Amino acid dipepetide frequency for [Polyangium] brachysporum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.779AlaAla: 18.779 ± 0.202
1.312AlaCys: 1.312 ± 0.028
6.468AlaAsp: 6.468 ± 0.08
7.192AlaGlu: 7.192 ± 0.072
3.685AlaPhe: 3.685 ± 0.057
10.853AlaGly: 10.853 ± 0.099
2.802AlaHis: 2.802 ± 0.039
4.039AlaIle: 4.039 ± 0.055
3.196AlaLys: 3.196 ± 0.06
14.973AlaLeu: 14.973 ± 0.165
2.91AlaMet: 2.91 ± 0.042
2.431AlaAsn: 2.431 ± 0.042
6.801AlaPro: 6.801 ± 0.099
5.788AlaGln: 5.788 ± 0.086
9.471AlaArg: 9.471 ± 0.088
6.794AlaSer: 6.794 ± 0.077
6.162AlaThr: 6.162 ± 0.09
9.637AlaVal: 9.637 ± 0.093
1.979AlaTrp: 1.979 ± 0.042
2.665AlaTyr: 2.665 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
1.126CysAla: 1.126 ± 0.03
0.132CysCys: 0.132 ± 0.009
0.541CysAsp: 0.541 ± 0.016
0.57CysGlu: 0.57 ± 0.019
0.318CysPhe: 0.318 ± 0.014
0.995CysGly: 0.995 ± 0.024
0.291CysHis: 0.291 ± 0.013
0.356CysIle: 0.356 ± 0.016
0.19CysLys: 0.19 ± 0.011
0.903CysLeu: 0.903 ± 0.024
0.183CysMet: 0.183 ± 0.014
0.202CysAsn: 0.202 ± 0.011
0.484CysPro: 0.484 ± 0.018
0.27CysGln: 0.27 ± 0.012
0.704CysArg: 0.704 ± 0.019
0.525CysSer: 0.525 ± 0.016
0.449CysThr: 0.449 ± 0.016
0.721CysVal: 0.721 ± 0.019
0.155CysTrp: 0.155 ± 0.008
0.206CysTyr: 0.206 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.247AspAla: 7.247 ± 0.084
0.444AspCys: 0.444 ± 0.017
3.066AspAsp: 3.066 ± 0.049
3.339AspGlu: 3.339 ± 0.047
1.845AspPhe: 1.845 ± 0.036
4.835AspGly: 4.835 ± 0.059
1.256AspHis: 1.256 ± 0.03
2.037AspIle: 2.037 ± 0.038
1.416AspLys: 1.416 ± 0.037
5.564AspLeu: 5.564 ± 0.054
0.912AspMet: 0.912 ± 0.025
1.158AspAsn: 1.158 ± 0.027
3.252AspPro: 3.252 ± 0.049
1.732AspGln: 1.732 ± 0.034
3.845AspArg: 3.845 ± 0.046
2.155AspSer: 2.155 ± 0.038
2.869AspThr: 2.869 ± 0.06
4.213AspVal: 4.213 ± 0.048
0.882AspTrp: 0.882 ± 0.022
1.345AspTyr: 1.345 ± 0.027
0.0AspXaa: 0.0 ± 0.0
Glu
7.343GluAla: 7.343 ± 0.077
0.416GluCys: 0.416 ± 0.015
2.28GluAsp: 2.28 ± 0.039
2.527GluGlu: 2.527 ± 0.043
1.728GluPhe: 1.728 ± 0.035
3.932GluGly: 3.932 ± 0.05
1.586GluHis: 1.586 ± 0.031
2.328GluIle: 2.328 ± 0.043
1.407GluLys: 1.407 ± 0.034
6.429GluLeu: 6.429 ± 0.068
1.245GluMet: 1.245 ± 0.024
1.05GluAsn: 1.05 ± 0.028
2.863GluPro: 2.863 ± 0.041
3.117GluGln: 3.117 ± 0.043
5.506GluArg: 5.506 ± 0.068
2.362GluSer: 2.362 ± 0.038
2.69GluThr: 2.69 ± 0.039
4.528GluVal: 4.528 ± 0.054
0.761GluTrp: 0.761 ± 0.022
1.085GluTyr: 1.085 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
3.718PheAla: 3.718 ± 0.049
0.346PheCys: 0.346 ± 0.014
2.476PheAsp: 2.476 ± 0.043
2.245PheGlu: 2.245 ± 0.038
1.238PhePhe: 1.238 ± 0.027
3.093PheGly: 3.093 ± 0.039
0.744PheHis: 0.744 ± 0.021
1.279PheIle: 1.279 ± 0.025
1.02PheLys: 1.02 ± 0.027
2.677PheLeu: 2.677 ± 0.04
0.634PheMet: 0.634 ± 0.018
1.009PheAsn: 1.009 ± 0.025
1.361PhePro: 1.361 ± 0.032
1.032PheGln: 1.032 ± 0.024
2.043PheArg: 2.043 ± 0.039
1.968PheSer: 1.968 ± 0.043
1.734PheThr: 1.734 ± 0.038
2.687PheVal: 2.687 ± 0.041
0.505PheTrp: 0.505 ± 0.019
0.808PheTyr: 0.808 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
9.411GlyAla: 9.411 ± 0.098
0.895GlyCys: 0.895 ± 0.024
4.223GlyAsp: 4.223 ± 0.056
4.638GlyGlu: 4.638 ± 0.063
2.983GlyPhe: 2.983 ± 0.042
7.265GlyGly: 7.265 ± 0.091
2.11GlyHis: 2.11 ± 0.036
3.112GlyIle: 3.112 ± 0.05
2.68GlyLys: 2.68 ± 0.049
8.893GlyLeu: 8.893 ± 0.078
1.92GlyMet: 1.92 ± 0.04
2.023GlyAsn: 2.023 ± 0.052
3.638GlyPro: 3.638 ± 0.054
3.505GlyGln: 3.505 ± 0.047
6.497GlyArg: 6.497 ± 0.071
4.778GlySer: 4.778 ± 0.068
4.498GlyThr: 4.498 ± 0.079
6.629GlyVal: 6.629 ± 0.058
1.619GlyTrp: 1.619 ± 0.03
2.261GlyTyr: 2.261 ± 0.034
0.0GlyXaa: 0.0 ± 0.0
His
2.882HisAla: 2.882 ± 0.038
0.274HisCys: 0.274 ± 0.012
1.4HisAsp: 1.4 ± 0.031
1.387HisGlu: 1.387 ± 0.03
0.874HisPhe: 0.874 ± 0.02
2.292HisGly: 2.292 ± 0.04
0.797HisHis: 0.797 ± 0.028
0.785HisIle: 0.785 ± 0.022
0.518HisLys: 0.518 ± 0.017
2.574HisLeu: 2.574 ± 0.038
0.421HisMet: 0.421 ± 0.015
0.527HisAsn: 0.527 ± 0.02
1.621HisPro: 1.621 ± 0.034
0.875HisGln: 0.875 ± 0.02
1.945HisArg: 1.945 ± 0.038
1.033HisSer: 1.033 ± 0.025
1.196HisThr: 1.196 ± 0.029
1.719HisVal: 1.719 ± 0.035
0.447HisTrp: 0.447 ± 0.015
0.712HisTyr: 0.712 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
4.997IleAla: 4.997 ± 0.058
0.311IleCys: 0.311 ± 0.015
2.747IleAsp: 2.747 ± 0.04
3.053IleGlu: 3.053 ± 0.046
0.944IlePhe: 0.944 ± 0.027
3.563IleGly: 3.563 ± 0.048
0.703IleHis: 0.703 ± 0.019
1.076IleIle: 1.076 ± 0.029
1.138IleLys: 1.138 ± 0.032
2.508IleLeu: 2.508 ± 0.038
0.524IleMet: 0.524 ± 0.018
1.026IleAsn: 1.026 ± 0.026
1.542IlePro: 1.542 ± 0.035
1.025IleGln: 1.025 ± 0.027
2.286IleArg: 2.286 ± 0.035
1.833IleSer: 1.833 ± 0.032
2.059IleThr: 2.059 ± 0.036
2.996IleVal: 2.996 ± 0.041
0.409IleTrp: 0.409 ± 0.016
0.814IleTyr: 0.814 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
3.436LysAla: 3.436 ± 0.056
0.161LysCys: 0.161 ± 0.011
1.291LysAsp: 1.291 ± 0.031
1.243LysGlu: 1.243 ± 0.035
0.732LysPhe: 0.732 ± 0.022
2.033LysGly: 2.033 ± 0.044
0.579LysHis: 0.579 ± 0.019
1.147LysIle: 1.147 ± 0.028
1.015LysLys: 1.015 ± 0.036
3.086LysLeu: 3.086 ± 0.047
0.589LysMet: 0.589 ± 0.021
0.651LysAsn: 0.651 ± 0.02
1.722LysPro: 1.722 ± 0.036
1.185LysGln: 1.185 ± 0.026
2.099LysArg: 2.099 ± 0.036
1.405LysSer: 1.405 ± 0.033
1.62LysThr: 1.62 ± 0.038
2.281LysVal: 2.281 ± 0.043
0.284LysTrp: 0.284 ± 0.011
0.553LysTyr: 0.553 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
14.703LeuAla: 14.703 ± 0.129
1.059LeuCys: 1.059 ± 0.024
6.203LeuAsp: 6.203 ± 0.075
5.548LeuGlu: 5.548 ± 0.062
3.261LeuPhe: 3.261 ± 0.05
8.762LeuGly: 8.762 ± 0.085
2.639LeuHis: 2.639 ± 0.042
3.694LeuIle: 3.694 ± 0.049
3.381LeuLys: 3.381 ± 0.047
11.65LeuLeu: 11.65 ± 0.123
2.265LeuMet: 2.265 ± 0.037
2.556LeuAsn: 2.556 ± 0.037
6.617LeuPro: 6.617 ± 0.081
5.209LeuGln: 5.209 ± 0.07
8.544LeuArg: 8.544 ± 0.086
6.265LeuSer: 6.265 ± 0.067
5.631LeuThr: 5.631 ± 0.077
8.006LeuVal: 8.006 ± 0.083
1.446LeuTrp: 1.446 ± 0.031
2.27LeuTyr: 2.27 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
2.505MetAla: 2.505 ± 0.041
0.144MetCys: 0.144 ± 0.009
0.936MetAsp: 0.936 ± 0.026
0.88MetGlu: 0.88 ± 0.021
0.642MetPhe: 0.642 ± 0.018
1.464MetGly: 1.464 ± 0.034
0.469MetHis: 0.469 ± 0.016
0.715MetIle: 0.715 ± 0.02
0.82MetLys: 0.82 ± 0.021
2.369MetLeu: 2.369 ± 0.034
0.467MetMet: 0.467 ± 0.016
0.683MetAsn: 0.683 ± 0.021
1.33MetPro: 1.33 ± 0.028
0.968MetGln: 0.968 ± 0.023
1.642MetArg: 1.642 ± 0.034
1.475MetSer: 1.475 ± 0.031
1.299MetThr: 1.299 ± 0.03
1.535MetVal: 1.535 ± 0.03
0.209MetTrp: 0.209 ± 0.01
0.359MetTyr: 0.359 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
2.827AsnAla: 2.827 ± 0.043
0.249AsnCys: 0.249 ± 0.013
1.232AsnAsp: 1.232 ± 0.036
1.138AsnGlu: 1.138 ± 0.027
0.845AsnPhe: 0.845 ± 0.023
2.143AsnGly: 2.143 ± 0.042
0.47AsnHis: 0.47 ± 0.016
0.89AsnIle: 0.89 ± 0.026
0.602AsnLys: 0.602 ± 0.021
2.339AsnLeu: 2.339 ± 0.04
0.444AsnMet: 0.444 ± 0.013
0.662AsnAsn: 0.662 ± 0.022
1.556AsnPro: 1.556 ± 0.03
0.865AsnGln: 0.865 ± 0.029
1.571AsnArg: 1.571 ± 0.029
1.041AsnSer: 1.041 ± 0.025
1.321AsnThr: 1.321 ± 0.029
1.825AsnVal: 1.825 ± 0.044
0.361AsnTrp: 0.361 ± 0.015
0.613AsnTyr: 0.613 ± 0.017
0.0AsnXaa: 0.0 ± 0.0
Pro
7.702ProAla: 7.702 ± 0.113
0.405ProCys: 0.405 ± 0.018
3.356ProAsp: 3.356 ± 0.041
3.467ProGlu: 3.467 ± 0.045
1.635ProPhe: 1.635 ± 0.036
4.984ProGly: 4.984 ± 0.066
1.279ProHis: 1.279 ± 0.03
1.671ProIle: 1.671 ± 0.032
1.383ProLys: 1.383 ± 0.031
5.661ProLeu: 5.661 ± 0.068
1.156ProMet: 1.156 ± 0.028
1.234ProAsn: 1.234 ± 0.031
3.462ProPro: 3.462 ± 0.071
2.396ProGln: 2.396 ± 0.04
3.429ProArg: 3.429 ± 0.045
3.059ProSer: 3.059 ± 0.047
2.74ProThr: 2.74 ± 0.043
4.571ProVal: 4.571 ± 0.051
0.839ProTrp: 0.839 ± 0.028
1.209ProTyr: 1.209 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
6.091GlnAla: 6.091 ± 0.068
0.303GlnCys: 0.303 ± 0.013
1.763GlnAsp: 1.763 ± 0.037
1.725GlnGlu: 1.725 ± 0.031
1.176GlnPhe: 1.176 ± 0.028
3.432GlnGly: 3.432 ± 0.05
1.163GlnHis: 1.163 ± 0.027
1.532GlnIle: 1.532 ± 0.028
0.884GlnLys: 0.884 ± 0.027
4.859GlnLeu: 4.859 ± 0.057
0.864GlnMet: 0.864 ± 0.022
0.743GlnAsn: 0.743 ± 0.021
2.581GlnPro: 2.581 ± 0.042
2.468GlnGln: 2.468 ± 0.048
4.144GlnArg: 4.144 ± 0.059
1.892GlnSer: 1.892 ± 0.031
1.977GlnThr: 1.977 ± 0.037
3.576GlnVal: 3.576 ± 0.073
0.703GlnTrp: 0.703 ± 0.021
0.804GlnTyr: 0.804 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
8.213ArgAla: 8.213 ± 0.085
0.771ArgCys: 0.771 ± 0.018
3.963ArgAsp: 3.963 ± 0.051
4.652ArgGlu: 4.652 ± 0.062
2.912ArgPhe: 2.912 ± 0.042
5.223ArgGly: 5.223 ± 0.053
2.321ArgHis: 2.321 ± 0.04
3.004ArgIle: 3.004 ± 0.043
1.859ArgLys: 1.859 ± 0.035
9.514ArgLeu: 9.514 ± 0.09
1.768ArgMet: 1.768 ± 0.036
1.722ArgAsn: 1.722 ± 0.034
3.999ArgPro: 3.999 ± 0.053
3.428ArgGln: 3.428 ± 0.05
6.474ArgArg: 6.474 ± 0.074
3.959ArgSer: 3.959 ± 0.044
3.383ArgThr: 3.383 ± 0.045
5.79ArgVal: 5.79 ± 0.057
1.504ArgTrp: 1.504 ± 0.033
2.195ArgTyr: 2.195 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
6.447SerAla: 6.447 ± 0.068
0.463SerCys: 0.463 ± 0.018
2.592SerAsp: 2.592 ± 0.04
2.536SerGlu: 2.536 ± 0.04
2.075SerPhe: 2.075 ± 0.043
5.156SerGly: 5.156 ± 0.067
1.194SerHis: 1.194 ± 0.027
2.035SerIle: 2.035 ± 0.031
1.327SerLys: 1.327 ± 0.031
5.798SerLeu: 5.798 ± 0.059
1.183SerMet: 1.183 ± 0.025
1.226SerAsn: 1.226 ± 0.027
2.984SerPro: 2.984 ± 0.045
1.879SerGln: 1.879 ± 0.036
3.752SerArg: 3.752 ± 0.051
3.058SerSer: 3.058 ± 0.05
2.903SerThr: 2.903 ± 0.042
4.178SerVal: 4.178 ± 0.062
0.814SerTrp: 0.814 ± 0.021
1.292SerTyr: 1.292 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
6.279ThrAla: 6.279 ± 0.114
0.421ThrCys: 0.421 ± 0.017
2.529ThrAsp: 2.529 ± 0.058
2.535ThrGlu: 2.535 ± 0.045
1.588ThrPhe: 1.588 ± 0.03
4.776ThrGly: 4.776 ± 0.069
1.147ThrHis: 1.147 ± 0.027
1.627ThrIle: 1.627 ± 0.031
0.991ThrLys: 0.991 ± 0.024
6.589ThrLeu: 6.589 ± 0.076
0.954ThrMet: 0.954 ± 0.024
1.052ThrAsn: 1.052 ± 0.029
3.72ThrPro: 3.72 ± 0.051
1.97ThrGln: 1.97 ± 0.05
3.539ThrArg: 3.539 ± 0.051
2.731ThrSer: 2.731 ± 0.041
2.939ThrThr: 2.939 ± 0.093
4.51ThrVal: 4.51 ± 0.099
0.747ThrTrp: 0.747 ± 0.025
1.151ThrTyr: 1.151 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
9.909ValAla: 9.909 ± 0.102
0.78ValCys: 0.78 ± 0.022
4.311ValAsp: 4.311 ± 0.051
4.678ValGlu: 4.678 ± 0.054
2.685ValPhe: 2.685 ± 0.044
5.773ValGly: 5.773 ± 0.055
1.781ValHis: 1.781 ± 0.031
2.93ValIle: 2.93 ± 0.044
2.285ValLys: 2.285 ± 0.041
8.782ValLeu: 8.782 ± 0.08
1.71ValMet: 1.71 ± 0.033
1.989ValAsn: 1.989 ± 0.045
4.218ValPro: 4.218 ± 0.049
3.249ValGln: 3.249 ± 0.042
5.676ValArg: 5.676 ± 0.059
4.478ValSer: 4.478 ± 0.069
4.228ValThr: 4.228 ± 0.081
6.942ValVal: 6.942 ± 0.065
1.152ValTrp: 1.152 ± 0.027
1.68ValTyr: 1.68 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.579TrpAla: 1.579 ± 0.035
0.176TrpCys: 0.176 ± 0.009
0.688TrpAsp: 0.688 ± 0.025
0.611TrpGlu: 0.611 ± 0.017
0.565TrpPhe: 0.565 ± 0.02
1.007TrpGly: 1.007 ± 0.025
0.424TrpHis: 0.424 ± 0.015
0.574TrpIle: 0.574 ± 0.018
0.415TrpLys: 0.415 ± 0.015
2.072TrpLeu: 2.072 ± 0.038
0.388TrpMet: 0.388 ± 0.016
0.44TrpAsn: 0.44 ± 0.019
0.788TrpPro: 0.788 ± 0.025
0.854TrpGln: 0.854 ± 0.024
1.513TrpArg: 1.513 ± 0.029
0.907TrpSer: 0.907 ± 0.025
0.73TrpThr: 0.73 ± 0.024
1.174TrpVal: 1.174 ± 0.028
0.358TrpTrp: 0.358 ± 0.015
0.314TrpTyr: 0.314 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.742TyrAla: 2.742 ± 0.042
0.259TyrCys: 0.259 ± 0.014
1.349TyrAsp: 1.349 ± 0.046
1.22TyrGlu: 1.22 ± 0.028
0.886TyrPhe: 0.886 ± 0.022
1.996TyrGly: 1.996 ± 0.035
0.522TyrHis: 0.522 ± 0.016
0.72TyrIle: 0.72 ± 0.021
0.583TyrLys: 0.583 ± 0.017
2.47TyrLeu: 2.47 ± 0.04
0.372TyrMet: 0.372 ± 0.018
0.615TyrAsn: 0.615 ± 0.019
1.096TyrPro: 1.096 ± 0.028
0.866TyrGln: 0.866 ± 0.026
1.972TyrArg: 1.972 ± 0.039
1.174TyrSer: 1.174 ± 0.028
1.368TyrThr: 1.368 ± 0.042
1.719TyrVal: 1.719 ± 0.037
0.404TyrTrp: 0.404 ± 0.016
0.592TyrTyr: 0.592 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5541 proteins (1876769 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski