Amino acid dipepetide frequency for Streptococcus satellite phage Javan748

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.379AlaAla: 0.379 ± 0.343
0.0AlaCys: 0.0 ± 0.0
2.273AlaAsp: 2.273 ± 0.936
5.303AlaGlu: 5.303 ± 1.688
3.409AlaPhe: 3.409 ± 0.98
1.515AlaGly: 1.515 ± 0.592
0.379AlaHis: 0.379 ± 0.434
4.545AlaIle: 4.545 ± 1.215
6.818AlaLys: 6.818 ± 1.586
2.273AlaLeu: 2.273 ± 1.098
3.03AlaMet: 3.03 ± 1.403
2.273AlaAsn: 2.273 ± 0.825
1.136AlaPro: 1.136 ± 0.696
4.167AlaGln: 4.167 ± 1.509
2.652AlaArg: 2.652 ± 1.262
4.167AlaSer: 4.167 ± 1.346
4.167AlaThr: 4.167 ± 1.12
2.273AlaVal: 2.273 ± 0.726
0.379AlaTrp: 0.379 ± 0.304
2.652AlaTyr: 2.652 ± 0.732
0.0AlaXaa: 0.0 ± 0.0
Cys
0.758CysAla: 0.758 ± 0.525
0.0CysCys: 0.0 ± 0.0
0.379CysAsp: 0.379 ± 0.343
0.758CysGlu: 0.758 ± 0.427
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.379CysHis: 0.379 ± 0.326
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.758CysLeu: 0.758 ± 0.472
0.379CysMet: 0.379 ± 0.392
0.379CysAsn: 0.379 ± 0.453
0.379CysPro: 0.379 ± 0.326
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.379CysVal: 0.379 ± 0.304
0.0CysTrp: 0.0 ± 0.0
0.379CysTyr: 0.379 ± 0.345
0.0CysXaa: 0.0 ± 0.0
Asp
1.515AspAla: 1.515 ± 0.756
0.379AspCys: 0.379 ± 0.326
3.03AspAsp: 3.03 ± 1.469
6.061AspGlu: 6.061 ± 2.489
2.652AspPhe: 2.652 ± 0.705
3.03AspGly: 3.03 ± 0.769
0.379AspHis: 0.379 ± 0.304
6.061AspIle: 6.061 ± 1.508
4.924AspLys: 4.924 ± 1.571
7.955AspLeu: 7.955 ± 2.376
1.515AspMet: 1.515 ± 0.501
2.652AspAsn: 2.652 ± 1.063
0.379AspPro: 0.379 ± 0.304
0.758AspGln: 0.758 ± 0.69
3.788AspArg: 3.788 ± 1.158
2.273AspSer: 2.273 ± 0.836
1.515AspThr: 1.515 ± 0.689
0.758AspVal: 0.758 ± 0.434
0.379AspTrp: 0.379 ± 0.304
3.03AspTyr: 3.03 ± 1.0
0.0AspXaa: 0.0 ± 0.0
Glu
4.545GluAla: 4.545 ± 1.421
1.136GluCys: 1.136 ± 0.516
4.167GluAsp: 4.167 ± 1.287
5.303GluGlu: 5.303 ± 1.269
3.03GluPhe: 3.03 ± 1.285
2.273GluGly: 2.273 ± 0.934
1.515GluHis: 1.515 ± 0.713
5.303GluIle: 5.303 ± 1.279
10.606GluLys: 10.606 ± 2.435
9.091GluLeu: 9.091 ± 2.419
4.545GluMet: 4.545 ± 1.585
6.061GluAsn: 6.061 ± 1.446
1.894GluPro: 1.894 ± 0.955
4.167GluGln: 4.167 ± 0.983
4.924GluArg: 4.924 ± 1.477
4.167GluSer: 4.167 ± 1.441
4.924GluThr: 4.924 ± 1.157
6.061GluVal: 6.061 ± 1.837
0.379GluTrp: 0.379 ± 0.345
6.061GluTyr: 6.061 ± 1.252
0.0GluXaa: 0.0 ± 0.0
Phe
1.136PheAla: 1.136 ± 0.739
0.0PheCys: 0.0 ± 0.0
3.409PheAsp: 3.409 ± 1.416
4.545PheGlu: 4.545 ± 1.436
3.788PhePhe: 3.788 ± 1.785
4.167PheGly: 4.167 ± 1.191
1.136PheHis: 1.136 ± 0.594
3.03PheIle: 3.03 ± 1.021
3.409PheLys: 3.409 ± 1.619
4.545PheLeu: 4.545 ± 1.274
1.136PheMet: 1.136 ± 0.888
1.894PheAsn: 1.894 ± 0.971
0.758PhePro: 0.758 ± 0.392
0.379PheGln: 0.379 ± 0.343
2.273PheArg: 2.273 ± 0.954
3.03PheSer: 3.03 ± 1.064
3.409PheThr: 3.409 ± 1.354
2.652PheVal: 2.652 ± 1.218
0.379PheTrp: 0.379 ± 0.304
1.515PheTyr: 1.515 ± 0.816
0.0PheXaa: 0.0 ± 0.0
Gly
4.167GlyAla: 4.167 ± 1.312
0.0GlyCys: 0.0 ± 0.0
3.03GlyAsp: 3.03 ± 1.203
3.409GlyGlu: 3.409 ± 1.238
2.273GlyPhe: 2.273 ± 0.755
1.136GlyGly: 1.136 ± 0.831
1.136GlyHis: 1.136 ± 0.53
3.03GlyIle: 3.03 ± 0.937
4.545GlyLys: 4.545 ± 1.288
6.439GlyLeu: 6.439 ± 1.457
0.758GlyMet: 0.758 ± 0.608
0.758GlyAsn: 0.758 ± 0.46
0.0GlyPro: 0.0 ± 0.0
1.894GlyGln: 1.894 ± 0.562
2.652GlyArg: 2.652 ± 1.027
2.273GlySer: 2.273 ± 1.018
1.136GlyThr: 1.136 ± 0.531
3.409GlyVal: 3.409 ± 1.084
1.894GlyTrp: 1.894 ± 1.036
2.652GlyTyr: 2.652 ± 0.918
0.0GlyXaa: 0.0 ± 0.0
His
2.652HisAla: 2.652 ± 1.181
0.0HisCys: 0.0 ± 0.0
0.758HisAsp: 0.758 ± 0.448
1.515HisGlu: 1.515 ± 0.84
1.136HisPhe: 1.136 ± 0.946
0.758HisGly: 0.758 ± 0.392
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
1.894HisLys: 1.894 ± 0.82
3.03HisLeu: 3.03 ± 1.013
0.758HisMet: 0.758 ± 0.392
1.515HisAsn: 1.515 ± 0.598
0.379HisPro: 0.379 ± 0.446
0.379HisGln: 0.379 ± 0.446
1.515HisArg: 1.515 ± 1.155
0.0HisSer: 0.0 ± 0.0
1.136HisThr: 1.136 ± 0.692
0.379HisVal: 0.379 ± 0.343
0.0HisTrp: 0.0 ± 0.0
1.515HisTyr: 1.515 ± 0.929
0.0HisXaa: 0.0 ± 0.0
Ile
3.788IleAla: 3.788 ± 1.455
0.379IleCys: 0.379 ± 0.453
2.273IleAsp: 2.273 ± 1.247
6.061IleGlu: 6.061 ± 1.589
2.652IlePhe: 2.652 ± 1.22
3.03IleGly: 3.03 ± 1.076
0.379IleHis: 0.379 ± 0.343
4.924IleIle: 4.924 ± 0.928
9.091IleLys: 9.091 ± 2.319
6.061IleLeu: 6.061 ± 1.004
0.758IleMet: 0.758 ± 0.618
2.652IleAsn: 2.652 ± 1.028
3.03IlePro: 3.03 ± 1.137
2.273IleGln: 2.273 ± 0.715
3.788IleArg: 3.788 ± 1.27
4.924IleSer: 4.924 ± 1.451
3.03IleThr: 3.03 ± 0.968
3.788IleVal: 3.788 ± 1.19
0.0IleTrp: 0.0 ± 0.0
3.788IleTyr: 3.788 ± 1.042
0.0IleXaa: 0.0 ± 0.0
Lys
6.439LysAla: 6.439 ± 1.746
0.0LysCys: 0.0 ± 0.0
8.333LysAsp: 8.333 ± 1.716
9.848LysGlu: 9.848 ± 2.437
4.924LysPhe: 4.924 ± 1.516
5.303LysGly: 5.303 ± 1.241
2.273LysHis: 2.273 ± 1.466
7.955LysIle: 7.955 ± 1.557
9.47LysLys: 9.47 ± 2.369
8.712LysLeu: 8.712 ± 2.074
1.894LysMet: 1.894 ± 0.797
6.061LysAsn: 6.061 ± 1.237
3.409LysPro: 3.409 ± 1.087
3.788LysGln: 3.788 ± 1.194
6.818LysArg: 6.818 ± 1.095
7.576LysSer: 7.576 ± 1.145
4.924LysThr: 4.924 ± 2.247
3.03LysVal: 3.03 ± 0.833
1.136LysTrp: 1.136 ± 0.551
3.788LysTyr: 3.788 ± 1.146
0.0LysXaa: 0.0 ± 0.0
Leu
5.303LeuAla: 5.303 ± 1.435
0.379LeuCys: 0.379 ± 0.392
5.303LeuAsp: 5.303 ± 1.72
9.47LeuGlu: 9.47 ± 1.463
4.167LeuPhe: 4.167 ± 1.544
3.788LeuGly: 3.788 ± 0.992
1.515LeuHis: 1.515 ± 1.062
4.924LeuIle: 4.924 ± 1.514
11.742LeuLys: 11.742 ± 1.941
9.091LeuLeu: 9.091 ± 2.879
1.894LeuMet: 1.894 ± 0.814
7.197LeuAsn: 7.197 ± 1.86
4.167LeuPro: 4.167 ± 0.887
3.788LeuGln: 3.788 ± 1.405
3.788LeuArg: 3.788 ± 1.203
4.924LeuSer: 4.924 ± 1.078
7.576LeuThr: 7.576 ± 1.979
5.682LeuVal: 5.682 ± 1.392
0.379LeuTrp: 0.379 ± 0.446
3.03LeuTyr: 3.03 ± 1.127
0.0LeuXaa: 0.0 ± 0.0
Met
1.515MetAla: 1.515 ± 0.647
0.0MetCys: 0.0 ± 0.0
1.894MetAsp: 1.894 ± 0.72
1.894MetGlu: 1.894 ± 1.048
1.136MetPhe: 1.136 ± 0.69
1.515MetGly: 1.515 ± 0.845
0.0MetHis: 0.0 ± 0.0
2.652MetIle: 2.652 ± 1.038
2.652MetLys: 2.652 ± 0.705
1.136MetLeu: 1.136 ± 0.601
0.379MetMet: 0.379 ± 0.345
2.273MetAsn: 2.273 ± 0.877
0.0MetPro: 0.0 ± 0.0
1.515MetGln: 1.515 ± 0.692
1.894MetArg: 1.894 ± 0.983
0.758MetSer: 0.758 ± 0.538
1.136MetThr: 1.136 ± 0.694
2.652MetVal: 2.652 ± 0.978
0.0MetTrp: 0.0 ± 0.0
0.758MetTyr: 0.758 ± 0.392
0.0MetXaa: 0.0 ± 0.0
Asn
2.652AsnAla: 2.652 ± 1.165
0.758AsnCys: 0.758 ± 0.472
3.409AsnAsp: 3.409 ± 1.234
3.409AsnGlu: 3.409 ± 1.184
0.758AsnPhe: 0.758 ± 0.59
3.03AsnGly: 3.03 ± 1.31
3.03AsnHis: 3.03 ± 0.904
0.758AsnIle: 0.758 ± 0.392
5.682AsnLys: 5.682 ± 1.334
7.197AsnLeu: 7.197 ± 1.53
0.379AsnMet: 0.379 ± 0.317
1.136AsnAsn: 1.136 ± 0.593
1.894AsnPro: 1.894 ± 0.882
3.409AsnGln: 3.409 ± 1.02
3.409AsnArg: 3.409 ± 0.905
4.167AsnSer: 4.167 ± 1.091
2.273AsnThr: 2.273 ± 0.995
1.515AsnVal: 1.515 ± 0.647
1.136AsnTrp: 1.136 ± 0.484
1.894AsnTyr: 1.894 ± 0.765
0.0AsnXaa: 0.0 ± 0.0
Pro
0.758ProAla: 0.758 ± 0.652
0.0ProCys: 0.0 ± 0.0
2.273ProAsp: 2.273 ± 0.748
3.409ProGlu: 3.409 ± 1.395
1.136ProPhe: 1.136 ± 0.507
0.758ProGly: 0.758 ± 0.672
0.0ProHis: 0.0 ± 0.0
1.894ProIle: 1.894 ± 0.871
3.409ProLys: 3.409 ± 1.451
1.515ProLeu: 1.515 ± 0.771
1.136ProMet: 1.136 ± 0.671
0.758ProAsn: 0.758 ± 0.427
2.273ProPro: 2.273 ± 1.178
0.379ProGln: 0.379 ± 0.326
1.136ProArg: 1.136 ± 0.735
1.136ProSer: 1.136 ± 0.845
1.515ProThr: 1.515 ± 0.648
1.136ProVal: 1.136 ± 0.515
0.379ProTrp: 0.379 ± 0.504
1.515ProTyr: 1.515 ± 0.676
0.0ProXaa: 0.0 ± 0.0
Gln
4.924GlnAla: 4.924 ± 2.045
0.0GlnCys: 0.0 ± 0.0
1.136GlnAsp: 1.136 ± 0.614
4.924GlnGlu: 4.924 ± 1.563
2.652GlnPhe: 2.652 ± 0.831
1.136GlnGly: 1.136 ± 0.627
1.515GlnHis: 1.515 ± 1.051
3.788GlnIle: 3.788 ± 1.652
4.167GlnLys: 4.167 ± 1.425
4.924GlnLeu: 4.924 ± 1.587
0.758GlnMet: 0.758 ± 0.587
2.273GlnAsn: 2.273 ± 0.855
0.379GlnPro: 0.379 ± 0.421
2.273GlnGln: 2.273 ± 0.977
1.515GlnArg: 1.515 ± 1.002
1.136GlnSer: 1.136 ± 0.738
1.515GlnThr: 1.515 ± 0.64
2.652GlnVal: 2.652 ± 1.145
0.758GlnTrp: 0.758 ± 0.519
1.136GlnTyr: 1.136 ± 0.487
0.0GlnXaa: 0.0 ± 0.0
Arg
3.03ArgAla: 3.03 ± 1.498
0.0ArgCys: 0.0 ± 0.0
3.788ArgAsp: 3.788 ± 0.887
5.682ArgGlu: 5.682 ± 1.548
2.273ArgPhe: 2.273 ± 0.987
3.03ArgGly: 3.03 ± 1.285
1.515ArgHis: 1.515 ± 0.672
3.03ArgIle: 3.03 ± 1.134
4.924ArgLys: 4.924 ± 1.433
4.924ArgLeu: 4.924 ± 1.367
1.894ArgMet: 1.894 ± 1.064
1.515ArgAsn: 1.515 ± 0.799
1.136ArgPro: 1.136 ± 0.612
3.409ArgGln: 3.409 ± 0.981
2.273ArgArg: 2.273 ± 1.047
2.652ArgSer: 2.652 ± 0.913
2.652ArgThr: 2.652 ± 0.778
2.273ArgVal: 2.273 ± 0.925
0.0ArgTrp: 0.0 ± 0.0
3.788ArgTyr: 3.788 ± 1.07
0.0ArgXaa: 0.0 ± 0.0
Ser
2.273SerAla: 2.273 ± 0.829
0.758SerCys: 0.758 ± 0.392
2.273SerAsp: 2.273 ± 0.928
5.303SerGlu: 5.303 ± 1.793
3.409SerPhe: 3.409 ± 0.994
3.03SerGly: 3.03 ± 0.598
1.515SerHis: 1.515 ± 0.836
4.545SerIle: 4.545 ± 1.695
5.303SerLys: 5.303 ± 1.19
4.167SerLeu: 4.167 ± 0.914
1.894SerMet: 1.894 ± 0.724
2.652SerAsn: 2.652 ± 0.764
1.515SerPro: 1.515 ± 0.635
1.515SerGln: 1.515 ± 0.824
2.652SerArg: 2.652 ± 0.863
3.03SerSer: 3.03 ± 0.963
4.545SerThr: 4.545 ± 1.471
2.273SerVal: 2.273 ± 0.872
0.379SerTrp: 0.379 ± 0.392
1.515SerTyr: 1.515 ± 0.639
0.0SerXaa: 0.0 ± 0.0
Thr
1.894ThrAla: 1.894 ± 0.87
0.0ThrCys: 0.0 ± 0.0
1.515ThrAsp: 1.515 ± 1.217
3.788ThrGlu: 3.788 ± 1.002
2.273ThrPhe: 2.273 ± 0.521
4.167ThrGly: 4.167 ± 1.265
0.758ThrHis: 0.758 ± 0.427
3.03ThrIle: 3.03 ± 1.2
3.409ThrLys: 3.409 ± 1.06
4.924ThrLeu: 4.924 ± 1.492
0.758ThrMet: 0.758 ± 0.502
4.167ThrAsn: 4.167 ± 1.146
1.515ThrPro: 1.515 ± 0.638
3.409ThrGln: 3.409 ± 1.085
1.894ThrArg: 1.894 ± 0.749
3.03ThrSer: 3.03 ± 0.831
1.894ThrThr: 1.894 ± 0.863
6.061ThrVal: 6.061 ± 2.188
0.758ThrTrp: 0.758 ± 0.525
3.788ThrTyr: 3.788 ± 1.608
0.0ThrXaa: 0.0 ± 0.0
Val
4.167ValAla: 4.167 ± 1.71
0.379ValCys: 0.379 ± 0.343
1.894ValAsp: 1.894 ± 0.72
4.167ValGlu: 4.167 ± 1.027
2.273ValPhe: 2.273 ± 0.928
1.894ValGly: 1.894 ± 0.576
0.758ValHis: 0.758 ± 0.392
3.03ValIle: 3.03 ± 1.268
6.061ValLys: 6.061 ± 1.32
4.167ValLeu: 4.167 ± 1.284
0.758ValMet: 0.758 ± 0.483
3.788ValAsn: 3.788 ± 1.028
0.379ValPro: 0.379 ± 0.326
1.894ValGln: 1.894 ± 0.771
2.652ValArg: 2.652 ± 1.142
2.273ValSer: 2.273 ± 1.46
3.409ValThr: 3.409 ± 0.86
1.894ValVal: 1.894 ± 0.746
0.379ValTrp: 0.379 ± 0.453
3.03ValTyr: 3.03 ± 1.1
0.0ValXaa: 0.0 ± 0.0
Trp
0.379TrpAla: 0.379 ± 0.326
0.379TrpCys: 0.379 ± 0.304
0.0TrpAsp: 0.0 ± 0.0
1.515TrpGlu: 1.515 ± 0.732
0.379TrpPhe: 0.379 ± 0.343
0.379TrpGly: 0.379 ± 0.304
0.0TrpHis: 0.0 ± 0.0
1.515TrpIle: 1.515 ± 0.914
0.758TrpLys: 0.758 ± 0.545
1.136TrpLeu: 1.136 ± 0.557
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.379TrpGln: 0.379 ± 0.345
1.136TrpArg: 1.136 ± 0.639
0.379TrpSer: 0.379 ± 0.326
0.758TrpThr: 0.758 ± 0.392
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.515TyrAla: 1.515 ± 0.754
0.379TyrCys: 0.379 ± 0.326
1.894TyrAsp: 1.894 ± 0.521
3.788TyrGlu: 3.788 ± 1.147
2.273TyrPhe: 2.273 ± 1.04
2.652TyrGly: 2.652 ± 1.004
1.136TyrHis: 1.136 ± 0.507
3.03TyrIle: 3.03 ± 0.828
6.818TyrLys: 6.818 ± 2.063
6.061TyrLeu: 6.061 ± 1.634
0.758TyrMet: 0.758 ± 0.656
1.894TyrAsn: 1.894 ± 0.986
1.894TyrPro: 1.894 ± 0.713
3.788TyrGln: 3.788 ± 1.004
3.03TyrArg: 3.03 ± 1.229
2.652TyrSer: 2.652 ± 0.996
1.515TyrThr: 1.515 ± 0.635
0.379TyrVal: 0.379 ± 0.453
0.379TyrTrp: 0.379 ± 0.345
1.894TyrTyr: 1.894 ± 0.964
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 15 proteins (2641 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski