Amino acid dipepetide frequency for Criibacterium bergeronii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.182AlaAla: 4.182 ± 0.134
0.67AlaCys: 0.67 ± 0.037
3.495AlaAsp: 3.495 ± 0.078
3.555AlaGlu: 3.555 ± 0.094
2.756AlaPhe: 2.756 ± 0.067
4.145AlaGly: 4.145 ± 0.097
0.924AlaHis: 0.924 ± 0.04
5.823AlaIle: 5.823 ± 0.128
5.847AlaLys: 5.847 ± 0.116
6.064AlaLeu: 6.064 ± 0.107
1.981AlaMet: 1.981 ± 0.051
3.177AlaAsn: 3.177 ± 0.077
1.593AlaPro: 1.593 ± 0.061
2.32AlaGln: 2.32 ± 0.074
2.026AlaArg: 2.026 ± 0.063
3.6AlaSer: 3.6 ± 0.087
3.634AlaThr: 3.634 ± 0.1
4.362AlaVal: 4.362 ± 0.101
0.294AlaTrp: 0.294 ± 0.023
2.33AlaTyr: 2.33 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.566CysAla: 0.566 ± 0.03
0.109CysCys: 0.109 ± 0.014
0.619CysAsp: 0.619 ± 0.033
0.595CysGlu: 0.595 ± 0.029
0.363CysPhe: 0.363 ± 0.025
0.875CysGly: 0.875 ± 0.04
0.217CysHis: 0.217 ± 0.022
0.804CysIle: 0.804 ± 0.038
0.797CysLys: 0.797 ± 0.036
0.732CysLeu: 0.732 ± 0.039
0.249CysMet: 0.249 ± 0.02
0.46CysAsn: 0.46 ± 0.028
0.431CysPro: 0.431 ± 0.034
0.212CysGln: 0.212 ± 0.019
0.26CysArg: 0.26 ± 0.022
0.646CysSer: 0.646 ± 0.035
0.466CysThr: 0.466 ± 0.029
0.616CysVal: 0.616 ± 0.033
0.055CysTrp: 0.055 ± 0.011
0.341CysTyr: 0.341 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
3.719AspAla: 3.719 ± 0.082
0.543AspCys: 0.543 ± 0.034
3.359AspAsp: 3.359 ± 0.097
5.278AspGlu: 5.278 ± 0.115
3.338AspPhe: 3.338 ± 0.082
3.817AspGly: 3.817 ± 0.075
0.551AspHis: 0.551 ± 0.03
6.235AspIle: 6.235 ± 0.109
6.283AspLys: 6.283 ± 0.111
5.326AspLeu: 5.326 ± 0.093
1.884AspMet: 1.884 ± 0.057
3.249AspAsn: 3.249 ± 0.069
1.396AspPro: 1.396 ± 0.05
0.995AspGln: 0.995 ± 0.038
1.891AspArg: 1.891 ± 0.062
3.225AspSer: 3.225 ± 0.076
3.323AspThr: 3.323 ± 0.081
3.934AspVal: 3.934 ± 0.082
0.336AspTrp: 0.336 ± 0.028
3.019AspTyr: 3.019 ± 0.079
0.0AspXaa: 0.0 ± 0.0
Glu
3.408GluAla: 3.408 ± 0.09
0.432GluCys: 0.432 ± 0.028
3.886GluAsp: 3.886 ± 0.094
5.275GluGlu: 5.275 ± 0.113
2.844GluPhe: 2.844 ± 0.072
2.987GluGly: 2.987 ± 0.076
0.969GluHis: 0.969 ± 0.038
6.468GluIle: 6.468 ± 0.115
8.047GluLys: 8.047 ± 0.143
6.454GluLeu: 6.454 ± 0.132
1.929GluMet: 1.929 ± 0.056
5.249GluAsn: 5.249 ± 0.093
1.667GluPro: 1.667 ± 0.051
2.859GluGln: 2.859 ± 0.078
2.164GluArg: 2.164 ± 0.063
3.04GluSer: 3.04 ± 0.073
3.23GluThr: 3.23 ± 0.085
4.389GluVal: 4.389 ± 0.093
0.333GluTrp: 0.333 ± 0.026
2.957GluTyr: 2.957 ± 0.077
0.0GluXaa: 0.0 ± 0.0
Phe
3.023PheAla: 3.023 ± 0.076
0.494PheCys: 0.494 ± 0.028
3.209PheAsp: 3.209 ± 0.077
3.098PheGlu: 3.098 ± 0.08
2.159PhePhe: 2.159 ± 0.073
2.704PheGly: 2.704 ± 0.088
0.539PheHis: 0.539 ± 0.031
3.873PheIle: 3.873 ± 0.093
3.249PheLys: 3.249 ± 0.077
4.045PheLeu: 4.045 ± 0.101
1.182PheMet: 1.182 ± 0.044
2.388PheAsn: 2.388 ± 0.06
1.093PhePro: 1.093 ± 0.04
0.923PheGln: 0.923 ± 0.038
1.269PheArg: 1.269 ± 0.045
3.447PheSer: 3.447 ± 0.083
2.56PheThr: 2.56 ± 0.061
2.99PheVal: 2.99 ± 0.076
0.312PheTrp: 0.312 ± 0.024
1.896PheTyr: 1.896 ± 0.067
0.0PheXaa: 0.0 ± 0.0
Gly
4.055GlyAla: 4.055 ± 0.113
0.582GlyCys: 0.582 ± 0.039
3.285GlyAsp: 3.285 ± 0.074
3.822GlyGlu: 3.822 ± 0.094
2.979GlyPhe: 2.979 ± 0.079
3.965GlyGly: 3.965 ± 0.109
0.939GlyHis: 0.939 ± 0.042
5.698GlyIle: 5.698 ± 0.127
5.809GlyLys: 5.809 ± 0.124
5.105GlyLeu: 5.105 ± 0.122
1.693GlyMet: 1.693 ± 0.062
2.846GlyAsn: 2.846 ± 0.082
0.9GlyPro: 0.9 ± 0.045
1.873GlyGln: 1.873 ± 0.05
1.992GlyArg: 1.992 ± 0.065
3.664GlySer: 3.664 ± 0.092
3.347GlyThr: 3.347 ± 0.1
4.267GlyVal: 4.267 ± 0.089
0.405GlyTrp: 0.405 ± 0.031
3.023GlyTyr: 3.023 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
0.728HisAla: 0.728 ± 0.037
0.177HisCys: 0.177 ± 0.018
0.804HisAsp: 0.804 ± 0.037
0.841HisGlu: 0.841 ± 0.037
0.704HisPhe: 0.704 ± 0.035
0.851HisGly: 0.851 ± 0.04
0.291HisHis: 0.291 ± 0.024
1.294HisIle: 1.294 ± 0.046
1.034HisLys: 1.034 ± 0.043
1.162HisLeu: 1.162 ± 0.045
0.32HisMet: 0.32 ± 0.023
0.699HisAsn: 0.699 ± 0.033
0.561HisPro: 0.561 ± 0.031
0.386HisGln: 0.386 ± 0.023
0.468HisArg: 0.468 ± 0.026
0.839HisSer: 0.839 ± 0.036
0.781HisThr: 0.781 ± 0.04
0.624HisVal: 0.624 ± 0.032
0.079HisTrp: 0.079 ± 0.011
0.572HisTyr: 0.572 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.074IleAla: 6.074 ± 0.111
0.99IleCys: 0.99 ± 0.042
6.119IleAsp: 6.119 ± 0.098
5.966IleGlu: 5.966 ± 0.115
4.14IlePhe: 4.14 ± 0.098
5.648IleGly: 5.648 ± 0.132
1.084IleHis: 1.084 ± 0.044
7.691IleIle: 7.691 ± 0.135
7.986IleLys: 7.986 ± 0.126
7.727IleLeu: 7.727 ± 0.132
2.195IleMet: 2.195 ± 0.069
5.251IleAsn: 5.251 ± 0.095
2.931IlePro: 2.931 ± 0.072
2.447IleGln: 2.447 ± 0.063
2.839IleArg: 2.839 ± 0.071
6.775IleSer: 6.775 ± 0.123
4.921IleThr: 4.921 ± 0.103
5.847IleVal: 5.847 ± 0.096
0.408IleTrp: 0.408 ± 0.028
3.518IleTyr: 3.518 ± 0.081
0.0IleXaa: 0.0 ± 0.0
Lys
5.447LysAla: 5.447 ± 0.103
0.614LysCys: 0.614 ± 0.039
6.034LysAsp: 6.034 ± 0.133
7.331LysGlu: 7.331 ± 0.117
3.058LysPhe: 3.058 ± 0.079
4.492LysGly: 4.492 ± 0.098
0.997LysHis: 0.997 ± 0.04
8.515LysIle: 8.515 ± 0.133
9.042LysLys: 9.042 ± 0.14
7.655LysLeu: 7.655 ± 0.109
2.595LysMet: 2.595 ± 0.061
7.032LysAsn: 7.032 ± 0.137
2.14LysPro: 2.14 ± 0.069
3.328LysGln: 3.328 ± 0.074
2.957LysArg: 2.957 ± 0.061
5.696LysSer: 5.696 ± 0.11
4.902LysThr: 4.902 ± 0.108
5.347LysVal: 5.347 ± 0.092
0.479LysTrp: 0.479 ± 0.031
4.206LysTyr: 4.206 ± 0.091
0.0LysXaa: 0.0 ± 0.0
Leu
5.836LeuAla: 5.836 ± 0.101
0.952LeuCys: 0.952 ± 0.041
5.544LeuAsp: 5.544 ± 0.106
5.966LeuGlu: 5.966 ± 0.108
3.751LeuPhe: 3.751 ± 0.089
5.494LeuGly: 5.494 ± 0.107
1.069LeuHis: 1.069 ± 0.039
7.412LeuIle: 7.412 ± 0.137
8.061LeuLys: 8.061 ± 0.141
7.664LeuLeu: 7.664 ± 0.153
2.478LeuMet: 2.478 ± 0.067
5.203LeuAsn: 5.203 ± 0.113
2.915LeuPro: 2.915 ± 0.083
2.839LeuGln: 2.839 ± 0.065
3.045LeuArg: 3.045 ± 0.077
7.061LeuSer: 7.061 ± 0.123
4.693LeuThr: 4.693 ± 0.083
5.445LeuVal: 5.445 ± 0.108
0.416LeuTrp: 0.416 ± 0.025
3.262LeuTyr: 3.262 ± 0.082
0.0LeuXaa: 0.0 ± 0.0
Met
1.777MetAla: 1.777 ± 0.051
0.24MetCys: 0.24 ± 0.021
1.736MetAsp: 1.736 ± 0.054
1.715MetGlu: 1.715 ± 0.056
1.066MetPhe: 1.066 ± 0.038
1.791MetGly: 1.791 ± 0.065
0.312MetHis: 0.312 ± 0.021
2.232MetIle: 2.232 ± 0.063
2.468MetLys: 2.468 ± 0.058
2.667MetLeu: 2.667 ± 0.078
0.817MetMet: 0.817 ± 0.039
1.545MetAsn: 1.545 ± 0.048
1.011MetPro: 1.011 ± 0.043
1.275MetGln: 1.275 ± 0.05
0.92MetArg: 0.92 ± 0.043
1.859MetSer: 1.859 ± 0.061
1.481MetThr: 1.481 ± 0.046
1.608MetVal: 1.608 ± 0.058
0.148MetTrp: 0.148 ± 0.016
0.978MetTyr: 0.978 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
3.42AsnAla: 3.42 ± 0.08
0.547AsnCys: 0.547 ± 0.029
3.193AsnAsp: 3.193 ± 0.073
3.735AsnGlu: 3.735 ± 0.082
2.576AsnPhe: 2.576 ± 0.072
3.51AsnGly: 3.51 ± 0.09
0.822AsnHis: 0.822 ± 0.038
5.851AsnIle: 5.851 ± 0.107
5.135AsnLys: 5.135 ± 0.09
5.561AsnLeu: 5.561 ± 0.112
1.675AsnMet: 1.675 ± 0.055
3.331AsnAsn: 3.331 ± 0.082
2.09AsnPro: 2.09 ± 0.067
1.822AsnGln: 1.822 ± 0.06
1.831AsnArg: 1.831 ± 0.057
3.855AsnSer: 3.855 ± 0.075
2.916AsnThr: 2.916 ± 0.067
3.471AsnVal: 3.471 ± 0.072
0.376AsnTrp: 0.376 ± 0.031
2.535AsnTyr: 2.535 ± 0.084
0.0AsnXaa: 0.0 ± 0.0
Pro
1.712ProAla: 1.712 ± 0.063
0.248ProCys: 0.248 ± 0.019
1.703ProAsp: 1.703 ± 0.052
2.066ProGlu: 2.066 ± 0.066
1.334ProPhe: 1.334 ± 0.044
1.342ProGly: 1.342 ± 0.045
0.436ProHis: 0.436 ± 0.028
2.638ProIle: 2.638 ± 0.078
2.304ProLys: 2.304 ± 0.06
2.368ProLeu: 2.368 ± 0.073
0.752ProMet: 0.752 ± 0.037
1.617ProAsn: 1.617 ± 0.051
0.666ProPro: 0.666 ± 0.044
0.998ProGln: 0.998 ± 0.046
0.793ProArg: 0.793 ± 0.034
1.863ProSer: 1.863 ± 0.054
1.646ProThr: 1.646 ± 0.055
2.17ProVal: 2.17 ± 0.063
0.19ProTrp: 0.19 ± 0.017
1.339ProTyr: 1.339 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
2.068GlnAla: 2.068 ± 0.06
0.204GlnCys: 0.204 ± 0.02
2.047GlnAsp: 2.047 ± 0.062
2.508GlnGlu: 2.508 ± 0.069
0.981GlnPhe: 0.981 ± 0.042
1.711GlnGly: 1.711 ± 0.06
0.344GlnHis: 0.344 ± 0.023
3.008GlnIle: 3.008 ± 0.073
3.322GlnLys: 3.322 ± 0.088
2.532GlnLeu: 2.532 ± 0.065
1.05GlnMet: 1.05 ± 0.044
2.252GlnAsn: 2.252 ± 0.067
0.754GlnPro: 0.754 ± 0.038
1.129GlnGln: 1.129 ± 0.056
1.376GlnArg: 1.376 ± 0.056
1.836GlnSer: 1.836 ± 0.059
1.807GlnThr: 1.807 ± 0.06
1.804GlnVal: 1.804 ± 0.052
0.191GlnTrp: 0.191 ± 0.02
1.042GlnTyr: 1.042 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
2.265ArgAla: 2.265 ± 0.069
0.336ArgCys: 0.336 ± 0.024
1.769ArgAsp: 1.769 ± 0.06
2.129ArgGlu: 2.129 ± 0.061
1.487ArgPhe: 1.487 ± 0.045
1.904ArgGly: 1.904 ± 0.067
0.484ArgHis: 0.484 ± 0.031
2.748ArgIle: 2.748 ± 0.073
2.847ArgLys: 2.847 ± 0.078
3.188ArgLeu: 3.188 ± 0.071
0.887ArgMet: 0.887 ± 0.042
1.754ArgAsn: 1.754 ± 0.062
0.995ArgPro: 0.995 ± 0.041
1.391ArgGln: 1.391 ± 0.04
1.341ArgArg: 1.341 ± 0.053
1.555ArgSer: 1.555 ± 0.05
1.717ArgThr: 1.717 ± 0.054
2.018ArgVal: 2.018 ± 0.061
0.215ArgTrp: 0.215 ± 0.017
1.494ArgTyr: 1.494 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
3.908SerAla: 3.908 ± 0.086
0.579SerCys: 0.579 ± 0.03
3.904SerAsp: 3.904 ± 0.083
4.064SerGlu: 4.064 ± 0.09
3.158SerPhe: 3.158 ± 0.079
4.458SerGly: 4.458 ± 0.098
0.92SerHis: 0.92 ± 0.04
5.757SerIle: 5.757 ± 0.11
5.709SerLys: 5.709 ± 0.1
5.915SerLeu: 5.915 ± 0.111
1.698SerMet: 1.698 ± 0.049
3.362SerAsn: 3.362 ± 0.077
1.724SerPro: 1.724 ± 0.052
2.215SerGln: 2.215 ± 0.068
2.077SerArg: 2.077 ± 0.059
4.452SerSer: 4.452 ± 0.105
3.195SerThr: 3.195 ± 0.079
3.953SerVal: 3.953 ± 0.088
0.415SerTrp: 0.415 ± 0.026
2.873SerTyr: 2.873 ± 0.077
0.0SerXaa: 0.0 ± 0.0
Thr
3.656ThrAla: 3.656 ± 0.09
0.437ThrCys: 0.437 ± 0.027
3.265ThrAsp: 3.265 ± 0.082
2.984ThrGlu: 2.984 ± 0.085
2.404ThrPhe: 2.404 ± 0.066
3.757ThrGly: 3.757 ± 0.089
0.793ThrHis: 0.793 ± 0.033
4.666ThrIle: 4.666 ± 0.099
4.373ThrLys: 4.373 ± 0.079
5.097ThrLeu: 5.097 ± 0.103
1.314ThrMet: 1.314 ± 0.047
2.812ThrAsn: 2.812 ± 0.068
1.957ThrPro: 1.957 ± 0.069
1.844ThrGln: 1.844 ± 0.062
1.69ThrArg: 1.69 ± 0.053
3.484ThrSer: 3.484 ± 0.085
3.026ThrThr: 3.026 ± 0.103
3.765ThrVal: 3.765 ± 0.112
0.293ThrTrp: 0.293 ± 0.024
2.05ThrTyr: 2.05 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
4.281ValAla: 4.281 ± 0.077
0.715ValCys: 0.715 ± 0.038
4.291ValAsp: 4.291 ± 0.081
4.193ValGlu: 4.193 ± 0.092
2.875ValPhe: 2.875 ± 0.065
4.005ValGly: 4.005 ± 0.1
0.815ValHis: 0.815 ± 0.033
5.659ValIle: 5.659 ± 0.108
5.447ValLys: 5.447 ± 0.096
5.629ValLeu: 5.629 ± 0.095
1.748ValMet: 1.748 ± 0.053
3.368ValAsn: 3.368 ± 0.064
2.063ValPro: 2.063 ± 0.073
1.667ValGln: 1.667 ± 0.051
2.003ValArg: 2.003 ± 0.059
4.492ValSer: 4.492 ± 0.094
3.466ValThr: 3.466 ± 0.091
4.354ValVal: 4.354 ± 0.096
0.338ValTrp: 0.338 ± 0.023
2.45ValTyr: 2.45 ± 0.065
0.0ValXaa: 0.0 ± 0.0
Trp
0.362TrpAla: 0.362 ± 0.021
0.074TrpCys: 0.074 ± 0.012
0.326TrpAsp: 0.326 ± 0.024
0.376TrpGlu: 0.376 ± 0.03
0.254TrpPhe: 0.254 ± 0.02
0.396TrpGly: 0.396 ± 0.025
0.116TrpHis: 0.116 ± 0.013
0.439TrpIle: 0.439 ± 0.032
0.4TrpLys: 0.4 ± 0.028
0.489TrpLeu: 0.489 ± 0.032
0.162TrpMet: 0.162 ± 0.017
0.314TrpAsn: 0.314 ± 0.026
0.079TrpPro: 0.079 ± 0.012
0.236TrpGln: 0.236 ± 0.019
0.232TrpArg: 0.232 ± 0.02
0.344TrpSer: 0.344 ± 0.027
0.328TrpThr: 0.328 ± 0.026
0.339TrpVal: 0.339 ± 0.023
0.053TrpTrp: 0.053 ± 0.009
0.256TrpTyr: 0.256 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.291TyrAla: 2.291 ± 0.066
0.469TyrCys: 0.469 ± 0.027
3.116TyrAsp: 3.116 ± 0.073
3.09TyrGlu: 3.09 ± 0.078
2.225TyrPhe: 2.225 ± 0.069
2.397TyrGly: 2.397 ± 0.064
0.595TyrHis: 0.595 ± 0.036
3.748TyrIle: 3.748 ± 0.092
3.706TyrLys: 3.706 ± 0.082
3.727TyrLeu: 3.727 ± 0.076
1.034TyrMet: 1.034 ± 0.039
2.344TyrAsn: 2.344 ± 0.075
1.222TyrPro: 1.222 ± 0.044
1.206TyrGln: 1.206 ± 0.044
1.351TyrArg: 1.351 ± 0.054
2.601TyrSer: 2.601 ± 0.072
2.225TyrThr: 2.225 ± 0.063
2.555TyrVal: 2.555 ± 0.056
0.238TyrTrp: 0.238 ± 0.021
1.926TyrTyr: 1.926 ± 0.067
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2051 proteins (621987 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski