Amino acid dipepetide frequency for Poliovirus type 1 (strain Mahoney)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.279AlaAla: 5.279 ± 2.087
2.64AlaCys: 2.64 ± 1.043
2.2AlaAsp: 2.2 ± 0.87
0.88AlaGlu: 0.88 ± 0.348
3.52AlaPhe: 3.52 ± 1.391
5.279AlaGly: 5.279 ± 4.042
0.88AlaHis: 0.88 ± 0.348
2.2AlaIle: 2.2 ± 0.87
2.64AlaLys: 2.64 ± 1.043
7.039AlaLeu: 7.039 ± 2.783
3.52AlaMet: 3.52 ± 1.391
3.08AlaAsn: 3.08 ± 4.911
3.96AlaPro: 3.96 ± 4.563
1.76AlaGln: 1.76 ± 0.696
3.96AlaArg: 3.96 ± 1.565
7.479AlaSer: 7.479 ± 2.956
4.839AlaThr: 4.839 ± 1.913
7.039AlaVal: 7.039 ± 2.783
0.88AlaTrp: 0.88 ± 0.348
3.08AlaTyr: 3.08 ± 1.217
0.0AlaXaa: 0.0 ± 0.0
Cys
0.88CysAla: 0.88 ± 0.348
0.88CysCys: 0.88 ± 0.348
1.32CysAsp: 1.32 ± 0.522
1.32CysGlu: 1.32 ± 0.522
0.0CysPhe: 0.0 ± 0.0
2.2CysGly: 2.2 ± 0.87
0.88CysHis: 0.88 ± 0.348
0.44CysIle: 0.44 ± 0.174
0.44CysLys: 0.44 ± 0.174
2.2CysLeu: 2.2 ± 0.87
0.44CysMet: 0.44 ± 0.174
2.64CysAsn: 2.64 ± 1.043
1.76CysPro: 1.76 ± 0.696
0.44CysGln: 0.44 ± 0.174
0.44CysArg: 0.44 ± 0.174
0.88CysSer: 0.88 ± 5.781
0.88CysThr: 0.88 ± 0.348
0.88CysVal: 0.88 ± 0.348
0.0CysTrp: 0.0 ± 0.0
0.44CysTyr: 0.44 ± 5.955
0.0CysXaa: 0.0 ± 0.0
Asp
3.52AspAla: 3.52 ± 1.391
0.88AspCys: 0.88 ± 5.781
2.64AspAsp: 2.64 ± 1.043
1.32AspGlu: 1.32 ± 0.522
1.76AspPhe: 1.76 ± 0.696
3.52AspGly: 3.52 ± 1.391
1.76AspHis: 1.76 ± 0.696
3.96AspIle: 3.96 ± 1.565
2.64AspLys: 2.64 ± 1.043
4.839AspLeu: 4.839 ± 1.913
1.76AspMet: 1.76 ± 0.696
2.2AspAsn: 2.2 ± 0.87
3.52AspPro: 3.52 ± 1.391
1.76AspGln: 1.76 ± 0.696
0.88AspArg: 0.88 ± 0.348
4.839AspSer: 4.839 ± 1.913
3.52AspThr: 3.52 ± 1.391
2.2AspVal: 2.2 ± 0.87
0.44AspTrp: 0.44 ± 0.174
3.96AspTyr: 3.96 ± 1.565
0.0AspXaa: 0.0 ± 0.0
Glu
6.599GluAla: 6.599 ± 2.609
0.44GluCys: 0.44 ± 0.174
1.32GluAsp: 1.32 ± 0.522
3.08GluGlu: 3.08 ± 1.217
2.64GluPhe: 2.64 ± 1.043
1.32GluGly: 1.32 ± 0.522
0.88GluHis: 0.88 ± 0.348
4.399GluIle: 4.399 ± 1.739
4.399GluLys: 4.399 ± 1.739
1.76GluLeu: 1.76 ± 0.696
2.64GluMet: 2.64 ± 1.043
1.76GluAsn: 1.76 ± 0.696
2.2GluPro: 2.2 ± 0.87
2.2GluGln: 2.2 ± 0.87
1.32GluArg: 1.32 ± 0.522
4.839GluSer: 4.839 ± 4.216
2.2GluThr: 2.2 ± 0.87
2.64GluVal: 2.64 ± 1.043
0.44GluTrp: 0.44 ± 0.174
2.2GluTyr: 2.2 ± 0.87
0.0GluXaa: 0.0 ± 0.0
Phe
5.279PheAla: 5.279 ± 4.042
1.32PheCys: 1.32 ± 0.522
3.08PheAsp: 3.08 ± 1.217
1.76PheGlu: 1.76 ± 0.696
1.32PhePhe: 1.32 ± 0.522
2.64PheGly: 2.64 ± 1.043
1.32PheHis: 1.32 ± 0.522
1.32PheIle: 1.32 ± 5.607
0.88PheLys: 0.88 ± 0.348
1.76PheLeu: 1.76 ± 0.696
0.88PheMet: 0.88 ± 0.304
1.32PheAsn: 1.32 ± 0.522
0.88PhePro: 0.88 ± 0.348
1.32PheGln: 1.32 ± 0.522
0.88PheArg: 0.88 ± 0.348
2.2PheSer: 2.2 ± 0.87
5.719PheThr: 5.719 ± 3.868
2.2PheVal: 2.2 ± 0.87
0.44PheTrp: 0.44 ± 0.174
1.76PheTyr: 1.76 ± 0.696
0.0PheXaa: 0.0 ± 0.0
Gly
5.719GlyAla: 5.719 ± 2.261
1.76GlyCys: 1.76 ± 5.433
2.64GlyAsp: 2.64 ± 1.043
3.52GlyGlu: 3.52 ± 1.391
4.399GlyPhe: 4.399 ± 4.389
3.96GlyGly: 3.96 ± 1.565
2.2GlyHis: 2.2 ± 5.259
3.96GlyIle: 3.96 ± 1.565
3.96GlyLys: 3.96 ± 1.565
4.399GlyLeu: 4.399 ± 1.739
0.88GlyMet: 0.88 ± 0.348
3.08GlyAsn: 3.08 ± 1.217
2.2GlyPro: 2.2 ± 0.87
1.76GlyGln: 1.76 ± 0.696
2.2GlyArg: 2.2 ± 5.259
3.52GlySer: 3.52 ± 4.737
4.839GlyThr: 4.839 ± 1.913
4.839GlyVal: 4.839 ± 1.913
0.88GlyTrp: 0.88 ± 0.348
3.96GlyTyr: 3.96 ± 1.565
0.0GlyXaa: 0.0 ± 0.0
His
0.88HisAla: 0.88 ± 0.348
0.0HisCys: 0.0 ± 0.0
0.44HisAsp: 0.44 ± 0.174
1.32HisGlu: 1.32 ± 0.522
0.88HisPhe: 0.88 ± 0.348
1.76HisGly: 1.76 ± 0.696
0.88HisHis: 0.88 ± 0.348
1.32HisIle: 1.32 ± 0.522
0.88HisLys: 0.88 ± 5.781
1.32HisLeu: 1.32 ± 0.522
0.44HisMet: 0.44 ± 0.174
1.76HisAsn: 1.76 ± 5.433
0.88HisPro: 0.88 ± 5.781
3.08HisGln: 3.08 ± 1.217
0.88HisArg: 0.88 ± 0.348
1.32HisSer: 1.32 ± 0.522
1.76HisThr: 1.76 ± 0.696
2.2HisVal: 2.2 ± 0.87
0.44HisTrp: 0.44 ± 0.174
1.32HisTyr: 1.32 ± 0.522
0.0HisXaa: 0.0 ± 0.0
Ile
3.08IleAla: 3.08 ± 1.217
0.44IleCys: 0.44 ± 0.174
4.839IleAsp: 4.839 ± 1.913
2.64IleGlu: 2.64 ± 1.043
1.32IlePhe: 1.32 ± 0.522
3.52IleGly: 3.52 ± 4.737
1.32IleHis: 1.32 ± 0.522
4.399IleIle: 4.399 ± 4.389
2.2IleLys: 2.2 ± 0.87
5.279IleLeu: 5.279 ± 2.087
1.32IleMet: 1.32 ± 0.522
4.839IleAsn: 4.839 ± 1.913
3.96IlePro: 3.96 ± 1.565
2.64IleGln: 2.64 ± 1.043
3.96IleArg: 3.96 ± 4.563
4.839IleSer: 4.839 ± 10.344
8.359IleThr: 8.359 ± 8.953
2.2IleVal: 2.2 ± 0.87
0.44IleTrp: 0.44 ± 0.174
0.44IleTyr: 0.44 ± 5.955
0.0IleXaa: 0.0 ± 0.0
Lys
2.64LysAla: 2.64 ± 5.085
0.0LysCys: 0.0 ± 0.0
4.399LysAsp: 4.399 ± 1.739
4.399LysGlu: 4.399 ± 1.739
3.08LysPhe: 3.08 ± 1.217
3.08LysGly: 3.08 ± 1.217
1.32LysHis: 1.32 ± 0.522
5.279LysIle: 5.279 ± 2.087
3.52LysLys: 3.52 ± 1.391
6.159LysLeu: 6.159 ± 2.435
0.88LysMet: 0.88 ± 0.348
3.08LysAsn: 3.08 ± 1.217
1.32LysPro: 1.32 ± 0.522
1.76LysGln: 1.76 ± 0.696
3.96LysArg: 3.96 ± 1.565
2.2LysSer: 2.2 ± 0.87
3.08LysThr: 3.08 ± 1.217
3.08LysVal: 3.08 ± 4.911
0.44LysTrp: 0.44 ± 0.174
1.76LysTyr: 1.76 ± 0.696
0.0LysXaa: 0.0 ± 0.0
Leu
5.719LeuAla: 5.719 ± 2.261
0.88LeuCys: 0.88 ± 0.348
3.08LeuAsp: 3.08 ± 1.217
6.599LeuGlu: 6.599 ± 2.609
4.839LeuPhe: 4.839 ± 4.216
6.159LeuGly: 6.159 ± 2.435
0.0LeuHis: 0.0 ± 0.0
3.96LeuIle: 3.96 ± 4.563
6.159LeuLys: 6.159 ± 2.435
7.039LeuLeu: 7.039 ± 2.783
1.76LeuMet: 1.76 ± 0.696
4.839LeuAsn: 4.839 ± 1.913
5.279LeuPro: 5.279 ± 2.087
3.08LeuGln: 3.08 ± 1.217
4.399LeuArg: 4.399 ± 1.739
5.719LeuSer: 5.719 ± 9.996
4.399LeuThr: 4.399 ± 1.739
3.96LeuVal: 3.96 ± 1.565
0.0LeuTrp: 0.0 ± 0.0
3.08LeuTyr: 3.08 ± 4.911
0.0LeuXaa: 0.0 ± 0.0
Met
2.64MetAla: 2.64 ± 1.043
1.76MetCys: 1.76 ± 0.696
1.76MetAsp: 1.76 ± 0.696
3.08MetGlu: 3.08 ± 1.217
0.0MetPhe: 0.0 ± 0.0
1.32MetGly: 1.32 ± 0.522
0.88MetHis: 0.88 ± 0.348
2.2MetIle: 2.2 ± 0.87
1.32MetLys: 1.32 ± 0.522
3.08MetLeu: 3.08 ± 1.217
0.88MetMet: 0.88 ± 0.348
0.88MetAsn: 0.88 ± 0.348
0.88MetPro: 0.88 ± 0.348
0.44MetGln: 0.44 ± 0.174
0.88MetArg: 0.88 ± 0.348
0.44MetSer: 0.44 ± 0.174
1.32MetThr: 1.32 ± 0.522
2.64MetVal: 2.64 ± 5.085
0.44MetTrp: 0.44 ± 0.174
3.08MetTyr: 3.08 ± 1.217
0.0MetXaa: 0.0 ± 0.0
Asn
3.96AsnAla: 3.96 ± 1.565
1.76AsnCys: 1.76 ± 0.696
3.08AsnAsp: 3.08 ± 1.217
1.32AsnGlu: 1.32 ± 0.522
2.2AsnPhe: 2.2 ± 0.87
2.64AsnGly: 2.64 ± 5.085
0.44AsnHis: 0.44 ± 0.174
2.64AsnIle: 2.64 ± 1.043
3.52AsnLys: 3.52 ± 1.391
3.52AsnLeu: 3.52 ± 1.391
2.2AsnMet: 2.2 ± 0.87
3.52AsnAsn: 3.52 ± 1.391
3.52AsnPro: 3.52 ± 1.391
2.2AsnGln: 2.2 ± 0.87
1.32AsnArg: 1.32 ± 0.522
3.08AsnSer: 3.08 ± 1.217
4.399AsnThr: 4.399 ± 1.739
2.2AsnVal: 2.2 ± 0.87
0.88AsnTrp: 0.88 ± 5.781
3.96AsnTyr: 3.96 ± 1.565
0.0AsnXaa: 0.0 ± 0.0
Pro
4.399ProAla: 4.399 ± 1.739
0.44ProCys: 0.44 ± 0.174
2.64ProAsp: 2.64 ± 1.043
3.08ProGlu: 3.08 ± 1.217
0.88ProPhe: 0.88 ± 0.348
4.839ProGly: 4.839 ± 1.913
1.76ProHis: 1.76 ± 0.696
2.64ProIle: 2.64 ± 1.043
0.88ProLys: 0.88 ± 0.348
4.839ProLeu: 4.839 ± 4.216
1.76ProMet: 1.76 ± 0.696
2.2ProAsn: 2.2 ± 0.87
4.399ProPro: 4.399 ± 1.739
0.44ProGln: 0.44 ± 0.174
3.08ProArg: 3.08 ± 1.217
3.96ProSer: 3.96 ± 1.565
3.96ProThr: 3.96 ± 1.565
4.399ProVal: 4.399 ± 4.389
0.88ProTrp: 0.88 ± 0.348
1.76ProTyr: 1.76 ± 0.696
0.0ProXaa: 0.0 ± 0.0
Gln
1.76GlnAla: 1.76 ± 0.696
0.88GlnCys: 0.88 ± 0.348
1.76GlnAsp: 1.76 ± 0.696
1.76GlnGlu: 1.76 ± 0.696
0.44GlnPhe: 0.44 ± 0.174
5.719GlnGly: 5.719 ± 2.261
0.44GlnHis: 0.44 ± 0.174
2.64GlnIle: 2.64 ± 1.043
1.76GlnLys: 1.76 ± 0.696
2.64GlnLeu: 2.64 ± 5.085
1.32GlnMet: 1.32 ± 0.522
2.2GlnAsn: 2.2 ± 0.87
0.88GlnPro: 0.88 ± 0.348
0.88GlnGln: 0.88 ± 0.348
0.0GlnArg: 0.0 ± 0.0
3.52GlnSer: 3.52 ± 1.391
3.52GlnThr: 3.52 ± 1.391
1.76GlnVal: 1.76 ± 0.696
0.88GlnTrp: 0.88 ± 0.348
1.32GlnTyr: 1.32 ± 0.522
0.0GlnXaa: 0.0 ± 0.0
Arg
3.52ArgAla: 3.52 ± 1.391
1.32ArgCys: 1.32 ± 0.522
5.719ArgAsp: 5.719 ± 2.261
1.32ArgGlu: 1.32 ± 0.522
2.64ArgPhe: 2.64 ± 1.043
0.88ArgGly: 0.88 ± 0.348
0.44ArgHis: 0.44 ± 0.174
2.2ArgIle: 2.2 ± 0.87
1.76ArgLys: 1.76 ± 0.696
3.08ArgLeu: 3.08 ± 4.911
0.44ArgMet: 0.44 ± 0.174
3.08ArgAsn: 3.08 ± 1.217
1.32ArgPro: 1.32 ± 0.522
1.76ArgGln: 1.76 ± 5.433
2.64ArgArg: 2.64 ± 1.043
3.52ArgSer: 3.52 ± 1.391
2.2ArgThr: 2.2 ± 5.259
3.08ArgVal: 3.08 ± 1.217
1.76ArgTrp: 1.76 ± 0.696
0.88ArgTyr: 0.88 ± 0.348
0.0ArgXaa: 0.0 ± 0.0
Ser
3.96SerAla: 3.96 ± 4.563
0.88SerCys: 0.88 ± 0.348
3.08SerAsp: 3.08 ± 1.217
1.32SerGlu: 1.32 ± 0.522
1.76SerPhe: 1.76 ± 0.696
3.52SerGly: 3.52 ± 10.866
2.64SerHis: 2.64 ± 1.043
4.399SerIle: 4.399 ± 4.389
7.039SerLys: 7.039 ± 2.783
6.159SerLeu: 6.159 ± 2.435
1.32SerMet: 1.32 ± 0.522
4.399SerAsn: 4.399 ± 1.739
5.279SerPro: 5.279 ± 2.087
2.64SerGln: 2.64 ± 1.043
4.839SerArg: 4.839 ± 1.913
3.96SerSer: 3.96 ± 1.565
6.159SerThr: 6.159 ± 9.822
3.52SerVal: 3.52 ± 4.737
0.88SerTrp: 0.88 ± 0.348
1.76SerTyr: 1.76 ± 0.696
0.0SerXaa: 0.0 ± 0.0
Thr
4.399ThrAla: 4.399 ± 1.739
0.44ThrCys: 0.44 ± 0.174
2.2ThrAsp: 2.2 ± 5.259
7.039ThrGlu: 7.039 ± 3.346
3.52ThrPhe: 3.52 ± 1.391
3.52ThrGly: 3.52 ± 1.391
2.2ThrHis: 2.2 ± 0.87
6.159ThrIle: 6.159 ± 9.822
4.399ThrLys: 4.399 ± 1.739
5.719ThrLeu: 5.719 ± 3.868
3.52ThrMet: 3.52 ± 1.586
4.399ThrAsn: 4.399 ± 1.739
2.64ThrPro: 2.64 ± 1.043
2.64ThrGln: 2.64 ± 1.043
2.2ThrArg: 2.2 ± 0.87
6.159ThrSer: 6.159 ± 2.435
5.719ThrThr: 5.719 ± 2.261
5.279ThrVal: 5.279 ± 4.042
0.88ThrTrp: 0.88 ± 0.348
4.399ThrTyr: 4.399 ± 1.739
0.0ThrXaa: 0.0 ± 0.0
Val
4.839ValAla: 4.839 ± 1.913
0.88ValCys: 0.88 ± 0.348
3.96ValAsp: 3.96 ± 1.565
2.2ValGlu: 2.2 ± 0.87
2.2ValPhe: 2.2 ± 5.259
3.96ValGly: 3.96 ± 1.565
1.32ValHis: 1.32 ± 0.522
4.839ValIle: 4.839 ± 4.216
2.64ValLys: 2.64 ± 5.085
4.399ValLeu: 4.399 ± 1.739
2.2ValMet: 2.2 ± 0.87
2.2ValAsn: 2.2 ± 0.87
4.839ValPro: 4.839 ± 1.913
2.64ValGln: 2.64 ± 1.043
3.96ValArg: 3.96 ± 4.563
3.08ValSer: 3.08 ± 1.217
6.159ValThr: 6.159 ± 3.694
3.52ValVal: 3.52 ± 1.391
0.88ValTrp: 0.88 ± 0.348
2.2ValTyr: 2.2 ± 0.87
0.0ValXaa: 0.0 ± 0.0
Trp
0.44TrpAla: 0.44 ± 0.174
0.44TrpCys: 0.44 ± 0.174
0.88TrpAsp: 0.88 ± 0.348
0.44TrpGlu: 0.44 ± 0.174
0.44TrpPhe: 0.44 ± 0.174
0.44TrpGly: 0.44 ± 0.174
0.44TrpHis: 0.44 ± 0.174
1.32TrpIle: 1.32 ± 5.607
0.88TrpLys: 0.88 ± 0.348
2.2TrpLeu: 2.2 ± 0.87
0.44TrpMet: 0.44 ± 0.174
0.0TrpAsn: 0.0 ± 0.0
0.44TrpPro: 0.44 ± 0.174
0.88TrpGln: 0.88 ± 0.348
0.0TrpArg: 0.0 ± 0.0
0.88TrpSer: 0.88 ± 0.348
0.88TrpThr: 0.88 ± 0.348
0.44TrpVal: 0.44 ± 0.174
0.88TrpTrp: 0.88 ± 0.348
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.64TyrAla: 2.64 ± 1.043
1.32TyrCys: 1.32 ± 0.522
0.88TyrAsp: 0.88 ± 0.348
0.88TyrGlu: 0.88 ± 0.348
0.44TyrPhe: 0.44 ± 0.174
4.399TyrGly: 4.399 ± 1.739
1.76TyrHis: 1.76 ± 11.561
1.76TyrIle: 1.76 ± 0.696
3.52TyrLys: 3.52 ± 1.391
3.52TyrLeu: 3.52 ± 4.737
0.88TyrMet: 0.88 ± 0.348
0.88TyrAsn: 0.88 ± 0.348
3.08TyrPro: 3.08 ± 1.217
1.76TyrGln: 1.76 ± 0.696
1.76TyrArg: 1.76 ± 0.696
3.08TyrSer: 3.08 ± 1.217
3.96TyrThr: 3.96 ± 1.565
4.839TyrVal: 4.839 ± 1.913
0.0TyrTrp: 0.0 ± 0.0
3.08TyrTyr: 3.08 ± 1.217
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2274 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski