Amino acid dipepetide frequency for Flavobacterium caeni

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.478AlaAla: 6.478 ± 0.117	0.667AlaCys: 0.667 ± 0.028	4.423AlaAsp: 4.423 ± 0.065	4.519AlaGlu: 4.519 ± 0.081	3.839AlaPhe: 3.839 ± 0.065	5.506AlaGly: 5.506 ± 0.101	1.508AlaHis: 1.508 ± 0.04	5.228AlaIle: 5.228 ± 0.077	4.828AlaLys: 4.828 ± 0.105	7.45AlaLeu: 7.45 ± 0.095	1.909AlaMet: 1.909 ± 0.043	4.188AlaAsn: 4.188 ± 0.084	2.817AlaPro: 2.817 ± 0.08	3.692AlaGln: 3.692 ± 0.056	2.534AlaArg: 2.534 ± 0.053	4.752AlaSer: 4.752 ± 0.089	5.465AlaThr: 5.465 ± 0.151	5.396AlaVal: 5.396 ± 0.078	0.769AlaTrp: 0.769 ± 0.026	2.71AlaTyr: 2.71 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.706CysAla: 0.706 ± 0.036	0.128CysCys: 0.128 ± 0.011	0.473CysAsp: 0.473 ± 0.026	0.49CysGlu: 0.49 ± 0.022	0.4CysPhe: 0.4 ± 0.018	0.756CysGly: 0.756 ± 0.031	0.212CysHis: 0.212 ± 0.015	0.538CysIle: 0.538 ± 0.022	0.412CysLys: 0.412 ± 0.02	0.645CysLeu: 0.645 ± 0.023	0.157CysMet: 0.157 ± 0.011	0.409CysAsn: 0.409 ± 0.018	0.378CysPro: 0.378 ± 0.03	0.259CysGln: 0.259 ± 0.016	0.265CysArg: 0.265 ± 0.016	0.633CysSer: 0.633 ± 0.031	0.517CysThr: 0.517 ± 0.03	0.55CysVal: 0.55 ± 0.021	0.076CysTrp: 0.076 ± 0.007	0.307CysTyr: 0.307 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.842AspAla: 4.842 ± 0.072	0.486AspCys: 0.486 ± 0.026	3.177AspAsp: 3.177 ± 0.063	3.352AspGlu: 3.352 ± 0.066	3.641AspPhe: 3.641 ± 0.062	4.343AspGly: 4.343 ± 0.085	1.068AspHis: 1.068 ± 0.037	3.704AspIle: 3.704 ± 0.072	3.681AspLys: 3.681 ± 0.074	5.169AspLeu: 5.169 ± 0.081	1.155AspMet: 1.155 ± 0.037	2.875AspAsn: 2.875 ± 0.056	1.924AspPro: 1.924 ± 0.05	1.938AspGln: 1.938 ± 0.046	2.195AspArg: 2.195 ± 0.046	2.643AspSer: 2.643 ± 0.051	2.842AspThr: 2.842 ± 0.059	3.781AspVal: 3.781 ± 0.06	0.83AspTrp: 0.83 ± 0.034	2.82AspTyr: 2.82 ± 0.054	0.001AspXaa: 0.001 ± 0.001
Glu	4.271GluAla: 4.271 ± 0.083	0.333GluCys: 0.333 ± 0.019	2.708GluAsp: 2.708 ± 0.06	3.24GluGlu: 3.24 ± 0.072	2.627GluPhe: 2.627 ± 0.053	3.158GluGly: 3.158 ± 0.063	1.166GluHis: 1.166 ± 0.035	4.607GluIle: 4.607 ± 0.084	4.965GluLys: 4.965 ± 0.094	5.211GluLeu: 5.211 ± 0.086	1.471GluMet: 1.471 ± 0.038	3.67GluAsn: 3.67 ± 0.067	1.742GluPro: 1.742 ± 0.049	2.43GluGln: 2.43 ± 0.045	2.467GluArg: 2.467 ± 0.055	3.064GluSer: 3.064 ± 0.054	3.484GluThr: 3.484 ± 0.055	3.697GluVal: 3.697 ± 0.061	0.586GluTrp: 0.586 ± 0.024	1.953GluTyr: 1.953 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	4.02PheAla: 4.02 ± 0.071	0.534PheCys: 0.534 ± 0.027	3.634PheAsp: 3.634 ± 0.062	3.346PheGlu: 3.346 ± 0.059	2.643PhePhe: 2.643 ± 0.068	3.853PheGly: 3.853 ± 0.075	0.886PheHis: 0.886 ± 0.029	2.942PheIle: 2.942 ± 0.067	3.071PheLys: 3.071 ± 0.062	4.475PheLeu: 4.475 ± 0.093	1.09PheMet: 1.09 ± 0.038	2.807PheAsn: 2.807 ± 0.057	1.857PhePro: 1.857 ± 0.045	1.569PheGln: 1.569 ± 0.037	1.847PheArg: 1.847 ± 0.045	3.698PheSer: 3.698 ± 0.069	3.311PheThr: 3.311 ± 0.067	3.565PheVal: 3.565 ± 0.061	0.618PheTrp: 0.618 ± 0.026	2.117PheTyr: 2.117 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	5.185GlyAla: 5.185 ± 0.111	0.766GlyCys: 0.766 ± 0.037	3.531GlyAsp: 3.531 ± 0.056	3.26GlyGlu: 3.26 ± 0.057	3.817GlyPhe: 3.817 ± 0.065	5.11GlyGly: 5.11 ± 0.11	1.342GlyHis: 1.342 ± 0.041	5.069GlyIle: 5.069 ± 0.078	4.844GlyLys: 4.844 ± 0.078	5.876GlyLeu: 5.876 ± 0.079	1.699GlyMet: 1.699 ± 0.045	4.055GlyAsn: 4.055 ± 0.082	1.583GlyPro: 1.583 ± 0.048	2.673GlyGln: 2.673 ± 0.059	2.328GlyArg: 2.328 ± 0.056	4.443GlySer: 4.443 ± 0.081	5.226GlyThr: 5.226 ± 0.152	4.658GlyVal: 4.658 ± 0.066	0.831GlyTrp: 0.831 ± 0.03	3.006GlyTyr: 3.006 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.3HisAla: 1.3 ± 0.03	0.21HisCys: 0.21 ± 0.015	1.074HisAsp: 1.074 ± 0.034	1.012HisGlu: 1.012 ± 0.033	1.303HisPhe: 1.303 ± 0.038	1.211HisGly: 1.211 ± 0.038	0.557HisHis: 0.557 ± 0.025	1.259HisIle: 1.259 ± 0.036	1.031HisLys: 1.031 ± 0.038	1.88HisLeu: 1.88 ± 0.046	0.357HisMet: 0.357 ± 0.019	0.936HisAsn: 0.936 ± 0.031	0.987HisPro: 0.987 ± 0.035	0.831HisGln: 0.831 ± 0.03	0.788HisArg: 0.788 ± 0.027	0.97HisSer: 0.97 ± 0.032	1.063HisThr: 1.063 ± 0.035	1.054HisVal: 1.054 ± 0.037	0.256HisTrp: 0.256 ± 0.014	0.956HisTyr: 0.956 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.012IleAla: 6.012 ± 0.079	0.616IleCys: 0.616 ± 0.025	4.81IleAsp: 4.81 ± 0.078	4.475IleGlu: 4.475 ± 0.085	3.033IlePhe: 3.033 ± 0.071	4.922IleGly: 4.922 ± 0.085	1.204IleHis: 1.204 ± 0.036	4.156IleIle: 4.156 ± 0.078	4.269IleLys: 4.269 ± 0.07	5.662IleLeu: 5.662 ± 0.09	1.213IleMet: 1.213 ± 0.035	3.607IleAsn: 3.607 ± 0.064	2.842IlePro: 2.842 ± 0.049	2.353IleGln: 2.353 ± 0.053	2.59IleArg: 2.59 ± 0.05	4.212IleSer: 4.212 ± 0.07	4.111IleThr: 4.111 ± 0.082	4.891IleVal: 4.891 ± 0.078	0.642IleTrp: 0.642 ± 0.021	2.41IleTyr: 2.41 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.722LysAla: 4.722 ± 0.097	0.322LysCys: 0.322 ± 0.018	3.777LysAsp: 3.777 ± 0.071	4.04LysGlu: 4.04 ± 0.085	2.783LysPhe: 2.783 ± 0.054	3.802LysGly: 3.802 ± 0.077	1.223LysHis: 1.223 ± 0.034	5.272LysIle: 5.272 ± 0.097	5.476LysLys: 5.476 ± 0.103	5.508LysLeu: 5.508 ± 0.094	1.956LysMet: 1.956 ± 0.049	3.954LysAsn: 3.954 ± 0.086	2.633LysPro: 2.633 ± 0.055	2.554LysGln: 2.554 ± 0.058	2.623LysArg: 2.623 ± 0.053	3.777LysSer: 3.777 ± 0.068	4.192LysThr: 4.192 ± 0.075	4.206LysVal: 4.206 ± 0.075	0.687LysTrp: 0.687 ± 0.03	2.485LysTyr: 2.485 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	7.187LeuAla: 7.187 ± 0.101	0.729LeuCys: 0.729 ± 0.029	4.975LeuAsp: 4.975 ± 0.065	5.217LeuGlu: 5.217 ± 0.084	4.668LeuPhe: 4.668 ± 0.09	5.908LeuGly: 5.908 ± 0.09	1.668LeuHis: 1.668 ± 0.041	5.539LeuIle: 5.539 ± 0.087	5.913LeuLys: 5.913 ± 0.107	8.749LeuLeu: 8.749 ± 0.138	2.083LeuMet: 2.083 ± 0.046	4.517LeuAsn: 4.517 ± 0.083	3.722LeuPro: 3.722 ± 0.068	3.549LeuGln: 3.549 ± 0.057	3.662LeuArg: 3.662 ± 0.062	6.259LeuSer: 6.259 ± 0.088	5.487LeuThr: 5.487 ± 0.091	5.976LeuVal: 5.976 ± 0.088	0.828LeuTrp: 0.828 ± 0.032	3.083LeuTyr: 3.083 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.962MetAla: 1.962 ± 0.056	0.13MetCys: 0.13 ± 0.011	1.123MetAsp: 1.123 ± 0.032	1.216MetGlu: 1.216 ± 0.034	0.868MetPhe: 0.868 ± 0.031	1.569MetGly: 1.569 ± 0.046	0.441MetHis: 0.441 ± 0.021	1.416MetIle: 1.416 ± 0.037	2.08MetLys: 2.08 ± 0.044	2.083MetLeu: 2.083 ± 0.053	0.604MetMet: 0.604 ± 0.026	1.183MetAsn: 1.183 ± 0.034	0.948MetPro: 0.948 ± 0.031	0.944MetGln: 0.944 ± 0.028	1.047MetArg: 1.047 ± 0.025	1.28MetSer: 1.28 ± 0.032	1.448MetThr: 1.448 ± 0.039	1.53MetVal: 1.53 ± 0.033	0.193MetTrp: 0.193 ± 0.014	0.694MetTyr: 0.694 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	4.436AsnAla: 4.436 ± 0.084	0.429AsnCys: 0.429 ± 0.026	2.982AsnAsp: 2.982 ± 0.063	2.864AsnGlu: 2.864 ± 0.057	2.819AsnPhe: 2.819 ± 0.061	4.315AsnGly: 4.315 ± 0.086	1.083AsnHis: 1.083 ± 0.034	3.734AsnIle: 3.734 ± 0.081	3.044AsnLys: 3.044 ± 0.062	4.934AsnLeu: 4.934 ± 0.079	1.096AsnMet: 1.096 ± 0.037	3.166AsnAsn: 3.166 ± 0.078	3.033AsnPro: 3.033 ± 0.07	2.232AsnGln: 2.232 ± 0.056	2.205AsnArg: 2.205 ± 0.051	2.907AsnSer: 2.907 ± 0.056	3.46AsnThr: 3.46 ± 0.081	3.599AsnVal: 3.599 ± 0.066	0.731AsnTrp: 0.731 ± 0.033	2.482AsnTyr: 2.482 ± 0.061	0.0AsnXaa: 0.0 ± 0.0
Pro	3.054ProAla: 3.054 ± 0.09	0.259ProCys: 0.259 ± 0.019	2.434ProAsp: 2.434 ± 0.045	2.724ProGlu: 2.724 ± 0.059	1.961ProPhe: 1.961 ± 0.043	2.46ProGly: 2.46 ± 0.056	0.668ProHis: 0.668 ± 0.027	2.631ProIle: 2.631 ± 0.053	2.374ProLys: 2.374 ± 0.053	3.081ProLeu: 3.081 ± 0.062	0.953ProMet: 0.953 ± 0.029	2.433ProAsn: 2.433 ± 0.058	1.043ProPro: 1.043 ± 0.048	1.402ProGln: 1.402 ± 0.043	1.076ProArg: 1.076 ± 0.034	2.346ProSer: 2.346 ± 0.054	2.657ProThr: 2.657 ± 0.082	2.903ProVal: 2.903 ± 0.059	0.347ProTrp: 0.347 ± 0.018	1.413ProTyr: 1.413 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.627GlnAla: 2.627 ± 0.048	0.286GlnCys: 0.286 ± 0.019	1.785GlnAsp: 1.785 ± 0.045	1.883GlnGlu: 1.883 ± 0.049	1.973GlnPhe: 1.973 ± 0.04	2.124GlnGly: 2.124 ± 0.046	0.756GlnHis: 0.756 ± 0.028	2.802GlnIle: 2.802 ± 0.045	2.996GlnLys: 2.996 ± 0.06	3.659GlnLeu: 3.659 ± 0.064	0.966GlnMet: 0.966 ± 0.033	2.301GlnAsn: 2.301 ± 0.052	1.497GlnPro: 1.497 ± 0.043	1.821GlnGln: 1.821 ± 0.05	1.509GlnArg: 1.509 ± 0.039	2.43GlnSer: 2.43 ± 0.048	2.804GlnThr: 2.804 ± 0.064	2.226GlnVal: 2.226 ± 0.051	0.519GlnTrp: 0.519 ± 0.026	1.586GlnTyr: 1.586 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.548ArgAla: 2.548 ± 0.055	0.238ArgCys: 0.238 ± 0.017	1.995ArgAsp: 1.995 ± 0.045	2.393ArgGlu: 2.393 ± 0.051	2.174ArgPhe: 2.174 ± 0.045	1.939ArgGly: 1.939 ± 0.042	0.765ArgHis: 0.765 ± 0.029	3.025ArgIle: 3.025 ± 0.057	2.818ArgLys: 2.818 ± 0.06	3.515ArgLeu: 3.515 ± 0.066	1.122ArgMet: 1.122 ± 0.029	2.202ArgAsn: 2.202 ± 0.051	1.207ArgPro: 1.207 ± 0.032	1.41ArgGln: 1.41 ± 0.043	1.532ArgArg: 1.532 ± 0.046	1.982ArgSer: 1.982 ± 0.042	2.095ArgThr: 2.095 ± 0.043	2.298ArgVal: 2.298 ± 0.05	0.49ArgTrp: 0.49 ± 0.021	1.708ArgTyr: 1.708 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	4.674SerAla: 4.674 ± 0.084	0.611SerCys: 0.611 ± 0.029	3.293SerAsp: 3.293 ± 0.059	3.23SerGlu: 3.23 ± 0.055	3.428SerPhe: 3.428 ± 0.058	5.318SerGly: 5.318 ± 0.086	1.113SerHis: 1.113 ± 0.033	4.09SerIle: 4.09 ± 0.063	3.642SerLys: 3.642 ± 0.07	5.191SerLeu: 5.191 ± 0.079	1.306SerMet: 1.306 ± 0.039	3.186SerAsn: 3.186 ± 0.059	2.278SerPro: 2.278 ± 0.059	2.241SerGln: 2.241 ± 0.049	2.051SerArg: 2.051 ± 0.05	3.515SerSer: 3.515 ± 0.075	3.594SerThr: 3.594 ± 0.075	4.516SerVal: 4.516 ± 0.075	0.734SerTrp: 0.734 ± 0.028	2.399SerTyr: 2.399 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	5.449ThrAla: 5.449 ± 0.131	0.428ThrCys: 0.428 ± 0.022	3.422ThrAsp: 3.422 ± 0.063	3.248ThrGlu: 3.248 ± 0.058	3.214ThrPhe: 3.214 ± 0.058	5.202ThrGly: 5.202 ± 0.146	1.146ThrHis: 1.146 ± 0.03	4.627ThrIle: 4.627 ± 0.092	3.264ThrLys: 3.264 ± 0.061	5.785ThrLeu: 5.785 ± 0.089	1.112ThrMet: 1.112 ± 0.035	3.331ThrAsn: 3.331 ± 0.08	3.212ThrPro: 3.212 ± 0.09	2.391ThrGln: 2.391 ± 0.049	1.922ThrArg: 1.922 ± 0.038	3.678ThrSer: 3.678 ± 0.102	4.395ThrThr: 4.395 ± 0.139	4.952ThrVal: 4.952 ± 0.121	0.712ThrTrp: 0.712 ± 0.032	2.508ThrTyr: 2.508 ± 0.084	0.001ThrXaa: 0.001 ± 0.001
Val	5.622ValAla: 5.622 ± 0.074	0.672ValCys: 0.672 ± 0.03	3.791ValAsp: 3.791 ± 0.069	3.673ValGlu: 3.673 ± 0.064	3.657ValPhe: 3.657 ± 0.067	4.419ValGly: 4.419 ± 0.073	1.126ValHis: 1.126 ± 0.036	4.368ValIle: 4.368 ± 0.075	4.311ValLys: 4.311 ± 0.083	6.137ValLeu: 6.137 ± 0.087	1.441ValMet: 1.441 ± 0.04	3.578ValAsn: 3.578 ± 0.064	2.699ValPro: 2.699 ± 0.057	2.141ValGln: 2.141 ± 0.046	2.533ValArg: 2.533 ± 0.045	4.716ValSer: 4.716 ± 0.075	4.58ValThr: 4.58 ± 0.12	5.146ValVal: 5.146 ± 0.084	0.73ValTrp: 0.73 ± 0.031	2.658ValTyr: 2.658 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.801TrpAla: 0.801 ± 0.028	0.107TrpCys: 0.107 ± 0.01	0.651TrpAsp: 0.651 ± 0.027	0.588TrpGlu: 0.588 ± 0.023	0.618TrpPhe: 0.618 ± 0.025	0.714TrpGly: 0.714 ± 0.027	0.236TrpHis: 0.236 ± 0.014	0.724TrpIle: 0.724 ± 0.026	0.704TrpLys: 0.704 ± 0.028	1.036TrpLeu: 1.036 ± 0.034	0.306TrpMet: 0.306 ± 0.019	0.741TrpAsn: 0.741 ± 0.028	0.283TrpPro: 0.283 ± 0.016	0.502TrpGln: 0.502 ± 0.024	0.444TrpArg: 0.444 ± 0.019	0.716TrpSer: 0.716 ± 0.028	0.763TrpThr: 0.763 ± 0.033	0.689TrpVal: 0.689 ± 0.028	0.143TrpTrp: 0.143 ± 0.012	0.467TrpTyr: 0.467 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.782TyrAla: 2.782 ± 0.05	0.361TyrCys: 0.361 ± 0.02	2.407TyrAsp: 2.407 ± 0.047	2.079TyrGlu: 2.079 ± 0.043	2.416TyrPhe: 2.416 ± 0.053	2.675TyrGly: 2.675 ± 0.06	0.865TyrHis: 0.865 ± 0.028	2.301TyrIle: 2.301 ± 0.047	2.272TyrLys: 2.272 ± 0.049	3.673TyrLeu: 3.673 ± 0.066	0.762TyrMet: 0.762 ± 0.026	2.413TyrAsn: 2.413 ± 0.054	1.534TyrPro: 1.534 ± 0.038	1.621TyrGln: 1.621 ± 0.041	1.836TyrArg: 1.836 ± 0.042	2.389TyrSer: 2.389 ± 0.053	2.504TyrThr: 2.504 ± 0.08	2.363TyrVal: 2.363 ± 0.05	0.51TyrTrp: 0.51 ± 0.023	1.797TyrTyr: 1.797 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.005XaaXaa: 0.005 ± 0.003

Statistics based on 3216 proteins (1096505 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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