Amino acid dipepetide frequency for Halobaculum gomorrense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.842AlaAla: 17.842 ± 0.258	0.815AlaCys: 0.815 ± 0.034	11.966AlaAsp: 11.966 ± 0.147	9.569AlaGlu: 9.569 ± 0.139	4.317AlaPhe: 4.317 ± 0.068	12.182AlaGly: 12.182 ± 0.159	1.897AlaHis: 1.897 ± 0.048	4.051AlaIle: 4.051 ± 0.074	1.739AlaLys: 1.739 ± 0.051	11.454AlaLeu: 11.454 ± 0.159	2.162AlaMet: 2.162 ± 0.048	2.469AlaAsn: 2.469 ± 0.052	4.732AlaPro: 4.732 ± 0.09	1.964AlaGln: 1.964 ± 0.044	7.229AlaArg: 7.229 ± 0.099	5.848AlaSer: 5.848 ± 0.085	7.561AlaThr: 7.561 ± 0.104	13.058AlaVal: 13.058 ± 0.188	1.204AlaTrp: 1.204 ± 0.04	2.865AlaTyr: 2.865 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.663CysAla: 0.663 ± 0.029	0.079CysCys: 0.079 ± 0.009	0.604CysAsp: 0.604 ± 0.026	0.555CysGlu: 0.555 ± 0.025	0.191CysPhe: 0.191 ± 0.014	0.928CysGly: 0.928 ± 0.035	0.172CysHis: 0.172 ± 0.014	0.229CysIle: 0.229 ± 0.015	0.095CysLys: 0.095 ± 0.011	0.517CysLeu: 0.517 ± 0.023	0.107CysMet: 0.107 ± 0.012	0.165CysAsn: 0.165 ± 0.014	0.549CysPro: 0.549 ± 0.026	0.132CysGln: 0.132 ± 0.013	0.462CysArg: 0.462 ± 0.024	0.411CysSer: 0.411 ± 0.02	0.368CysThr: 0.368 ± 0.019	0.534CysVal: 0.534 ± 0.026	0.07CysTrp: 0.07 ± 0.008	0.146CysTyr: 0.146 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	12.917AspAla: 12.917 ± 0.184	0.605AspCys: 0.605 ± 0.025	8.579AspAsp: 8.579 ± 0.135	7.631AspGlu: 7.631 ± 0.118	1.891AspPhe: 1.891 ± 0.046	9.554AspGly: 9.554 ± 0.139	1.858AspHis: 1.858 ± 0.045	2.919AspIle: 2.919 ± 0.062	0.884AspLys: 0.884 ± 0.034	7.638AspLeu: 7.638 ± 0.098	1.22AspMet: 1.22 ± 0.036	1.132AspAsn: 1.132 ± 0.041	5.242AspPro: 5.242 ± 0.088	1.414AspGln: 1.414 ± 0.041	7.164AspArg: 7.164 ± 0.095	3.696AspSer: 3.696 ± 0.069	4.177AspThr: 4.177 ± 0.066	6.74AspVal: 6.74 ± 0.094	1.031AspTrp: 1.031 ± 0.034	1.722AspTyr: 1.722 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	9.486GluAla: 9.486 ± 0.122	0.548GluCys: 0.548 ± 0.027	4.905GluAsp: 4.905 ± 0.092	6.472GluGlu: 6.472 ± 0.13	2.93GluPhe: 2.93 ± 0.056	5.701GluGly: 5.701 ± 0.093	2.046GluHis: 2.046 ± 0.054	3.023GluIle: 3.023 ± 0.074	1.508GluLys: 1.508 ± 0.046	6.788GluLeu: 6.788 ± 0.104	1.668GluMet: 1.668 ± 0.048	1.778GluAsn: 1.778 ± 0.049	3.785GluPro: 3.785 ± 0.077	2.195GluGln: 2.195 ± 0.049	7.837GluArg: 7.837 ± 0.106	4.72GluSer: 4.72 ± 0.085	5.725GluThr: 5.725 ± 0.087	6.173GluVal: 6.173 ± 0.094	1.084GluTrp: 1.084 ± 0.041	2.456GluTyr: 2.456 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.988PheAla: 3.988 ± 0.067	0.272PheCys: 0.272 ± 0.017	3.252PheAsp: 3.252 ± 0.066	2.865PheGlu: 2.865 ± 0.062	0.948PhePhe: 0.948 ± 0.041	3.205PheGly: 3.205 ± 0.061	0.639PheHis: 0.639 ± 0.025	0.869PheIle: 0.869 ± 0.035	0.405PheLys: 0.405 ± 0.023	2.712PheLeu: 2.712 ± 0.066	0.467PheMet: 0.467 ± 0.021	0.597PheAsn: 0.597 ± 0.028	1.311PhePro: 1.311 ± 0.035	0.616PheGln: 0.616 ± 0.027	1.868PheArg: 1.868 ± 0.049	1.659PheSer: 1.659 ± 0.05	1.854PheThr: 1.854 ± 0.044	3.098PheVal: 3.098 ± 0.07	0.346PheTrp: 0.346 ± 0.022	0.78PheTyr: 0.78 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.281GlyAla: 10.281 ± 0.148	0.703GlyCys: 0.703 ± 0.029	8.72GlyAsp: 8.72 ± 0.123	7.342GlyGlu: 7.342 ± 0.097	3.189GlyPhe: 3.189 ± 0.067	9.13GlyGly: 9.13 ± 0.134	1.737GlyHis: 1.737 ± 0.051	3.598GlyIle: 3.598 ± 0.077	1.663GlyLys: 1.663 ± 0.044	7.353GlyLeu: 7.353 ± 0.106	1.673GlyMet: 1.673 ± 0.047	1.825GlyAsn: 1.825 ± 0.05	3.677GlyPro: 3.677 ± 0.07	1.808GlyGln: 1.808 ± 0.05	5.529GlyArg: 5.529 ± 0.092	5.245GlySer: 5.245 ± 0.081	6.008GlyThr: 6.008 ± 0.084	9.102GlyVal: 9.102 ± 0.119	1.162GlyTrp: 1.162 ± 0.043	2.641GlyTyr: 2.641 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.178HisAla: 2.178 ± 0.052	0.183HisCys: 0.183 ± 0.015	1.804HisAsp: 1.804 ± 0.052	1.684HisGlu: 1.684 ± 0.044	0.517HisPhe: 0.517 ± 0.026	2.016HisGly: 2.016 ± 0.049	0.503HisHis: 0.503 ± 0.028	0.556HisIle: 0.556 ± 0.025	0.283HisLys: 0.283 ± 0.018	1.653HisLeu: 1.653 ± 0.051	0.251HisMet: 0.251 ± 0.017	0.429HisAsn: 0.429 ± 0.025	1.226HisPro: 1.226 ± 0.03	0.347HisGln: 0.347 ± 0.02	1.27HisArg: 1.27 ± 0.038	0.84HisSer: 0.84 ± 0.033	1.04HisThr: 1.04 ± 0.04	1.867HisVal: 1.867 ± 0.049	0.229HisTrp: 0.229 ± 0.019	0.5HisTyr: 0.5 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	4.499IleAla: 4.499 ± 0.071	0.25IleCys: 0.25 ± 0.015	3.584IleAsp: 3.584 ± 0.07	3.404IleGlu: 3.404 ± 0.068	0.671IlePhe: 0.671 ± 0.03	3.414IleGly: 3.414 ± 0.061	0.704IleHis: 0.704 ± 0.029	0.863IleIle: 0.863 ± 0.037	0.592IleLys: 0.592 ± 0.028	2.191IleLeu: 2.191 ± 0.063	0.402IleMet: 0.402 ± 0.02	0.801IleAsn: 0.801 ± 0.032	1.81IlePro: 1.81 ± 0.048	0.779IleGln: 0.779 ± 0.031	2.339IleArg: 2.339 ± 0.055	1.641IleSer: 1.641 ± 0.043	1.982IleThr: 1.982 ± 0.051	3.171IleVal: 3.171 ± 0.068	0.233IleTrp: 0.233 ± 0.014	0.678IleTyr: 0.678 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	1.684LysAla: 1.684 ± 0.047	0.101LysCys: 0.101 ± 0.01	0.892LysAsp: 0.892 ± 0.038	1.132LysGlu: 1.132 ± 0.041	0.483LysPhe: 0.483 ± 0.023	1.248LysGly: 1.248 ± 0.039	0.41LysHis: 0.41 ± 0.02	0.571LysIle: 0.571 ± 0.025	0.451LysLys: 0.451 ± 0.026	1.551LysLeu: 1.551 ± 0.037	0.316LysMet: 0.316 ± 0.018	0.443LysAsn: 0.443 ± 0.022	0.917LysPro: 0.917 ± 0.035	0.673LysGln: 0.673 ± 0.028	1.625LysArg: 1.625 ± 0.046	0.93LysSer: 0.93 ± 0.035	1.187LysThr: 1.187 ± 0.039	1.066LysVal: 1.066 ± 0.04	0.173LysTrp: 0.173 ± 0.015	0.514LysTyr: 0.514 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.214LeuAla: 12.214 ± 0.15	0.562LeuCys: 0.562 ± 0.025	7.716LeuAsp: 7.716 ± 0.112	5.444LeuGlu: 5.444 ± 0.09	2.926LeuPhe: 2.926 ± 0.057	7.84LeuGly: 7.84 ± 0.118	1.462LeuHis: 1.462 ± 0.044	2.615LeuIle: 2.615 ± 0.058	1.441LeuLys: 1.441 ± 0.045	8.092LeuLeu: 8.092 ± 0.125	1.189LeuMet: 1.189 ± 0.041	1.701LeuAsn: 1.701 ± 0.046	4.239LeuPro: 4.239 ± 0.084	1.721LeuGln: 1.721 ± 0.048	6.002LeuArg: 6.002 ± 0.08	5.398LeuSer: 5.398 ± 0.087	5.003LeuThr: 5.003 ± 0.066	8.368LeuVal: 8.368 ± 0.124	0.82LeuTrp: 0.82 ± 0.034	1.963LeuTyr: 1.963 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	1.773MetAla: 1.773 ± 0.049	0.105MetCys: 0.105 ± 0.011	1.221MetAsp: 1.221 ± 0.038	1.047MetGlu: 1.047 ± 0.032	0.458MetPhe: 0.458 ± 0.025	1.353MetGly: 1.353 ± 0.037	0.332MetHis: 0.332 ± 0.021	0.536MetIle: 0.536 ± 0.029	0.399MetLys: 0.399 ± 0.023	1.455MetLeu: 1.455 ± 0.039	0.274MetMet: 0.274 ± 0.018	0.579MetAsn: 0.579 ± 0.024	0.79MetPro: 0.79 ± 0.03	0.431MetGln: 0.431 ± 0.026	1.173MetArg: 1.173 ± 0.034	1.551MetSer: 1.551 ± 0.04	1.476MetThr: 1.476 ± 0.042	1.105MetVal: 1.105 ± 0.037	0.148MetTrp: 0.148 ± 0.013	0.377MetTyr: 0.377 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.582AsnAla: 2.582 ± 0.053	0.199AsnCys: 0.199 ± 0.015	1.59AsnAsp: 1.59 ± 0.042	1.473AsnGlu: 1.473 ± 0.049	0.587AsnPhe: 0.587 ± 0.025	1.952AsnGly: 1.952 ± 0.049	0.433AsnHis: 0.433 ± 0.022	0.707AsnIle: 0.707 ± 0.034	0.399AsnLys: 0.399 ± 0.023	1.693AsnLeu: 1.693 ± 0.049	0.365AsnMet: 0.365 ± 0.02	0.49AsnAsn: 0.49 ± 0.027	1.438AsnPro: 1.438 ± 0.04	0.488AsnGln: 0.488 ± 0.02	1.473AsnArg: 1.473 ± 0.037	0.891AsnSer: 0.891 ± 0.032	1.202AsnThr: 1.202 ± 0.04	2.061AsnVal: 2.061 ± 0.049	0.278AsnTrp: 0.278 ± 0.02	0.592AsnTyr: 0.592 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	5.639ProAla: 5.639 ± 0.085	0.252ProCys: 0.252 ± 0.014	4.92ProAsp: 4.92 ± 0.081	4.676ProGlu: 4.676 ± 0.079	1.588ProPhe: 1.588 ± 0.038	4.205ProGly: 4.205 ± 0.079	0.912ProHis: 0.912 ± 0.034	1.571ProIle: 1.571 ± 0.044	0.792ProLys: 0.792 ± 0.029	3.748ProLeu: 3.748 ± 0.066	0.854ProMet: 0.854 ± 0.031	1.074ProAsn: 1.074 ± 0.038	2.278ProPro: 2.278 ± 0.057	0.883ProGln: 0.883 ± 0.031	2.426ProArg: 2.426 ± 0.053	2.625ProSer: 2.625 ± 0.05	3.247ProThr: 3.247 ± 0.075	4.46ProVal: 4.46 ± 0.075	0.497ProTrp: 0.497 ± 0.023	1.127ProTyr: 1.127 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.223GlnAla: 2.223 ± 0.045	0.134GlnCys: 0.134 ± 0.012	0.997GlnAsp: 0.997 ± 0.036	1.373GlnGlu: 1.373 ± 0.047	0.884GlnPhe: 0.884 ± 0.03	1.434GlnGly: 1.434 ± 0.04	0.438GlnHis: 0.438 ± 0.021	0.966GlnIle: 0.966 ± 0.038	0.462GlnLys: 0.462 ± 0.026	1.883GlnLeu: 1.883 ± 0.05	0.392GlnMet: 0.392 ± 0.023	0.585GlnAsn: 0.585 ± 0.023	0.921GlnPro: 0.921 ± 0.029	0.802GlnGln: 0.802 ± 0.036	1.78GlnArg: 1.78 ± 0.051	1.241GlnSer: 1.241 ± 0.032	1.364GlnThr: 1.364 ± 0.044	1.623GlnVal: 1.623 ± 0.041	0.314GlnTrp: 0.314 ± 0.019	0.673GlnTyr: 0.673 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.666ArgAla: 7.666 ± 0.109	0.488ArgCys: 0.488 ± 0.022	5.603ArgAsp: 5.603 ± 0.08	7.19ArgGlu: 7.19 ± 0.101	2.393ArgPhe: 2.393 ± 0.055	5.135ArgGly: 5.135 ± 0.085	1.231ArgHis: 1.231 ± 0.036	2.758ArgIle: 2.758 ± 0.053	1.244ArgLys: 1.244 ± 0.039	6.275ArgLeu: 6.275 ± 0.093	1.429ArgMet: 1.429 ± 0.043	1.439ArgAsn: 1.439 ± 0.043	2.828ArgPro: 2.828 ± 0.058	1.473ArgGln: 1.473 ± 0.049	5.457ArgArg: 5.457 ± 0.094	3.579ArgSer: 3.579 ± 0.062	4.107ArgThr: 4.107 ± 0.061	6.386ArgVal: 6.386 ± 0.101	0.783ArgTrp: 0.783 ± 0.034	1.946ArgTyr: 1.946 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	5.941SerAla: 5.941 ± 0.075	0.289SerCys: 0.289 ± 0.02	4.479SerAsp: 4.479 ± 0.075	3.861SerGlu: 3.861 ± 0.072	1.796SerPhe: 1.796 ± 0.044	5.436SerGly: 5.436 ± 0.086	0.935SerHis: 0.935 ± 0.034	1.908SerIle: 1.908 ± 0.04	1.042SerLys: 1.042 ± 0.035	4.664SerLeu: 4.664 ± 0.071	0.999SerMet: 0.999 ± 0.036	1.141SerAsn: 1.141 ± 0.037	2.582SerPro: 2.582 ± 0.057	1.103SerGln: 1.103 ± 0.036	3.147SerArg: 3.147 ± 0.061	2.678SerSer: 2.678 ± 0.07	3.458SerThr: 3.458 ± 0.066	5.014SerVal: 5.014 ± 0.081	0.573SerTrp: 0.573 ± 0.026	1.265SerTyr: 1.265 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	7.434ThrAla: 7.434 ± 0.095	0.344ThrCys: 0.344 ± 0.022	5.743ThrAsp: 5.743 ± 0.074	4.391ThrGlu: 4.391 ± 0.072	1.954ThrPhe: 1.954 ± 0.044	5.985ThrGly: 5.985 ± 0.085	1.142ThrHis: 1.142 ± 0.036	2.158ThrIle: 2.158 ± 0.05	0.921ThrLys: 0.921 ± 0.034	5.808ThrLeu: 5.808 ± 0.09	0.96ThrMet: 0.96 ± 0.028	1.358ThrAsn: 1.358 ± 0.044	3.324ThrPro: 3.324 ± 0.073	1.112ThrGln: 1.112 ± 0.04	3.475ThrArg: 3.475 ± 0.059	2.561ThrSer: 2.561 ± 0.06	3.839ThrThr: 3.839 ± 0.073	7.042ThrVal: 7.042 ± 0.091	0.614ThrTrp: 0.614 ± 0.026	1.602ThrTyr: 1.602 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	12.031ValAla: 12.031 ± 0.181	0.74ValCys: 0.74 ± 0.027	8.255ValAsp: 8.255 ± 0.108	7.707ValGlu: 7.707 ± 0.097	2.91ValPhe: 2.91 ± 0.053	8.499ValGly: 8.499 ± 0.118	1.708ValHis: 1.708 ± 0.044	3.125ValIle: 3.125 ± 0.068	1.419ValLys: 1.419 ± 0.04	7.777ValLeu: 7.777 ± 0.108	1.284ValMet: 1.284 ± 0.038	2.009ValAsn: 2.009 ± 0.047	4.497ValPro: 4.497 ± 0.071	1.627ValGln: 1.627 ± 0.044	6.307ValArg: 6.307 ± 0.106	5.124ValSer: 5.124 ± 0.081	6.101ValThr: 6.101 ± 0.099	9.456ValVal: 9.456 ± 0.131	0.816ValTrp: 0.816 ± 0.032	2.107ValTyr: 2.107 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.048TrpAla: 1.048 ± 0.034	0.088TrpCys: 0.088 ± 0.01	0.73TrpAsp: 0.73 ± 0.029	0.805TrpGlu: 0.805 ± 0.034	0.378TrpPhe: 0.378 ± 0.023	0.877TrpGly: 0.877 ± 0.027	0.226TrpHis: 0.226 ± 0.016	0.403TrpIle: 0.403 ± 0.024	0.218TrpLys: 0.218 ± 0.015	1.123TrpLeu: 1.123 ± 0.044	0.209TrpMet: 0.209 ± 0.016	0.337TrpAsn: 0.337 ± 0.022	0.431TrpPro: 0.431 ± 0.023	0.286TrpGln: 0.286 ± 0.017	0.936TrpArg: 0.936 ± 0.031	0.577TrpSer: 0.577 ± 0.028	0.753TrpThr: 0.753 ± 0.029	0.886TrpVal: 0.886 ± 0.035	0.181TrpTrp: 0.181 ± 0.014	0.367TrpTyr: 0.367 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.836TyrAla: 2.836 ± 0.057	0.219TyrCys: 0.219 ± 0.015	2.457TyrAsp: 2.457 ± 0.054	2.208TyrGlu: 2.208 ± 0.054	0.742TyrPhe: 0.742 ± 0.032	2.291TyrGly: 2.291 ± 0.047	0.587TyrHis: 0.587 ± 0.023	0.581TyrIle: 0.581 ± 0.027	0.41TyrLys: 0.41 ± 0.022	2.341TyrLeu: 2.341 ± 0.056	0.36TyrMet: 0.36 ± 0.018	0.54TyrAsn: 0.54 ± 0.023	1.197TyrPro: 1.197 ± 0.035	0.637TyrGln: 0.637 ± 0.026	1.912TyrArg: 1.912 ± 0.048	1.099TyrSer: 1.099 ± 0.034	1.313TyrThr: 1.313 ± 0.04	2.288TyrVal: 2.288 ± 0.044	0.302TyrTrp: 0.302 ± 0.018	0.742TyrTyr: 0.742 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3149 proteins (922802 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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