Amino acid dipepetide frequency for Tranquillimonas alkanivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.02AlaAla: 18.02 ± 0.176	1.121AlaCys: 1.121 ± 0.032	6.911AlaAsp: 6.911 ± 0.081	9.197AlaGlu: 9.197 ± 0.091	4.479AlaPhe: 4.479 ± 0.055	10.72AlaGly: 10.72 ± 0.104	2.392AlaHis: 2.392 ± 0.04	5.345AlaIle: 5.345 ± 0.064	3.305AlaLys: 3.305 ± 0.058	14.155AlaLeu: 14.155 ± 0.147	3.695AlaMet: 3.695 ± 0.056	2.302AlaAsn: 2.302 ± 0.043	6.291AlaPro: 6.291 ± 0.078	4.146AlaGln: 4.146 ± 0.065	9.9AlaArg: 9.9 ± 0.117	5.464AlaSer: 5.464 ± 0.067	6.074AlaThr: 6.074 ± 0.074	9.193AlaVal: 9.193 ± 0.087	1.696AlaTrp: 1.696 ± 0.04	2.337AlaTyr: 2.337 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.058CysAla: 1.058 ± 0.031	0.105CysCys: 0.105 ± 0.008	0.618CysAsp: 0.618 ± 0.023	0.454CysGlu: 0.454 ± 0.017	0.304CysPhe: 0.304 ± 0.015	0.98CysGly: 0.98 ± 0.026	0.274CysHis: 0.274 ± 0.015	0.363CysIle: 0.363 ± 0.018	0.153CysLys: 0.153 ± 0.011	0.847CysLeu: 0.847 ± 0.024	0.15CysMet: 0.15 ± 0.012	0.183CysAsn: 0.183 ± 0.012	0.505CysPro: 0.505 ± 0.021	0.205CysGln: 0.205 ± 0.012	0.64CysArg: 0.64 ± 0.023	0.414CysSer: 0.414 ± 0.016	0.406CysThr: 0.406 ± 0.019	0.624CysVal: 0.624 ± 0.023	0.122CysTrp: 0.122 ± 0.01	0.185CysTyr: 0.185 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.912AspAla: 7.912 ± 0.099	0.459AspCys: 0.459 ± 0.018	3.501AspAsp: 3.501 ± 0.06	4.231AspGlu: 4.231 ± 0.069	2.2AspPhe: 2.2 ± 0.046	5.6AspGly: 5.6 ± 0.073	1.296AspHis: 1.296 ± 0.037	2.829AspIle: 2.829 ± 0.054	1.333AspLys: 1.333 ± 0.039	6.479AspLeu: 6.479 ± 0.073	1.456AspMet: 1.456 ± 0.031	1.101AspAsn: 1.101 ± 0.032	3.846AspPro: 3.846 ± 0.055	1.56AspGln: 1.56 ± 0.034	5.033AspArg: 5.033 ± 0.06	1.961AspSer: 1.961 ± 0.038	2.83AspThr: 2.83 ± 0.049	4.558AspVal: 4.558 ± 0.071	1.2AspTrp: 1.2 ± 0.027	1.478AspTyr: 1.478 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	9.132GluAla: 9.132 ± 0.097	0.41GluCys: 0.41 ± 0.017	3.944GluAsp: 3.944 ± 0.058	4.503GluGlu: 4.503 ± 0.069	1.769GluPhe: 1.769 ± 0.042	5.553GluGly: 5.553 ± 0.082	1.359GluHis: 1.359 ± 0.034	3.48GluIle: 3.48 ± 0.054	2.135GluLys: 2.135 ± 0.049	5.647GluLeu: 5.647 ± 0.071	2.019GluMet: 2.019 ± 0.047	1.591GluAsn: 1.591 ± 0.035	3.048GluPro: 3.048 ± 0.046	2.144GluGln: 2.144 ± 0.046	5.556GluArg: 5.556 ± 0.069	2.444GluSer: 2.444 ± 0.047	3.947GluThr: 3.947 ± 0.064	5.03GluVal: 5.03 ± 0.064	0.815GluTrp: 0.815 ± 0.024	1.17GluTyr: 1.17 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.439PheAla: 4.439 ± 0.059	0.402PheCys: 0.402 ± 0.017	2.714PheAsp: 2.714 ± 0.047	2.267PheGlu: 2.267 ± 0.043	1.374PhePhe: 1.374 ± 0.044	3.611PheGly: 3.611 ± 0.061	0.744PheHis: 0.744 ± 0.023	1.424PheIle: 1.424 ± 0.038	0.708PheLys: 0.708 ± 0.027	3.503PheLeu: 3.503 ± 0.062	0.789PheMet: 0.789 ± 0.028	0.902PheAsn: 0.902 ± 0.027	1.618PhePro: 1.618 ± 0.035	0.916PheGln: 0.916 ± 0.027	2.394PheArg: 2.394 ± 0.045	1.955PheSer: 1.955 ± 0.041	1.931PheThr: 1.931 ± 0.039	2.803PheVal: 2.803 ± 0.048	0.587PheTrp: 0.587 ± 0.025	0.863PheTyr: 0.863 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.288GlyAla: 10.288 ± 0.104	0.858GlyCys: 0.858 ± 0.027	4.719GlyAsp: 4.719 ± 0.061	5.458GlyGlu: 5.458 ± 0.064	3.473GlyPhe: 3.473 ± 0.06	7.671GlyGly: 7.671 ± 0.104	1.951GlyHis: 1.951 ± 0.045	4.106GlyIle: 4.106 ± 0.056	2.693GlyLys: 2.693 ± 0.054	9.243GlyLeu: 9.243 ± 0.1	2.572GlyMet: 2.572 ± 0.045	1.781GlyAsn: 1.781 ± 0.039	3.922GlyPro: 3.922 ± 0.059	2.89GlyGln: 2.89 ± 0.055	6.757GlyArg: 6.757 ± 0.087	3.953GlySer: 3.953 ± 0.056	4.674GlyThr: 4.674 ± 0.055	6.631GlyVal: 6.631 ± 0.075	1.527GlyTrp: 1.527 ± 0.033	2.263GlyTyr: 2.263 ± 0.048	0.001GlyXaa: 0.001 ± 0.001
His	2.455HisAla: 2.455 ± 0.05	0.222HisCys: 0.222 ± 0.012	1.371HisAsp: 1.371 ± 0.037	1.247HisGlu: 1.247 ± 0.031	0.754HisPhe: 0.754 ± 0.026	2.091HisGly: 2.091 ± 0.043	0.591HisHis: 0.591 ± 0.02	0.783HisIle: 0.783 ± 0.025	0.444HisLys: 0.444 ± 0.017	2.091HisLeu: 2.091 ± 0.045	0.522HisMet: 0.522 ± 0.019	0.375HisAsn: 0.375 ± 0.016	1.463HisPro: 1.463 ± 0.039	0.515HisGln: 0.515 ± 0.021	1.506HisArg: 1.506 ± 0.036	0.841HisSer: 0.841 ± 0.025	0.823HisThr: 0.823 ± 0.023	1.705HisVal: 1.705 ± 0.037	0.337HisTrp: 0.337 ± 0.017	0.538HisTyr: 0.538 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.267IleAla: 6.267 ± 0.065	0.508IleCys: 0.508 ± 0.021	3.159IleAsp: 3.159 ± 0.047	3.407IleGlu: 3.407 ± 0.052	1.664IlePhe: 1.664 ± 0.04	4.35IleGly: 4.35 ± 0.065	0.828IleHis: 0.828 ± 0.025	1.718IleIle: 1.718 ± 0.04	0.994IleLys: 0.994 ± 0.031	4.447IleLeu: 4.447 ± 0.065	0.872IleMet: 0.872 ± 0.026	1.013IleAsn: 1.013 ± 0.027	2.213IlePro: 2.213 ± 0.043	1.001IleGln: 1.001 ± 0.032	3.11IleArg: 3.11 ± 0.049	2.525IleSer: 2.525 ± 0.051	2.314IleThr: 2.314 ± 0.038	3.828IleVal: 3.828 ± 0.058	0.614IleTrp: 0.614 ± 0.023	1.008IleTyr: 1.008 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.355LysAla: 3.355 ± 0.058	0.158LysCys: 0.158 ± 0.011	1.428LysAsp: 1.428 ± 0.035	1.448LysGlu: 1.448 ± 0.035	0.734LysPhe: 0.734 ± 0.024	2.305LysGly: 2.305 ± 0.041	0.541LysHis: 0.541 ± 0.021	1.349LysIle: 1.349 ± 0.037	1.078LysLys: 1.078 ± 0.036	2.627LysLeu: 2.627 ± 0.049	0.737LysMet: 0.737 ± 0.024	0.693LysAsn: 0.693 ± 0.024	1.609LysPro: 1.609 ± 0.036	0.806LysGln: 0.806 ± 0.028	2.196LysArg: 2.196 ± 0.041	1.454LysSer: 1.454 ± 0.033	1.64LysThr: 1.64 ± 0.037	2.09LysVal: 2.09 ± 0.046	0.346LysTrp: 0.346 ± 0.015	0.55LysTyr: 0.55 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.336LeuAla: 13.336 ± 0.132	0.907LeuCys: 0.907 ± 0.026	6.487LeuAsp: 6.487 ± 0.077	5.837LeuGlu: 5.837 ± 0.066	3.533LeuPhe: 3.533 ± 0.063	8.573LeuGly: 8.573 ± 0.097	1.949LeuHis: 1.949 ± 0.038	4.743LeuIle: 4.743 ± 0.083	2.853LeuLys: 2.853 ± 0.049	9.38LeuLeu: 9.38 ± 0.108	2.555LeuMet: 2.555 ± 0.046	2.314LeuAsn: 2.314 ± 0.037	5.625LeuPro: 5.625 ± 0.066	2.495LeuGln: 2.495 ± 0.041	7.699LeuArg: 7.699 ± 0.087	6.585LeuSer: 6.585 ± 0.08	5.682LeuThr: 5.682 ± 0.066	7.238LeuVal: 7.238 ± 0.078	1.351LeuTrp: 1.351 ± 0.037	1.975LeuTyr: 1.975 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.11MetAla: 3.11 ± 0.049	0.187MetCys: 0.187 ± 0.011	1.276MetAsp: 1.276 ± 0.032	1.444MetGlu: 1.444 ± 0.035	0.735MetPhe: 0.735 ± 0.026	2.106MetGly: 2.106 ± 0.044	0.523MetHis: 0.523 ± 0.023	1.407MetIle: 1.407 ± 0.033	1.002MetLys: 1.002 ± 0.028	2.429MetLeu: 2.429 ± 0.041	0.7MetMet: 0.7 ± 0.026	0.78MetAsn: 0.78 ± 0.025	1.529MetPro: 1.529 ± 0.028	0.913MetGln: 0.913 ± 0.027	1.93MetArg: 1.93 ± 0.04	1.769MetSer: 1.769 ± 0.034	1.961MetThr: 1.961 ± 0.041	1.722MetVal: 1.722 ± 0.033	0.236MetTrp: 0.236 ± 0.014	0.349MetTyr: 0.349 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.767AsnAla: 2.767 ± 0.05	0.216AsnCys: 0.216 ± 0.011	1.24AsnAsp: 1.24 ± 0.033	1.22AsnGlu: 1.22 ± 0.033	0.858AsnPhe: 0.858 ± 0.029	2.009AsnGly: 2.009 ± 0.045	0.466AsnHis: 0.466 ± 0.018	1.106AsnIle: 1.106 ± 0.03	0.467AsnLys: 0.467 ± 0.024	2.265AsnLeu: 2.265 ± 0.04	0.547AsnMet: 0.547 ± 0.023	0.52AsnAsn: 0.52 ± 0.02	1.592AsnPro: 1.592 ± 0.033	0.577AsnGln: 0.577 ± 0.021	1.597AsnArg: 1.597 ± 0.039	0.923AsnSer: 0.923 ± 0.028	1.093AsnThr: 1.093 ± 0.03	1.771AsnVal: 1.771 ± 0.04	0.37AsnTrp: 0.37 ± 0.017	0.575AsnTyr: 0.575 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	6.251ProAla: 6.251 ± 0.062	0.361ProCys: 0.361 ± 0.016	4.155ProAsp: 4.155 ± 0.059	4.724ProGlu: 4.724 ± 0.065	1.978ProPhe: 1.978 ± 0.039	4.879ProGly: 4.879 ± 0.07	1.165ProHis: 1.165 ± 0.03	1.929ProIle: 1.929 ± 0.046	1.455ProLys: 1.455 ± 0.032	4.812ProLeu: 4.812 ± 0.055	1.255ProMet: 1.255 ± 0.029	1.179ProAsn: 1.179 ± 0.032	2.71ProPro: 2.71 ± 0.054	1.614ProGln: 1.614 ± 0.04	3.33ProArg: 3.33 ± 0.049	2.596ProSer: 2.596 ± 0.048	2.313ProThr: 2.313 ± 0.041	4.659ProVal: 4.659 ± 0.07	0.761ProTrp: 0.761 ± 0.025	1.123ProTyr: 1.123 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.826GlnAla: 3.826 ± 0.063	0.189GlnCys: 0.189 ± 0.012	1.661GlnAsp: 1.661 ± 0.038	1.799GlnGlu: 1.799 ± 0.041	0.916GlnPhe: 0.916 ± 0.026	2.402GlnGly: 2.402 ± 0.043	0.531GlnHis: 0.531 ± 0.024	1.611GlnIle: 1.611 ± 0.036	0.938GlnLys: 0.938 ± 0.028	2.485GlnLeu: 2.485 ± 0.042	0.961GlnMet: 0.961 ± 0.028	0.738GlnAsn: 0.738 ± 0.026	1.579GlnPro: 1.579 ± 0.037	1.017GlnGln: 1.017 ± 0.038	2.253GlnArg: 2.253 ± 0.041	1.476GlnSer: 1.476 ± 0.037	1.561GlnThr: 1.561 ± 0.035	2.391GlnVal: 2.391 ± 0.045	0.373GlnTrp: 0.373 ± 0.019	0.525GlnTyr: 0.525 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.045ArgAla: 9.045 ± 0.077	0.537ArgCys: 0.537 ± 0.022	4.936ArgAsp: 4.936 ± 0.065	4.85ArgGlu: 4.85 ± 0.066	2.768ArgPhe: 2.768 ± 0.049	5.218ArgGly: 5.218 ± 0.068	1.735ArgHis: 1.735 ± 0.041	3.754ArgIle: 3.754 ± 0.05	2.267ArgLys: 2.267 ± 0.05	8.299ArgLeu: 8.299 ± 0.087	2.09ArgMet: 2.09 ± 0.036	1.72ArgAsn: 1.72 ± 0.041	4.055ArgPro: 4.055 ± 0.059	2.479ArgGln: 2.479 ± 0.039	6.574ArgArg: 6.574 ± 0.095	3.482ArgSer: 3.482 ± 0.05	3.701ArgThr: 3.701 ± 0.059	5.47ArgVal: 5.47 ± 0.069	1.051ArgTrp: 1.051 ± 0.029	1.624ArgTyr: 1.624 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.703SerAla: 5.703 ± 0.068	0.39SerCys: 0.39 ± 0.017	3.272SerAsp: 3.272 ± 0.054	2.989SerGlu: 2.989 ± 0.048	2.062SerPhe: 2.062 ± 0.042	5.245SerGly: 5.245 ± 0.065	0.997SerHis: 0.997 ± 0.025	2.19SerIle: 2.19 ± 0.044	1.24SerLys: 1.24 ± 0.03	4.699SerLeu: 4.699 ± 0.07	1.27SerMet: 1.27 ± 0.033	1.122SerAsn: 1.122 ± 0.031	2.527SerPro: 2.527 ± 0.045	1.366SerGln: 1.366 ± 0.031	3.402SerArg: 3.402 ± 0.053	2.475SerSer: 2.475 ± 0.051	2.314SerThr: 2.314 ± 0.043	3.802SerVal: 3.802 ± 0.062	0.703SerTrp: 0.703 ± 0.024	1.168SerTyr: 1.168 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	6.243ThrAla: 6.243 ± 0.08	0.484ThrCys: 0.484 ± 0.021	2.965ThrAsp: 2.965 ± 0.051	3.023ThrGlu: 3.023 ± 0.046	1.981ThrPhe: 1.981 ± 0.037	5.336ThrGly: 5.336 ± 0.068	1.093ThrHis: 1.093 ± 0.026	2.413ThrIle: 2.413 ± 0.044	1.22ThrLys: 1.22 ± 0.035	6.008ThrLeu: 6.008 ± 0.073	1.182ThrMet: 1.182 ± 0.028	1.037ThrAsn: 1.037 ± 0.029	3.291ThrPro: 3.291 ± 0.046	1.365ThrGln: 1.365 ± 0.031	3.632ThrArg: 3.632 ± 0.05	2.491ThrSer: 2.491 ± 0.039	2.679ThrThr: 2.679 ± 0.052	4.291ThrVal: 4.291 ± 0.053	0.684ThrTrp: 0.684 ± 0.023	1.156ThrTyr: 1.156 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	9.629ValAla: 9.629 ± 0.089	0.673ValCys: 0.673 ± 0.022	4.112ValAsp: 4.112 ± 0.065	5.465ValGlu: 5.465 ± 0.063	2.934ValPhe: 2.934 ± 0.052	5.707ValGly: 5.707 ± 0.074	1.454ValHis: 1.454 ± 0.035	3.777ValIle: 3.777 ± 0.056	2.004ValLys: 2.004 ± 0.042	7.809ValLeu: 7.809 ± 0.088	1.965ValMet: 1.965 ± 0.041	1.901ValAsn: 1.901 ± 0.043	4.048ValPro: 4.048 ± 0.062	2.066ValGln: 2.066 ± 0.041	5.209ValArg: 5.209 ± 0.071	4.203ValSer: 4.203 ± 0.062	4.702ValThr: 4.702 ± 0.053	6.112ValVal: 6.112 ± 0.075	1.042ValTrp: 1.042 ± 0.03	1.524ValTyr: 1.524 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.371TrpAla: 1.371 ± 0.032	0.139TrpCys: 0.139 ± 0.01	0.808TrpAsp: 0.808 ± 0.027	0.764TrpGlu: 0.764 ± 0.026	0.569TrpPhe: 0.569 ± 0.022	1.025TrpGly: 1.025 ± 0.032	0.311TrpHis: 0.311 ± 0.013	0.711TrpIle: 0.711 ± 0.024	0.413TrpLys: 0.413 ± 0.017	1.721TrpLeu: 1.721 ± 0.043	0.376TrpMet: 0.376 ± 0.017	0.41TrpAsn: 0.41 ± 0.017	0.745TrpPro: 0.745 ± 0.025	0.565TrpGln: 0.565 ± 0.021	1.333TrpArg: 1.333 ± 0.034	0.869TrpSer: 0.869 ± 0.025	0.86TrpThr: 0.86 ± 0.025	0.905TrpVal: 0.905 ± 0.027	0.255TrpTrp: 0.255 ± 0.013	0.269TrpTyr: 0.269 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.537TyrAla: 2.537 ± 0.04	0.262TyrCys: 0.262 ± 0.015	1.585TyrAsp: 1.585 ± 0.039	1.371TyrGlu: 1.371 ± 0.032	0.859TyrPhe: 0.859 ± 0.027	2.045TyrGly: 2.045 ± 0.041	0.47TyrHis: 0.47 ± 0.017	0.804TyrIle: 0.804 ± 0.027	0.441TyrLys: 0.441 ± 0.018	2.175TyrLeu: 2.175 ± 0.046	0.395TyrMet: 0.395 ± 0.017	0.519TyrAsn: 0.519 ± 0.019	1.031TyrPro: 1.031 ± 0.028	0.594TyrGln: 0.594 ± 0.021	1.605TyrArg: 1.605 ± 0.038	1.057TyrSer: 1.057 ± 0.031	1.069TyrThr: 1.069 ± 0.031	1.513TyrVal: 1.513 ± 0.033	0.35TyrTrp: 0.35 ± 0.016	0.58TyrTyr: 0.58 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 4454 proteins (1345483 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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