Amino acid dipepetide frequency for Streptococcus phage Javan456

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.907AlaAla: 4.907 ± 1.392
0.505AlaCys: 0.505 ± 0.164
4.979AlaAsp: 4.979 ± 0.579
6.206AlaGlu: 6.206 ± 0.798
3.536AlaPhe: 3.536 ± 0.676
4.258AlaGly: 4.258 ± 1.107
0.505AlaHis: 0.505 ± 0.217
5.485AlaIle: 5.485 ± 1.098
8.371AlaLys: 8.371 ± 1.149
6.278AlaLeu: 6.278 ± 0.734
2.814AlaMet: 2.814 ± 0.528
3.969AlaAsn: 3.969 ± 0.543
1.155AlaPro: 1.155 ± 0.263
2.887AlaGln: 2.887 ± 0.539
2.526AlaArg: 2.526 ± 0.361
4.619AlaSer: 4.619 ± 0.879
4.763AlaThr: 4.763 ± 1.0
4.546AlaVal: 4.546 ± 1.115
0.505AlaTrp: 0.505 ± 0.183
2.381AlaTyr: 2.381 ± 0.408
0.0AlaXaa: 0.0 ± 0.0
Cys
0.289CysAla: 0.289 ± 0.152
0.072CysCys: 0.072 ± 0.074
0.361CysAsp: 0.361 ± 0.165
0.577CysGlu: 0.577 ± 0.204
0.289CysPhe: 0.289 ± 0.139
0.361CysGly: 0.361 ± 0.163
0.144CysHis: 0.144 ± 0.09
0.289CysIle: 0.289 ± 0.132
0.433CysLys: 0.433 ± 0.237
0.794CysLeu: 0.794 ± 0.249
0.072CysMet: 0.072 ± 0.075
0.144CysAsn: 0.144 ± 0.097
0.072CysPro: 0.072 ± 0.067
0.216CysGln: 0.216 ± 0.118
0.361CysArg: 0.361 ± 0.158
0.216CysSer: 0.216 ± 0.128
0.216CysThr: 0.216 ± 0.159
0.577CysVal: 0.577 ± 0.219
0.144CysTrp: 0.144 ± 0.086
0.289CysTyr: 0.289 ± 0.146
0.0CysXaa: 0.0 ± 0.0
Asp
3.392AspAla: 3.392 ± 0.489
0.433AspCys: 0.433 ± 0.22
3.536AspAsp: 3.536 ± 0.557
5.34AspGlu: 5.34 ± 0.703
3.897AspPhe: 3.897 ± 0.527
3.753AspGly: 3.753 ± 0.484
0.794AspHis: 0.794 ± 0.26
4.907AspIle: 4.907 ± 0.736
6.134AspLys: 6.134 ± 0.828
5.99AspLeu: 5.99 ± 0.683
2.093AspMet: 2.093 ± 0.394
3.175AspAsn: 3.175 ± 0.511
1.515AspPro: 1.515 ± 0.365
1.588AspGln: 1.588 ± 0.34
2.454AspArg: 2.454 ± 0.469
3.608AspSer: 3.608 ± 0.568
2.742AspThr: 2.742 ± 0.488
3.464AspVal: 3.464 ± 0.455
0.938AspTrp: 0.938 ± 0.317
2.959AspTyr: 2.959 ± 0.461
0.0AspXaa: 0.0 ± 0.0
Glu
5.557GluAla: 5.557 ± 0.618
0.433GluCys: 0.433 ± 0.161
3.392GluAsp: 3.392 ± 0.574
6.856GluGlu: 6.856 ± 1.079
3.031GluPhe: 3.031 ± 0.431
4.113GluGly: 4.113 ± 0.473
1.588GluHis: 1.588 ± 0.321
6.134GluIle: 6.134 ± 0.838
6.495GluLys: 6.495 ± 0.82
9.309GluLeu: 9.309 ± 1.279
2.67GluMet: 2.67 ± 0.482
3.969GluAsn: 3.969 ± 0.589
1.948GluPro: 1.948 ± 0.385
3.175GluGln: 3.175 ± 0.366
3.392GluArg: 3.392 ± 0.536
4.041GluSer: 4.041 ± 0.479
4.113GluThr: 4.113 ± 0.678
5.34GluVal: 5.34 ± 0.885
0.794GluTrp: 0.794 ± 0.247
2.959GluTyr: 2.959 ± 0.501
0.0GluXaa: 0.0 ± 0.0
Phe
2.742PheAla: 2.742 ± 0.571
0.216PheCys: 0.216 ± 0.126
3.536PheAsp: 3.536 ± 0.505
2.959PheGlu: 2.959 ± 0.481
1.01PhePhe: 1.01 ± 0.292
2.742PheGly: 2.742 ± 0.605
0.866PheHis: 0.866 ± 0.301
1.948PheIle: 1.948 ± 0.346
4.258PheLys: 4.258 ± 0.627
2.526PheLeu: 2.526 ± 0.512
0.794PheMet: 0.794 ± 0.242
2.526PheAsn: 2.526 ± 0.423
0.722PhePro: 0.722 ± 0.256
0.505PheGln: 0.505 ± 0.187
1.588PheArg: 1.588 ± 0.273
3.031PheSer: 3.031 ± 0.399
2.67PheThr: 2.67 ± 0.368
3.32PheVal: 3.32 ± 0.421
0.794PheTrp: 0.794 ± 0.218
1.443PheTyr: 1.443 ± 0.285
0.0PheXaa: 0.0 ± 0.0
Gly
4.258GlyAla: 4.258 ± 1.068
0.216GlyCys: 0.216 ± 0.107
3.897GlyAsp: 3.897 ± 0.568
3.464GlyGlu: 3.464 ± 0.468
2.67GlyPhe: 2.67 ± 0.511
4.041GlyGly: 4.041 ± 0.6
0.866GlyHis: 0.866 ± 0.243
3.536GlyIle: 3.536 ± 0.789
5.99GlyLys: 5.99 ± 0.631
7.433GlyLeu: 7.433 ± 1.011
2.093GlyMet: 2.093 ± 0.362
2.526GlyAsn: 2.526 ± 0.463
1.082GlyPro: 1.082 ± 0.535
2.165GlyGln: 2.165 ± 0.456
2.526GlyArg: 2.526 ± 0.529
3.031GlySer: 3.031 ± 0.624
4.113GlyThr: 4.113 ± 0.649
4.186GlyVal: 4.186 ± 0.673
0.577GlyTrp: 0.577 ± 0.339
2.959GlyTyr: 2.959 ± 0.522
0.0GlyXaa: 0.0 ± 0.0
His
1.299HisAla: 1.299 ± 0.33
0.072HisCys: 0.072 ± 0.068
0.938HisAsp: 0.938 ± 0.294
1.082HisGlu: 1.082 ± 0.289
0.577HisPhe: 0.577 ± 0.179
1.01HisGly: 1.01 ± 0.306
0.289HisHis: 0.289 ± 0.155
0.649HisIle: 0.649 ± 0.23
1.01HisLys: 1.01 ± 0.253
0.938HisLeu: 0.938 ± 0.229
0.0HisMet: 0.0 ± 0.0
0.722HisAsn: 0.722 ± 0.234
0.866HisPro: 0.866 ± 0.321
0.794HisGln: 0.794 ± 0.212
0.722HisArg: 0.722 ± 0.217
0.938HisSer: 0.938 ± 0.274
0.794HisThr: 0.794 ± 0.239
0.938HisVal: 0.938 ± 0.248
0.216HisTrp: 0.216 ± 0.136
0.361HisTyr: 0.361 ± 0.173
0.0HisXaa: 0.0 ± 0.0
Ile
4.691IleAla: 4.691 ± 0.649
0.361IleCys: 0.361 ± 0.151
5.485IleAsp: 5.485 ± 0.738
4.979IleGlu: 4.979 ± 0.57
1.804IlePhe: 1.804 ± 0.316
4.33IleGly: 4.33 ± 0.483
1.155IleHis: 1.155 ± 0.276
3.825IleIle: 3.825 ± 0.479
6.856IleLys: 6.856 ± 0.734
5.052IleLeu: 5.052 ± 0.519
0.938IleMet: 0.938 ± 0.272
4.186IleAsn: 4.186 ± 0.663
1.588IlePro: 1.588 ± 0.309
2.237IleGln: 2.237 ± 0.387
2.887IleArg: 2.887 ± 0.465
4.691IleSer: 4.691 ± 0.929
4.402IleThr: 4.402 ± 0.565
4.186IleVal: 4.186 ± 0.573
0.289IleTrp: 0.289 ± 0.159
2.093IleTyr: 2.093 ± 0.4
0.0IleXaa: 0.0 ± 0.0
Lys
6.856LysAla: 6.856 ± 0.558
0.216LysCys: 0.216 ± 0.115
4.979LysAsp: 4.979 ± 0.749
6.784LysGlu: 6.784 ± 0.961
3.031LysPhe: 3.031 ± 0.509
4.546LysGly: 4.546 ± 0.46
1.01LysHis: 1.01 ± 0.229
6.423LysIle: 6.423 ± 0.61
8.083LysLys: 8.083 ± 0.978
7.938LysLeu: 7.938 ± 0.815
2.67LysMet: 2.67 ± 0.396
5.701LysAsn: 5.701 ± 0.635
2.67LysPro: 2.67 ± 0.49
4.113LysGln: 4.113 ± 0.544
3.68LysArg: 3.68 ± 0.539
4.474LysSer: 4.474 ± 0.499
5.918LysThr: 5.918 ± 0.636
6.639LysVal: 6.639 ± 0.907
1.443LysTrp: 1.443 ± 0.352
3.247LysTyr: 3.247 ± 0.536
0.0LysXaa: 0.0 ± 0.0
Leu
6.856LeuAla: 6.856 ± 0.927
0.216LeuCys: 0.216 ± 0.124
6.206LeuAsp: 6.206 ± 0.587
9.093LeuGlu: 9.093 ± 0.899
2.887LeuPhe: 2.887 ± 0.419
5.485LeuGly: 5.485 ± 0.839
0.866LeuHis: 0.866 ± 0.241
5.412LeuIle: 5.412 ± 0.671
8.299LeuLys: 8.299 ± 0.851
7.794LeuLeu: 7.794 ± 1.11
2.021LeuMet: 2.021 ± 0.383
5.052LeuAsn: 5.052 ± 0.709
3.247LeuPro: 3.247 ± 0.659
3.247LeuGln: 3.247 ± 0.36
4.041LeuArg: 4.041 ± 0.687
5.99LeuSer: 5.99 ± 0.718
5.196LeuThr: 5.196 ± 0.544
4.33LeuVal: 4.33 ± 0.521
0.722LeuTrp: 0.722 ± 0.271
2.67LeuTyr: 2.67 ± 0.524
0.0LeuXaa: 0.0 ± 0.0
Met
2.67MetAla: 2.67 ± 0.452
0.216MetCys: 0.216 ± 0.148
1.227MetAsp: 1.227 ± 0.289
1.732MetGlu: 1.732 ± 0.367
0.938MetPhe: 0.938 ± 0.242
1.082MetGly: 1.082 ± 0.244
0.289MetHis: 0.289 ± 0.143
1.443MetIle: 1.443 ± 0.3
1.227MetLys: 1.227 ± 0.3
2.165MetLeu: 2.165 ± 0.36
0.505MetMet: 0.505 ± 0.198
1.876MetAsn: 1.876 ± 0.399
0.794MetPro: 0.794 ± 0.224
1.155MetGln: 1.155 ± 0.274
1.876MetArg: 1.876 ± 0.28
1.948MetSer: 1.948 ± 0.392
1.515MetThr: 1.515 ± 0.358
0.866MetVal: 0.866 ± 0.303
0.072MetTrp: 0.072 ± 0.068
0.505MetTyr: 0.505 ± 0.158
0.0MetXaa: 0.0 ± 0.0
Asn
4.691AsnAla: 4.691 ± 0.621
0.216AsnCys: 0.216 ± 0.129
2.454AsnAsp: 2.454 ± 0.431
3.32AsnGlu: 3.32 ± 0.489
2.598AsnPhe: 2.598 ± 0.484
3.608AsnGly: 3.608 ± 0.517
0.938AsnHis: 0.938 ± 0.264
3.464AsnIle: 3.464 ± 0.606
4.691AsnLys: 4.691 ± 0.607
4.763AsnLeu: 4.763 ± 0.478
0.866AsnMet: 0.866 ± 0.249
2.309AsnAsn: 2.309 ± 0.507
1.732AsnPro: 1.732 ± 0.372
2.021AsnGln: 2.021 ± 0.384
1.588AsnArg: 1.588 ± 0.4
3.68AsnSer: 3.68 ± 0.493
2.598AsnThr: 2.598 ± 0.465
2.021AsnVal: 2.021 ± 0.364
0.794AsnTrp: 0.794 ± 0.214
2.381AsnTyr: 2.381 ± 0.465
0.0AsnXaa: 0.0 ± 0.0
Pro
1.443ProAla: 1.443 ± 0.309
0.361ProCys: 0.361 ± 0.202
2.165ProAsp: 2.165 ± 0.365
2.021ProGlu: 2.021 ± 0.477
1.01ProPhe: 1.01 ± 0.257
1.227ProGly: 1.227 ± 0.293
0.433ProHis: 0.433 ± 0.177
2.165ProIle: 2.165 ± 0.327
2.237ProLys: 2.237 ± 0.431
1.443ProLeu: 1.443 ± 0.455
0.577ProMet: 0.577 ± 0.187
1.371ProAsn: 1.371 ± 0.31
0.577ProPro: 0.577 ± 0.195
1.082ProGln: 1.082 ± 0.279
1.371ProArg: 1.371 ± 0.371
1.876ProSer: 1.876 ± 0.344
1.732ProThr: 1.732 ± 0.424
1.876ProVal: 1.876 ± 0.409
0.289ProTrp: 0.289 ± 0.181
1.082ProTyr: 1.082 ± 0.28
0.0ProXaa: 0.0 ± 0.0
Gln
3.536GlnAla: 3.536 ± 0.984
0.361GlnCys: 0.361 ± 0.189
2.093GlnAsp: 2.093 ± 0.348
3.68GlnGlu: 3.68 ± 0.576
1.732GlnPhe: 1.732 ± 0.458
2.814GlnGly: 2.814 ± 0.387
0.433GlnHis: 0.433 ± 0.167
3.031GlnIle: 3.031 ± 0.547
3.392GlnLys: 3.392 ± 0.529
3.536GlnLeu: 3.536 ± 0.485
0.866GlnMet: 0.866 ± 0.273
1.804GlnAsn: 1.804 ± 0.402
0.938GlnPro: 0.938 ± 0.267
1.732GlnGln: 1.732 ± 0.495
1.227GlnArg: 1.227 ± 0.249
3.031GlnSer: 3.031 ± 0.611
2.742GlnThr: 2.742 ± 0.471
1.515GlnVal: 1.515 ± 0.32
0.433GlnTrp: 0.433 ± 0.324
0.866GlnTyr: 0.866 ± 0.236
0.0GlnXaa: 0.0 ± 0.0
Arg
3.175ArgAla: 3.175 ± 0.509
0.289ArgCys: 0.289 ± 0.156
2.309ArgAsp: 2.309 ± 0.506
3.536ArgGlu: 3.536 ± 0.652
1.876ArgPhe: 1.876 ± 0.341
2.381ArgGly: 2.381 ± 0.402
0.577ArgHis: 0.577 ± 0.159
3.32ArgIle: 3.32 ± 0.473
3.753ArgLys: 3.753 ± 0.633
4.546ArgLeu: 4.546 ± 0.576
0.649ArgMet: 0.649 ± 0.225
2.454ArgAsn: 2.454 ± 0.486
0.866ArgPro: 0.866 ± 0.224
1.515ArgGln: 1.515 ± 0.253
1.443ArgArg: 1.443 ± 0.362
2.021ArgSer: 2.021 ± 0.298
1.515ArgThr: 1.515 ± 0.299
2.526ArgVal: 2.526 ± 0.559
0.433ArgTrp: 0.433 ± 0.206
2.309ArgTyr: 2.309 ± 0.448
0.0ArgXaa: 0.0 ± 0.0
Ser
5.412SerAla: 5.412 ± 1.387
0.577SerCys: 0.577 ± 0.211
2.887SerAsp: 2.887 ± 0.478
4.546SerGlu: 4.546 ± 0.674
2.454SerPhe: 2.454 ± 0.427
4.186SerGly: 4.186 ± 0.734
1.01SerHis: 1.01 ± 0.345
3.969SerIle: 3.969 ± 0.658
4.979SerLys: 4.979 ± 0.665
4.546SerLeu: 4.546 ± 0.614
1.515SerMet: 1.515 ± 0.528
2.381SerAsn: 2.381 ± 0.494
1.371SerPro: 1.371 ± 0.265
3.103SerGln: 3.103 ± 0.835
2.742SerArg: 2.742 ± 0.495
5.918SerSer: 5.918 ± 1.089
3.392SerThr: 3.392 ± 0.586
4.691SerVal: 4.691 ± 0.523
0.866SerTrp: 0.866 ± 0.277
2.093SerTyr: 2.093 ± 0.416
0.0SerXaa: 0.0 ± 0.0
Thr
4.619ThrAla: 4.619 ± 0.965
0.433ThrCys: 0.433 ± 0.191
3.753ThrAsp: 3.753 ± 0.58
3.969ThrGlu: 3.969 ± 0.565
2.959ThrPhe: 2.959 ± 0.452
4.979ThrGly: 4.979 ± 0.942
0.938ThrHis: 0.938 ± 0.254
3.32ThrIle: 3.32 ± 0.505
4.835ThrLys: 4.835 ± 0.698
5.918ThrLeu: 5.918 ± 0.712
0.866ThrMet: 0.866 ± 0.242
2.237ThrAsn: 2.237 ± 0.445
1.588ThrPro: 1.588 ± 0.319
2.093ThrGln: 2.093 ± 0.482
2.454ThrArg: 2.454 ± 0.397
3.103ThrSer: 3.103 ± 0.381
4.619ThrThr: 4.619 ± 0.783
4.402ThrVal: 4.402 ± 0.586
0.866ThrTrp: 0.866 ± 0.334
1.732ThrTyr: 1.732 ± 0.281
0.0ThrXaa: 0.0 ± 0.0
Val
5.268ValAla: 5.268 ± 0.912
0.289ValCys: 0.289 ± 0.143
4.258ValAsp: 4.258 ± 0.543
5.268ValGlu: 5.268 ± 0.837
2.526ValPhe: 2.526 ± 0.422
4.474ValGly: 4.474 ± 0.759
0.866ValHis: 0.866 ± 0.263
3.608ValIle: 3.608 ± 0.592
5.196ValLys: 5.196 ± 0.676
4.186ValLeu: 4.186 ± 0.452
1.299ValMet: 1.299 ± 0.326
1.948ValAsn: 1.948 ± 0.26
2.237ValPro: 2.237 ± 0.394
3.103ValGln: 3.103 ± 0.496
2.165ValArg: 2.165 ± 0.413
3.753ValSer: 3.753 ± 0.598
4.186ValThr: 4.186 ± 0.55
4.907ValVal: 4.907 ± 0.563
0.866ValTrp: 0.866 ± 0.304
1.876ValTyr: 1.876 ± 0.432
0.0ValXaa: 0.0 ± 0.0
Trp
0.866TrpAla: 0.866 ± 0.279
0.0TrpCys: 0.0 ± 0.0
0.722TrpAsp: 0.722 ± 0.234
1.082TrpGlu: 1.082 ± 0.229
0.577TrpPhe: 0.577 ± 0.201
1.01TrpGly: 1.01 ± 0.325
0.144TrpHis: 0.144 ± 0.095
0.649TrpIle: 0.649 ± 0.206
0.938TrpLys: 0.938 ± 0.215
1.299TrpLeu: 1.299 ± 0.359
0.216TrpMet: 0.216 ± 0.106
0.505TrpAsn: 0.505 ± 0.226
0.433TrpPro: 0.433 ± 0.2
0.722TrpGln: 0.722 ± 0.216
0.794TrpArg: 0.794 ± 0.254
0.577TrpSer: 0.577 ± 0.215
0.144TrpThr: 0.144 ± 0.132
0.577TrpVal: 0.577 ± 0.245
0.144TrpTrp: 0.144 ± 0.092
0.216TrpTyr: 0.216 ± 0.113
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.67TyrAla: 2.67 ± 0.449
0.433TyrCys: 0.433 ± 0.167
3.536TyrAsp: 3.536 ± 0.6
2.814TyrGlu: 2.814 ± 0.502
0.794TyrPhe: 0.794 ± 0.257
1.227TyrGly: 1.227 ± 0.281
0.505TyrHis: 0.505 ± 0.202
2.454TyrIle: 2.454 ± 0.393
3.247TyrLys: 3.247 ± 0.604
3.175TyrLeu: 3.175 ± 0.6
0.505TyrMet: 0.505 ± 0.204
1.876TyrAsn: 1.876 ± 0.391
0.938TyrPro: 0.938 ± 0.286
2.309TyrGln: 2.309 ± 0.441
1.732TyrArg: 1.732 ± 0.48
2.093TyrSer: 2.093 ± 0.347
2.309TyrThr: 2.309 ± 0.426
1.371TyrVal: 1.371 ± 0.347
0.433TyrTrp: 0.433 ± 0.164
1.66TyrTyr: 1.66 ± 0.451
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 64 proteins (13858 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski