Amino acid dipepetide frequency for Monosiga brevicollis (Choanoflagellate)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.197AlaAla: 13.197 ± 0.089	1.909AlaCys: 1.909 ± 0.029	5.715AlaAsp: 5.715 ± 0.035	6.119AlaGlu: 6.119 ± 0.057	3.272AlaPhe: 3.272 ± 0.027	6.209AlaGly: 6.209 ± 0.056	2.582AlaHis: 2.582 ± 0.025	3.735AlaIle: 3.735 ± 0.031	3.684AlaLys: 3.684 ± 0.04	10.425AlaLeu: 10.425 ± 0.069	2.425AlaMet: 2.425 ± 0.02	3.382AlaAsn: 3.382 ± 0.028	6.065AlaPro: 6.065 ± 0.059	4.918AlaGln: 4.918 ± 0.041	6.429AlaArg: 6.429 ± 0.052	8.96AlaSer: 8.96 ± 0.06	7.115AlaThr: 7.115 ± 0.057	6.804AlaVal: 6.804 ± 0.052	1.327AlaTrp: 1.327 ± 0.02	2.16AlaTyr: 2.16 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	1.532CysAla: 1.532 ± 0.03	0.387CysCys: 0.387 ± 0.012	0.965CysAsp: 0.965 ± 0.02	0.835CysGlu: 0.835 ± 0.016	0.675CysPhe: 0.675 ± 0.012	1.102CysGly: 1.102 ± 0.02	0.541CysHis: 0.541 ± 0.012	0.724CysIle: 0.724 ± 0.012	0.571CysLys: 0.571 ± 0.012	1.913CysLeu: 1.913 ± 0.027	0.349CysMet: 0.349 ± 0.009	0.644CysAsn: 0.644 ± 0.016	1.034CysPro: 1.034 ± 0.022	0.788CysGln: 0.788 ± 0.018	1.116CysArg: 1.116 ± 0.019	1.27CysSer: 1.27 ± 0.024	1.117CysThr: 1.117 ± 0.025	1.987CysVal: 1.987 ± 0.056	0.222CysTrp: 0.222 ± 0.007	0.419CysTyr: 0.419 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.217AspAla: 6.217 ± 0.044	0.869AspCys: 0.869 ± 0.018	4.573AspAsp: 4.573 ± 0.064	4.252AspGlu: 4.252 ± 0.038	2.054AspPhe: 2.054 ± 0.022	4.218AspGly: 4.218 ± 0.05	1.405AspHis: 1.405 ± 0.018	2.325AspIle: 2.325 ± 0.022	1.915AspLys: 1.915 ± 0.024	5.771AspLeu: 5.771 ± 0.045	1.433AspMet: 1.433 ± 0.019	1.935AspAsn: 1.935 ± 0.028	2.829AspPro: 2.829 ± 0.026	2.328AspGln: 2.328 ± 0.026	3.055AspArg: 3.055 ± 0.032	3.528AspSer: 3.528 ± 0.028	3.035AspThr: 3.035 ± 0.035	4.498AspVal: 4.498 ± 0.048	0.701AspTrp: 0.701 ± 0.013	1.42AspTyr: 1.42 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	7.011GluAla: 7.011 ± 0.056	0.816GluCys: 0.816 ± 0.019	3.743GluAsp: 3.743 ± 0.038	4.37GluGlu: 4.37 ± 0.058	1.568GluPhe: 1.568 ± 0.018	3.107GluGly: 3.107 ± 0.028	1.71GluHis: 1.71 ± 0.02	1.915GluIle: 1.915 ± 0.022	1.995GluLys: 1.995 ± 0.03	6.242GluLeu: 6.242 ± 0.062	1.202GluMet: 1.202 ± 0.017	1.643GluAsn: 1.643 ± 0.019	2.962GluPro: 2.962 ± 0.037	3.144GluGln: 3.144 ± 0.035	4.143GluArg: 4.143 ± 0.051	3.37GluSer: 3.37 ± 0.028	3.155GluThr: 3.155 ± 0.032	3.598GluVal: 3.598 ± 0.039	0.608GluTrp: 0.608 ± 0.013	1.351GluTyr: 1.351 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.286PheAla: 3.286 ± 0.028	0.649PheCys: 0.649 ± 0.012	2.367PheAsp: 2.367 ± 0.022	2.154PheGlu: 2.154 ± 0.025	1.426PhePhe: 1.426 ± 0.021	2.486PheGly: 2.486 ± 0.03	0.855PheHis: 0.855 ± 0.016	1.204PheIle: 1.204 ± 0.017	1.189PheLys: 1.189 ± 0.018	3.07PheLeu: 3.07 ± 0.029	0.705PheMet: 0.705 ± 0.012	1.287PheAsn: 1.287 ± 0.018	1.394PhePro: 1.394 ± 0.019	1.277PheGln: 1.277 ± 0.017	1.808PheArg: 1.808 ± 0.019	2.464PheSer: 2.464 ± 0.027	1.711PheThr: 1.711 ± 0.023	2.656PheVal: 2.656 ± 0.028	0.431PheTrp: 0.431 ± 0.01	0.927PheTyr: 0.927 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.908GlyAla: 5.908 ± 0.061	1.044GlyCys: 1.044 ± 0.017	3.445GlyAsp: 3.445 ± 0.038	2.93GlyGlu: 2.93 ± 0.027	2.276GlyPhe: 2.276 ± 0.028	4.343GlyGly: 4.343 ± 0.069	1.845GlyHis: 1.845 ± 0.024	2.32GlyIle: 2.32 ± 0.022	2.17GlyLys: 2.17 ± 0.029	5.753GlyLeu: 5.753 ± 0.044	1.387GlyMet: 1.387 ± 0.022	2.169GlyAsn: 2.169 ± 0.026	3.049GlyPro: 3.049 ± 0.036	2.743GlyGln: 2.743 ± 0.027	3.815GlyArg: 3.815 ± 0.038	5.011GlySer: 5.011 ± 0.044	3.939GlyThr: 3.939 ± 0.056	4.048GlyVal: 4.048 ± 0.04	0.833GlyTrp: 0.833 ± 0.015	1.66GlyTyr: 1.66 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	2.747HisAla: 2.747 ± 0.032	0.491HisCys: 0.491 ± 0.01	1.633HisAsp: 1.633 ± 0.019	1.592HisGlu: 1.592 ± 0.021	0.989HisPhe: 0.989 ± 0.015	1.923HisGly: 1.923 ± 0.022	1.076HisHis: 1.076 ± 0.023	1.081HisIle: 1.081 ± 0.018	0.837HisLys: 0.837 ± 0.017	2.873HisLeu: 2.873 ± 0.032	0.605HisMet: 0.605 ± 0.014	0.951HisAsn: 0.951 ± 0.014	1.596HisPro: 1.596 ± 0.022	1.313HisGln: 1.313 ± 0.02	1.889HisArg: 1.889 ± 0.025	1.774HisSer: 1.774 ± 0.022	1.57HisThr: 1.57 ± 0.026	2.035HisVal: 2.035 ± 0.022	0.331HisTrp: 0.331 ± 0.007	0.705HisTyr: 0.705 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	3.402IleAla: 3.402 ± 0.029	0.71IleCys: 0.71 ± 0.014	2.411IleAsp: 2.411 ± 0.025	2.278IleGlu: 2.278 ± 0.026	1.441IlePhe: 1.441 ± 0.021	2.106IleGly: 2.106 ± 0.02	0.944IleHis: 0.944 ± 0.015	1.601IleIle: 1.601 ± 0.019	1.666IleLys: 1.666 ± 0.025	3.365IleLeu: 3.365 ± 0.03	0.907IleMet: 0.907 ± 0.013	1.672IleAsn: 1.672 ± 0.021	1.714IlePro: 1.714 ± 0.02	1.545IleGln: 1.545 ± 0.018	2.116IleArg: 2.116 ± 0.029	2.636IleSer: 2.636 ± 0.023	2.159IleThr: 2.159 ± 0.029	2.788IleVal: 2.788 ± 0.036	0.418IleTrp: 0.418 ± 0.008	0.979IleTyr: 0.979 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	3.797LysAla: 3.797 ± 0.041	0.477LysCys: 0.477 ± 0.012	1.818LysAsp: 1.818 ± 0.023	1.992LysGlu: 1.992 ± 0.028	1.023LysPhe: 1.023 ± 0.015	1.898LysGly: 1.898 ± 0.031	1.064LysHis: 1.064 ± 0.019	1.301LysIle: 1.301 ± 0.02	1.896LysLys: 1.896 ± 0.041	3.567LysLeu: 3.567 ± 0.049	0.752LysMet: 0.752 ± 0.013	1.125LysAsn: 1.125 ± 0.02	2.028LysPro: 2.028 ± 0.029	1.796LysGln: 1.796 ± 0.025	2.669LysArg: 2.669 ± 0.033	2.316LysSer: 2.316 ± 0.028	2.056LysThr: 2.056 ± 0.023	2.104LysVal: 2.104 ± 0.024	0.344LysTrp: 0.344 ± 0.009	0.831LysTyr: 0.831 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	10.313LeuAla: 10.313 ± 0.065	1.891LeuCys: 1.891 ± 0.026	6.12LeuAsp: 6.12 ± 0.053	6.055LeuGlu: 6.055 ± 0.041	3.215LeuPhe: 3.215 ± 0.03	5.564LeuGly: 5.564 ± 0.04	2.944LeuHis: 2.944 ± 0.03	3.326LeuIle: 3.326 ± 0.034	3.601LeuLys: 3.601 ± 0.035	10.221LeuLeu: 10.221 ± 0.07	1.95LeuMet: 1.95 ± 0.02	3.379LeuAsn: 3.379 ± 0.034	5.56LeuPro: 5.56 ± 0.039	5.323LeuGln: 5.323 ± 0.044	6.844LeuArg: 6.844 ± 0.048	9.525LeuSer: 9.525 ± 0.102	5.797LeuThr: 5.797 ± 0.062	6.591LeuVal: 6.591 ± 0.065	1.027LeuTrp: 1.027 ± 0.014	2.245LeuTyr: 2.245 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.789MetAla: 2.789 ± 0.023	0.331MetCys: 0.331 ± 0.009	1.244MetAsp: 1.244 ± 0.016	1.12MetGlu: 1.12 ± 0.015	0.624MetPhe: 0.624 ± 0.011	1.352MetGly: 1.352 ± 0.018	0.617MetHis: 0.617 ± 0.012	0.749MetIle: 0.749 ± 0.013	0.666MetLys: 0.666 ± 0.012	2.18MetLeu: 2.18 ± 0.021	0.581MetMet: 0.581 ± 0.014	0.644MetAsn: 0.644 ± 0.013	1.374MetPro: 1.374 ± 0.019	1.088MetGln: 1.088 ± 0.015	1.413MetArg: 1.413 ± 0.018	1.582MetSer: 1.582 ± 0.019	1.424MetThr: 1.424 ± 0.015	1.292MetVal: 1.292 ± 0.018	0.216MetTrp: 0.216 ± 0.006	0.495MetTyr: 0.495 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.444AsnAla: 3.444 ± 0.035	0.584AsnCys: 0.584 ± 0.012	2.041AsnAsp: 2.041 ± 0.03	1.829AsnGlu: 1.829 ± 0.022	1.208AsnPhe: 1.208 ± 0.016	2.505AsnGly: 2.505 ± 0.032	0.829AsnHis: 0.829 ± 0.014	1.485AsnIle: 1.485 ± 0.02	1.329AsnLys: 1.329 ± 0.023	3.253AsnLeu: 3.253 ± 0.032	0.896AsnMet: 0.896 ± 0.014	1.497AsnAsn: 1.497 ± 0.024	1.832AsnPro: 1.832 ± 0.019	1.327AsnGln: 1.327 ± 0.017	1.759AsnArg: 1.759 ± 0.02	2.34AsnSer: 2.34 ± 0.029	2.033AsnThr: 2.033 ± 0.026	2.562AsnVal: 2.562 ± 0.031	0.403AsnTrp: 0.403 ± 0.009	0.852AsnTyr: 0.852 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	6.439ProAla: 6.439 ± 0.054	0.844ProCys: 0.844 ± 0.02	3.053ProAsp: 3.053 ± 0.026	3.328ProGlu: 3.328 ± 0.032	1.657ProPhe: 1.657 ± 0.02	3.255ProGly: 3.255 ± 0.038	1.412ProHis: 1.412 ± 0.019	1.873ProIle: 1.873 ± 0.02	1.792ProLys: 1.792 ± 0.024	4.729ProLeu: 4.729 ± 0.033	1.105ProMet: 1.105 ± 0.016	1.858ProAsn: 1.858 ± 0.023	4.217ProPro: 4.217 ± 0.064	2.118ProGln: 2.118 ± 0.028	3.156ProArg: 3.156 ± 0.035	5.158ProSer: 5.158 ± 0.041	3.956ProThr: 3.956 ± 0.036	3.701ProVal: 3.701 ± 0.036	0.579ProTrp: 0.579 ± 0.011	1.143ProTyr: 1.143 ± 0.017	0.001ProXaa: 0.001 ± 0.0
Gln	5.515GlnAla: 5.515 ± 0.042	0.689GlnCys: 0.689 ± 0.017	2.265GlnAsp: 2.265 ± 0.024	2.629GlnGlu: 2.629 ± 0.033	1.231GlnPhe: 1.231 ± 0.016	2.537GlnGly: 2.537 ± 0.023	1.577GlnHis: 1.577 ± 0.023	1.547GlnIle: 1.547 ± 0.023	1.363GlnLys: 1.363 ± 0.022	5.376GlnLeu: 5.376 ± 0.044	0.943GlnMet: 0.943 ± 0.016	1.302GlnAsn: 1.302 ± 0.017	2.787GlnPro: 2.787 ± 0.028	3.408GlnGln: 3.408 ± 0.077	3.6GlnArg: 3.6 ± 0.038	2.911GlnSer: 2.911 ± 0.023	2.595GlnThr: 2.595 ± 0.022	2.79GlnVal: 2.79 ± 0.025	0.496GlnTrp: 0.496 ± 0.01	1.022GlnTyr: 1.022 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	6.339ArgAla: 6.339 ± 0.049	1.115ArgCys: 1.115 ± 0.016	3.466ArgAsp: 3.466 ± 0.034	3.748ArgGlu: 3.748 ± 0.047	2.215ArgPhe: 2.215 ± 0.024	3.464ArgGly: 3.464 ± 0.034	2.1ArgHis: 2.1 ± 0.024	2.39ArgIle: 2.39 ± 0.021	2.271ArgLys: 2.271 ± 0.029	6.77ArgLeu: 6.77 ± 0.046	1.265ArgMet: 1.265 ± 0.017	2.034ArgAsn: 2.034 ± 0.021	3.333ArgPro: 3.333 ± 0.038	3.309ArgGln: 3.309 ± 0.037	5.352ArgArg: 5.352 ± 0.062	4.406ArgSer: 4.406 ± 0.044	3.258ArgThr: 3.258 ± 0.027	4.074ArgVal: 4.074 ± 0.034	0.791ArgTrp: 0.791 ± 0.012	1.504ArgTyr: 1.504 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	7.653SerAla: 7.653 ± 0.051	1.318SerCys: 1.318 ± 0.027	4.167SerAsp: 4.167 ± 0.031	3.666SerGlu: 3.666 ± 0.031	2.593SerPhe: 2.593 ± 0.027	4.925SerGly: 4.925 ± 0.046	2.005SerHis: 2.005 ± 0.024	2.778SerIle: 2.778 ± 0.024	2.57SerLys: 2.57 ± 0.03	9.219SerLeu: 9.219 ± 0.095	1.615SerMet: 1.615 ± 0.02	2.739SerAsn: 2.739 ± 0.028	4.365SerPro: 4.365 ± 0.049	3.114SerGln: 3.114 ± 0.028	4.331SerArg: 4.331 ± 0.043	7.616SerSer: 7.616 ± 0.098	5.668SerThr: 5.668 ± 0.098	4.714SerVal: 4.714 ± 0.05	0.896SerTrp: 0.896 ± 0.016	1.564SerTyr: 1.564 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	6.599ThrAla: 6.599 ± 0.052	1.228ThrCys: 1.228 ± 0.033	3.111ThrAsp: 3.111 ± 0.036	2.922ThrGlu: 2.922 ± 0.035	2.175ThrPhe: 2.175 ± 0.027	3.779ThrGly: 3.779 ± 0.045	1.612ThrHis: 1.612 ± 0.025	2.49ThrIle: 2.49 ± 0.034	1.906ThrLys: 1.906 ± 0.025	6.179ThrLeu: 6.179 ± 0.063	1.359ThrMet: 1.359 ± 0.017	2.044ThrAsn: 2.044 ± 0.023	3.995ThrPro: 3.995 ± 0.034	2.33ThrGln: 2.33 ± 0.022	3.377ThrArg: 3.377 ± 0.028	5.501ThrSer: 5.501 ± 0.1	5.744ThrThr: 5.744 ± 0.149	4.102ThrVal: 4.102 ± 0.052	0.737ThrTrp: 0.737 ± 0.014	1.397ThrTyr: 1.397 ± 0.023	0.001ThrXaa: 0.001 ± 0.0
Val	7.213ValAla: 7.213 ± 0.058	2.14ValCys: 2.14 ± 0.057	4.064ValAsp: 4.064 ± 0.039	3.907ValGlu: 3.907 ± 0.062	2.308ValPhe: 2.308 ± 0.026	3.758ValGly: 3.758 ± 0.036	1.793ValHis: 1.793 ± 0.021	2.568ValIle: 2.568 ± 0.029	2.252ValLys: 2.252 ± 0.023	6.916ValLeu: 6.916 ± 0.059	1.457ValMet: 1.457 ± 0.017	2.242ValAsn: 2.242 ± 0.035	3.68ValPro: 3.68 ± 0.027	3.034ValGln: 3.034 ± 0.026	3.94ValArg: 3.94 ± 0.033	4.7ValSer: 4.7 ± 0.045	4.122ValThr: 4.122 ± 0.061	5.285ValVal: 5.285 ± 0.071	0.785ValTrp: 0.785 ± 0.014	1.709ValTyr: 1.709 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	0.97TrpAla: 0.97 ± 0.015	0.237TrpCys: 0.237 ± 0.006	0.618TrpAsp: 0.618 ± 0.013	0.542TrpGlu: 0.542 ± 0.01	0.419TrpPhe: 0.419 ± 0.009	0.543TrpGly: 0.543 ± 0.011	0.403TrpHis: 0.403 ± 0.01	0.48TrpIle: 0.48 ± 0.008	0.378TrpLys: 0.378 ± 0.009	1.35TrpLeu: 1.35 ± 0.018	0.286TrpMet: 0.286 ± 0.007	0.435TrpAsn: 0.435 ± 0.011	0.552TrpPro: 0.552 ± 0.011	0.641TrpGln: 0.641 ± 0.011	0.864TrpArg: 0.864 ± 0.017	0.942TrpSer: 0.942 ± 0.017	0.768TrpThr: 0.768 ± 0.013	0.649TrpVal: 0.649 ± 0.012	0.187TrpTrp: 0.187 ± 0.007	0.377TrpTyr: 0.377 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.062TyrAla: 2.062 ± 0.019	0.464TyrCys: 0.464 ± 0.011	1.541TyrAsp: 1.541 ± 0.022	1.383TyrGlu: 1.383 ± 0.021	0.978TyrPhe: 0.978 ± 0.015	1.612TyrGly: 1.612 ± 0.021	0.697TyrHis: 0.697 ± 0.012	0.965TyrIle: 0.965 ± 0.017	0.805TyrLys: 0.805 ± 0.014	2.316TyrLeu: 2.316 ± 0.026	0.559TyrMet: 0.559 ± 0.011	1.026TyrAsn: 1.026 ± 0.017	1.006TyrPro: 1.006 ± 0.017	1.043TyrGln: 1.043 ± 0.016	1.529TyrArg: 1.529 ± 0.019	1.507TyrSer: 1.507 ± 0.02	1.366TyrThr: 1.366 ± 0.019	1.594TyrVal: 1.594 ± 0.017	0.308TyrTrp: 0.308 ± 0.008	0.787TyrTyr: 0.787 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9188 proteins (5511963 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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