Amino acid dipepetide frequency for Haloechinothrix halophila YIM 93223

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.822AlaAla: 17.822 ± 0.733
0.936AlaCys: 0.936 ± 0.095
8.264AlaAsp: 8.264 ± 0.284
9.127AlaGlu: 9.127 ± 0.335
3.339AlaPhe: 3.339 ± 0.209
11.126AlaGly: 11.126 ± 0.405
2.22AlaHis: 2.22 ± 0.138
4.953AlaIle: 4.953 ± 0.242
3.495AlaLys: 3.495 ± 0.2
11.576AlaLeu: 11.576 ± 0.406
2.788AlaMet: 2.788 ± 0.151
2.798AlaAsn: 2.798 ± 0.185
5.714AlaPro: 5.714 ± 0.302
3.614AlaGln: 3.614 ± 0.203
7.943AlaArg: 7.943 ± 0.347
6.769AlaSer: 6.769 ± 0.291
7.164AlaThr: 7.164 ± 0.334
11.154AlaVal: 11.154 ± 0.402
1.348AlaTrp: 1.348 ± 0.128
2.302AlaTyr: 2.302 ± 0.146
0.0AlaXaa: 0.0 ± 0.0
Cys
0.899CysAla: 0.899 ± 0.094
0.156CysCys: 0.156 ± 0.05
0.532CysAsp: 0.532 ± 0.076
0.431CysGlu: 0.431 ± 0.073
0.165CysPhe: 0.165 ± 0.041
0.835CysGly: 0.835 ± 0.089
0.165CysHis: 0.165 ± 0.038
0.202CysIle: 0.202 ± 0.051
0.156CysLys: 0.156 ± 0.034
0.504CysLeu: 0.504 ± 0.072
0.138CysMet: 0.138 ± 0.039
0.064CysAsn: 0.064 ± 0.021
0.468CysPro: 0.468 ± 0.07
0.238CysGln: 0.238 ± 0.046
0.596CysArg: 0.596 ± 0.086
0.459CysSer: 0.459 ± 0.068
0.431CysThr: 0.431 ± 0.063
0.605CysVal: 0.605 ± 0.08
0.092CysTrp: 0.092 ± 0.03
0.193CysTyr: 0.193 ± 0.042
0.0CysXaa: 0.0 ± 0.0
Asp
8.558AspAla: 8.558 ± 0.346
0.367AspCys: 0.367 ± 0.063
4.632AspAsp: 4.632 ± 0.248
4.559AspGlu: 4.559 ± 0.224
1.724AspPhe: 1.724 ± 0.131
6.375AspGly: 6.375 ± 0.194
1.119AspHis: 1.119 ± 0.124
2.587AspIle: 2.587 ± 0.17
1.853AspLys: 1.853 ± 0.148
5.338AspLeu: 5.338 ± 0.216
0.835AspMet: 0.835 ± 0.089
1.339AspAsn: 1.339 ± 0.107
3.935AspPro: 3.935 ± 0.187
1.651AspGln: 1.651 ± 0.132
4.128AspArg: 4.128 ± 0.198
2.66AspSer: 2.66 ± 0.152
3.541AspThr: 3.541 ± 0.197
6.503AspVal: 6.503 ± 0.283
0.826AspTrp: 0.826 ± 0.078
1.257AspTyr: 1.257 ± 0.111
0.0AspXaa: 0.0 ± 0.0
Glu
6.43GluAla: 6.43 ± 0.292
0.404GluCys: 0.404 ± 0.063
3.155GluAsp: 3.155 ± 0.23
3.201GluGlu: 3.201 ± 0.256
1.596GluPhe: 1.596 ± 0.121
3.715GluGly: 3.715 ± 0.208
1.715GluHis: 1.715 ± 0.161
2.596GluIle: 2.596 ± 0.167
1.89GluLys: 1.89 ± 0.152
7.521GluLeu: 7.521 ± 0.314
1.183GluMet: 1.183 ± 0.099
1.403GluAsn: 1.403 ± 0.112
4.091GluPro: 4.091 ± 0.229
2.733GluGln: 2.733 ± 0.196
5.503GluArg: 5.503 ± 0.239
3.421GluSer: 3.421 ± 0.217
3.073GluThr: 3.073 ± 0.173
4.623GluVal: 4.623 ± 0.237
0.725GluTrp: 0.725 ± 0.094
1.092GluTyr: 1.092 ± 0.111
0.0GluXaa: 0.0 ± 0.0
Phe
4.008PheAla: 4.008 ± 0.213
0.248PheCys: 0.248 ± 0.048
2.201PheAsp: 2.201 ± 0.17
1.458PheGlu: 1.458 ± 0.123
0.936PhePhe: 0.936 ± 0.106
3.55PheGly: 3.55 ± 0.211
0.532PheHis: 0.532 ± 0.062
1.073PheIle: 1.073 ± 0.115
0.642PheLys: 0.642 ± 0.088
2.532PheLeu: 2.532 ± 0.179
0.468PheMet: 0.468 ± 0.068
0.816PheAsn: 0.816 ± 0.105
1.119PhePro: 1.119 ± 0.105
0.688PheGln: 0.688 ± 0.084
1.789PheArg: 1.789 ± 0.14
1.624PheSer: 1.624 ± 0.108
1.807PheThr: 1.807 ± 0.136
2.284PheVal: 2.284 ± 0.143
0.394PheTrp: 0.394 ± 0.063
0.77PheTyr: 0.77 ± 0.082
0.0PheXaa: 0.0 ± 0.0
Gly
10.255GlyAla: 10.255 ± 0.388
0.826GlyCys: 0.826 ± 0.102
5.237GlyAsp: 5.237 ± 0.191
5.338GlyGlu: 5.338 ± 0.274
2.944GlyPhe: 2.944 ± 0.175
9.218GlyGly: 9.218 ± 0.492
1.816GlyHis: 1.816 ± 0.15
4.302GlyIle: 4.302 ± 0.226
3.293GlyLys: 3.293 ± 0.219
8.494GlyLeu: 8.494 ± 0.339
2.394GlyMet: 2.394 ± 0.144
1.779GlyAsn: 1.779 ± 0.136
4.265GlyPro: 4.265 ± 0.209
3.082GlyGln: 3.082 ± 0.218
5.907GlyArg: 5.907 ± 0.222
4.999GlySer: 4.999 ± 0.252
5.632GlyThr: 5.632 ± 0.289
7.971GlyVal: 7.971 ± 0.353
1.532GlyTrp: 1.532 ± 0.109
2.495GlyTyr: 2.495 ± 0.174
0.0GlyXaa: 0.0 ± 0.0
His
2.284HisAla: 2.284 ± 0.158
0.202HisCys: 0.202 ± 0.044
1.431HisAsp: 1.431 ± 0.123
1.046HisGlu: 1.046 ± 0.101
0.624HisPhe: 0.624 ± 0.094
2.1HisGly: 2.1 ± 0.137
0.504HisHis: 0.504 ± 0.075
0.697HisIle: 0.697 ± 0.094
0.477HisLys: 0.477 ± 0.074
1.779HisLeu: 1.779 ± 0.139
0.312HisMet: 0.312 ± 0.059
0.44HisAsn: 0.44 ± 0.057
1.385HisPro: 1.385 ± 0.101
0.587HisGln: 0.587 ± 0.074
1.578HisArg: 1.578 ± 0.125
0.936HisSer: 0.936 ± 0.091
1.284HisThr: 1.284 ± 0.098
1.633HisVal: 1.633 ± 0.11
0.303HisTrp: 0.303 ± 0.058
0.587HisTyr: 0.587 ± 0.072
0.0HisXaa: 0.0 ± 0.0
Ile
6.356IleAla: 6.356 ± 0.259
0.303IleCys: 0.303 ± 0.047
3.201IleAsp: 3.201 ± 0.178
2.743IleGlu: 2.743 ± 0.192
0.871IlePhe: 0.871 ± 0.094
4.568IleGly: 4.568 ± 0.236
0.605IleHis: 0.605 ± 0.082
1.697IleIle: 1.697 ± 0.142
1.302IleLys: 1.302 ± 0.107
2.403IleLeu: 2.403 ± 0.163
0.587IleMet: 0.587 ± 0.074
1.293IleAsn: 1.293 ± 0.105
2.293IlePro: 2.293 ± 0.153
0.844IleGln: 0.844 ± 0.085
2.256IleArg: 2.256 ± 0.13
2.293IleSer: 2.293 ± 0.14
2.871IleThr: 2.871 ± 0.178
3.458IleVal: 3.458 ± 0.208
0.422IleTrp: 0.422 ± 0.064
0.67IleTyr: 0.67 ± 0.077
0.0IleXaa: 0.0 ± 0.0
Lys
3.339LysAla: 3.339 ± 0.226
0.156LysCys: 0.156 ± 0.037
1.624LysAsp: 1.624 ± 0.145
1.523LysGlu: 1.523 ± 0.142
0.624LysPhe: 0.624 ± 0.074
2.275LysGly: 2.275 ± 0.16
0.651LysHis: 0.651 ± 0.077
1.376LysIle: 1.376 ± 0.122
1.367LysLys: 1.367 ± 0.148
2.889LysLeu: 2.889 ± 0.196
0.44LysMet: 0.44 ± 0.074
0.642LysAsn: 0.642 ± 0.08
1.935LysPro: 1.935 ± 0.149
1.192LysGln: 1.192 ± 0.132
2.477LysArg: 2.477 ± 0.173
1.605LysSer: 1.605 ± 0.13
1.752LysThr: 1.752 ± 0.135
2.614LysVal: 2.614 ± 0.179
0.238LysTrp: 0.238 ± 0.051
0.578LysTyr: 0.578 ± 0.064
0.0LysXaa: 0.0 ± 0.0
Leu
13.896LeuAla: 13.896 ± 0.484
0.66LeuCys: 0.66 ± 0.077
5.815LeuAsp: 5.815 ± 0.256
4.265LeuGlu: 4.265 ± 0.234
2.651LeuPhe: 2.651 ± 0.175
8.961LeuGly: 8.961 ± 0.337
1.724LeuHis: 1.724 ± 0.135
3.66LeuIle: 3.66 ± 0.197
1.963LeuLys: 1.963 ± 0.169
10.429LeuLeu: 10.429 ± 0.461
1.596LeuMet: 1.596 ± 0.112
2.009LeuAsn: 2.009 ± 0.133
5.724LeuPro: 5.724 ± 0.28
1.844LeuGln: 1.844 ± 0.125
7.943LeuArg: 7.943 ± 0.291
5.265LeuSer: 5.265 ± 0.225
5.751LeuThr: 5.751 ± 0.254
8.521LeuVal: 8.521 ± 0.349
0.826LeuTrp: 0.826 ± 0.09
1.559LeuTyr: 1.559 ± 0.123
0.0LeuXaa: 0.0 ± 0.0
Met
2.559MetAla: 2.559 ± 0.146
0.165MetCys: 0.165 ± 0.041
0.862MetAsp: 0.862 ± 0.089
0.752MetGlu: 0.752 ± 0.083
0.66MetPhe: 0.66 ± 0.101
1.367MetGly: 1.367 ± 0.127
0.367MetHis: 0.367 ± 0.059
0.78MetIle: 0.78 ± 0.091
0.56MetLys: 0.56 ± 0.077
2.137MetLeu: 2.137 ± 0.156
0.431MetMet: 0.431 ± 0.082
0.504MetAsn: 0.504 ± 0.065
1.312MetPro: 1.312 ± 0.103
0.422MetGln: 0.422 ± 0.074
1.486MetArg: 1.486 ± 0.116
1.568MetSer: 1.568 ± 0.115
1.807MetThr: 1.807 ± 0.122
1.513MetVal: 1.513 ± 0.135
0.202MetTrp: 0.202 ± 0.049
0.321MetTyr: 0.321 ± 0.054
0.0MetXaa: 0.0 ± 0.0
Asn
2.541AsnAla: 2.541 ± 0.173
0.165AsnCys: 0.165 ± 0.042
1.211AsnAsp: 1.211 ± 0.11
1.348AsnGlu: 1.348 ± 0.132
0.642AsnPhe: 0.642 ± 0.084
2.201AsnGly: 2.201 ± 0.151
0.385AsnHis: 0.385 ± 0.055
0.926AsnIle: 0.926 ± 0.103
0.615AsnLys: 0.615 ± 0.091
1.981AsnLeu: 1.981 ± 0.135
0.376AsnMet: 0.376 ± 0.06
0.633AsnAsn: 0.633 ± 0.079
1.568AsnPro: 1.568 ± 0.123
0.706AsnGln: 0.706 ± 0.082
1.578AsnArg: 1.578 ± 0.138
1.101AsnSer: 1.101 ± 0.094
1.367AsnThr: 1.367 ± 0.127
1.596AsnVal: 1.596 ± 0.109
0.257AsnTrp: 0.257 ± 0.04
0.486AsnTyr: 0.486 ± 0.07
0.0AsnXaa: 0.0 ± 0.0
Pro
6.246ProAla: 6.246 ± 0.291
0.275ProCys: 0.275 ± 0.06
4.669ProAsp: 4.669 ± 0.211
4.045ProGlu: 4.045 ± 0.233
1.486ProPhe: 1.486 ± 0.097
5.751ProGly: 5.751 ± 0.294
1.394ProHis: 1.394 ± 0.116
2.192ProIle: 2.192 ± 0.149
1.779ProLys: 1.779 ± 0.119
4.77ProLeu: 4.77 ± 0.208
1.147ProMet: 1.147 ± 0.097
1.064ProAsn: 1.064 ± 0.095
3.669ProPro: 3.669 ± 0.331
1.862ProGln: 1.862 ± 0.182
3.22ProArg: 3.22 ± 0.207
3.137ProSer: 3.137 ± 0.238
3.256ProThr: 3.256 ± 0.183
5.228ProVal: 5.228 ± 0.219
0.587ProTrp: 0.587 ± 0.098
1.119ProTyr: 1.119 ± 0.116
0.0ProXaa: 0.0 ± 0.0
Gln
3.348GlnAla: 3.348 ± 0.203
0.202GlnCys: 0.202 ± 0.047
1.376GlnAsp: 1.376 ± 0.108
1.394GlnGlu: 1.394 ± 0.126
0.899GlnPhe: 0.899 ± 0.092
2.211GlnGly: 2.211 ± 0.154
0.789GlnHis: 0.789 ± 0.083
1.284GlnIle: 1.284 ± 0.113
0.633GlnLys: 0.633 ± 0.083
3.275GlnLeu: 3.275 ± 0.208
0.624GlnMet: 0.624 ± 0.088
0.422GlnAsn: 0.422 ± 0.07
2.559GlnPro: 2.559 ± 0.295
1.935GlnGln: 1.935 ± 0.198
3.009GlnArg: 3.009 ± 0.205
1.513GlnSer: 1.513 ± 0.105
1.202GlnThr: 1.202 ± 0.093
2.715GlnVal: 2.715 ± 0.169
0.385GlnTrp: 0.385 ± 0.063
0.651GlnTyr: 0.651 ± 0.086
0.0GlnXaa: 0.0 ± 0.0
Arg
7.989ArgAla: 7.989 ± 0.302
0.532ArgCys: 0.532 ± 0.072
4.164ArgAsp: 4.164 ± 0.198
4.568ArgGlu: 4.568 ± 0.211
2.422ArgPhe: 2.422 ± 0.139
5.265ArgGly: 5.265 ± 0.238
1.559ArgHis: 1.559 ± 0.126
3.302ArgIle: 3.302 ± 0.177
2.779ArgLys: 2.779 ± 0.188
6.714ArgLeu: 6.714 ± 0.254
1.963ArgMet: 1.963 ± 0.106
1.724ArgAsn: 1.724 ± 0.132
3.724ArgPro: 3.724 ± 0.225
2.706ArgGln: 2.706 ± 0.158
6.301ArgArg: 6.301 ± 0.313
3.843ArgSer: 3.843 ± 0.203
4.412ArgThr: 4.412 ± 0.243
5.604ArgVal: 5.604 ± 0.282
1.376ArgTrp: 1.376 ± 0.134
1.825ArgTyr: 1.825 ± 0.127
0.0ArgXaa: 0.0 ± 0.0
Ser
6.714SerAla: 6.714 ± 0.255
0.33SerCys: 0.33 ± 0.066
3.568SerAsp: 3.568 ± 0.21
3.651SerGlu: 3.651 ± 0.22
1.834SerPhe: 1.834 ± 0.126
6.246SerGly: 6.246 ± 0.257
1.064SerHis: 1.064 ± 0.102
1.972SerIle: 1.972 ± 0.121
1.486SerLys: 1.486 ± 0.132
4.228SerLeu: 4.228 ± 0.193
1.403SerMet: 1.403 ± 0.123
1.192SerAsn: 1.192 ± 0.113
3.009SerPro: 3.009 ± 0.206
1.596SerGln: 1.596 ± 0.124
3.641SerArg: 3.641 ± 0.196
3.394SerSer: 3.394 ± 0.222
3.568SerThr: 3.568 ± 0.216
4.311SerVal: 4.311 ± 0.195
0.789SerTrp: 0.789 ± 0.078
1.275SerTyr: 1.275 ± 0.103
0.0SerXaa: 0.0 ± 0.0
Thr
7.375ThrAla: 7.375 ± 0.341
0.312ThrCys: 0.312 ± 0.06
4.063ThrAsp: 4.063 ± 0.247
3.715ThrGlu: 3.715 ± 0.177
1.688ThrPhe: 1.688 ± 0.117
6.136ThrGly: 6.136 ± 0.27
1.165ThrHis: 1.165 ± 0.109
2.412ThrIle: 2.412 ± 0.163
1.862ThrLys: 1.862 ± 0.121
5.494ThrLeu: 5.494 ± 0.201
1.183ThrMet: 1.183 ± 0.096
1.009ThrAsn: 1.009 ± 0.093
3.541ThrPro: 3.541 ± 0.198
1.614ThrGln: 1.614 ± 0.135
3.486ThrArg: 3.486 ± 0.196
3.944ThrSer: 3.944 ± 0.216
4.632ThrThr: 4.632 ± 0.424
5.531ThrVal: 5.531 ± 0.269
0.807ThrTrp: 0.807 ± 0.079
1.238ThrTyr: 1.238 ± 0.126
0.0ThrXaa: 0.0 ± 0.0
Val
10.411ValAla: 10.411 ± 0.385
0.78ValCys: 0.78 ± 0.093
5.687ValAsp: 5.687 ± 0.223
5.054ValGlu: 5.054 ± 0.244
2.477ValPhe: 2.477 ± 0.162
6.898ValGly: 6.898 ± 0.253
1.779ValHis: 1.779 ± 0.124
3.962ValIle: 3.962 ± 0.178
2.339ValLys: 2.339 ± 0.153
9.337ValLeu: 9.337 ± 0.389
1.431ValMet: 1.431 ± 0.131
1.981ValAsn: 1.981 ± 0.144
4.806ValPro: 4.806 ± 0.206
1.862ValGln: 1.862 ± 0.129
6.723ValArg: 6.723 ± 0.274
4.815ValSer: 4.815 ± 0.201
5.797ValThr: 5.797 ± 0.275
8.466ValVal: 8.466 ± 0.332
0.835ValTrp: 0.835 ± 0.1
1.468ValTyr: 1.468 ± 0.107
0.0ValXaa: 0.0 ± 0.0
Trp
1.202TrpAla: 1.202 ± 0.121
0.128TrpCys: 0.128 ± 0.032
0.578TrpAsp: 0.578 ± 0.074
0.615TrpGlu: 0.615 ± 0.085
0.605TrpPhe: 0.605 ± 0.07
0.761TrpGly: 0.761 ± 0.075
0.248TrpHis: 0.248 ± 0.053
0.449TrpIle: 0.449 ± 0.062
0.303TrpLys: 0.303 ± 0.06
1.688TrpLeu: 1.688 ± 0.138
0.229TrpMet: 0.229 ± 0.045
0.174TrpAsn: 0.174 ± 0.039
0.706TrpPro: 0.706 ± 0.081
0.523TrpGln: 0.523 ± 0.07
1.202TrpArg: 1.202 ± 0.111
0.816TrpSer: 0.816 ± 0.097
0.826TrpThr: 0.826 ± 0.076
0.972TrpVal: 0.972 ± 0.104
0.349TrpTrp: 0.349 ± 0.061
0.22TrpTyr: 0.22 ± 0.044
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.22TyrAla: 2.22 ± 0.143
0.183TyrCys: 0.183 ± 0.038
1.513TyrAsp: 1.513 ± 0.111
1.238TyrGlu: 1.238 ± 0.126
0.752TyrPhe: 0.752 ± 0.089
2.22TyrGly: 2.22 ± 0.168
0.385TyrHis: 0.385 ± 0.067
0.615TyrIle: 0.615 ± 0.09
0.504TyrLys: 0.504 ± 0.065
1.972TyrLeu: 1.972 ± 0.136
0.238TyrMet: 0.238 ± 0.05
0.394TyrAsn: 0.394 ± 0.061
1.082TyrPro: 1.082 ± 0.104
0.725TyrGln: 0.725 ± 0.086
2.009TyrArg: 2.009 ± 0.139
1.11TyrSer: 1.11 ± 0.106
1.036TyrThr: 1.036 ± 0.094
1.605TyrVal: 1.605 ± 0.13
0.303TyrTrp: 0.303 ± 0.054
0.422TyrTyr: 0.422 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 356 proteins (109024 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski