Amino acid dipepetide frequency for Collinsella sp. An307

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.475AlaAla: 16.475 ± 0.261
2.047AlaCys: 2.047 ± 0.064
7.488AlaAsp: 7.488 ± 0.12
8.783AlaGlu: 8.783 ± 0.136
4.321AlaPhe: 4.321 ± 0.101
10.344AlaGly: 10.344 ± 0.161
2.648AlaHis: 2.648 ± 0.061
5.845AlaIle: 5.845 ± 0.112
3.676AlaLys: 3.676 ± 0.082
12.619AlaLeu: 12.619 ± 0.197
2.934AlaMet: 2.934 ± 0.074
2.792AlaAsn: 2.792 ± 0.064
5.215AlaPro: 5.215 ± 0.128
3.711AlaGln: 3.711 ± 0.093
8.512AlaArg: 8.512 ± 0.141
6.697AlaSer: 6.697 ± 0.12
6.306AlaThr: 6.306 ± 0.121
8.871AlaVal: 8.871 ± 0.131
1.351AlaTrp: 1.351 ± 0.05
3.149AlaTyr: 3.149 ± 0.072
0.0AlaXaa: 0.0 ± 0.0
Cys
1.969CysAla: 1.969 ± 0.062
0.256CysCys: 0.256 ± 0.02
0.983CysAsp: 0.983 ± 0.04
0.949CysGlu: 0.949 ± 0.045
0.459CysPhe: 0.459 ± 0.024
1.588CysGly: 1.588 ± 0.057
0.332CysHis: 0.332 ± 0.027
0.657CysIle: 0.657 ± 0.032
0.34CysLys: 0.34 ± 0.023
1.07CysLeu: 1.07 ± 0.044
0.396CysMet: 0.396 ± 0.025
0.298CysAsn: 0.298 ± 0.021
0.78CysPro: 0.78 ± 0.04
0.315CysGln: 0.315 ± 0.025
0.925CysArg: 0.925 ± 0.038
0.746CysSer: 0.746 ± 0.034
0.839CysThr: 0.839 ± 0.038
1.094CysVal: 1.094 ± 0.046
0.137CysTrp: 0.137 ± 0.018
0.374CysTyr: 0.374 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
8.769AspAla: 8.769 ± 0.145
0.746AspCys: 0.746 ± 0.035
3.97AspAsp: 3.97 ± 0.105
5.563AspGlu: 5.563 ± 0.099
2.344AspPhe: 2.344 ± 0.056
5.323AspGly: 5.323 ± 0.119
1.116AspHis: 1.116 ± 0.035
3.403AspIle: 3.403 ± 0.081
1.598AspLys: 1.598 ± 0.059
5.558AspLeu: 5.558 ± 0.099
1.509AspMet: 1.509 ± 0.048
1.386AspAsn: 1.386 ± 0.045
3.191AspPro: 3.191 ± 0.081
1.333AspGln: 1.333 ± 0.053
3.683AspArg: 3.683 ± 0.079
2.512AspSer: 2.512 ± 0.069
3.179AspThr: 3.179 ± 0.068
4.945AspVal: 4.945 ± 0.087
0.729AspTrp: 0.729 ± 0.033
1.957AspTyr: 1.957 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
7.994GluAla: 7.994 ± 0.146
0.671GluCys: 0.671 ± 0.031
4.116GluAsp: 4.116 ± 0.111
4.742GluGlu: 4.742 ± 0.098
1.975GluPhe: 1.975 ± 0.053
5.642GluGly: 5.642 ± 0.107
1.696GluHis: 1.696 ± 0.064
3.136GluIle: 3.136 ± 0.079
2.309GluLys: 2.309 ± 0.072
7.454GluLeu: 7.454 ± 0.118
1.835GluMet: 1.835 ± 0.056
2.18GluAsn: 2.18 ± 0.06
2.926GluPro: 2.926 ± 0.074
2.289GluGln: 2.289 ± 0.061
6.276GluArg: 6.276 ± 0.131
2.893GluSer: 2.893 ± 0.076
3.216GluThr: 3.216 ± 0.08
5.413GluVal: 5.413 ± 0.097
0.574GluTrp: 0.574 ± 0.033
1.426GluTyr: 1.426 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
4.21PheAla: 4.21 ± 0.097
0.687PheCys: 0.687 ± 0.039
2.857PheAsp: 2.857 ± 0.071
2.392PheGlu: 2.392 ± 0.064
1.461PhePhe: 1.461 ± 0.05
3.233PheGly: 3.233 ± 0.083
0.63PheHis: 0.63 ± 0.027
1.819PheIle: 1.819 ± 0.065
0.98PheLys: 0.98 ± 0.033
2.849PheLeu: 2.849 ± 0.085
0.93PheMet: 0.93 ± 0.038
1.002PheAsn: 1.002 ± 0.044
1.331PhePro: 1.331 ± 0.046
0.841PheGln: 0.841 ± 0.03
1.801PheArg: 1.801 ± 0.051
2.316PheSer: 2.316 ± 0.068
2.281PheThr: 2.281 ± 0.061
2.724PheVal: 2.724 ± 0.063
0.426PheTrp: 0.426 ± 0.021
1.114PheTyr: 1.114 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
9.456GlyAla: 9.456 ± 0.174
1.39GlyCys: 1.39 ± 0.052
4.722GlyAsp: 4.722 ± 0.096
5.522GlyGlu: 5.522 ± 0.1
3.171GlyPhe: 3.171 ± 0.081
6.462GlyGly: 6.462 ± 0.127
1.59GlyHis: 1.59 ± 0.055
5.117GlyIle: 5.117 ± 0.106
3.129GlyLys: 3.129 ± 0.076
6.824GlyLeu: 6.824 ± 0.112
2.384GlyMet: 2.384 ± 0.067
2.125GlyAsn: 2.125 ± 0.07
2.292GlyPro: 2.292 ± 0.058
1.99GlyGln: 1.99 ± 0.051
4.96GlyArg: 4.96 ± 0.084
4.75GlySer: 4.75 ± 0.104
5.146GlyThr: 5.146 ± 0.101
6.7GlyVal: 6.7 ± 0.113
1.075GlyTrp: 1.075 ± 0.051
2.611GlyTyr: 2.611 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
2.391HisAla: 2.391 ± 0.062
0.234HisCys: 0.234 ± 0.019
1.295HisAsp: 1.295 ± 0.047
1.456HisGlu: 1.456 ± 0.053
0.665HisPhe: 0.665 ± 0.036
1.777HisGly: 1.777 ± 0.056
0.49HisHis: 0.49 ± 0.031
1.147HisIle: 1.147 ± 0.043
0.448HisLys: 0.448 ± 0.028
1.816HisLeu: 1.816 ± 0.054
0.46HisMet: 0.46 ± 0.028
0.51HisAsn: 0.51 ± 0.027
1.18HisPro: 1.18 ± 0.039
0.443HisGln: 0.443 ± 0.028
1.205HisArg: 1.205 ± 0.043
0.847HisSer: 0.847 ± 0.037
1.063HisThr: 1.063 ± 0.038
1.696HisVal: 1.696 ± 0.056
0.181HisTrp: 0.181 ± 0.018
0.566HisTyr: 0.566 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
7.02IleAla: 7.02 ± 0.128
0.858IleCys: 0.858 ± 0.04
4.177IleAsp: 4.177 ± 0.091
3.909IleGlu: 3.909 ± 0.071
1.646IlePhe: 1.646 ± 0.065
3.945IleGly: 3.945 ± 0.087
0.863IleHis: 0.863 ± 0.038
2.586IleIle: 2.586 ± 0.083
1.587IleLys: 1.587 ± 0.056
3.892IleLeu: 3.892 ± 0.089
1.306IleMet: 1.306 ± 0.048
1.425IleAsn: 1.425 ± 0.055
2.498IlePro: 2.498 ± 0.069
1.153IleGln: 1.153 ± 0.04
2.71IleArg: 2.71 ± 0.068
3.066IleSer: 3.066 ± 0.07
2.944IleThr: 2.944 ± 0.075
4.503IleVal: 4.503 ± 0.095
0.462IleTrp: 0.462 ± 0.025
1.223IleTyr: 1.223 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
3.107LysAla: 3.107 ± 0.084
0.331LysCys: 0.331 ± 0.027
1.578LysAsp: 1.578 ± 0.059
1.72LysGlu: 1.72 ± 0.053
0.81LysPhe: 0.81 ± 0.036
2.297LysGly: 2.297 ± 0.068
0.668LysHis: 0.668 ± 0.031
1.816LysIle: 1.816 ± 0.062
1.662LysLys: 1.662 ± 0.068
2.998LysLeu: 2.998 ± 0.075
0.868LysMet: 0.868 ± 0.04
1.099LysAsn: 1.099 ± 0.043
1.506LysPro: 1.506 ± 0.053
0.985LysGln: 0.985 ± 0.041
2.578LysArg: 2.578 ± 0.073
1.67LysSer: 1.67 ± 0.057
2.091LysThr: 2.091 ± 0.061
2.359LysVal: 2.359 ± 0.072
0.225LysTrp: 0.225 ± 0.02
0.838LysTyr: 0.838 ± 0.039
0.0LysXaa: 0.0 ± 0.0
Leu
12.783LeuAla: 12.783 ± 0.186
1.292LeuCys: 1.292 ± 0.048
6.189LeuAsp: 6.189 ± 0.112
5.897LeuGlu: 5.897 ± 0.11
3.353LeuPhe: 3.353 ± 0.086
7.671LeuGly: 7.671 ± 0.126
1.501LeuHis: 1.501 ± 0.049
4.616LeuIle: 4.616 ± 0.087
2.852LeuLys: 2.852 ± 0.072
7.836LeuLeu: 7.836 ± 0.161
2.495LeuMet: 2.495 ± 0.07
2.325LeuAsn: 2.325 ± 0.065
4.458LeuPro: 4.458 ± 0.096
1.813LeuGln: 1.813 ± 0.059
5.402LeuArg: 5.402 ± 0.101
5.923LeuSer: 5.923 ± 0.113
5.532LeuThr: 5.532 ± 0.098
7.491LeuVal: 7.491 ± 0.132
0.861LeuTrp: 0.861 ± 0.041
2.292LeuTyr: 2.292 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
3.124MetAla: 3.124 ± 0.074
0.345MetCys: 0.345 ± 0.023
1.411MetAsp: 1.411 ± 0.052
1.372MetGlu: 1.372 ± 0.05
0.758MetPhe: 0.758 ± 0.038
2.239MetGly: 2.239 ± 0.061
0.506MetHis: 0.506 ± 0.028
1.192MetIle: 1.192 ± 0.045
0.897MetLys: 0.897 ± 0.043
2.525MetLeu: 2.525 ± 0.068
0.598MetMet: 0.598 ± 0.035
0.882MetAsn: 0.882 ± 0.038
1.428MetPro: 1.428 ± 0.042
0.751MetGln: 0.751 ± 0.034
1.902MetArg: 1.902 ± 0.053
1.498MetSer: 1.498 ± 0.043
1.44MetThr: 1.44 ± 0.04
1.837MetVal: 1.837 ± 0.059
0.189MetTrp: 0.189 ± 0.017
0.476MetTyr: 0.476 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.015AsnAla: 3.015 ± 0.07
0.303AsnCys: 0.303 ± 0.023
1.651AsnAsp: 1.651 ± 0.052
1.735AsnGlu: 1.735 ± 0.054
0.886AsnPhe: 0.886 ± 0.033
2.217AsnGly: 2.217 ± 0.072
0.507AsnHis: 0.507 ± 0.026
1.606AsnIle: 1.606 ± 0.048
0.811AsnLys: 0.811 ± 0.038
2.684AsnLeu: 2.684 ± 0.068
0.708AsnMet: 0.708 ± 0.035
0.744AsnAsn: 0.744 ± 0.042
1.721AsnPro: 1.721 ± 0.06
0.754AsnGln: 0.754 ± 0.033
1.57AsnArg: 1.57 ± 0.055
1.195AsnSer: 1.195 ± 0.048
1.411AsnThr: 1.411 ± 0.051
2.131AsnVal: 2.131 ± 0.064
0.272AsnTrp: 0.272 ± 0.02
0.738AsnTyr: 0.738 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
5.944ProAla: 5.944 ± 0.133
0.552ProCys: 0.552 ± 0.03
2.823ProAsp: 2.823 ± 0.07
4.074ProGlu: 4.074 ± 0.09
1.712ProPhe: 1.712 ± 0.055
3.459ProGly: 3.459 ± 0.08
0.955ProHis: 0.955 ± 0.045
1.888ProIle: 1.888 ± 0.054
1.348ProLys: 1.348 ± 0.058
3.893ProLeu: 3.893 ± 0.093
0.827ProMet: 0.827 ± 0.037
1.127ProAsn: 1.127 ± 0.045
1.116ProPro: 1.116 ± 0.044
1.311ProGln: 1.311 ± 0.04
2.372ProArg: 2.372 ± 0.062
2.62ProSer: 2.62 ± 0.072
2.45ProThr: 2.45 ± 0.059
4.009ProVal: 4.009 ± 0.082
0.516ProTrp: 0.516 ± 0.032
1.281ProTyr: 1.281 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
3.158GlnAla: 3.158 ± 0.076
0.272GlnCys: 0.272 ± 0.021
1.354GlnAsp: 1.354 ± 0.046
1.61GlnGlu: 1.61 ± 0.058
0.871GlnPhe: 0.871 ± 0.036
2.119GlnGly: 2.119 ± 0.056
0.507GlnHis: 0.507 ± 0.029
1.592GlnIle: 1.592 ± 0.051
1.0GlnLys: 1.0 ± 0.039
2.509GlnLeu: 2.509 ± 0.067
0.844GlnMet: 0.844 ± 0.042
0.889GlnAsn: 0.889 ± 0.044
0.989GlnPro: 0.989 ± 0.039
0.936GlnGln: 0.936 ± 0.04
1.843GlnArg: 1.843 ± 0.065
1.333GlnSer: 1.333 ± 0.045
1.515GlnThr: 1.515 ± 0.05
2.156GlnVal: 2.156 ± 0.061
0.237GlnTrp: 0.237 ± 0.019
0.621GlnTyr: 0.621 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
8.289ArgAla: 8.289 ± 0.136
0.921ArgCys: 0.921 ± 0.04
3.954ArgAsp: 3.954 ± 0.078
5.034ArgGlu: 5.034 ± 0.099
2.45ArgPhe: 2.45 ± 0.069
4.444ArgGly: 4.444 ± 0.084
1.32ArgHis: 1.32 ± 0.048
3.7ArgIle: 3.7 ± 0.086
2.007ArgLys: 2.007 ± 0.069
5.794ArgLeu: 5.794 ± 0.103
1.904ArgMet: 1.904 ± 0.051
1.559ArgAsn: 1.559 ± 0.052
2.684ArgPro: 2.684 ± 0.071
1.745ArgGln: 1.745 ± 0.054
5.438ArgArg: 5.438 ± 0.114
3.352ArgSer: 3.352 ± 0.085
3.448ArgThr: 3.448 ± 0.078
4.978ArgVal: 4.978 ± 0.085
0.761ArgTrp: 0.761 ± 0.038
2.188ArgTyr: 2.188 ± 0.068
0.0ArgXaa: 0.0 ± 0.0
Ser
6.536SerAla: 6.536 ± 0.124
0.829SerCys: 0.829 ± 0.038
3.179SerAsp: 3.179 ± 0.083
3.086SerGlu: 3.086 ± 0.068
2.347SerPhe: 2.347 ± 0.053
4.876SerGly: 4.876 ± 0.091
1.109SerHis: 1.109 ± 0.04
2.848SerIle: 2.848 ± 0.075
1.603SerLys: 1.603 ± 0.053
5.07SerLeu: 5.07 ± 0.1
1.376SerMet: 1.376 ± 0.05
1.517SerAsn: 1.517 ± 0.049
2.264SerPro: 2.264 ± 0.06
1.368SerGln: 1.368 ± 0.049
3.366SerArg: 3.366 ± 0.077
3.458SerSer: 3.458 ± 0.105
3.094SerThr: 3.094 ± 0.077
4.191SerVal: 4.191 ± 0.087
0.724SerTrp: 0.724 ± 0.034
1.944SerTyr: 1.944 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
5.862ThrAla: 5.862 ± 0.098
0.872ThrCys: 0.872 ± 0.036
3.274ThrAsp: 3.274 ± 0.071
3.189ThrGlu: 3.189 ± 0.085
2.295ThrPhe: 2.295 ± 0.06
5.024ThrGly: 5.024 ± 0.113
1.139ThrHis: 1.139 ± 0.044
2.89ThrIle: 2.89 ± 0.079
1.542ThrLys: 1.542 ± 0.054
5.532ThrLeu: 5.532 ± 0.093
1.202ThrMet: 1.202 ± 0.046
1.409ThrAsn: 1.409 ± 0.052
3.193ThrPro: 3.193 ± 0.075
1.506ThrGln: 1.506 ± 0.053
3.096ThrArg: 3.096 ± 0.08
3.238ThrSer: 3.238 ± 0.085
2.93ThrThr: 2.93 ± 0.07
5.088ThrVal: 5.088 ± 0.115
0.651ThrTrp: 0.651 ± 0.031
1.851ThrTyr: 1.851 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
9.679ValAla: 9.679 ± 0.162
1.376ValCys: 1.376 ± 0.047
5.138ValAsp: 5.138 ± 0.1
5.285ValGlu: 5.285 ± 0.093
2.957ValPhe: 2.957 ± 0.073
5.655ValGly: 5.655 ± 0.105
1.411ValHis: 1.411 ± 0.047
4.258ValIle: 4.258 ± 0.095
2.317ValLys: 2.317 ± 0.067
7.548ValLeu: 7.548 ± 0.114
1.93ValMet: 1.93 ± 0.053
2.261ValAsn: 2.261 ± 0.057
3.737ValPro: 3.737 ± 0.086
1.791ValGln: 1.791 ± 0.061
5.319ValArg: 5.319 ± 0.098
4.884ValSer: 4.884 ± 0.094
4.675ValThr: 4.675 ± 0.103
6.792ValVal: 6.792 ± 0.129
0.738ValTrp: 0.738 ± 0.039
1.999ValTyr: 1.999 ± 0.053
0.0ValXaa: 0.0 ± 0.0
Trp
0.986TrpAla: 0.986 ± 0.042
0.2TrpCys: 0.2 ± 0.019
0.683TrpAsp: 0.683 ± 0.033
0.648TrpGlu: 0.648 ± 0.035
0.42TrpPhe: 0.42 ± 0.026
0.911TrpGly: 0.911 ± 0.039
0.27TrpHis: 0.27 ± 0.023
0.46TrpIle: 0.46 ± 0.028
0.337TrpLys: 0.337 ± 0.023
1.041TrpLeu: 1.041 ± 0.046
0.292TrpMet: 0.292 ± 0.022
0.346TrpAsn: 0.346 ± 0.023
0.387TrpPro: 0.387 ± 0.025
0.424TrpGln: 0.424 ± 0.027
0.852TrpArg: 0.852 ± 0.04
0.559TrpSer: 0.559 ± 0.031
0.552TrpThr: 0.552 ± 0.029
0.685TrpVal: 0.685 ± 0.034
0.173TrpTrp: 0.173 ± 0.018
0.354TrpTyr: 0.354 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.016TyrAla: 3.016 ± 0.069
0.329TyrCys: 0.329 ± 0.025
1.969TyrAsp: 1.969 ± 0.066
1.799TyrGlu: 1.799 ± 0.061
0.985TyrPhe: 0.985 ± 0.038
2.188TyrGly: 2.188 ± 0.055
0.612TyrHis: 0.612 ± 0.034
1.2TyrIle: 1.2 ± 0.039
0.758TyrLys: 0.758 ± 0.038
3.072TyrLeu: 3.072 ± 0.077
0.568TyrMet: 0.568 ± 0.027
0.785TyrAsn: 0.785 ± 0.037
1.381TyrPro: 1.381 ± 0.049
0.899TyrGln: 0.899 ± 0.036
2.158TyrArg: 2.158 ± 0.068
1.23TyrSer: 1.23 ± 0.047
1.67TyrThr: 1.67 ± 0.059
2.086TyrVal: 2.086 ± 0.065
0.298TyrTrp: 0.298 ± 0.02
0.874TyrTyr: 0.874 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1893 proteins (640865 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski