Amino acid dipepetide frequency for Changjiang narna-like virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.314AlaAla: 7.314 ± 2.948
1.995AlaCys: 1.995 ± 0.054
2.66AlaAsp: 2.66 ± 0.321
2.66AlaGlu: 2.66 ± 1.501
1.995AlaPhe: 1.995 ± 0.054
5.984AlaGly: 5.984 ± 3.699
1.33AlaHis: 1.33 ± 0.75
1.995AlaIle: 1.995 ± 0.054
4.654AlaLys: 4.654 ± 0.911
10.638AlaLeu: 10.638 ± 1.073
2.66AlaMet: 2.66 ± 0.321
1.995AlaAsn: 1.995 ± 1.233
3.989AlaPro: 3.989 ± 2.251
1.995AlaGln: 1.995 ± 0.054
8.644AlaArg: 8.644 ± 3.698
5.984AlaSer: 5.984 ± 1.018
7.314AlaThr: 7.314 ± 1.769
5.319AlaVal: 5.319 ± 0.536
1.33AlaTrp: 1.33 ± 0.429
0.665AlaTyr: 0.665 ± 0.804
0.0AlaXaa: 0.0 ± 0.0
Cys
1.33CysAla: 1.33 ± 0.75
0.0CysCys: 0.0 ± 0.0
0.665CysAsp: 0.665 ± 0.804
0.665CysGlu: 0.665 ± 0.804
0.0CysPhe: 0.0 ± 0.0
0.665CysGly: 0.665 ± 0.375
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.665CysLys: 0.665 ± 0.375
1.33CysLeu: 1.33 ± 0.75
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.665CysArg: 0.665 ± 0.375
1.33CysSer: 1.33 ± 1.608
1.33CysThr: 1.33 ± 0.429
0.665CysVal: 0.665 ± 0.375
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.995AspAla: 1.995 ± 0.054
0.665AspCys: 0.665 ± 0.804
1.995AspAsp: 1.995 ± 1.126
0.0AspGlu: 0.0 ± 0.0
1.995AspPhe: 1.995 ± 0.054
3.324AspGly: 3.324 ± 0.697
1.33AspHis: 1.33 ± 1.608
4.654AspIle: 4.654 ± 0.911
2.66AspLys: 2.66 ± 0.858
4.654AspLeu: 4.654 ± 0.268
1.33AspMet: 1.33 ± 0.75
0.0AspAsn: 0.0 ± 0.0
2.66AspPro: 2.66 ± 0.321
1.33AspGln: 1.33 ± 0.429
1.33AspArg: 1.33 ± 0.75
5.984AspSer: 5.984 ± 1.018
1.995AspThr: 1.995 ± 0.054
1.995AspVal: 1.995 ± 1.233
2.66AspTrp: 2.66 ± 1.501
3.324AspTyr: 3.324 ± 2.841
0.0AspXaa: 0.0 ± 0.0
Glu
3.989GluAla: 3.989 ± 1.072
0.665GluCys: 0.665 ± 0.804
4.654GluAsp: 4.654 ± 1.447
6.649GluGlu: 6.649 ± 3.752
1.995GluPhe: 1.995 ± 1.233
3.989GluGly: 3.989 ± 1.072
1.33GluHis: 1.33 ± 0.429
3.989GluIle: 3.989 ± 2.251
1.33GluLys: 1.33 ± 0.429
3.989GluLeu: 3.989 ± 1.072
0.0GluMet: 0.0 ± 0.0
1.33GluAsn: 1.33 ± 0.429
5.984GluPro: 5.984 ± 2.197
2.66GluGln: 2.66 ± 0.321
4.654GluArg: 4.654 ± 0.911
3.324GluSer: 3.324 ± 0.697
3.324GluThr: 3.324 ± 0.697
3.324GluVal: 3.324 ± 0.697
0.665GluTrp: 0.665 ± 0.375
1.995GluTyr: 1.995 ± 0.054
0.0GluXaa: 0.0 ± 0.0
Phe
3.324PheAla: 3.324 ± 1.876
0.0PheCys: 0.0 ± 0.0
1.995PheAsp: 1.995 ± 1.233
3.324PheGlu: 3.324 ± 0.697
2.66PhePhe: 2.66 ± 1.501
3.324PheGly: 3.324 ± 1.662
1.33PheHis: 1.33 ± 0.429
1.33PheIle: 1.33 ± 0.429
0.665PheLys: 0.665 ± 0.804
5.319PheLeu: 5.319 ± 0.643
0.0PheMet: 0.0 ± 0.0
1.33PheAsn: 1.33 ± 1.608
3.989PhePro: 3.989 ± 0.107
1.995PheGln: 1.995 ± 0.054
1.995PheArg: 1.995 ± 0.054
3.989PheSer: 3.989 ± 0.107
1.995PheThr: 1.995 ± 1.126
4.654PheVal: 4.654 ± 0.268
0.665PheTrp: 0.665 ± 0.375
1.33PheTyr: 1.33 ± 0.429
0.0PheXaa: 0.0 ± 0.0
Gly
4.654GlyAla: 4.654 ± 2.091
0.665GlyCys: 0.665 ± 0.804
4.654GlyAsp: 4.654 ± 3.27
2.66GlyGlu: 2.66 ± 0.858
3.989GlyPhe: 3.989 ± 1.072
4.654GlyGly: 4.654 ± 2.626
0.665GlyHis: 0.665 ± 0.804
1.995GlyIle: 1.995 ± 1.233
1.33GlyLys: 1.33 ± 0.429
6.649GlyLeu: 6.649 ± 0.214
1.33GlyMet: 1.33 ± 0.75
3.989GlyAsn: 3.989 ± 2.466
1.995GlyPro: 1.995 ± 0.054
3.989GlyGln: 3.989 ± 0.107
3.989GlyArg: 3.989 ± 1.287
5.319GlySer: 5.319 ± 0.536
7.314GlyThr: 7.314 ± 5.307
3.989GlyVal: 3.989 ± 1.072
1.33GlyTrp: 1.33 ± 0.429
2.66GlyTyr: 2.66 ± 0.858
0.0GlyXaa: 0.0 ± 0.0
His
3.324HisAla: 3.324 ± 0.697
0.0HisCys: 0.0 ± 0.0
0.665HisAsp: 0.665 ± 0.375
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
3.324HisGly: 3.324 ± 0.483
1.33HisHis: 1.33 ± 0.75
0.665HisIle: 0.665 ± 0.375
1.33HisLys: 1.33 ± 0.429
3.324HisLeu: 3.324 ± 0.697
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
1.995HisPro: 1.995 ± 1.126
0.0HisGln: 0.0 ± 0.0
0.665HisArg: 0.665 ± 0.375
2.66HisSer: 2.66 ± 0.858
0.665HisThr: 0.665 ± 0.804
0.665HisVal: 0.665 ± 0.375
0.0HisTrp: 0.0 ± 0.0
0.665HisTyr: 0.665 ± 0.375
0.0HisXaa: 0.0 ± 0.0
Ile
8.644IleAla: 8.644 ± 2.198
0.0IleCys: 0.0 ± 0.0
3.324IleAsp: 3.324 ± 1.662
2.66IleGlu: 2.66 ± 1.501
1.33IlePhe: 1.33 ± 0.75
1.995IleGly: 1.995 ± 1.233
1.33IleHis: 1.33 ± 0.75
0.665IleIle: 0.665 ± 0.375
0.665IleLys: 0.665 ± 0.375
5.319IleLeu: 5.319 ± 1.822
1.33IleMet: 1.33 ± 0.656
3.324IleAsn: 3.324 ± 0.483
3.989IlePro: 3.989 ± 0.107
1.995IleGln: 1.995 ± 0.054
3.324IleArg: 3.324 ± 0.697
2.66IleSer: 2.66 ± 0.321
3.989IleThr: 3.989 ± 2.466
2.66IleVal: 2.66 ± 0.858
0.0IleTrp: 0.0 ± 0.0
0.665IleTyr: 0.665 ± 0.375
0.0IleXaa: 0.0 ± 0.0
Lys
1.33LysAla: 1.33 ± 0.429
0.0LysCys: 0.0 ± 0.0
1.33LysAsp: 1.33 ± 0.429
0.0LysGlu: 0.0 ± 0.0
0.665LysPhe: 0.665 ± 0.804
3.324LysGly: 3.324 ± 1.662
1.33LysHis: 1.33 ± 0.75
0.665LysIle: 0.665 ± 0.804
1.33LysLys: 1.33 ± 1.608
3.324LysLeu: 3.324 ± 0.697
1.33LysMet: 1.33 ± 1.608
1.995LysAsn: 1.995 ± 0.054
1.995LysPro: 1.995 ± 1.233
1.995LysGln: 1.995 ± 1.233
1.995LysArg: 1.995 ± 0.054
0.665LysSer: 0.665 ± 0.375
1.33LysThr: 1.33 ± 0.75
4.654LysVal: 4.654 ± 1.447
1.33LysTrp: 1.33 ± 0.75
1.995LysTyr: 1.995 ± 1.126
0.0LysXaa: 0.0 ± 0.0
Leu
7.314LeuAla: 7.314 ± 2.948
1.33LeuCys: 1.33 ± 0.75
3.324LeuAsp: 3.324 ± 0.697
8.644LeuGlu: 8.644 ± 0.16
4.654LeuPhe: 4.654 ± 0.911
7.314LeuGly: 7.314 ± 4.128
3.324LeuHis: 3.324 ± 0.697
6.649LeuIle: 6.649 ± 1.393
2.66LeuLys: 2.66 ± 0.321
5.984LeuLeu: 5.984 ± 1.018
2.66LeuMet: 2.66 ± 0.321
1.995LeuAsn: 1.995 ± 1.126
9.973LeuPro: 9.973 ± 4.449
2.66LeuGln: 2.66 ± 1.501
5.984LeuArg: 5.984 ± 2.197
12.633LeuSer: 12.633 ± 0.053
1.995LeuThr: 1.995 ± 0.054
3.989LeuVal: 3.989 ± 1.072
1.33LeuTrp: 1.33 ± 0.429
1.33LeuTyr: 1.33 ± 0.75
0.0LeuXaa: 0.0 ± 0.0
Met
2.66MetAla: 2.66 ± 2.037
0.0MetCys: 0.0 ± 0.0
1.33MetAsp: 1.33 ± 0.75
3.324MetGlu: 3.324 ± 0.697
0.0MetPhe: 0.0 ± 0.0
0.665MetGly: 0.665 ± 0.375
0.0MetHis: 0.0 ± 0.0
1.995MetIle: 1.995 ± 0.054
0.0MetLys: 0.0 ± 0.0
0.665MetLeu: 0.665 ± 0.375
0.0MetMet: 0.0 ± 0.0
0.665MetAsn: 0.665 ± 0.375
0.665MetPro: 0.665 ± 0.804
0.0MetGln: 0.0 ± 0.0
0.665MetArg: 0.665 ± 0.375
0.665MetSer: 0.665 ± 0.804
1.33MetThr: 1.33 ± 0.429
1.33MetVal: 1.33 ± 0.75
0.0MetTrp: 0.0 ± 0.0
0.665MetTyr: 0.665 ± 0.804
0.0MetXaa: 0.0 ± 0.0
Asn
5.319AsnAla: 5.319 ± 1.716
0.665AsnCys: 0.665 ± 0.804
0.665AsnAsp: 0.665 ± 0.375
0.665AsnGlu: 0.665 ± 0.804
3.324AsnPhe: 3.324 ± 0.483
1.995AsnGly: 1.995 ± 0.054
0.665AsnHis: 0.665 ± 0.375
2.66AsnIle: 2.66 ± 0.858
0.665AsnLys: 0.665 ± 0.804
0.0AsnLeu: 0.0 ± 0.0
0.0AsnMet: 0.0 ± 0.0
2.66AsnAsn: 2.66 ± 2.037
2.66AsnPro: 2.66 ± 0.321
1.995AsnGln: 1.995 ± 0.054
3.324AsnArg: 3.324 ± 0.697
2.66AsnSer: 2.66 ± 0.858
1.33AsnThr: 1.33 ± 1.608
1.995AsnVal: 1.995 ± 1.233
0.665AsnTrp: 0.665 ± 0.804
0.665AsnTyr: 0.665 ± 0.375
0.0AsnXaa: 0.0 ± 0.0
Pro
1.995ProAla: 1.995 ± 1.126
0.0ProCys: 0.0 ± 0.0
3.989ProAsp: 3.989 ± 2.251
7.314ProGlu: 7.314 ± 2.948
3.989ProPhe: 3.989 ± 0.107
3.989ProGly: 3.989 ± 1.287
0.665ProHis: 0.665 ± 0.804
3.324ProIle: 3.324 ± 0.483
3.989ProLys: 3.989 ± 0.107
9.309ProLeu: 9.309 ± 4.073
0.665ProMet: 0.665 ± 0.375
2.66ProAsn: 2.66 ± 0.321
8.644ProPro: 8.644 ± 1.34
1.33ProGln: 1.33 ± 0.429
5.319ProArg: 5.319 ± 0.643
6.649ProSer: 6.649 ± 0.965
3.324ProThr: 3.324 ± 1.876
7.979ProVal: 7.979 ± 0.964
2.66ProTrp: 2.66 ± 0.321
1.995ProTyr: 1.995 ± 1.126
0.0ProXaa: 0.0 ± 0.0
Gln
3.324GlnAla: 3.324 ± 0.697
0.0GlnCys: 0.0 ± 0.0
1.995GlnAsp: 1.995 ± 1.126
1.33GlnGlu: 1.33 ± 0.429
2.66GlnPhe: 2.66 ± 0.321
1.995GlnGly: 1.995 ± 2.412
0.0GlnHis: 0.0 ± 0.0
2.66GlnIle: 2.66 ± 0.858
0.665GlnLys: 0.665 ± 0.375
3.324GlnLeu: 3.324 ± 0.697
0.665GlnMet: 0.665 ± 0.804
1.995GlnAsn: 1.995 ± 0.054
1.995GlnPro: 1.995 ± 1.126
2.66GlnGln: 2.66 ± 0.858
1.33GlnArg: 1.33 ± 0.75
4.654GlnSer: 4.654 ± 0.911
1.33GlnThr: 1.33 ± 0.429
2.66GlnVal: 2.66 ± 0.321
1.33GlnTrp: 1.33 ± 0.429
0.665GlnTyr: 0.665 ± 0.804
0.0GlnXaa: 0.0 ± 0.0
Arg
5.984ArgAla: 5.984 ± 0.161
0.665ArgCys: 0.665 ± 0.375
1.33ArgAsp: 1.33 ± 1.608
4.654ArgGlu: 4.654 ± 0.268
4.654ArgPhe: 4.654 ± 1.447
3.324ArgGly: 3.324 ± 0.483
2.66ArgHis: 2.66 ± 1.501
5.319ArgIle: 5.319 ± 0.643
0.665ArgLys: 0.665 ± 0.375
7.314ArgLeu: 7.314 ± 1.769
1.33ArgMet: 1.33 ± 0.75
1.995ArgAsn: 1.995 ± 1.233
4.654ArgPro: 4.654 ± 1.447
3.989ArgGln: 3.989 ± 2.251
7.314ArgArg: 7.314 ± 1.769
5.319ArgSer: 5.319 ± 0.643
3.324ArgThr: 3.324 ± 0.483
3.989ArgVal: 3.989 ± 1.072
0.0ArgTrp: 0.0 ± 0.0
3.324ArgTyr: 3.324 ± 0.697
0.0ArgXaa: 0.0 ± 0.0
Ser
5.984SerAla: 5.984 ± 0.161
1.995SerCys: 1.995 ± 1.126
2.66SerAsp: 2.66 ± 0.858
6.649SerGlu: 6.649 ± 0.214
3.324SerPhe: 3.324 ± 1.876
6.649SerGly: 6.649 ± 3.324
0.0SerHis: 0.0 ± 0.0
3.324SerIle: 3.324 ± 0.483
2.66SerLys: 2.66 ± 0.321
7.314SerLeu: 7.314 ± 2.949
0.665SerMet: 0.665 ± 0.375
1.33SerAsn: 1.33 ± 0.429
6.649SerPro: 6.649 ± 2.573
3.989SerGln: 3.989 ± 2.466
5.984SerArg: 5.984 ± 1.018
7.979SerSer: 7.979 ± 6.111
4.654SerThr: 4.654 ± 2.091
6.649SerVal: 6.649 ± 0.965
1.995SerTrp: 1.995 ± 1.126
3.324SerTyr: 3.324 ± 0.697
0.0SerXaa: 0.0 ± 0.0
Thr
3.324ThrAla: 3.324 ± 0.483
0.665ThrCys: 0.665 ± 0.375
3.324ThrAsp: 3.324 ± 0.483
1.995ThrGlu: 1.995 ± 0.054
2.66ThrPhe: 2.66 ± 2.037
6.649ThrGly: 6.649 ± 0.965
0.665ThrHis: 0.665 ± 0.375
1.33ThrIle: 1.33 ± 0.429
0.665ThrLys: 0.665 ± 0.804
2.66ThrLeu: 2.66 ± 0.321
0.665ThrMet: 0.665 ± 0.375
3.324ThrAsn: 3.324 ± 1.662
6.649ThrPro: 6.649 ± 2.144
1.995ThrGln: 1.995 ± 1.233
5.984ThrArg: 5.984 ± 2.52
3.324ThrSer: 3.324 ± 1.662
3.989ThrThr: 3.989 ± 1.287
4.654ThrVal: 4.654 ± 0.268
0.0ThrTrp: 0.0 ± 0.0
1.33ThrTyr: 1.33 ± 0.75
0.0ThrXaa: 0.0 ± 0.0
Val
5.319ValAla: 5.319 ± 0.536
0.0ValCys: 0.0 ± 0.0
2.66ValAsp: 2.66 ± 1.501
3.989ValGlu: 3.989 ± 2.251
3.324ValPhe: 3.324 ± 1.662
3.324ValGly: 3.324 ± 1.876
1.995ValHis: 1.995 ± 0.054
5.319ValIle: 5.319 ± 0.643
2.66ValLys: 2.66 ± 0.321
9.309ValLeu: 9.309 ± 2.894
0.665ValMet: 0.665 ± 1.223
2.66ValAsn: 2.66 ± 0.858
7.979ValPro: 7.979 ± 0.215
1.995ValGln: 1.995 ± 0.054
2.66ValArg: 2.66 ± 1.501
3.324ValSer: 3.324 ± 1.662
1.995ValThr: 1.995 ± 0.054
1.995ValVal: 1.995 ± 0.054
0.665ValTrp: 0.665 ± 0.375
2.66ValTyr: 2.66 ± 0.321
0.0ValXaa: 0.0 ± 0.0
Trp
1.995TrpAla: 1.995 ± 1.126
0.0TrpCys: 0.0 ± 0.0
0.665TrpAsp: 0.665 ± 0.804
1.33TrpGlu: 1.33 ± 0.429
1.33TrpPhe: 1.33 ± 0.429
0.0TrpGly: 0.0 ± 0.0
0.665TrpHis: 0.665 ± 0.375
1.33TrpIle: 1.33 ± 1.608
1.995TrpLys: 1.995 ± 1.126
2.66TrpLeu: 2.66 ± 0.321
0.0TrpMet: 0.0 ± 0.0
1.33TrpAsn: 1.33 ± 0.75
0.665TrpPro: 0.665 ± 0.375
0.0TrpGln: 0.0 ± 0.0
1.995TrpArg: 1.995 ± 1.126
1.33TrpSer: 1.33 ± 0.75
0.665TrpThr: 0.665 ± 0.375
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.995TyrAla: 1.995 ± 1.233
0.0TyrCys: 0.0 ± 0.0
1.995TyrAsp: 1.995 ± 1.233
1.33TyrGlu: 1.33 ± 0.75
0.665TyrPhe: 0.665 ± 0.375
1.33TyrGly: 1.33 ± 0.429
0.665TyrHis: 0.665 ± 0.375
0.0TyrIle: 0.0 ± 0.0
1.33TyrLys: 1.33 ± 0.429
2.66TyrLeu: 2.66 ± 0.321
0.665TyrMet: 0.665 ± 0.804
0.0TyrAsn: 0.0 ± 0.0
2.66TyrPro: 2.66 ± 0.321
0.665TyrGln: 0.665 ± 0.375
3.989TyrArg: 3.989 ± 0.107
3.324TyrSer: 3.324 ± 0.697
2.66TyrThr: 2.66 ± 0.858
1.995TyrVal: 1.995 ± 1.126
1.33TyrTrp: 1.33 ± 0.75
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (1505 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski