Amino acid dipepetide frequency for Litoreibacter arenae DSM 19593

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.485AlaAla: 14.485 ± 0.175	1.123AlaCys: 1.123 ± 0.036	6.851AlaAsp: 6.851 ± 0.085	7.498AlaGlu: 7.498 ± 0.106	4.359AlaPhe: 4.359 ± 0.059	9.588AlaGly: 9.588 ± 0.1	2.116AlaHis: 2.116 ± 0.048	5.848AlaIle: 5.848 ± 0.088	4.63AlaLys: 4.63 ± 0.081	12.601AlaLeu: 12.601 ± 0.138	3.755AlaMet: 3.755 ± 0.065	2.973AlaAsn: 2.973 ± 0.062	5.254AlaPro: 5.254 ± 0.096	4.414AlaGln: 4.414 ± 0.061	7.434AlaArg: 7.434 ± 0.099	5.945AlaSer: 5.945 ± 0.084	6.027AlaThr: 6.027 ± 0.088	8.015AlaVal: 8.015 ± 0.096	1.378AlaTrp: 1.378 ± 0.033	2.573AlaTyr: 2.573 ± 0.048	0.001AlaXaa: 0.001 ± 0.001
Cys	1.131CysAla: 1.131 ± 0.031	0.111CysCys: 0.111 ± 0.011	0.645CysAsp: 0.645 ± 0.025	0.481CysGlu: 0.481 ± 0.019	0.356CysPhe: 0.356 ± 0.021	0.959CysGly: 0.959 ± 0.032	0.264CysHis: 0.264 ± 0.016	0.457CysIle: 0.457 ± 0.019	0.235CysLys: 0.235 ± 0.014	0.82CysLeu: 0.82 ± 0.027	0.182CysMet: 0.182 ± 0.014	0.228CysAsn: 0.228 ± 0.013	0.493CysPro: 0.493 ± 0.025	0.241CysGln: 0.241 ± 0.015	0.511CysArg: 0.511 ± 0.024	0.472CysSer: 0.472 ± 0.021	0.477CysThr: 0.477 ± 0.026	0.663CysVal: 0.663 ± 0.026	0.119CysTrp: 0.119 ± 0.011	0.237CysTyr: 0.237 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.74AspAla: 7.74 ± 0.09	0.537AspCys: 0.537 ± 0.022	3.939AspAsp: 3.939 ± 0.081	3.832AspGlu: 3.832 ± 0.065	2.354AspPhe: 2.354 ± 0.052	5.969AspGly: 5.969 ± 0.11	1.393AspHis: 1.393 ± 0.04	3.398AspIle: 3.398 ± 0.056	2.088AspLys: 2.088 ± 0.053	6.263AspLeu: 6.263 ± 0.085	1.878AspMet: 1.878 ± 0.048	1.493AspAsn: 1.493 ± 0.042	3.387AspPro: 3.387 ± 0.062	1.92AspGln: 1.92 ± 0.039	4.01AspArg: 4.01 ± 0.056	2.285AspSer: 2.285 ± 0.052	3.392AspThr: 3.392 ± 0.08	4.626AspVal: 4.626 ± 0.072	1.132AspTrp: 1.132 ± 0.035	1.677AspTyr: 1.677 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.636GluAla: 7.636 ± 0.112	0.371GluCys: 0.371 ± 0.017	3.58GluAsp: 3.58 ± 0.064	3.437GluGlu: 3.437 ± 0.077	1.984GluPhe: 1.984 ± 0.045	4.758GluGly: 4.758 ± 0.066	1.218GluHis: 1.218 ± 0.038	3.429GluIle: 3.429 ± 0.061	2.396GluLys: 2.396 ± 0.054	5.409GluLeu: 5.409 ± 0.078	1.856GluMet: 1.856 ± 0.043	1.936GluAsn: 1.936 ± 0.042	2.47GluPro: 2.47 ± 0.056	2.131GluGln: 2.131 ± 0.05	4.128GluArg: 4.128 ± 0.071	2.138GluSer: 2.138 ± 0.046	3.718GluThr: 3.718 ± 0.053	4.457GluVal: 4.457 ± 0.06	0.728GluTrp: 0.728 ± 0.028	1.157GluTyr: 1.157 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.477PheAla: 4.477 ± 0.074	0.463PheCys: 0.463 ± 0.018	2.91PheAsp: 2.91 ± 0.054	2.367PheGlu: 2.367 ± 0.051	1.542PhePhe: 1.542 ± 0.044	3.82PheGly: 3.82 ± 0.069	0.73PheHis: 0.73 ± 0.026	1.857PheIle: 1.857 ± 0.049	1.228PheLys: 1.228 ± 0.036	3.425PheLeu: 3.425 ± 0.062	0.953PheMet: 0.953 ± 0.027	1.16PheAsn: 1.16 ± 0.035	1.568PhePro: 1.568 ± 0.04	1.112PheGln: 1.112 ± 0.03	2.03PheArg: 2.03 ± 0.046	2.289PheSer: 2.289 ± 0.053	2.252PheThr: 2.252 ± 0.051	2.818PheVal: 2.818 ± 0.053	0.577PheTrp: 0.577 ± 0.026	0.967PheTyr: 0.967 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	9.24GlyAla: 9.24 ± 0.101	0.851GlyCys: 0.851 ± 0.029	5.005GlyAsp: 5.005 ± 0.124	4.623GlyGlu: 4.623 ± 0.077	3.797GlyPhe: 3.797 ± 0.063	7.442GlyGly: 7.442 ± 0.128	1.844GlyHis: 1.844 ± 0.045	4.329GlyIle: 4.329 ± 0.072	3.516GlyLys: 3.516 ± 0.068	8.856GlyLeu: 8.856 ± 0.102	2.518GlyMet: 2.518 ± 0.056	2.339GlyAsn: 2.339 ± 0.058	3.446GlyPro: 3.446 ± 0.051	3.041GlyGln: 3.041 ± 0.056	5.144GlyArg: 5.144 ± 0.073	4.355GlySer: 4.355 ± 0.073	4.653GlyThr: 4.653 ± 0.068	6.53GlyVal: 6.53 ± 0.079	1.384GlyTrp: 1.384 ± 0.038	2.313GlyTyr: 2.313 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.163HisAla: 2.163 ± 0.053	0.247HisCys: 0.247 ± 0.015	1.289HisAsp: 1.289 ± 0.039	1.081HisGlu: 1.081 ± 0.031	0.793HisPhe: 0.793 ± 0.025	1.872HisGly: 1.872 ± 0.047	0.57HisHis: 0.57 ± 0.029	1.023HisIle: 1.023 ± 0.03	0.624HisLys: 0.624 ± 0.026	2.085HisLeu: 2.085 ± 0.053	0.615HisMet: 0.615 ± 0.025	0.501HisAsn: 0.501 ± 0.021	1.297HisPro: 1.297 ± 0.034	0.593HisGln: 0.593 ± 0.023	1.25HisArg: 1.25 ± 0.033	0.987HisSer: 0.987 ± 0.029	0.866HisThr: 0.866 ± 0.027	1.548HisVal: 1.548 ± 0.043	0.342HisTrp: 0.342 ± 0.019	0.543HisTyr: 0.543 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.8IleAla: 6.8 ± 0.091	0.652IleCys: 0.652 ± 0.024	3.618IleAsp: 3.618 ± 0.056	3.602IleGlu: 3.602 ± 0.061	1.935IlePhe: 1.935 ± 0.044	4.868IleGly: 4.868 ± 0.071	0.942IleHis: 0.942 ± 0.035	2.456IleIle: 2.456 ± 0.061	1.761IleLys: 1.761 ± 0.044	4.733IleLeu: 4.733 ± 0.068	1.225IleMet: 1.225 ± 0.033	1.567IleAsn: 1.567 ± 0.043	2.403IlePro: 2.403 ± 0.043	1.265IleGln: 1.265 ± 0.037	2.988IleArg: 2.988 ± 0.053	3.17IleSer: 3.17 ± 0.053	3.034IleThr: 3.034 ± 0.059	3.905IleVal: 3.905 ± 0.059	0.763IleTrp: 0.763 ± 0.031	1.241IleTyr: 1.241 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.495LysAla: 4.495 ± 0.074	0.219LysCys: 0.219 ± 0.014	2.258LysAsp: 2.258 ± 0.057	1.814LysGlu: 1.814 ± 0.048	1.175LysPhe: 1.175 ± 0.033	3.063LysGly: 3.063 ± 0.065	0.772LysHis: 0.772 ± 0.027	2.03LysIle: 2.03 ± 0.05	1.53LysLys: 1.53 ± 0.053	3.7LysLeu: 3.7 ± 0.064	1.059LysMet: 1.059 ± 0.034	0.964LysAsn: 0.964 ± 0.034	2.111LysPro: 2.111 ± 0.049	1.092LysGln: 1.092 ± 0.031	2.599LysArg: 2.599 ± 0.057	2.179LysSer: 2.179 ± 0.054	2.208LysThr: 2.208 ± 0.05	2.641LysVal: 2.641 ± 0.05	0.47LysTrp: 0.47 ± 0.021	0.772LysTyr: 0.772 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	11.662LeuAla: 11.662 ± 0.111	0.919LeuCys: 0.919 ± 0.028	6.126LeuAsp: 6.126 ± 0.067	5.479LeuGlu: 5.479 ± 0.071	3.604LeuPhe: 3.604 ± 0.068	8.024LeuGly: 8.024 ± 0.097	1.819LeuHis: 1.819 ± 0.042	5.326LeuIle: 5.326 ± 0.077	3.794LeuLys: 3.794 ± 0.07	8.655LeuLeu: 8.655 ± 0.12	2.737LeuMet: 2.737 ± 0.052	2.844LeuAsn: 2.844 ± 0.049	5.262LeuPro: 5.262 ± 0.074	2.72LeuGln: 2.72 ± 0.046	6.36LeuArg: 6.36 ± 0.085	6.571LeuSer: 6.571 ± 0.083	6.036LeuThr: 6.036 ± 0.074	6.679LeuVal: 6.679 ± 0.084	1.268LeuTrp: 1.268 ± 0.038	1.947LeuTyr: 1.947 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.376MetAla: 3.376 ± 0.061	0.203MetCys: 0.203 ± 0.013	1.534MetAsp: 1.534 ± 0.04	1.512MetGlu: 1.512 ± 0.038	0.916MetPhe: 0.916 ± 0.03	2.426MetGly: 2.426 ± 0.047	0.479MetHis: 0.479 ± 0.02	1.639MetIle: 1.639 ± 0.04	1.217MetLys: 1.217 ± 0.029	2.685MetLeu: 2.685 ± 0.045	0.803MetMet: 0.803 ± 0.027	0.903MetAsn: 0.903 ± 0.029	1.516MetPro: 1.516 ± 0.037	0.968MetGln: 0.968 ± 0.03	1.867MetArg: 1.867 ± 0.042	1.946MetSer: 1.946 ± 0.046	2.058MetThr: 2.058 ± 0.049	1.981MetVal: 1.981 ± 0.042	0.262MetTrp: 0.262 ± 0.015	0.404MetTyr: 0.404 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.384AsnAla: 3.384 ± 0.06	0.288AsnCys: 0.288 ± 0.016	1.682AsnAsp: 1.682 ± 0.047	1.345AsnGlu: 1.345 ± 0.033	1.076AsnPhe: 1.076 ± 0.033	2.521AsnGly: 2.521 ± 0.056	0.587AsnHis: 0.587 ± 0.024	1.521AsnIle: 1.521 ± 0.037	0.852AsnLys: 0.852 ± 0.029	2.665AsnLeu: 2.665 ± 0.055	0.791AsnMet: 0.791 ± 0.026	0.789AsnAsn: 0.789 ± 0.032	1.952AsnPro: 1.952 ± 0.041	0.77AsnGln: 0.77 ± 0.028	1.69AsnArg: 1.69 ± 0.044	1.416AsnSer: 1.416 ± 0.038	1.565AsnThr: 1.565 ± 0.054	2.033AsnVal: 2.033 ± 0.049	0.437AsnTrp: 0.437 ± 0.022	0.727AsnTyr: 0.727 ± 0.024	0.001AsnXaa: 0.001 ± 0.001
Pro	5.261ProAla: 5.261 ± 0.077	0.344ProCys: 0.344 ± 0.02	4.063ProAsp: 4.063 ± 0.061	3.948ProGlu: 3.948 ± 0.074	1.956ProPhe: 1.956 ± 0.036	3.543ProGly: 3.543 ± 0.061	1.106ProHis: 1.106 ± 0.033	2.28ProIle: 2.28 ± 0.052	1.958ProLys: 1.958 ± 0.047	4.466ProLeu: 4.466 ± 0.074	1.322ProMet: 1.322 ± 0.034	1.45ProAsn: 1.45 ± 0.039	2.131ProPro: 2.131 ± 0.051	1.598ProGln: 1.598 ± 0.042	2.488ProArg: 2.488 ± 0.05	2.605ProSer: 2.605 ± 0.055	2.56ProThr: 2.56 ± 0.052	4.054ProVal: 4.054 ± 0.062	0.624ProTrp: 0.624 ± 0.025	1.223ProTyr: 1.223 ± 0.031	0.001ProXaa: 0.001 ± 0.001
Gln	3.838GlnAla: 3.838 ± 0.067	0.211GlnCys: 0.211 ± 0.016	1.75GlnAsp: 1.75 ± 0.038	1.595GlnGlu: 1.595 ± 0.037	1.163GlnPhe: 1.163 ± 0.039	2.602GlnGly: 2.602 ± 0.052	0.616GlnHis: 0.616 ± 0.02	2.112GlnIle: 2.112 ± 0.05	1.183GlnLys: 1.183 ± 0.037	2.85GlnLeu: 2.85 ± 0.06	1.126GlnMet: 1.126 ± 0.03	0.995GlnAsn: 0.995 ± 0.027	1.589GlnPro: 1.589 ± 0.038	1.078GlnGln: 1.078 ± 0.038	2.02GlnArg: 2.02 ± 0.042	1.833GlnSer: 1.833 ± 0.042	1.94GlnThr: 1.94 ± 0.044	2.389GlnVal: 2.389 ± 0.049	0.38GlnTrp: 0.38 ± 0.018	0.634GlnTyr: 0.634 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	6.993ArgAla: 6.993 ± 0.086	0.486ArgCys: 0.486 ± 0.021	4.171ArgAsp: 4.171 ± 0.06	3.704ArgGlu: 3.704 ± 0.061	2.534ArgPhe: 2.534 ± 0.051	4.269ArgGly: 4.269 ± 0.07	1.355ArgHis: 1.355 ± 0.037	3.534ArgIle: 3.534 ± 0.053	2.5ArgLys: 2.5 ± 0.052	6.336ArgLeu: 6.336 ± 0.093	1.924ArgMet: 1.924 ± 0.043	1.779ArgAsn: 1.779 ± 0.036	2.878ArgPro: 2.878 ± 0.054	2.077ArgGln: 2.077 ± 0.043	4.108ArgArg: 4.108 ± 0.067	3.232ArgSer: 3.232 ± 0.059	3.015ArgThr: 3.015 ± 0.053	4.486ArgVal: 4.486 ± 0.062	0.832ArgTrp: 0.832 ± 0.032	1.545ArgTyr: 1.545 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.706SerAla: 5.706 ± 0.072	0.481SerCys: 0.481 ± 0.022	3.602SerAsp: 3.602 ± 0.06	3.094SerGlu: 3.094 ± 0.056	2.384SerPhe: 2.384 ± 0.045	5.457SerGly: 5.457 ± 0.091	1.116SerHis: 1.116 ± 0.032	2.71SerIle: 2.71 ± 0.053	1.949SerLys: 1.949 ± 0.046	5.072SerLeu: 5.072 ± 0.085	1.523SerMet: 1.523 ± 0.037	1.567SerAsn: 1.567 ± 0.037	2.588SerPro: 2.588 ± 0.057	1.648SerGln: 1.648 ± 0.037	3.182SerArg: 3.182 ± 0.065	2.787SerSer: 2.787 ± 0.06	2.723SerThr: 2.723 ± 0.055	3.961SerVal: 3.961 ± 0.065	0.668SerTrp: 0.668 ± 0.025	1.491SerTyr: 1.491 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.046ThrAla: 6.046 ± 0.09	0.53ThrCys: 0.53 ± 0.024	3.42ThrAsp: 3.42 ± 0.058	3.006ThrGlu: 3.006 ± 0.054	2.043ThrPhe: 2.043 ± 0.049	5.349ThrGly: 5.349 ± 0.079	1.211ThrHis: 1.211 ± 0.033	2.906ThrIle: 2.906 ± 0.07	1.952ThrLys: 1.952 ± 0.046	5.979ThrLeu: 5.979 ± 0.087	1.365ThrMet: 1.365 ± 0.035	1.481ThrAsn: 1.481 ± 0.049	3.458ThrPro: 3.458 ± 0.063	1.833ThrGln: 1.833 ± 0.042	3.482ThrArg: 3.482 ± 0.06	3.055ThrSer: 3.055 ± 0.053	3.038ThrThr: 3.038 ± 0.07	4.29ThrVal: 4.29 ± 0.097	0.663ThrTrp: 0.663 ± 0.026	1.375ThrTyr: 1.375 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	8.55ValAla: 8.55 ± 0.094	0.642ValCys: 0.642 ± 0.026	4.337ValAsp: 4.337 ± 0.066	4.55ValGlu: 4.55 ± 0.073	3.013ValPhe: 3.013 ± 0.054	5.52ValGly: 5.52 ± 0.075	1.273ValHis: 1.273 ± 0.039	4.323ValIle: 4.323 ± 0.072	2.517ValLys: 2.517 ± 0.057	7.333ValLeu: 7.333 ± 0.084	2.135ValMet: 2.135 ± 0.045	2.034ValAsn: 2.034 ± 0.045	3.426ValPro: 3.426 ± 0.055	2.147ValGln: 2.147 ± 0.044	3.94ValArg: 3.94 ± 0.065	4.453ValSer: 4.453 ± 0.07	4.881ValThr: 4.881 ± 0.108	5.771ValVal: 5.771 ± 0.083	0.937ValTrp: 0.937 ± 0.032	1.573ValTyr: 1.573 ± 0.038	0.001ValXaa: 0.001 ± 0.001
Trp	1.348TrpAla: 1.348 ± 0.036	0.152TrpCys: 0.152 ± 0.011	0.82TrpAsp: 0.82 ± 0.032	0.62TrpGlu: 0.62 ± 0.023	0.592TrpPhe: 0.592 ± 0.024	0.993TrpGly: 0.993 ± 0.031	0.339TrpHis: 0.339 ± 0.017	0.674TrpIle: 0.674 ± 0.025	0.479TrpLys: 0.479 ± 0.02	1.534TrpLeu: 1.534 ± 0.035	0.395TrpMet: 0.395 ± 0.02	0.413TrpAsn: 0.413 ± 0.02	0.68TrpPro: 0.68 ± 0.026	0.536TrpGln: 0.536 ± 0.021	1.029TrpArg: 1.029 ± 0.029	0.777TrpSer: 0.777 ± 0.024	0.789TrpThr: 0.789 ± 0.027	0.909TrpVal: 0.909 ± 0.03	0.222TrpTrp: 0.222 ± 0.016	0.267TrpTyr: 0.267 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.535TyrAla: 2.535 ± 0.051	0.251TyrCys: 0.251 ± 0.015	1.715TyrAsp: 1.715 ± 0.043	1.347TyrGlu: 1.347 ± 0.037	0.968TyrPhe: 0.968 ± 0.029	2.179TyrGly: 2.179 ± 0.05	0.538TyrHis: 0.538 ± 0.021	1.076TyrIle: 1.076 ± 0.028	0.743TyrLys: 0.743 ± 0.025	2.366TyrLeu: 2.366 ± 0.048	0.53TyrMet: 0.53 ± 0.022	0.679TyrAsn: 0.679 ± 0.027	1.069TyrPro: 1.069 ± 0.031	0.721TyrGln: 0.721 ± 0.028	1.497TyrArg: 1.497 ± 0.038	1.214TyrSer: 1.214 ± 0.033	1.252TyrThr: 1.252 ± 0.039	1.603TyrVal: 1.603 ± 0.041	0.379TyrTrp: 0.379 ± 0.02	0.618TyrTyr: 0.618 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3637 proteins (1101739 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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