ± 0.077	0.658GlyTrp: 0.658 ± 0.03	2.849GlyTyr: 2.849 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	0.884HisAla: 0.884 ± 0.034	0.166HisCys: 0.166 ± 0.014	0.813HisAsp: 0.813 ± 0.034	0.923HisGlu: 0.923 ± 0.031	1.082HisPhe: 1.082 ± 0.038	0.932HisGly: 0.932 ± 0.031	0.448HisHis: 0.448 ± 0.026	1.338HisIle: 1.338 ± 0.044	1.067HisLys: 1.067 ± 0.036	1.677HisLeu: 1.677 ± 0.056	0.313HisMet: 0.313 ± 0.02	0.919HisAsn: 0.919 ± 0.033	0.795HisPro: 0.795 ± 0.033	0.825HisGln: 0.825 ± 0.034	0.615HisArg: 0.615 ± 0.025	0.959HisSer: 0.959 ± 0.029	0.872HisThr: 0.872 ± 0.035	0.816HisVal: 0.816 ± 0.032	0.189HisTrp: 0.189 ± 0.016	0.79HisTyr: 0.79 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.484IleAla: 5.484 ± 0.102	0.617IleCys: 0.617 ± 0.03	5.311IleAsp: 5.311 ± 0.09	6.351IleGlu: 6.351 ± 0.106	4.148IlePhe: 4.148 ± 0.089	5.315IleGly: 5.315 ± 0.103	1.416IleHis: 1.416 ± 0.046	7.036IleIle: 7.036 ± 0.122	6.448IleLys: 6.448 ± 0.085	7.941IleLeu: 7.941 ± 0.119	1.376IleMet: 1.376 ± 0.043	5.926IleAsn: 5.926 ± 0.102	3.261IlePro: 3.261 ± 0.058	3.089IleGln: 3.089 ± 0.068	2.553IleArg: 2.553 ± 0.051	5.668IleSer: 5.668 ± 0.086	4.631IleThr: 4.631 ± 0.068	5.038IleVal: 5.038 ± 0.087	0.682IleTrp: 0.682 ± 0.032	3.372IleTyr: 3.372 ± 0.069	0.0IleXaa: 0.0 ± 0.0
Lys	4.709LysAla: 4.709 ± 0.086	0.335LysCys: 0.335 ± 0.019	4.817LysAsp: 4.817 ± 0.085	6.357LysGlu: 6.357 ± 0.098	3.594LysPhe: 3.594 ± 0.058	4.518LysGly: 4.518 ± 0.077	1.289LysHis: 1.289 ± 0.037	7.105LysIle: 7.105 ± 0.114	6.741LysLys: 6.741 ± 0.1	6.636LysLeu: 6.636 ± 0.087	2.19LysMet: 2.19 ± 0.046	5.73LysAsn: 5.73 ± 0.094	2.299LysPro: 2.299 ± 0.053	2.907LysGln: 2.907 ± 0.06	2.481LysArg: 2.481 ± 0.055	4.798LysSer: 4.798 ± 0.078	4.424LysThr: 4.424 ± 0.068	5.109LysVal: 5.109 ± 0.087	0.692LysTrp: 0.692 ± 0.032	3.527LysTyr: 3.527 ± 0.066	0.0LysXaa: 0.0 ± 0.0
Leu	5.73LeuAla: 5.73 ± 0.093	0.577LeuCys: 0.577 ± 0.027	5.176LeuAsp: 5.176 ± 0.079	5.964LeuGlu: 5.964 ± 0.104	4.787LeuPhe: 4.787 ± 0.092	5.729LeuGly: 5.729 ± 0.092	1.369LeuHis: 1.369 ± 0.042	7.574LeuIle: 7.574 ± 0.119	7.628LeuLys: 7.628 ± 0.106	7.571LeuLeu: 7.571 ± 0.114	2.181LeuMet: 2.181 ± 0.055	6.487LeuAsn: 6.487 ± 0.102	3.203LeuPro: 3.203 ± 0.061	3.022LeuGln: 3.022 ± 0.058	2.883LeuArg: 2.883 ± 0.058	5.941LeuSer: 5.941 ± 0.085	5.032LeuThr: 5.032 ± 0.074	5.325LeuVal: 5.325 ± 0.091	0.693LeuTrp: 0.693 ± 0.028	3.081LeuTyr: 3.081 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.426MetAla: 1.426 ± 0.039	0.132MetCys: 0.132 ± 0.011	1.173MetAsp: 1.173 ± 0.034	1.339MetGlu: 1.339 ± 0.043	0.927MetPhe: 0.927 ± 0.035	1.279MetGly: 1.279 ± 0.041	0.346MetHis: 0.346 ± 0.02	1.852MetIle: 1.852 ± 0.052	2.285MetLys: 2.285 ± 0.056	1.815MetLeu: 1.815 ± 0.046	0.639MetMet: 0.639 ± 0.033	1.63MetAsn: 1.63 ± 0.042	0.743MetPro: 0.743 ± 0.03	0.767MetGln: 0.767 ± 0.031	0.816MetArg: 0.816 ± 0.029	1.348MetSer: 1.348 ± 0.04	1.111MetThr: 1.111 ± 0.033	1.292MetVal: 1.292 ± 0.04	0.15MetTrp: 0.15 ± 0.014	0.76MetTyr: 0.76 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.709AsnAla: 3.709 ± 0.067	0.418AsnCys: 0.418 ± 0.022	3.543AsnAsp: 3.543 ± 0.063	4.568AsnGlu: 4.568 ± 0.072	3.674AsnPhe: 3.674 ± 0.061	4.188AsnGly: 4.188 ± 0.077	1.291AsnHis: 1.291 ± 0.042	5.221AsnIle: 5.221 ± 0.093	5.002AsnLys: 5.002 ± 0.082	6.043AsnLeu: 6.043 ± 0.096	1.221AsnMet: 1.221 ± 0.037	4.689AsnAsn: 4.689 ± 0.106	2.93AsnPro: 2.93 ± 0.062	3.203AsnGln: 3.203 ± 0.076	2.292AsnArg: 2.292 ± 0.065	4.235AsnSer: 4.235 ± 0.081	3.571AsnThr: 3.571 ± 0.07	3.968AsnVal: 3.968 ± 0.07	0.825AsnTrp: 0.825 ± 0.036	3.487AsnTyr: 3.487 ± 0.076	0.0AsnXaa: 0.0 ± 0.0
Pro	1.772ProAla: 1.772 ± 0.045	0.196ProCys: 0.196 ± 0.015	1.7ProAsp: 1.7 ± 0.048	2.5ProGlu: 2.5 ± 0.06	1.851ProPhe: 1.851 ± 0.049	1.707ProGly: 1.707 ± 0.048	0.528ProHis: 0.528 ± 0.025	2.959ProIle: 2.959 ± 0.059	2.493ProLys: 2.493 ± 0.05	2.547ProLeu: 2.547 ± 0.05	0.741ProMet: 0.741 ± 0.03	2.325ProAsn: 2.325 ± 0.059	0.591ProPro: 0.591 ± 0.025	1.148ProGln: 1.148 ± 0.037	0.832ProArg: 0.832 ± 0.029	1.88ProSer: 1.88 ± 0.044	2.161ProThr: 2.161 ± 0.059	2.054ProVal: 2.054 ± 0.05	0.28ProTrp: 0.28 ± 0.02	1.367ProTyr: 1.367 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.118GlnAla: 2.118 ± 0.051	0.15GlnCys: 0.15 ± 0.015	1.803GlnAsp: 1.803 ± 0.049	2.537GlnGlu: 2.537 ± 0.055	2.028GlnPhe: 2.028 ± 0.049	1.831GlnGly: 1.831 ± 0.048	0.591GlnHis: 0.591 ± 0.026	3.29GlnIle: 3.29 ± 0.059	3.005GlnLys: 3.005 ± 0.064	3.633GlnLeu: 3.633 ± 0.066	0.912GlnMet: 0.912 ± 0.034	2.728GlnAsn: 2.728 ± 0.061	1.079GlnPro: 1.079 ± 0.034	1.541GlnGln: 1.541 ± 0.046	1.22GlnArg: 1.22 ± 0.038	2.082GlnSer: 2.082 ± 0.045	2.02GlnThr: 2.02 ± 0.06	2.086GlnVal: 2.086 ± 0.052	0.355GlnTrp: 0.355 ± 0.019	1.619GlnTyr: 1.619 ± 0.047	0.0GlnXaa: 0.0 ± 0.0
Arg	1.832ArgAla: 1.832 ± 0.052	0.166ArgCys: 0.166 ± 0.015	1.635ArgAsp: 1.635 ± 0.049	2.265ArgGlu: 2.265 ± 0.052	1.885ArgPhe: 1.885 ± 0.06	1.797ArgGly: 1.797 ± 0.056	0.478ArgHis: 0.478 ± 0.024	2.925ArgIle: 2.925 ± 0.063	2.671ArgLys: 2.671 ± 0.063	3.002ArgLeu: 3.002 ± 0.061	0.848ArgMet: 0.848 ± 0.031	2.177ArgAsn: 2.177 ± 0.052	1.061ArgPro: 1.061 ± 0.036	1.069ArgGln: 1.069 ± 0.041	1.205ArgArg: 1.205 ± 0.044	1.616ArgSer: 1.616 ± 0.045	1.781ArgThr: 1.781 ± 0.048	1.972ArgVal: 1.972 ± 0.046	0.304ArgTrp: 0.304 ± 0.02	1.369ArgTyr: 1.369 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	3.425SerAla: 3.425 ± 0.066	0.548SerCys: 0.548 ± 0.025	3.274SerAsp: 3.274 ± 0.059	3.749SerGlu: 3.749 ± 0.071	3.804SerPhe: 3.804 ± 0.074	3.798SerGly: 3.798 ± 0.075	0.98SerHis: 0.98 ± 0.033	5.615SerIle: 5.615 ± 0.086	4.866SerLys: 4.866 ± 0.076	5.477SerLeu: 5.477 ± 0.08	1.183SerMet: 1.183 ± 0.037	4.145SerAsn: 4.145 ± 0.077	1.906SerPro: 1.906 ± 0.043	2.041SerGln: 2.041 ± 0.051	1.845SerArg: 1.845 ± 0.049	4.007SerSer: 4.007 ± 0.082	3.697SerThr: 3.697 ± 0.074	3.69SerVal: 3.69 ± 0.073	0.618SerTrp: 0.618 ± 0.025	2.756SerTyr: 2.756 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	3.278ThrAla: 3.278 ± 0.066	0.31ThrCys: 0.31 ± 0.021	3.043ThrAsp: 3.043 ± 0.06	3.705ThrGlu: 3.705 ± 0.07	3.007ThrPhe: 3.007 ± 0.054	3.41ThrGly: 3.41 ± 0.073	0.953ThrHis: 0.953 ± 0.036	4.981ThrIle: 4.981 ± 0.097	4.216ThrLys: 4.216 ± 0.073	5.003ThrLeu: 5.003 ± 0.077	0.967ThrMet: 0.967 ± 0.034	3.584ThrAsn: 3.584 ± 0.069	2.103ThrPro: 2.103 ± 0.052	1.828ThrGln: 1.828 ± 0.045	1.611ThrArg: 1.611 ± 0.048	3.68ThrSer: 3.68 ± 0.083	3.346ThrThr: 3.346 ± 0.068	3.231ThrVal: 3.231 ± 0.07	0.546ThrTrp: 0.546 ± 0.027	2.451ThrTyr: 2.451 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	3.913ValAla: 3.913 ± 0.081	0.444ValCys: 0.444 ± 0.023	3.756ValAsp: 3.756 ± 0.067	4.357ValGlu: 4.357 ± 0.08	3.137ValPhe: 3.137 ± 0.068	3.943ValGly: 3.943 ± 0.08	0.939ValHis: 0.939 ± 0.035	5.0ValIle: 5.0 ± 0.088	4.766ValLys: 4.766 ± 0.07	5.491ValLeu: 5.491 ± 0.088	1.321ValMet: 1.321 ± 0.038	4.041ValAsn: 4.041 ± 0.067	1.911ValPro: 1.911 ± 0.052	1.895ValGln: 1.895 ± 0.049	2.02ValArg: 2.02 ± 0.053	4.062ValSer: 4.062 ± 0.075	3.276ValThr: 3.276 ± 0.072	4.153ValVal: 4.153 ± 0.083	0.532ValTrp: 0.532 ± 0.024	2.447ValTyr: 2.447 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.575TrpAla: 0.575 ± 0.024	0.083TrpCys: 0.083 ± 0.011	0.512TrpAsp: 0.512 ± 0.027	0.633TrpGlu: 0.633 ± 0.03	0.549TrpPhe: 0.549 ± 0.025	0.587TrpGly: 0.587 ± 0.026	0.175TrpHis: 0.175 ± 0.015	0.883TrpIle: 0.883 ± 0.032	0.837TrpLys: 0.837 ± 0.031	0.815TrpLeu: 0.815 ± 0.032	0.295TrpMet: 0.295 ± 0.019	0.721TrpAsn: 0.721 ± 0.033	0.208TrpPro: 0.208 ± 0.016	0.363TrpGln: 0.363 ± 0.022	0.307TrpArg: 0.307 ± 0.02	0.55TrpSer: 0.55 ± 0.026	0.483TrpThr: 0.483 ± 0.027	0.54TrpVal: 0.54 ± 0.029	0.122TrpTrp: 0.122 ± 0.013	0.392TrpTyr: 0.392 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.345TyrAla: 2.345 ± 0.054	0.31TyrCys: 0.31 ± 0.019	2.531TyrAsp: 2.531 ± 0.057	2.593TyrGlu: 2.593 ± 0.053	2.659TyrPhe: 2.659 ± 0.056	2.538TyrGly: 2.538 ± 0.064	0.783TyrHis: 0.783 ± 0.03	3.245TyrIle: 3.245 ± 0.071	3.346TyrLys: 3.346 ± 0.075	3.888TyrLeu: 3.888 ± 0.07	0.752TyrMet: 0.752 ± 0.031	3.127TyrAsn: 3.127 ± 0.074	1.566TyrPro: 1.566 ± 0.045	1.958TyrGln: 1.958 ± 0.053	1.485TyrArg: 1.485 ± 0.051	2.835TyrSer: 2.835 ± 0.063	2.465TyrThr: 2.465 ± 0.067	2.264TyrVal: 2.264 ± 0.052	0.463TyrTrp: 0.463 ± 0.024	2.044TyrTyr: 2.044 ± 0.06	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2667 proteins (857452 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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